Research and Design of Respiratory Impedance Measurement System Based on Forced Oscillation Technique_Journal of Biomedical Engineering

Authors：

ZHANGNan ¹ , LIUXiaoli ² , ZHOUJuan ¹ , LIANGHong ¹ ,  ZHANGZhengbo ¹ , CAODesen ¹ , WANGWeidong ¹

1. The Medical Engineering&Maitenance Center, Chinese PLA General Hospital, Beijing 100853, China;
2. School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;

Corresponding author：

ZHANGZhengbo, Email: zhengbozhang@126.com

Keywords：

forced oscillation technique; respiratory impedance; system identification; pressure

DOI：

10.7507/1001-5515.20160177

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Abstract Full text Figures/Tables Video References Cited by

Forced oscillation technique (FOT) is an active method to test pulmonary function, which can derive the mechanical characteristics of the respiratory system with liner system identification theory by pushing in an oscillation air signal and measuring the changes of output pressure and flow. A pulmonary function determination system was developed based on the FOT in this paper. Several critical technologies of this determination system were analyzed, including the selection criteria of oscillation air generator, pressure and flow sensor, the signal design of oscillation air generator, and the synchronous sampling of pressure and flow data. A software program on LabVIEW platform was set up to control the determination system and get the measuring data. The performance of sensors and oscillation air generator was verified. According to the frequency response curve of the pressure, the amplitude of driving signal to the oscillation air generator was corrected at the frequency range between 4~40 Hz. A simulation experiment was carried out to measure the respiratory impedance of the active model lung ASL5000 and the results were close to the setting values of the model lung. The experiment testified that the pulmonary function determination system based on FOT had performance good enough to provide a tool for the in-depth research of the mechanical properties of the respiratory system.

Citation： ZHANGNan, LIUXiaoli, ZHOUJuan, LIANGHong, ZHANGZhengbo, CAODesen, WANGWeidong. Research and Design of Respiratory Impedance Measurement System Based on Forced Oscillation Technique. Journal of Biomedical Engineering, 2016, 33(6): 1110-1115. doi: 10.7507/1001-5515.20160177 Copy

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9.	HELLINCKX J, CAUBERGHS M, DE BOECK K, et al. Evaluation of impulse oscillation system: comparison with forced oscillation technique and body plethysmography[J]. Eur Respir J, 2001, 18(3): 564-570.
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11.	SHIRAI T, MORI K, MIKAMO M, et al. Usefulness of colored 3D imaging of respiratory impedance in asthma[J]. Allergy Asthma Immunol Res, 2013, 5(5): 322-328.
12.	MIKAMO M, SHIRAI T, MORI K, et al. Predictors of expiratory flow limitation measured by forced oscillation technique in COPD [J]. BMC Pulm Med, 2014, 14: 23.
13.	王华, 陈荣昌,何晟,等.无创通气下应用强迫振荡技术检测呼吸阻力[J].中华生物医学工程杂志,2008,14(5):358-363.
14.	谢敏崇, 卢毅荣,王华,等.新型阻抗式呼吸信号分析仪的实验研究和临床评价[J].中华生物医学工程杂志,2014,20(4):302-308.
15.	DELLACÀ R L, DUFFY N, POMPILIO P P, et al. Expiratory flow limitation detected by forced oscillation and negative expiratory pressure [J]. Eur Respir J, 2007, 29(2): 363-374.
16.	LIMA A N, FARIA A C, LOPES A J, et al. Forced oscillations and respiratory system modeling in adults with cystic fibrosis[J]. Biomed Eng Online, 2015, 14: 11.
17.	ROTGER M, PESLIN R, NAVAJAS D, et al. Density dependence of respiratory input impedance re-evaluated with a head generator minimizing upper airway shunt[J]. Eur Respir J, 1988, 1(5): 439-444.
18.	SMITH H J, REINHOLD P, GOLDMAN M D. Forced oscillation technique and impulse oscillometry[J]. Paediatr Respir Rev, 2005, 7(Suppl 1): S8-S10.

1. 魏复盛, 胡伟,吴国平,等.空气污染与儿童肺功能指标的相关分析[J].中国环境科学,2001,21(5):385-389.
2. 鲍俊. 慢性阻塞性肺疾病诊断情况与危险因素调查[D].合肥:安徽医科大学,2010.
3. BEYDON L, MALASSINÉ P, LORINO A M, et al. Respiratory resistance by end-inspiratory occlusion and forced oscillations in intubated patients [J]. J Appl Physiol (1985), 1996, 80(4): 1105-1111.
4. WILLIM G, TOMALAK W, STANKIEWICK J, et al. Forced oscillations technique in evaluating state of the respiratory system in children with chronic lung diseases[J]. Eur Respir J, 1997, 10: 328S.
5. DE MELO P L, WERNECK M M, GIANNELLA-NETO A. Effect of generator nonlinearities on the accuracy of respiratory impedance measurements by forced oscillation[J]. Med Biol Eng Comput, 2000, 38(1): 102-108.
6. DUBOIS A B, BRODY A W, LEWIS D H, et al. Oscillation mechanics of lungs and chest in man[J]. J Appl Physiol, 1956, 8(6): 587-594.
7. 张政波, 倪路,刘晓莉,等.振荡肺功能原理及技术实现[J].中国医疗器械杂志,2015,39(6):432-436.
8. BIRCH M, MACLEOD D, LEVINE M. An analogue instrument for the measurement of respiratory impedance using the forced oscillation technique[J]. Physiol Meas, 2001, 22(2): 323-339.
9. HELLINCKX J, CAUBERGHS M, DE BOECK K, et al. Evaluation of impulse oscillation system: comparison with forced oscillation technique and body plethysmography[J]. Eur Respir J, 2001, 18(3): 564-570.
10. OOSTVEEN E, MACLEOD D, LORINO H, et al. The forced oscillation technique in clinical practice: methodology, recommendations and future developments[J]. Eur Respir J, 2003, 22(6): 1026-1041.
11. SHIRAI T, MORI K, MIKAMO M, et al. Usefulness of colored 3D imaging of respiratory impedance in asthma[J]. Allergy Asthma Immunol Res, 2013, 5(5): 322-328.
12. MIKAMO M, SHIRAI T, MORI K, et al. Predictors of expiratory flow limitation measured by forced oscillation technique in COPD [J]. BMC Pulm Med, 2014, 14: 23.
13. 王华, 陈荣昌,何晟,等.无创通气下应用强迫振荡技术检测呼吸阻力[J].中华生物医学工程杂志,2008,14(5):358-363.
14. 谢敏崇, 卢毅荣,王华,等.新型阻抗式呼吸信号分析仪的实验研究和临床评价[J].中华生物医学工程杂志,2014,20(4):302-308.
15. DELLACÀ R L, DUFFY N, POMPILIO P P, et al. Expiratory flow limitation detected by forced oscillation and negative expiratory pressure [J]. Eur Respir J, 2007, 29(2): 363-374.
16. LIMA A N, FARIA A C, LOPES A J, et al. Forced oscillations and respiratory system modeling in adults with cystic fibrosis[J]. Biomed Eng Online, 2015, 14: 11.
17. ROTGER M, PESLIN R, NAVAJAS D, et al. Density dependence of respiratory input impedance re-evaluated with a head generator minimizing upper airway shunt[J]. Eur Respir J, 1988, 1(5): 439-444.
18. SMITH H J, REINHOLD P, GOLDMAN M D. Forced oscillation technique and impulse oscillometry[J]. Paediatr Respir Rev, 2005, 7(Suppl 1): S8-S10.

Journal of Biomedical Engineering

Research and Design of Respiratory Impedance Measurement System Based on Forced Oscillation Technique

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