Research progress on the technique and materials for three-dimensional bio-printing_Journal of Biomedical Engineering

Authors：

YANG Runhuai ,  CHEN Yueming , MA Changwang , WANG Huiqin , WANG Shuyue

Department of Bio-Medical Engineering, School of Life Science, Anhui Medical University, Hefei 230000, P.R.China;

Corresponding author：

CHEN Yueming, Email: ahchen123@foxmail.com

Keywords：

three-dimensional bio-printing; biomaterials; biocompatibility

DOI：

10.7507/1001-5515.201604026

Video：

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Abstract Full text Figures/Tables Video References Cited by

Three-dimensional (3D) bio-printing is a novel engineering technique by which the cells and support materials can be manufactured to a complex 3D structure. Compared with other 3D printing methods, 3D bio-printing should pay more attention to the biocompatible environment of the printing methods and the materials. Aimed at studying the feature of the 3D bio-printing, this paper mainly focuses on the current research state of 3D bio-printing, with the techniques and materials of the bio-printing especially emphasized. To introduce current printing methods, the inkjet method, extrusion method, stereolithography skill and laser-assisted technique are described. The printing precision, process, requirements and influence of all the techniques on cell status are compared. For introduction of the printing materials, the cross-link, biocompatibility and applications of common bio-printing materials are reviewed and compared. Most of the 3D bio-printing studies are being remained at the experimental stage up to now, so the review of 3D bio-printing could improve this technique for practical use, and it could also contribute to the further development of 3D bio-printing.

Citation： YANG Runhuai, CHEN Yueming, MA Changwang, WANG Huiqin, WANG Shuyue. Research progress on the technique and materials for three-dimensional bio-printing. Journal of Biomedical Engineering, 2017, 34(2): 320-324. doi: 10.7507/1001-5515.201604026 Copy

1.	张海荣, 鱼泳. 3D 打印技术在医学领域的应用. 医疗卫生装备, 2015, 36(3): 118-120.
2.	Gu Qi, Hao Jie, Lu Yangjie, et al. Three-dimensional bio-printing. Sci China Life Sci, 2015, 58(5): 411-419.
3.	Chua C K, Yeong W Y. Bioprinting: principles and applications. Singapore: World Scientific Publishing Co, 2015: 1-304.
4.	Iwanaga S, Arai K, Nakamura M. Inkjet bioprinting. In: Essentials of 3D Biofabrication and Translation[M]., 2015: 61-79.
5.	Saunders R E, Derby B. Inkjet printing biomaterials for tissue engineering: bioprinting. International Materials Reviews, 2014, 59(8): 430-448.
6.	Christensen K, Xu Changxue, Chai Wenxuan, et al. Freeform inkjet printing of cellular structures with bifurcations. Biotechnol Bioeng, 2015, 112(5): 1047-1055.
7.	Dababneh A B, Ozbolat I T. Bioprinting technology: a current State-of-the-Art review. Journal of Manufacturing Science and Engineering-Transactions of the ASME, 2014, 136(6, SI): 1016-1028.
8.	Kolesky D B, Truby R L, Gladman A S, et al. 3D bioprinting of vascularized, heterogeneous Cell-Laden tissue constructs. Advanced Materials, 2014, 26(19): 3124-3130.
9.	Ozbolat I T, Chen H, Yu Y. Development of"multi-arm bioprinter"for hybrid biofabrication of tissue engineering constructs. Robot Comput Integr Manuf, 2014, 30(3): 295-304.
10.	Billiet T, Gevaert E, De Schryver T, et al. The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability. Biomaterials, 2014, 35(1): 49-62.
11.	Markstedt K, Mantas A, Tournier I, et al. 3D bioprinting human chondrocytes with Nanocellulose-Alginate bioink for cartilage tissue engineering applications. Biomacromolecules, 2015, 16(5): 1489-1496.
12.	Gross B C, Erkal J L, Lockwood S Y, et al. Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. Anal Chem, 2014, 86(7): 3240-3253.
13.	Hong S, Sycks D, Chan H F, et al. 3D printing of highly stretchable and tough hydrogels into complex, cellularized structures. Adv Mater, 2015, 27(27): 4035-4040.
14.	Lee H, Fang N X. Micro 3D printing using a digital projector and its application in the study of soft materials mechanics. J Vis Exp, 2012, 69(69): e4457.
15.	Wang Zongjie, Abdulla R, Parker B, et al. A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks. Biofabrication, 2015, 7(4): 045009.
16.	Devillard R, Pagès E, Correa M M, et al. Cell patterning by laser-assisted bioprinting. Methods Cell Biol, 2014, 119: 159-174.
17.	Guillotin B, Catros S, Keriquel V, et al. Rapid prototyping of complex tissues with laser assisted bioprinting(Lab). Rapid Prototyping of Biomaterials, 2014, 1: 156-175.
18.	Guillotin B, Souquet A, Catros S, et al. Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials, 2010, 31(28): 7250-7256.
19.	Skardal A, Atala A. Biomaterials for integration with 3-D bioprinting. Ann Biomed Eng, 2015, 43(3): 730-746.
20.	Min L J, Edgar K, Zhang Z, et al. Biomaterials for bioprinting in: 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine. 2015: 129-148.
21.	Kanda N, Morimoto N, Ayvazyan A A, et al. Evaluation of a novel collagen-gelatin scaffold for achieving the sustained release of basic fibroblast growth factor in a diabetic mouse model. J Tissue Eng Regen Med, 2014, 8(1): 29-40.
22.	Hribar K C, Soman P, Warner J, et al. Light-assisted direct-write of 3D functional biomaterials. Lab Chip, 2014, 14(2): 268-275.
23.	Gao Guifang, Yonezawa T, Hubbell K, et al. Inkjet-bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging. Biotechnol J, 2015, 10(10): 1568-1577.
24.	Spiller K L, Maher S A, Lowman A M. Hydrogels for the repair of articular cartilage defects. Tissue Eng Part B Rev, 2011, 17(4): 281-299.
25.	Wüst S, Godla M E, Müller R, et al. Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting. Acta Biomater, 2014, 10(2): 630-640.
26.	Gasperini L, Maniglio D, Motta A, et al. An electrohydrodynamic bioprinter for alginate hydrogels containing living cells. Tissue Eng Part C Methods, 2015, 21(2): 123-132.
27.	Jia Jia, Richards D J, Pollard S, et al. Engineering alginate as bioink for bioprinting. Acta Biomater, 2014, 10(10): 4323-4331.
28.	Murphy S V, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol, 2014, 32(8): 773-785.
29.	Cvetkovic C, Raman R, Chan V, et al. Three-dimensionally printed biological machines powered by skeletal muscle. Proc Natl Acad Sci U S A, 2014, 111(28): 10125-10130.

1. 张海荣, 鱼泳. 3D 打印技术在医学领域的应用. 医疗卫生装备, 2015, 36(3): 118-120.
2. Gu Qi, Hao Jie, Lu Yangjie, et al. Three-dimensional bio-printing. Sci China Life Sci, 2015, 58(5): 411-419.
3. Chua C K, Yeong W Y. Bioprinting: principles and applications. Singapore: World Scientific Publishing Co, 2015: 1-304.
4. Iwanaga S, Arai K, Nakamura M. Inkjet bioprinting. In: Essentials of 3D Biofabrication and Translation[M]., 2015: 61-79.
5. Saunders R E, Derby B. Inkjet printing biomaterials for tissue engineering: bioprinting. International Materials Reviews, 2014, 59(8): 430-448.
6. Christensen K, Xu Changxue, Chai Wenxuan, et al. Freeform inkjet printing of cellular structures with bifurcations. Biotechnol Bioeng, 2015, 112(5): 1047-1055.
7. Dababneh A B, Ozbolat I T. Bioprinting technology: a current State-of-the-Art review. Journal of Manufacturing Science and Engineering-Transactions of the ASME, 2014, 136(6, SI): 1016-1028.
8. Kolesky D B, Truby R L, Gladman A S, et al. 3D bioprinting of vascularized, heterogeneous Cell-Laden tissue constructs. Advanced Materials, 2014, 26(19): 3124-3130.
9. Ozbolat I T, Chen H, Yu Y. Development of"multi-arm bioprinter"for hybrid biofabrication of tissue engineering constructs. Robot Comput Integr Manuf, 2014, 30(3): 295-304.
10. Billiet T, Gevaert E, De Schryver T, et al. The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability. Biomaterials, 2014, 35(1): 49-62.
11. Markstedt K, Mantas A, Tournier I, et al. 3D bioprinting human chondrocytes with Nanocellulose-Alginate bioink for cartilage tissue engineering applications. Biomacromolecules, 2015, 16(5): 1489-1496.
12. Gross B C, Erkal J L, Lockwood S Y, et al. Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. Anal Chem, 2014, 86(7): 3240-3253.
13. Hong S, Sycks D, Chan H F, et al. 3D printing of highly stretchable and tough hydrogels into complex, cellularized structures. Adv Mater, 2015, 27(27): 4035-4040.
14. Lee H, Fang N X. Micro 3D printing using a digital projector and its application in the study of soft materials mechanics. J Vis Exp, 2012, 69(69): e4457.
15. Wang Zongjie, Abdulla R, Parker B, et al. A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks. Biofabrication, 2015, 7(4): 045009.
16. Devillard R, Pagès E, Correa M M, et al. Cell patterning by laser-assisted bioprinting. Methods Cell Biol, 2014, 119: 159-174.
17. Guillotin B, Catros S, Keriquel V, et al. Rapid prototyping of complex tissues with laser assisted bioprinting(Lab). Rapid Prototyping of Biomaterials, 2014, 1: 156-175.
18. Guillotin B, Souquet A, Catros S, et al. Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials, 2010, 31(28): 7250-7256.
19. Skardal A, Atala A. Biomaterials for integration with 3-D bioprinting. Ann Biomed Eng, 2015, 43(3): 730-746.
20. Min L J, Edgar K, Zhang Z, et al. Biomaterials for bioprinting in: 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine. 2015: 129-148.
21. Kanda N, Morimoto N, Ayvazyan A A, et al. Evaluation of a novel collagen-gelatin scaffold for achieving the sustained release of basic fibroblast growth factor in a diabetic mouse model. J Tissue Eng Regen Med, 2014, 8(1): 29-40.
22. Hribar K C, Soman P, Warner J, et al. Light-assisted direct-write of 3D functional biomaterials. Lab Chip, 2014, 14(2): 268-275.
23. Gao Guifang, Yonezawa T, Hubbell K, et al. Inkjet-bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging. Biotechnol J, 2015, 10(10): 1568-1577.
24. Spiller K L, Maher S A, Lowman A M. Hydrogels for the repair of articular cartilage defects. Tissue Eng Part B Rev, 2011, 17(4): 281-299.
25. Wüst S, Godla M E, Müller R, et al. Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting. Acta Biomater, 2014, 10(2): 630-640.
26. Gasperini L, Maniglio D, Motta A, et al. An electrohydrodynamic bioprinter for alginate hydrogels containing living cells. Tissue Eng Part C Methods, 2015, 21(2): 123-132.
27. Jia Jia, Richards D J, Pollard S, et al. Engineering alginate as bioink for bioprinting. Acta Biomater, 2014, 10(10): 4323-4331.
28. Murphy S V, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol, 2014, 32(8): 773-785.
29. Cvetkovic C, Raman R, Chan V, et al. Three-dimensionally printed biological machines powered by skeletal muscle. Proc Natl Acad Sci U S A, 2014, 111(28): 10125-10130.

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