Research on the rest functional magnetic resonance imaging before and after smoking cessation_Journal of Biomedical Engineering

Authors：

MO Shaofeng ¹ , FENG Sihao ¹ ,  CHEN Hongbo ²

1. Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, P.R.China;
2. School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi 541004, P.R.China;

Corresponding author：

CHEN Hongbo, Email: hongbochen@163.com

Keywords：

resting state; functional magnetic resonance imaging; smoking cessation; regional homogeneity

DOI：

10.7507/1001-5515.201609026

Video：

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The aim of this paper is to reveal the change of the brain function for nicotine addicts after smoking cessation, and explore the basis of neural physiology for the nicotine addicts in the process of smoking cessation. Fourteen subjects, who have a strong dependence on nicotine, have agreed to give up smoking and insist on completing the test, and 11 volunteers were recruited as the controls. The resting state functional magnetic resonance imaging and the regional homogeneity (ReHo) algorithm have been used to study the neural activity before and after smoking cessation. A two factors mixed design was used to investigate within-group effects and between-group effects. After 2 weeks’ smoking cessation, the increased ReHo value were exhibited in the brain area of supplementary motor area, paracentral lobule, calcarine, cuneus and lingual gyrus. It suggested that the synchronization of neural activity was enhanced in these brain areas. And between-group interaction effects were appeared in supplementary motor area, paracentral lobule, precentral gyrus, postcentral gyrus, and superior frontal gyrus. The results indicate that the brain function in supplementary motor area of smoking addicts would be enhanced significantly after 2 weeks’ smoking cessation.

Citation： MO Shaofeng, FENG Sihao, CHEN Hongbo. Research on the rest functional magnetic resonance imaging before and after smoking cessation. Journal of Biomedical Engineering, 2018, 35(1): 87-91. doi: 10.7507/1001-5515.201609026 Copy

1.	Jamal A, Homa D M, O'connor E, et al. Current cigarette smoking among adults—United States, 2005–2014. MMWR Morb Mortal Wkly Rep, 2015, 64(44): 1233-1240.
2.	朱卫华, 岳晓军, 蓝芬, 等. 住院吸烟患者的戒烟干预效果评价. 实用心脑肺血管病杂志, 2013, 21(5): 21-23.
3.	Kanteti R, Dhanasingh I, El-Hashani E, et al. C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype. Cancer Biol Ther, 2016, 17(1): 91-103.
4.	Zanchi D, Brody A L, Montandon M L, et al. Cigarette smoking leads to persistent and dose-dependent alterations of brain activity and connectivity in anterior insula and anterior cingulate. Addict Biol, 2015, 20(6): 1033-1041.
5.	Gertz H, Hilger M, Hegele M, et al. Violating instructed human agency: An fMRI study on ocular tracking of biological and nonbiological motion stimuli. Neuroimage, 2016, 138: 109-122.
6.	Yee J R, Kenkel W M, Kulkarni P, et al. BOLD fMRI in awake prairie voles: A platform for translational social and affective neuroscience. Neuroimage, 2016, 138: 221-232.
7.	Kirk U, Gu Xiaosi, Sharp C, et al. Mindfulness training increases cooperative decision making in economic exchanges: Evidence from fMRI. Neuroimage, 2016, 138: 274-283.
8.	Chen Hongbo, Wang Liya, King T Z, et al. Increased frontal functional networks in adult survivors of childhood brain tumors. Neuroimage Clin, 2016, 11: 339-346.
9.	Siemann J, Herrmann M, Galashan D. fMRI-constrained source analysis reveals early top-down modulations of interference processing using a flanker task. Neuroimage, 2016, 136: 45-56.
10.	Addicott M A, Sweitzer M M, Froeliger B, et al. Increased functional connectivity in an insula-based network is associated with improved smoking cessation outcomes. Neuropsychopharmacology, 2015, 40(11): 2648-2656.
11.	Hawkshead B, Liebel S, Schwarz N, et al. Working memory and fMRI correlates of smoking cessation treatment outcome. Arch Clin Neuropsychol, 2014, 29(6): 577.
12.	Versace F, Engelmann J M, Robinson J D, et al. Prequit fMRI responses to pleasant cues and cigarette-related cues predict smoking cessation outcome. Nicotine Tob Res, 2014, 16(6): 697-708.
13.	莫少锋, 张晓凯, 陈洪波, 等. 基于功能磁共振成像的戒烟前后视觉诱导功能连接. 中南大学学报: 医学版, 2017, 42(1): 49-54.
14.	Zang Yufeng, Jiang Tianzi, Lu Yingli, et al. Regional homogeneity approach to fMRI data analysis. Neuroimage, 2004, 22(1): 394-400.
15.	Wang Chao, Shen Zhujing, Huang Peiyu, et al. Altered spontaneous activity of posterior cingulate cortex and superior temporal gyrus are associated with a smoking cessation treatment outcome using varenicline revealed by regional homogeneity. Brain Imaging Behav, 2016: 1-8.
16.	Wu Guangyao, Yang Shiqi, Zhu Ling, et al. Altered spontaneous brain activity in heavy smokers revealed by regional homogeneity. Psychopharmacology (Berl), 2015, 232(14): 2481-2489.
17.	Tang Jinsong, Liao Yanhui, Deng Qijian, et al. Altered spontaneous activity in young chronic cigarette smokers revealed by regional homogeneity. Behav Brain Funct, 2012, 8(1): 44.
18.	Song Xiaowei, Dong Zhangye, Long Xiangyu, et al. REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS One, 2011, 6(9): e25031.
19.	Liang Peifeng, Zhang Han, Xu Yachao, et al. Disruption of cortical integration during midazolam-induced light sedation. Hum Brain Mapp, 2015, 36(11): 4247-4261.
20.	McClernon F J, Kozink R V, Lutz A M, et al. 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. Psychopharmacology (Berl), 2009, 204(1): 25-35.
21.	Ding Xiaoyu, Lee S W. Changes of functional and effective connectivity in smoking replenishment on deprived heavy smokers: a resting-state FMRI study. PLoS One, 2013, 8(3): e59331.
22.	Claus E D, Blaine S K, Filbey F M, et al. Association between nicotine dependence severity, BOLD response to smoking cues, and functional connectivity. Neuropsychopharmacology, 2013, 38(12): 2363-2372.

1. Jamal A, Homa D M, O'connor E, et al. Current cigarette smoking among adults—United States, 2005–2014. MMWR Morb Mortal Wkly Rep, 2015, 64(44): 1233-1240.
2. 朱卫华, 岳晓军, 蓝芬, 等. 住院吸烟患者的戒烟干预效果评价. 实用心脑肺血管病杂志, 2013, 21(5): 21-23.
3. Kanteti R, Dhanasingh I, El-Hashani E, et al. C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype. Cancer Biol Ther, 2016, 17(1): 91-103.
4. Zanchi D, Brody A L, Montandon M L, et al. Cigarette smoking leads to persistent and dose-dependent alterations of brain activity and connectivity in anterior insula and anterior cingulate. Addict Biol, 2015, 20(6): 1033-1041.
5. Gertz H, Hilger M, Hegele M, et al. Violating instructed human agency: An fMRI study on ocular tracking of biological and nonbiological motion stimuli. Neuroimage, 2016, 138: 109-122.
6. Yee J R, Kenkel W M, Kulkarni P, et al. BOLD fMRI in awake prairie voles: A platform for translational social and affective neuroscience. Neuroimage, 2016, 138: 221-232.
7. Kirk U, Gu Xiaosi, Sharp C, et al. Mindfulness training increases cooperative decision making in economic exchanges: Evidence from fMRI. Neuroimage, 2016, 138: 274-283.
8. Chen Hongbo, Wang Liya, King T Z, et al. Increased frontal functional networks in adult survivors of childhood brain tumors. Neuroimage Clin, 2016, 11: 339-346.
9. Siemann J, Herrmann M, Galashan D. fMRI-constrained source analysis reveals early top-down modulations of interference processing using a flanker task. Neuroimage, 2016, 136: 45-56.
10. Addicott M A, Sweitzer M M, Froeliger B, et al. Increased functional connectivity in an insula-based network is associated with improved smoking cessation outcomes. Neuropsychopharmacology, 2015, 40(11): 2648-2656.
11. Hawkshead B, Liebel S, Schwarz N, et al. Working memory and fMRI correlates of smoking cessation treatment outcome. Arch Clin Neuropsychol, 2014, 29(6): 577.
12. Versace F, Engelmann J M, Robinson J D, et al. Prequit fMRI responses to pleasant cues and cigarette-related cues predict smoking cessation outcome. Nicotine Tob Res, 2014, 16(6): 697-708.
13. 莫少锋, 张晓凯, 陈洪波, 等. 基于功能磁共振成像的戒烟前后视觉诱导功能连接. 中南大学学报: 医学版, 2017, 42(1): 49-54.
14. Zang Yufeng, Jiang Tianzi, Lu Yingli, et al. Regional homogeneity approach to fMRI data analysis. Neuroimage, 2004, 22(1): 394-400.
15. Wang Chao, Shen Zhujing, Huang Peiyu, et al. Altered spontaneous activity of posterior cingulate cortex and superior temporal gyrus are associated with a smoking cessation treatment outcome using varenicline revealed by regional homogeneity. Brain Imaging Behav, 2016: 1-8.
16. Wu Guangyao, Yang Shiqi, Zhu Ling, et al. Altered spontaneous brain activity in heavy smokers revealed by regional homogeneity. Psychopharmacology (Berl), 2015, 232(14): 2481-2489.
17. Tang Jinsong, Liao Yanhui, Deng Qijian, et al. Altered spontaneous activity in young chronic cigarette smokers revealed by regional homogeneity. Behav Brain Funct, 2012, 8(1): 44.
18. Song Xiaowei, Dong Zhangye, Long Xiangyu, et al. REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS One, 2011, 6(9): e25031.
19. Liang Peifeng, Zhang Han, Xu Yachao, et al. Disruption of cortical integration during midazolam-induced light sedation. Hum Brain Mapp, 2015, 36(11): 4247-4261.
20. McClernon F J, Kozink R V, Lutz A M, et al. 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. Psychopharmacology (Berl), 2009, 204(1): 25-35.
21. Ding Xiaoyu, Lee S W. Changes of functional and effective connectivity in smoking replenishment on deprived heavy smokers: a resting-state FMRI study. PLoS One, 2013, 8(3): e59331.
22. Claus E D, Blaine S K, Filbey F M, et al. Association between nicotine dependence severity, BOLD response to smoking cues, and functional connectivity. Neuropsychopharmacology, 2013, 38(12): 2363-2372.

Journal of Biomedical Engineering

Research on the rest functional magnetic resonance imaging before and after smoking cessation

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