Experimental study on the in vivo continuous measurement of pressure difference between the anterior and the posterior chambers_Journal of Biomedical Engineering

Authors：

SONG Hongfang ^1,2 , WANG Wenjia ^1,2 , YANG Hongyu ^1,2 ,  LIU Zhicheng ^1,2

1. School of Biomedical Engineering, Capital Medical University, Beijing 100069, P.R.China;
2. Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, P.R.China;

Corresponding author：

LIU Zhicheng, Email: zcliu@ccmu.edu.cn

Keywords：

pressure difference between the anterior and the posterior chambers; ocular biomechanics; aqueous humor; experiment study

DOI：

10.7507/1001-5515.201611020

Video：

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Abstract Full text Figures/Tables Video References Cited by

A set of device for the in vivo measurement of the pressure difference between the anterior and the posterior chambers (PDAP) was designed to investigate the temporal varying rules of PDAP in the anterior segment of rabbit eyes. A platform was established for the in vivo measurement of PDPA according to the mechanism of joint implement. Rabbit models with high intraocular pressure (IOP) were constructed by means of injecting Carbomer into anterior chamber to increase IOP. The in vivo 24 hours continuous measurements of PDAP were performed for normal rabbit eye and eye with high IOP. The developed device could sensitively response to the small pressure difference in eye. The pressure difference in the normal rabbit eye varied with time, and the variation range during a whole day was 5.84–96.84 Pa which reflected the existence of physiological rule. For the rabbit eye with high IOP, pressure in anterior chamber was higher than that in posterior chamber which was in consistence with the theory of self-adaptation adjustment. The present study indicates that the approaches and device designed in this paper can well implement the measurement of PDAP as well as the temporal varying rules of PDAP in the anterior segment during a whole day.

Citation： SONG Hongfang, WANG Wenjia, YANG Hongyu, LIU Zhicheng. Experimental study on the in vivo continuous measurement of pressure difference between the anterior and the posterior chambers. Journal of Biomedical Engineering, 2018, 35(3): 390-395. doi: 10.7507/1001-5515.201611020 Copy

1.	Flammer J, Orgül S, Costa V P, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res, 2002, 21(4): 359-393.
2.	Kondo T, Miura M. A method measuring papillary blocking force in the human eye. Graefe Arch Clin Exp Ophthalmol, 1987, 225(5): 361-364.
3.	Stamper R L, Lieberman M F, Drake M V. Becker-Shaffer’s diagnosis and therapy of the glaucomas. 8th ed. United Kingdom: Elsevier, 2009: 200-220.
4.	Liu X, Zhang K, Song H, et al. Experimental research on the biomechanical properties of the rabbit Iris//Proceeding of The 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Shanghai: IEEE Engineering in Medicine and Biology Society, 2005, 6: 6196-9198.
5.	Quigley H A, Friedman D S, Congdon N G. Possible mechanisms of primary angle-closure and malignant glaucoma. J Glaucoma, 2003, 12(2): 167-180.
6.	贾莉君, 蒋幼芹, 吴振中. 兔眼压正常值与前房穿刺直接测量法. 眼科研究, 1994, 12(4): 267-268.
7.	张虹, 李贵刚, 胡军, 等. Tono-Pen 眼压计对兔眼不同部位眼压测量值的相关性研究. 眼科新进展, 2006, 26(10): 744-746.
8.	McLaren J W, Brubaker R F, Fitzsimon J S. Continuous measurement of intraocular pressure in rabbits by telemetry. Invest Ophthalmol Vis Sci, 1996, 37(6): 966-975.
9.	Campos T V, Jacobovitz S, Almeida H G, et al. Computerized invasive measurement of time-dependent intraocular pressure. Braz J Med Biol Res, 2006, 39(9): 1249-1253.
10.	全海英, 薄雪峰, 刘敬华, 等. 兔眼前房压强在体连续测量方法的研究. 生物医学工程研究, 2008, 27(4): 251-253.
11.	Schnell C R, Debon C, Percicot C L. Measurement of intraocular pressure by telemetry in conscious, unrestrained rabbits. Invest Ophthalmol Vis Sci, 1996, 37(6): 958-965.
12.	Schnakenberg U, Walter P, Bögel G V, et al. Initial investigations on systems for measuring intraocular pressure. Sensors & Actuators A Physical, 2000, 85(1): 287-291.
13.	Lu Anhui, Smått J-H, Backlund S, et al. Easy and flexible preparation of nanocasted carbon monoliths exhibiting a multimodal hierarchical porosity. Microporous and Mesoporous Materials, 2004, 72(1-3): 59-65.
14.	刘晓华, 陈琛, 张昆亚, 等. 虹膜组织力学特性及瞳孔阻滞力定量研究的方法学探索. 中国医学物理学杂志, 2005, 22(1): 382-383, 403.
15.	李婷. 动物眼前后房压强差变化规律的在体实验研究. 北京: 首都医科大学, 2008.
16.	任燕如, 于静. 复方卡波姆溶液诱导慢性实验性兔高眼压模型研究现状. 眼科新进展, 2010, 30(7): 686-689.
17.	宋红芳. 基于在体实测前后房压强差的房水循流仿真研究. 北京: 首都医科大学, 2012.
18.	Pavlin C J, Macken P, Trope G E, et al. Accommodation and iridotomy in the pigment dispersion syndrome. Ophthalmic Surg Lasers, 1996, 27(2): 113-120.
19.	Campbell D G. Pigmentary dispersion and glaucoma. Arch Ophthalmol, 1979, 97: 1667-1672.
20.	Karickhoff J R. Pigmentary dispersion syndrome and pigmentary glaucoma: a new mechanism concept, a new treatment, and a new technique. Ophthalmic Surg, 1992, 23(4): 269-277.
21.	Heys J J, Barocas V H. Computational evaluation of the role of accommodation in pigmentary glaucoma. Invest Ophthalmol Vis Sci, 2002, 43(3): 700-708.

1. Flammer J, Orgül S, Costa V P, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res, 2002, 21(4): 359-393.
2. Kondo T, Miura M. A method measuring papillary blocking force in the human eye. Graefe Arch Clin Exp Ophthalmol, 1987, 225(5): 361-364.
3. Stamper R L, Lieberman M F, Drake M V. Becker-Shaffer’s diagnosis and therapy of the glaucomas. 8th ed. United Kingdom: Elsevier, 2009: 200-220.
4. Liu X, Zhang K, Song H, et al. Experimental research on the biomechanical properties of the rabbit Iris//Proceeding of The 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Shanghai: IEEE Engineering in Medicine and Biology Society, 2005, 6: 6196-9198.
5. Quigley H A, Friedman D S, Congdon N G. Possible mechanisms of primary angle-closure and malignant glaucoma. J Glaucoma, 2003, 12(2): 167-180.
6. 贾莉君, 蒋幼芹, 吴振中. 兔眼压正常值与前房穿刺直接测量法. 眼科研究, 1994, 12(4): 267-268.
7. 张虹, 李贵刚, 胡军, 等. Tono-Pen 眼压计对兔眼不同部位眼压测量值的相关性研究. 眼科新进展, 2006, 26(10): 744-746.
8. McLaren J W, Brubaker R F, Fitzsimon J S. Continuous measurement of intraocular pressure in rabbits by telemetry. Invest Ophthalmol Vis Sci, 1996, 37(6): 966-975.
9. Campos T V, Jacobovitz S, Almeida H G, et al. Computerized invasive measurement of time-dependent intraocular pressure. Braz J Med Biol Res, 2006, 39(9): 1249-1253.
10. 全海英, 薄雪峰, 刘敬华, 等. 兔眼前房压强在体连续测量方法的研究. 生物医学工程研究, 2008, 27(4): 251-253.
11. Schnell C R, Debon C, Percicot C L. Measurement of intraocular pressure by telemetry in conscious, unrestrained rabbits. Invest Ophthalmol Vis Sci, 1996, 37(6): 958-965.
12. Schnakenberg U, Walter P, Bögel G V, et al. Initial investigations on systems for measuring intraocular pressure. Sensors & Actuators A Physical, 2000, 85(1): 287-291.
13. Lu Anhui, Smått J-H, Backlund S, et al. Easy and flexible preparation of nanocasted carbon monoliths exhibiting a multimodal hierarchical porosity. Microporous and Mesoporous Materials, 2004, 72(1-3): 59-65.
14. 刘晓华, 陈琛, 张昆亚, 等. 虹膜组织力学特性及瞳孔阻滞力定量研究的方法学探索. 中国医学物理学杂志, 2005, 22(1): 382-383, 403.
15. 李婷. 动物眼前后房压强差变化规律的在体实验研究. 北京: 首都医科大学, 2008.
16. 任燕如, 于静. 复方卡波姆溶液诱导慢性实验性兔高眼压模型研究现状. 眼科新进展, 2010, 30(7): 686-689.
17. 宋红芳. 基于在体实测前后房压强差的房水循流仿真研究. 北京: 首都医科大学, 2012.
18. Pavlin C J, Macken P, Trope G E, et al. Accommodation and iridotomy in the pigment dispersion syndrome. Ophthalmic Surg Lasers, 1996, 27(2): 113-120.
19. Campbell D G. Pigmentary dispersion and glaucoma. Arch Ophthalmol, 1979, 97: 1667-1672.
20. Karickhoff J R. Pigmentary dispersion syndrome and pigmentary glaucoma: a new mechanism concept, a new treatment, and a new technique. Ophthalmic Surg, 1992, 23(4): 269-277.
21. Heys J J, Barocas V H. Computational evaluation of the role of accommodation in pigmentary glaucoma. Invest Ophthalmol Vis Sci, 2002, 43(3): 700-708.

Journal of Biomedical Engineering

Experimental study on the in vivo continuous measurement of pressure difference between the anterior and the posterior chambers

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