Research progress of neurobiological function of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline_Journal of Biomedical Engineering

Authors：

ZHENG Xiaotong ¹ ,  CHEN Xuechai ¹ , CHEN Zixuan ² , QING Hong ² , DENG Yulin ² , ZHONG Rugang ¹ , GUO Minjun ¹

1. College of Life science and Bioengineering, Beijing University of Technology, Beijing 100124, P.R.China;
2. School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, P.R.China;

Corresponding author：

CHEN Xuechai, Email: chenxuechai@bjut.edu.cn

Keywords：

Salsolinol; Parkinson’s disease; alcohol addiction; neuroregulation; dopamine

DOI：

10.7507/1001-5515.201612027

Video：

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1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (Sal) is a kind of catechol isoquinoline compound, which mainly exists in mammalian brain and performs a variety of biological functions. Through in vivo metabolism, Sal can be transformed into endogenous neurotoxins and can participate the occurrence of Parkinson’s disease (PD). This has attracted widespread concern of researchers. Recently, many research works have shown that Sal may lead to alcohol addiction and regulate hormone release of the neuroendocrine system, which indicated that it is a potential regulator of dopaminergic neurons. In this paper, we discuss the neural functions of Sal on the above aspects, and wish to provide some theoretical supports for further research on its mechanism.

Citation： ZHENG Xiaotong, CHEN Xuechai, CHEN Zixuan, QING Hong, DENG Yulin, ZHONG Rugang, GUO Minjun. Research progress of neurobiological function of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline. Journal of Biomedical Engineering, 2017, 34(4): 643-647. doi: 10.7507/1001-5515.201612027 Copy

1.	Kalia L V. Lang A E, Parkinson’s disease. Lancet, 2015, 386(9996): 896-912.
2.	Schneider S A, Obeso J A. Clinical and pathological features of Parkinson’s disease. Curr Top Behav Neurosci, 2014, 22: 205-220.
3.	Francesca M, Alessandro P, Pierluigi T, et al. Pathophysiology of motor dysfunction in parkinson’s disease as the rationale for drug treatment and rehabilitation. parkinson’s disease, 2016, 2016: 1-18.
4.	Herraiz T. N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids. Food and Chemical Toxicology, 2016, 97: 23-39.
5.	王玉敏, 赵丽楠, 崔其福, 等. 内源性神经毒素 1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉在帕金森病模型中的研究进展. 中国药学杂志, 2016, 51(9): 685-689.
6.	Islam M T. Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res, 2017, 39(1): 73-82.
7.	Wang Fuli, Ni Junjun, Wang Xianghan, et al. Salsolinol damaged neuroblastoma SH-SY5Y cells induce proliferation of human monocyte THP-1 cells through the mTOR pathway in a co-culture system. Neurochem Res, 2015, 40(5): 932-941.
8.	Qualls Z, Brown D, Ramlochansingh C, et al. Protective effects of curcumin against rotenone and Salsolinol-Induced toxicity: implications for parkinson’s disease. Neurotox Res, 2014, 25(1): 81-89.
9.	Możdżeń E, Kajta M, Wasik A, et al. Salsolinol, an endogenous compound triggers a Two-Phase opposing action in the central nervous system. Neurotox Res, 2015, 27(3): 300-313.
10.	崔占军, 赵凯冰, 邓锦波. 长期酒精暴露对小鼠海马及大脑皮质神经细胞的影响. 药学学报, 2016(4): 573-579.
11.	Mcclain J A, Morris S A, Marshall S A, et al. Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence. Addict Biol, 2014, 19(4): 687-699.
12.	Peana A T, Rosas M, Porru S, et al. From ethanol to salsolinol: role of ethanol metabolites in the effects of ethanol. J Exp Neurosci, 2016, 10: 137-146.
13.	Quintanilla M E, Rivera-Meza M, Berrios-Carcamo P, et al. (R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake. Addict Biol, 2016, 21(6): 1063-1071.
14.	Quintanilla M E, Rivera-Meza M, Berrios-Carcamo P, et al. Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake. Alcohol, 2014, 48: 551-559.
15.	Zuo Wanhong, Fu Rao, Hopf F W, et al. Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons. Addict Biol, 2017, 22(1): 103-116.
16.	Rodd Z A, Oster S M, Ding Zm, et al. The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine. Alcohol Clin Exp Res, 2008, 32(2): 230-239.
17.	Melis M, Carboni E, Caboni P, et al. Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area. Addict Biol, 2015, 20(1): 182-193.
18.	Xie G, Hipólito L, Zuo W, et al. Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating μ-opioid receptors. Journal of Pharmacology & Experimental Therapeutics, 2012, 341(1): 43-50.
19.	Marti-Prats L, Orrico A, Polache A, et al. Dual motor responses elicited by ethanol in the posterior VTA: Consequences of the blockade of mu-opioid receptors. Journal of Psychopharmacology, 2015, 29(9): 1029-1034.
20.	Xie Guiqin, Krnjevic K, Ye Jianghong. Salsolinol modulation of dopamine neurons. Front Behav Neurosci, 2013, 7(2): 183-188.
21.	Xie Guiqin, Ye Jianghong. Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats. PLoS One, 2012, 7(5): e36716.
22.	Berríos-Cárcamo P, Quintanilla M E, Herrera-Marschitz M, et al. Racemic salsolinol and its enantiomers act as agonists of the μ-Opioid receptor by activating the Gi protein-adenylate cyclase pathway. Front Behav Neurosci, 2016, 10: 253.
23.	Hashizume T, Onodera Y, Shida R, et al. Characteristics of prolactin-releasing response to salsolinol(SAL) and thyrotropin-releasing hormone(TRH) in ruminants. Domest Anim Endocrinol, 2009, 36(2): 99-104.
24.	Inaba Y, Kato Y, Itou A, et al. Effects of extracerebral dopamine on salsolinol-or thyrotropin-releasing hormone-induced prolactin (PRL) secretion in goats. Animal Science Journal, 2016, 87(12): 1522-1527.
25.	Jin Jin, Hara S, Sawai K, et al. Effects of hypothalamic dopamine (DA) on salsolinol (SAL)-induced prolactin (PRL) secretion in male goats. Animal Science Journal, 2014, 85(4): 461-467.
26.	Górski K, Marciniak E, Zielińskagórska M, et al. Salsolinol upregulates oxytocin expression and release during lactation in sheep. J Neuroendocrinol, 2016, 28(3): 1-9.
27.	Hasiec M, Tomaszewska-Zaremba D, Misztal T, Suckling and salsolinol attenuate responsiveness of the hypothalamic-pituitary-adrenal axis to stress: focus on catecholamines. corticotrophin-releasing hormone, adrenocorticotrophic hormone, cortisol and prolactin secretion in lactating sheep. J Neuroendocrinol, 2014, 26(12): 844-852.
28.	Hasiec M, Herman A P, Misztal T. Salsolinol: a potential modulator of the activity of the hypothalamic-pituitary-adrenal axis in nursing and postweaning sheep. Domest Anim Endocrinol, 2015, 53: 26-34.
29.	Marciniak E, Hasiec M, Fulop F, et al. Salsolinol-a potential inhibitor of the gonadotropic axis in sheep during lactation. Domest Anim Endocrinol, 2017, 58: 97-103.
30.	Kurnik M, Gil K, Gajda M, et al. Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol. Folia Histochemica et Cytobiologica, 2015, 53(1): 49-61.
31.	Naoi M, Maruyama W, Dostert P, et al. A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl (R)salsolinol. Neurosci Lett, 1996, 212(3): 183-186.
32.	Chen X C, Chen Y, Wu G S, et al. Existence and characterization of Salsolinol synthase in neuronal cells and rat brain. Neurochemical Journal, 2013, 7(3): 192-197.

1. Kalia L V. Lang A E, Parkinson’s disease. Lancet, 2015, 386(9996): 896-912.
2. Schneider S A, Obeso J A. Clinical and pathological features of Parkinson’s disease. Curr Top Behav Neurosci, 2014, 22: 205-220.
3. Francesca M, Alessandro P, Pierluigi T, et al. Pathophysiology of motor dysfunction in parkinson’s disease as the rationale for drug treatment and rehabilitation. parkinson’s disease, 2016, 2016: 1-18.
4. Herraiz T. N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids. Food and Chemical Toxicology, 2016, 97: 23-39.
5. 王玉敏, 赵丽楠, 崔其福, 等. 内源性神经毒素 1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉在帕金森病模型中的研究进展. 中国药学杂志, 2016, 51(9): 685-689.
6. Islam M T. Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res, 2017, 39(1): 73-82.
7. Wang Fuli, Ni Junjun, Wang Xianghan, et al. Salsolinol damaged neuroblastoma SH-SY5Y cells induce proliferation of human monocyte THP-1 cells through the mTOR pathway in a co-culture system. Neurochem Res, 2015, 40(5): 932-941.
8. Qualls Z, Brown D, Ramlochansingh C, et al. Protective effects of curcumin against rotenone and Salsolinol-Induced toxicity: implications for parkinson’s disease. Neurotox Res, 2014, 25(1): 81-89.
9. Możdżeń E, Kajta M, Wasik A, et al. Salsolinol, an endogenous compound triggers a Two-Phase opposing action in the central nervous system. Neurotox Res, 2015, 27(3): 300-313.
10. 崔占军, 赵凯冰, 邓锦波. 长期酒精暴露对小鼠海马及大脑皮质神经细胞的影响. 药学学报, 2016(4): 573-579.
11. Mcclain J A, Morris S A, Marshall S A, et al. Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence. Addict Biol, 2014, 19(4): 687-699.
12. Peana A T, Rosas M, Porru S, et al. From ethanol to salsolinol: role of ethanol metabolites in the effects of ethanol. J Exp Neurosci, 2016, 10: 137-146.
13. Quintanilla M E, Rivera-Meza M, Berrios-Carcamo P, et al. (R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake. Addict Biol, 2016, 21(6): 1063-1071.
14. Quintanilla M E, Rivera-Meza M, Berrios-Carcamo P, et al. Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake. Alcohol, 2014, 48: 551-559.
15. Zuo Wanhong, Fu Rao, Hopf F W, et al. Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons. Addict Biol, 2017, 22(1): 103-116.
16. Rodd Z A, Oster S M, Ding Zm, et al. The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine. Alcohol Clin Exp Res, 2008, 32(2): 230-239.
17. Melis M, Carboni E, Caboni P, et al. Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area. Addict Biol, 2015, 20(1): 182-193.
18. Xie G, Hipólito L, Zuo W, et al. Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating μ-opioid receptors. Journal of Pharmacology & Experimental Therapeutics, 2012, 341(1): 43-50.
19. Marti-Prats L, Orrico A, Polache A, et al. Dual motor responses elicited by ethanol in the posterior VTA: Consequences of the blockade of mu-opioid receptors. Journal of Psychopharmacology, 2015, 29(9): 1029-1034.
20. Xie Guiqin, Krnjevic K, Ye Jianghong. Salsolinol modulation of dopamine neurons. Front Behav Neurosci, 2013, 7(2): 183-188.
21. Xie Guiqin, Ye Jianghong. Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats. PLoS One, 2012, 7(5): e36716.
22. Berríos-Cárcamo P, Quintanilla M E, Herrera-Marschitz M, et al. Racemic salsolinol and its enantiomers act as agonists of the μ-Opioid receptor by activating the Gi protein-adenylate cyclase pathway. Front Behav Neurosci, 2016, 10: 253.
23. Hashizume T, Onodera Y, Shida R, et al. Characteristics of prolactin-releasing response to salsolinol(SAL) and thyrotropin-releasing hormone(TRH) in ruminants. Domest Anim Endocrinol, 2009, 36(2): 99-104.
24. Inaba Y, Kato Y, Itou A, et al. Effects of extracerebral dopamine on salsolinol-or thyrotropin-releasing hormone-induced prolactin (PRL) secretion in goats. Animal Science Journal, 2016, 87(12): 1522-1527.
25. Jin Jin, Hara S, Sawai K, et al. Effects of hypothalamic dopamine (DA) on salsolinol (SAL)-induced prolactin (PRL) secretion in male goats. Animal Science Journal, 2014, 85(4): 461-467.
26. Górski K, Marciniak E, Zielińskagórska M, et al. Salsolinol upregulates oxytocin expression and release during lactation in sheep. J Neuroendocrinol, 2016, 28(3): 1-9.
27. Hasiec M, Tomaszewska-Zaremba D, Misztal T, Suckling and salsolinol attenuate responsiveness of the hypothalamic-pituitary-adrenal axis to stress: focus on catecholamines. corticotrophin-releasing hormone, adrenocorticotrophic hormone, cortisol and prolactin secretion in lactating sheep. J Neuroendocrinol, 2014, 26(12): 844-852.
28. Hasiec M, Herman A P, Misztal T. Salsolinol: a potential modulator of the activity of the hypothalamic-pituitary-adrenal axis in nursing and postweaning sheep. Domest Anim Endocrinol, 2015, 53: 26-34.
29. Marciniak E, Hasiec M, Fulop F, et al. Salsolinol-a potential inhibitor of the gonadotropic axis in sheep during lactation. Domest Anim Endocrinol, 2017, 58: 97-103.
30. Kurnik M, Gil K, Gajda M, et al. Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol. Folia Histochemica et Cytobiologica, 2015, 53(1): 49-61.
31. Naoi M, Maruyama W, Dostert P, et al. A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl (R)salsolinol. Neurosci Lett, 1996, 212(3): 183-186.
32. Chen X C, Chen Y, Wu G S, et al. Existence and characterization of Salsolinol synthase in neuronal cells and rat brain. Neurochemical Journal, 2013, 7(3): 192-197.

Journal of Biomedical Engineering

Research progress of neurobiological function of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline

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