Research on cortical cross-modal reorganization of children with congenital severe deafness after cochlear implant_Journal of Biomedical Engineering

Authors：

WANG Xianjun ¹ , LIANG Maojin ² , ZHANG Junpeng ^1,2 , HUANG Hua ¹ ,  ZHENG Yiqing ²

1. The Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu 610065, P.R.China;
2. The Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, P.R.China;

Corresponding author：

ZHENG Yiqing, Email: yiqingzheng@hotmail.com

Keywords：

children with congenital severe deafness; cochlear implant; event related potential; source localization; cross-modal reorganization

DOI：

10.7507/1001-5515.201612060

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Cochlear implant (CI) is the only method for efficacious treatment of congenital severe deafness at present. However, for children with congenital severe deafness after CI, the mechanism of the structural and functional changes of their cerebral cortex is not clear. This study was based on the cross-modal reorganization of deaf patients. Event related potential (ERP) and source localization technique were used to visualize the change of cortical activity in children with congenital severe deafness during 1-year period (0, 1, 3, 6, 9 and 12 months after CI). We aimed to investigate the association between hearing restoration and cross-modal reorganization in children with congenital severe deafness after CI. The results showed that the cross-modal reorganization exists in children with congenital severe deafness. During hearing restoration, the function of the cross-modal reorganization reversed to the normal state. The method and conclusions of this study may be of significance in guiding the training and evaluation of hearing rehabilitation after CI in patients.

Citation： WANG Xianjun, LIANG Maojin, ZHANG Junpeng, HUANG Hua, ZHENG Yiqing. Research on cortical cross-modal reorganization of children with congenital severe deafness after cochlear implant. Journal of Biomedical Engineering, 2017, 34(5): 667-673. doi: 10.7507/1001-5515.201612060 Copy

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12.	Campbell R, Macsweeney M, Woll B. Cochlear implantation (CI) for prelingual deafness: the relevance of studies of brain organization and the role of first language acquisition in considering outcome success. Front Hum Neurosci, 2014, 8(4): 834.
13.	Luu P, Jiang Zhongqing, Poulsen C, et al. Learning and the development of contexts for action. Front Hum Neurosci, 2011, 5(24): 11626-11630.
14.	Ruytjens L, Albers F, van Dijk P, et al. Activation in primary auditory cortex during silent lipreading is determined by sex. Audiol Neurootol, 2007, 12(6): 371-377.
15.	Finney E M, Clementz B A, Hickok G, et al. Visual stimuli activate auditory cortex in deaf subjects: evidence from MEG. Neuroreport, 2003, 14(11): 1425-1427.
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1. 张晶, 徐学海. 先天性耳聋基因筛查与诊断的临床应用进展. 西北国防医学杂志, 2013, 1(2): 152-1550.
2. He Shuman, Grose J H, Teagle H F, et al. Acoustically evoked auditory change complex in children with auditory neuropathy spectrum disorder: a potential objective tool for identifying cochlear implant candidates. Ear Hear, 2015, 36(3): 289-301.
3. Jung J, Morlet D, Mercier B, et al. Mismatch negativity (MMN) in multiple sclerosis: an event-related potentials study in 46 patients. Clin Neurophysiol, 2006, 117(1): 85-93.
4. Hocking J, Price C J. The role of the posterior superior temporal sulcus in audiovisual processing. Cereb Cortex, 2008, 18(10): 2439-2449.
5. Merabet L B, Pascual-Leone A. Neural reorganization following sensory loss: the opportunity of change. Nat Rev Neurosci, 2010, 11(1): 44-52.
6. Sandmann P, Dillier N, Eichele T, et al. Visual activation of auditory cortex reflects maladaptive plasticity in cochlear implant users. Brain, 2012, 135(Pt 2): 555-568.
7. Cardon G, Campbell J, Sharma A. Plasticity in the developing auditory cortex: evidence from children with sensorineural hearing loss and auditory neuropathy spectrum disorder. J Am Acad Audiol, 2012, 23(6): 396-411; quiz 495.
8. Doucet M E, Bergeron F, Lassonde M, et al. Cross-modal reorganization and speech perception in cochlear implant users. Brain, 2006, 129(Pt 12): 3376-3383.
9. 谷丰. 用听觉事件相关电位研究声调语言词的长时程记忆痕迹. 合肥: 中国科学技术大学, 2012.
10. Proverbio A M, D'aniello G E, Adorni R, et al. When a photograph can be heard: vision activates the auditory cortex within 110 ms. Sci Rep, 2011, 1(6043): 54.
11. Liang Maojin, Zhang Xueyuan, Chen Tao, et al. Evaluation of auditory cortical development in the early stages of post cochlear implantation using mismatch negativity measurement. Otol Neurotol, 2014, 35(1): e7-14.
12. Campbell R, Macsweeney M, Woll B. Cochlear implantation (CI) for prelingual deafness: the relevance of studies of brain organization and the role of first language acquisition in considering outcome success. Front Hum Neurosci, 2014, 8(4): 834.
13. Luu P, Jiang Zhongqing, Poulsen C, et al. Learning and the development of contexts for action. Front Hum Neurosci, 2011, 5(24): 11626-11630.
14. Ruytjens L, Albers F, van Dijk P, et al. Activation in primary auditory cortex during silent lipreading is determined by sex. Audiol Neurootol, 2007, 12(6): 371-377.
15. Finney E M, Clementz B A, Hickok G, et al. Visual stimuli activate auditory cortex in deaf subjects: evidence from MEG. Neuroreport, 2003, 14(11): 1425-1427.
16. Mitchell T V, Maslin M T. How vision matters for individuals with hearing loss. Audiology, 2007, 46(9): 500-511.

Journal of Biomedical Engineering

Research on cortical cross-modal reorganization of children with congenital severe deafness after cochlear implant

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