Effect of simulated microgravity on peripheral oxygen saturation in rats_Journal of Biomedical Engineering

Authors：

CHEN Guangfei ¹ ,  ZHANG Yahui ¹ , YUAN Ming ² , HE Shilin ¹ , YING Jun ¹ , LI Chen ³

1. Biomedical Engineering Department, Chinese Military General Hospital, Beijing 100853, P.R.China;
2. Chinese Astronaut Research and Training Center, Beijing 100094, P.R.China;
3. Beijing Runkang Medical Instrument Co., Ldt, Beijing 102609, P.R.China;

Corresponding author：

ZHANG Yahui, Email: zhangyahui1991@126.com

Keywords：

simulated microgravity; pulse oximeter; SpO₂; SaO₂; space medical engineering

DOI：

10.7507/1001-5515.201701023

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

To study the effect of microgravity on peripheral oxygen saturation (SpO₂) in rats, tail-suspended rats were applied to simulate microgravity environment. SpO₂ and arterial oxygen saturation (SaO₂) were measured by pulse oximeter and arterial blood gas analyzer (ABGA) respectively on the 14th day, 21st day and 28th day in tail-suspended group and control group. Paired t-test shows that SpO₂ was significantly lower than SaO₂ in tail-suspended group on the 14th day (P < 0.05), the 21st day ( P < 0.05) and the 28th day ( P < 0.01). The ANOVA results shows that modeling time had significant effect on SpO ₂ value but no effect on SaO₂ value in tail-suspended group. These results indicate that pulse oximeter may be not suitable for oxygen saturation test in microgravity environment.

Citation： CHEN Guangfei, ZHANG Yahui, YUAN Ming, HE Shilin, YING Jun, LI Chen. Effect of simulated microgravity on peripheral oxygen saturation in rats. Journal of Biomedical Engineering, 2018, 35(1): 57-59. doi: 10.7507/1001-5515.201701023 Copy

1.	于巍. 反射式血氧饱和度无创检测的实验研究. 广州: 南方医科大学, 2006.
2.	华子千, 梁学, 梁宇和, 等. 在空间微重力条件下斑头雁血红蛋白晶体生长. 北京大学学报:自然科学版, 1999, 35(2): 237-242.
3.	曹慧玲, 马晓亮, 郭云珠, 等. 空间微重力环境下蛋白质晶体生长的研究进展. 材料导报, 2011, 25(15): 69-74, 95.
4.	梁宇和, 查正, 华子千, 等. 空间和地面条件下斑头雁血红蛋白晶体结构的比较研究. 北京大学学报:自然科学版, 2001, 37(4): 483-489.
5.	陈万春, 宋友庭. 空间微重力环境中的晶体生长研究进展. 科技导报, 2012, 30(2): 46-57.
6.	Hanna G, Fontanella A, Palmer G, et al. Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy. Am J Physiol Lung Cell Mol Physiol, 2013, 304(2): L86-L91.
7.	Müller H C, Hellwig K, Rosseau S, et al. Simvastatin attenuates ventilator-induced lung injury in mice. Critical Care, 2010, 14(4): R143.
8.	Tipton C M. Animal models and their importance to human physiological responses in microgravity. Med Sci Sports Exerc, 1996, 28(10 Suppl): S94-100.
9.	Dong Qi, Shen Xianyun, Chen Jianhe, et al. Effects of simulated weightlessness on erythrocyte deformability in rats. Space Med Med Eng (Beijing), 1997, 10(4): 240-244.
10.	董丽, 王琼, 刘新民, 等. 地面模拟失重实验方法概况. 中国实验动物学报, 2013, 21(5): 90-94.

1. 于巍. 反射式血氧饱和度无创检测的实验研究. 广州: 南方医科大学, 2006.
2. 华子千, 梁学, 梁宇和, 等. 在空间微重力条件下斑头雁血红蛋白晶体生长. 北京大学学报:自然科学版, 1999, 35(2): 237-242.
3. 曹慧玲, 马晓亮, 郭云珠, 等. 空间微重力环境下蛋白质晶体生长的研究进展. 材料导报, 2011, 25(15): 69-74, 95.
4. 梁宇和, 查正, 华子千, 等. 空间和地面条件下斑头雁血红蛋白晶体结构的比较研究. 北京大学学报:自然科学版, 2001, 37(4): 483-489.
5. 陈万春, 宋友庭. 空间微重力环境中的晶体生长研究进展. 科技导报, 2012, 30(2): 46-57.
6. Hanna G, Fontanella A, Palmer G, et al. Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy. Am J Physiol Lung Cell Mol Physiol, 2013, 304(2): L86-L91.
7. Müller H C, Hellwig K, Rosseau S, et al. Simvastatin attenuates ventilator-induced lung injury in mice. Critical Care, 2010, 14(4): R143.
8. Tipton C M. Animal models and their importance to human physiological responses in microgravity. Med Sci Sports Exerc, 1996, 28(10 Suppl): S94-100.
9. Dong Qi, Shen Xianyun, Chen Jianhe, et al. Effects of simulated weightlessness on erythrocyte deformability in rats. Space Med Med Eng (Beijing), 1997, 10(4): 240-244.
10. 董丽, 王琼, 刘新民, 等. 地面模拟失重实验方法概况. 中国实验动物学报, 2013, 21(5): 90-94.

Previous Article
Security research of laparoscopic graspers during tissue clamping operation
Next Article
A study on the classification of intestinal contents based on miniature reflection ultrasound

Journal of Biomedical Engineering

Effect of simulated microgravity on peripheral oxygen saturation in rats

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content