Research progress on characteristics and applications of melanin nanoparticles_Journal of Biomedical Engineering

Authors：

YANG Liu , ZHAO Yinghu , WANG Fang , LIU Haiying , LI Qinqin , WANG Linbian ,  GAO Li

School of Chemical Engineering and Technology, North University of China, Taiyuan 030051, P.R.China;

Corresponding author：

GAO Li, Email: gaoli@nuc.edu.cn

Keywords：

melanin nanoparticles; characteristic; preparation; application

DOI：

10.7507/1001-5515.201701038

Video：

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Abstract Full text Figures/Tables Video References Cited by

Melanin nanoparticles (MNPs) not only retain the inherent characteristics of melanin (metal ion chelation, photothermal conversion property, etc.), but also can exhibit more excellent properties, such as high dispersion stability, good biocompatibility and biodegradability, etc. Furthermore, these performances can be enhanced to target the specific sites and treat diseases by the surface modification or combination with functional substance. In this paper, the characteristics, preparation methods and applications of MNPs were reviewed. It provides a reference for further development of application for MNPs, and theoretical basis for practice in biology, medicine and so on.

Citation： YANG Liu, ZHAO Yinghu, WANG Fang, LIU Haiying, LI Qinqin, WANG Linbian, GAO Li. Research progress on characteristics and applications of melanin nanoparticles. Journal of Biomedical Engineering, 2017, 34(6): 972-976. doi: 10.7507/1001-5515.201701038 Copy

1.	李红姣, 李巨秀, 赵忠. 酶法辅助提取山杏种皮黑色素工艺优化及其稳定性. 食品科学, 2016, 37(10): 69-75.
2.	Capozzi V, Perna G, Carmone P, et al. Optical and photoelectronic properties of melanin. Thin Solid Films, 2006, 511(19): 362-366.
3.	Menter J M. Melanin from a physicochemical point of view. Polym Int, 2016, 65(11): 1300-1305.
4.	Liu Y C, Chen S M, Liu J H, et al. Mechanical and photo-fragmentation processes for nanonization of melanin to improve its efficacy in protecting cells from reactive oxygen species stress. J Appl Phys, 2015, 117(6): 1129.
5.	Karlsson O, Lindquist N G. Melanin and neuromelanin binding of drugs and chemicals: toxicological implications. Arch Toxicol, 2016, 90(8): 1883-1891.
6.	Song Sheng, Yang Liu, Ye Ming, et al. Antioxidant activity of a Lachnum YM226 melanin-iron complex and its influence on cytokine production in mice with iron deficiency anemia. Food Funct, 2016, 7(3): 1508-1514.
7.	Dadachova E, Casadevall A. Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin. Curr Opin Microbiol, 2008, 11(6): 525-531.
8.	Chen Y S, Hung Y C, Hong M Y, et al. Control of in vivo transport and toxicity of nanoparticles by tea melanin. J Nanomater, 2012(6b): 9.
9.	Sun Y, Hong S, Ma X, et al. Recyclable Cu(I)/melanin dots for cycloaddition, bioconjugation and cell labelling. Chemical Science, 2016, 7(9): 5888-5892.
10.	Castellanos G, Fernández-Seara M A, Lorenzo-Betancor O, et al. Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease. Mov Disord, 2015, 30(7): 945-952.
11.	方丽梅, 刘星星, 江颖, 等. 棕榈纤维黑色素提取工艺及性质. 河南工程学院学报: 自然科学版, 2016, 28(3): 10-15.
12.	Rageh M M, El-Gebaly R H, Abou-Shady H, et al. Melanin nanoparticles (MNPs) provide protection against whole-body γ-irradiation pound in mice via restoration of hematopoietic tissues. Mol Cell Biochem, 2015, 399(1/2): 59-69.
13.	Liu Yanlan, Ai Kelong, Liu Jianhua, et al. Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv Mater, 2013, 25(9): 1353-1359.
14.	Liopo A, Su R, Oraevsky A A. Melanin nanoparticles as a novel contrast agent for optoacoustic tomography. Photoacoustics, 2015, 3(1): 35-43.
15.	Pyo J, Ju K Y, Lee J K. Artificial pheomelanin nanoparticles and their photo-sensitization properties. J Photochem Photobiol B, 2016, 160: 330-335.
16.	Zhang R, Fan Q, Yang M, et al. Drug delivery: engineering melanin nanoparticles as an efficient drug-delivery system for imaging-guided chemotherapy. Adv Mater, 2015, 27(34): 5063-5069.
17.	Ju K Y, Lee Y, Lee S, et al. Bioinspired polymerization of dopamine to generate melanin-like nanoparticles having an excellent free-radical-scavenging property. Biomacromolecules, 2011, 12(3): 625-632.
18.	Saini A S, Tripathi A, Melo J S. On-column enzymatic synthesis of melanin nanoparticles using cryogenic poly(AAM-co-AGE) monolith and its free radical scavenging and electro-catalytic properties. RSC Adv, 2015, 5(16): 87206-87215.
19.	Zhang Pengjun, Yue Yuanyuan, Pan Donghui, et al. Pharmacokinetics study of Zr-89-labeled melanin nanoparticle in iron-overload mice. Nucl Med Biol, 2016, 43(9): 529-533.
20.	Fan Quli, Cheng Kai, Hu Xiang, et al. Transferring biomarker into molecular probe: melanin nanoparticle as a naturally active platform for multimodality imaging. J Am Chem Soc, 2014, 136(43): 15185-15194.
21.	Chu Maoquan, Hai Wangxi, Zhang Zheyu, et al. Melanin nanoparticles derived from a homology of medicine and food for sentinel lymph node mapping and photothermal in vivo cancer therapy. Biomaterials, 2016, 91: 182-199.
22.	Wang Xinyu, Zhang Jishen, Wang Yitong, et al. Multi-responsive photothermal-chemotherapy with drug-loaded melanin-like nanoparticles for synergetic tumor ablation. Biomaterials, 2016, 81: 114-124.
23.	Longo D L, Stefania R, Callari C, et al. Water soluble melanin derivatives for dynamic contrast enhanced photoacoustic imaging of tumor vasculature and response to antiangiogenic therapy. Adv Healthc Mater, 2017, 6(1):1-6.
24.	Ju K Y, Lee J W, Im G H, et al. Bio-inspired, melanin-like nanoparticles as a highly efficient contrast agent for T1-weighted magnetic resonance imaging. Biomacromolecules, 2013, 14(10): 3491-3497.
25.	雷敏. 鱿鱼墨黑色素及黑色素铁生物活性的研究. 青岛: 中国海洋大学, 2008.
26.	Wang Yang, Li Ting, Wang Xuefei, et al. Superior performance of polyurethane based on natural melanin nanoparticles. Biomacromolecules, 2016, 17(11): 3782-3789.
27.	Kim D J, Ju K Y, Lee J K. The synthetic melanin nanoparticles having an excellent binding capacity of heavy metal ions. Bull Korean Chem Soc, 2012, 33(11): 3788-3792.
28.	Chalmers A W, Shammo J M. Evaluation of a new tablet formulation of deferasirox to reduce chronic iron overload after long-term blood transfusions. Ther Clin Risk Manag, 2016, 12: 201-208.
29.	张瑜. 淫羊藿、黄芪、葛根有效成分组方对阿尔茨海默病脑铁超载的干预作用及其机制研究. 石家庄: 河北医科大学, 2016.
30.	Yan Junjie, Ji Yu, Zhang Pengjun, et al. Melanin nanoparticles as an endogenous agent for efficient iron overload therapy. J Mater Chem B, 2016, 4(45): 7233-7240.
31.	杨卫东, 张明如. 多模态分子探针的研究进展. 功能与分子医学影像学杂志(电子版), 2016, 5(2): 944-948.
32.	Ko G B, Yoon H S, Kim K Y, et al. Simultaneous multiparametric PET/MRI with silicon photomultiplier PET and ultra-high-field MRI for small-animal imaging. J Nucl Med, 2016, 57(8): 1309-1315.
33.	Chen Gang, Zhu Junyi, Zhang Zhiling, et al. Transformation of cell-derived microparticles into quantum-dot-labeled nanovectors for antitumor siRNA delivery. Angew Chem Int Ed Engl, 2015, 54(3): 1036-1040.
34.	Hong S H, Sun Y, Tang C, et al. Chelator-free and biocompatible melanin nanoplatform with facile loading gadolinium and copper-64 for bioimaging. Bioconjug Chem, 2017, 28(7): 1925-1930.
35.	Yang Min, Fan Quli, Zhang Ruiping, et al. Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging. Biomaterials, 2015, 69: 30-37.
36.	Sun Mengmeng, Liu Fei, Zhu Yukun, et al. Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale, 2016, 8(8): 4452-4457.
37.	Shi Saige, Chen Xiaolan, Wei Jingping, et al. Platinum(Ⅳ) prodrug conjugated Pd@Au nanoplates for chemotherapy and photothermal therapy. Nanoscale, 2016, 8(10): 5706-5713.
38.	Choi W I, Kim J Y, Kang C, et al. Tumor regression in vivo by photothermal therapy based on gold-nanorod-loaded, functional nanocarriers. ACS Nano, 2011, 5(3): 1995-2003.
39.	何华. 生物可降解纳米载体用于药物基因的递送. 苏州: 苏州大学, 2015.
40.	Araújo M, Viveiros R, Correia T R, et al. Natural melanin: a potential pH-responsive drug release device. Int J Pharm, 2014, 469(1): 140-145.

1. 李红姣, 李巨秀, 赵忠. 酶法辅助提取山杏种皮黑色素工艺优化及其稳定性. 食品科学, 2016, 37(10): 69-75.
2. Capozzi V, Perna G, Carmone P, et al. Optical and photoelectronic properties of melanin. Thin Solid Films, 2006, 511(19): 362-366.
3. Menter J M. Melanin from a physicochemical point of view. Polym Int, 2016, 65(11): 1300-1305.
4. Liu Y C, Chen S M, Liu J H, et al. Mechanical and photo-fragmentation processes for nanonization of melanin to improve its efficacy in protecting cells from reactive oxygen species stress. J Appl Phys, 2015, 117(6): 1129.
5. Karlsson O, Lindquist N G. Melanin and neuromelanin binding of drugs and chemicals: toxicological implications. Arch Toxicol, 2016, 90(8): 1883-1891.
6. Song Sheng, Yang Liu, Ye Ming, et al. Antioxidant activity of a Lachnum YM226 melanin-iron complex and its influence on cytokine production in mice with iron deficiency anemia. Food Funct, 2016, 7(3): 1508-1514.
7. Dadachova E, Casadevall A. Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin. Curr Opin Microbiol, 2008, 11(6): 525-531.
8. Chen Y S, Hung Y C, Hong M Y, et al. Control of in vivo transport and toxicity of nanoparticles by tea melanin. J Nanomater, 2012(6b): 9.
9. Sun Y, Hong S, Ma X, et al. Recyclable Cu(I)/melanin dots for cycloaddition, bioconjugation and cell labelling. Chemical Science, 2016, 7(9): 5888-5892.
10. Castellanos G, Fernández-Seara M A, Lorenzo-Betancor O, et al. Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease. Mov Disord, 2015, 30(7): 945-952.
11. 方丽梅, 刘星星, 江颖, 等. 棕榈纤维黑色素提取工艺及性质. 河南工程学院学报: 自然科学版, 2016, 28(3): 10-15.
12. Rageh M M, El-Gebaly R H, Abou-Shady H, et al. Melanin nanoparticles (MNPs) provide protection against whole-body γ-irradiation pound in mice via restoration of hematopoietic tissues. Mol Cell Biochem, 2015, 399(1/2): 59-69.
13. Liu Yanlan, Ai Kelong, Liu Jianhua, et al. Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv Mater, 2013, 25(9): 1353-1359.
14. Liopo A, Su R, Oraevsky A A. Melanin nanoparticles as a novel contrast agent for optoacoustic tomography. Photoacoustics, 2015, 3(1): 35-43.
15. Pyo J, Ju K Y, Lee J K. Artificial pheomelanin nanoparticles and their photo-sensitization properties. J Photochem Photobiol B, 2016, 160: 330-335.
16. Zhang R, Fan Q, Yang M, et al. Drug delivery: engineering melanin nanoparticles as an efficient drug-delivery system for imaging-guided chemotherapy. Adv Mater, 2015, 27(34): 5063-5069.
17. Ju K Y, Lee Y, Lee S, et al. Bioinspired polymerization of dopamine to generate melanin-like nanoparticles having an excellent free-radical-scavenging property. Biomacromolecules, 2011, 12(3): 625-632.
18. Saini A S, Tripathi A, Melo J S. On-column enzymatic synthesis of melanin nanoparticles using cryogenic poly(AAM-co-AGE) monolith and its free radical scavenging and electro-catalytic properties. RSC Adv, 2015, 5(16): 87206-87215.
19. Zhang Pengjun, Yue Yuanyuan, Pan Donghui, et al. Pharmacokinetics study of Zr-89-labeled melanin nanoparticle in iron-overload mice. Nucl Med Biol, 2016, 43(9): 529-533.
20. Fan Quli, Cheng Kai, Hu Xiang, et al. Transferring biomarker into molecular probe: melanin nanoparticle as a naturally active platform for multimodality imaging. J Am Chem Soc, 2014, 136(43): 15185-15194.
21. Chu Maoquan, Hai Wangxi, Zhang Zheyu, et al. Melanin nanoparticles derived from a homology of medicine and food for sentinel lymph node mapping and photothermal in vivo cancer therapy. Biomaterials, 2016, 91: 182-199.
22. Wang Xinyu, Zhang Jishen, Wang Yitong, et al. Multi-responsive photothermal-chemotherapy with drug-loaded melanin-like nanoparticles for synergetic tumor ablation. Biomaterials, 2016, 81: 114-124.
23. Longo D L, Stefania R, Callari C, et al. Water soluble melanin derivatives for dynamic contrast enhanced photoacoustic imaging of tumor vasculature and response to antiangiogenic therapy. Adv Healthc Mater, 2017, 6(1):1-6.
24. Ju K Y, Lee J W, Im G H, et al. Bio-inspired, melanin-like nanoparticles as a highly efficient contrast agent for T1-weighted magnetic resonance imaging. Biomacromolecules, 2013, 14(10): 3491-3497.
25. 雷敏. 鱿鱼墨黑色素及黑色素铁生物活性的研究. 青岛: 中国海洋大学, 2008.
26. Wang Yang, Li Ting, Wang Xuefei, et al. Superior performance of polyurethane based on natural melanin nanoparticles. Biomacromolecules, 2016, 17(11): 3782-3789.
27. Kim D J, Ju K Y, Lee J K. The synthetic melanin nanoparticles having an excellent binding capacity of heavy metal ions. Bull Korean Chem Soc, 2012, 33(11): 3788-3792.
28. Chalmers A W, Shammo J M. Evaluation of a new tablet formulation of deferasirox to reduce chronic iron overload after long-term blood transfusions. Ther Clin Risk Manag, 2016, 12: 201-208.
29. 张瑜. 淫羊藿、黄芪、葛根有效成分组方对阿尔茨海默病脑铁超载的干预作用及其机制研究. 石家庄: 河北医科大学, 2016.
30. Yan Junjie, Ji Yu, Zhang Pengjun, et al. Melanin nanoparticles as an endogenous agent for efficient iron overload therapy. J Mater Chem B, 2016, 4(45): 7233-7240.
31. 杨卫东, 张明如. 多模态分子探针的研究进展. 功能与分子医学影像学杂志(电子版), 2016, 5(2): 944-948.
32. Ko G B, Yoon H S, Kim K Y, et al. Simultaneous multiparametric PET/MRI with silicon photomultiplier PET and ultra-high-field MRI for small-animal imaging. J Nucl Med, 2016, 57(8): 1309-1315.
33. Chen Gang, Zhu Junyi, Zhang Zhiling, et al. Transformation of cell-derived microparticles into quantum-dot-labeled nanovectors for antitumor siRNA delivery. Angew Chem Int Ed Engl, 2015, 54(3): 1036-1040.
34. Hong S H, Sun Y, Tang C, et al. Chelator-free and biocompatible melanin nanoplatform with facile loading gadolinium and copper-64 for bioimaging. Bioconjug Chem, 2017, 28(7): 1925-1930.
35. Yang Min, Fan Quli, Zhang Ruiping, et al. Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging. Biomaterials, 2015, 69: 30-37.
36. Sun Mengmeng, Liu Fei, Zhu Yukun, et al. Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale, 2016, 8(8): 4452-4457.
37. Shi Saige, Chen Xiaolan, Wei Jingping, et al. Platinum(Ⅳ) prodrug conjugated Pd@Au nanoplates for chemotherapy and photothermal therapy. Nanoscale, 2016, 8(10): 5706-5713.
38. Choi W I, Kim J Y, Kang C, et al. Tumor regression in vivo by photothermal therapy based on gold-nanorod-loaded, functional nanocarriers. ACS Nano, 2011, 5(3): 1995-2003.
39. 何华. 生物可降解纳米载体用于药物基因的递送. 苏州: 苏州大学, 2015.
40. Araújo M, Viveiros R, Correia T R, et al. Natural melanin: a potential pH-responsive drug release device. Int J Pharm, 2014, 469(1): 140-145.

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