The simulative study of a new probe for the <i>in vivo</i> dielectric measurement of anisotropic tissue in radio frequency band _Journal of Biomedical Engineering

Authors：

ZHANG Liang ¹ , ZHANG Xiaojun ¹ , ZHOU Dongming ² , LI Gaosheng ² ,  LIU Peiguo ²

1. Faculty of Biomedical Engineering, Fourth Military Medical University, Xi’an 710032, P.R.China;
2. College of Electronic Science and Engineering, National University of Defense Technology, Changsha 410073, P.R.China;

Corresponding author：

LIU Peiguo, Email: peiguo_Liu@hotmail.com

Keywords：

in vivo measurement; radio frequency; anisotropy; dielectric properties

DOI：

10.7507/1001-5515.201702021

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In this paper, a new probe is proposed for the in vivo dielectric measurement of anisotropic tissue in radio frequency band, which could accomplish the dielectric measurement in perpendicular directions by one operation. The simulative studies are performed in the frequency range from 1–1 000 MHz in order to investigate the influence of probe dimension on the energy coupling and sensitivity of measurement. The suitable probe is designed and validated for the actual measurement in this frequency band. According to the simulation results, the energy coupling of the probe could be kept below –12 dB in the frequency range from 200–400 MHz with high sensitivity of measurement for the dielectric properties of anisotropic tissue. That indicates the new type of probe has the potential to achieve the dielectric measurement of anisotropic tissue in radio frequency band and could avoid the measurement error by multi-operations in the conventional method. This new type of probe could provide a new method for the in vivo dielectric measurement of anisotropic tissue in radio frequency band.

Citation： ZHANG Liang, ZHANG Xiaojun, ZHOU Dongming, LI Gaosheng, LIU Peiguo. The simulative study of a new probe for the in vivo dielectric measurement of anisotropic tissue in radio frequency band . Journal of Biomedical Engineering, 2018, 35(1): 106-114. doi: 10.7507/1001-5515.201702021 Copy

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8.	Zhang Liang, Shi Xuetao, You Fusheng, et al. Improved circuit model of open-ended coaxial probe for measurement of the biological tissue dielectric properties between megahertz and gigahertz. Physiol Meas, 2013, 34(10): N83-N96.
9.	Gabriel S, Lau R W, Gabriel C. The dielectric properties of biological tissues: III. parametric models for the dielectric spectrum of tissues. Phys Med Biol, 1996, 41(11): 2271-2293.
10.	毛钧杰, 刘荧, 朱建清. 电磁场与微波工程. 北京: 电子工业出版社, 2004: 222-224.
11.	Laufer S, Ivorra A, Reuter V E, et al. Electrical impedance characterization of normal and cancerous human hepatic tissue. Physiol Meas, 2010, 31(7): 995-1009.

1. Misra D K. A quasi-Static analysis of open-ended coaxial lines. IEEE Trans.on Microw Theory, 1987, 35(10): 925-928.
2. Gabriel C, Chan T A, Grant E H. Admittance models for open ended coaxial probes and their place in dielectric spectroscopy. Phys Med and Biol, 1994, 39(6): 2183-2200.
3. Epstein B R, Foster K R. Anisotropy in the dielectric properties of skeletal muscle. Med Biol Eng Comput, 1983, 21(1): 51-55.
4. Mccrae D A, Esrick M A. Changes in electrical impedance of skeletal muscle measured during hyperthermia. International Journal of Hyperthermia, 1993, 9(2): 247-261.
5. Hart F X, Bemer N J, Mcmillen R L. Modeling the anisotropic electrical properties of muscle. Phys Med and Biol, 1998, 44(11): 413-421.
6. Peters M J, Stinstra J G, Hendriks M. Estimation of the electrical conductivity of human tissue. Electromagnetics, 2001, 21(1): 545-557.
7. Hart F X, Dunfee W R. In vivo measurement of the low-frequency dielectric spectra of frog skeletal muscle. Phys Med Biol, 1993, 38(8): 1099-1112.
8. Zhang Liang, Shi Xuetao, You Fusheng, et al. Improved circuit model of open-ended coaxial probe for measurement of the biological tissue dielectric properties between megahertz and gigahertz. Physiol Meas, 2013, 34(10): N83-N96.
9. Gabriel S, Lau R W, Gabriel C. The dielectric properties of biological tissues: III. parametric models for the dielectric spectrum of tissues. Phys Med Biol, 1996, 41(11): 2271-2293.
10. 毛钧杰, 刘荧, 朱建清. 电磁场与微波工程. 北京: 电子工业出版社, 2004: 222-224.
11. Laufer S, Ivorra A, Reuter V E, et al. Electrical impedance characterization of normal and cancerous human hepatic tissue. Physiol Meas, 2010, 31(7): 995-1009.

Journal of Biomedical Engineering

The simulative study of a new probe for the in vivo dielectric measurement of anisotropic tissue in radio frequency band

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