A capillary blood flow velocity detection system based on linear array charge-coupled devices_Journal of Biomedical Engineering

Authors：

ZHOU Houming , WANG Ruofeng , DANG Qi , YANG Li ,  WANG Xiang

School of Biological Engineering, Chongqing University, Chongqing 400030, P.R.China;

Corresponding author：

WANG Xiang, Email: xwangchn@vip.sina.com

Keywords：

linear array charge-coupled device; field-programmable gate array; AD9826; blood flow curve

DOI：

10.7507/1001-5515.201703045

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In order to detect the flow characteristics of blood samples in the capillary, this paper introduces a blood flow velocity measurement system based on field-programmable gate array (FPGA), linear charge-coupled devices (CCD) and personal computer (PC) software structure. Based on the analysis of the TCD1703C and AD9826 device data sheets, Verilog HDL hardware description language was used to design and simulate the driver. Image signal acquisition and the extraction of the real-time edge information of the blood sample were carried out synchronously in the FPGA. Then a series of discrete displacement were performed in a differential operation to scan each of the blood samples displacement, so that the sample flow rate could be obtained. Finally, the feasibility of the blood flow velocity detection system was verified by simulation and debugging. After drawing the flow velocity curve and analyzing the velocity characteristics, the significance of measuring blood flow velocity is analyzed. The results show that the measurement of the system is less time-consuming and less complex than other flow rate monitoring schemes.

Citation： ZHOU Houming, WANG Ruofeng, DANG Qi, YANG Li, WANG Xiang. A capillary blood flow velocity detection system based on linear array charge-coupled devices. Journal of Biomedical Engineering, 2017, 34(6): 900-906. doi: 10.7507/1001-5515.201703045 Copy

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1. 韩建新, 王学民, 王明时. 在体实时血液粘度的测量研究. 生物医学工程学杂志, 2000, 17(3): 313-315, 342.
2. 董伟, 秦东兴, 伍瑾斐. 基于血液流变学理论的血液流变仪的设计. 微计算机信息, 2006, 22(9-1): 170-172, 182.
3. 常志娟, 石健, 贾妙兴. 血流变仪重复检测差异性及相关影响因素的分析. 中国疗养医学, 2012, 21(4): 348.
4. 王忠立, 刘佳音, 贾云得. 基于 CCD 与 CMOS 的图像传感技术. 光学技术, 2003, 29(3): 361-364.
5. 李守政, 汤斌, 欧红师, 等. 一种基于 FPGA 的 CCD 图像传感器驱动系统设计. 国外电子测量技术, 2012, 31(1): 74-78.
6. 刘恩超, 邹鹏, 李新, 等. 基于线阵 CCD 的光斑定位电路系统设计. 传感器与微系统, 2013, 32(8): 85-87, 91.
7. 夏宇闻. Verilog 数字系统设计. 北京: 北京航空航天大学出版社, 2005.
8. 任慧建, 殷兴辉. 基于 FPGA 的高速线阵 CCD 图像采集系统. 电子测量技术, 2014, 37(11): 33-36, 51.
9. 胡宏伟, 李鸿鹏, 李世诚. 浮动阈值算法在小目标图像提取中的应用. 光电技术应用, 2012, 27(3): 74-76, 88.
10. 于源, 丁美莹, 张连凯. 位移传感器特性区域直线拟合算法分析. 传感技术学报, 2010, 23(6): 840-843.
11. 刘奋飞, 赵辉, 陶卫. 改进的直线拟合线阵 CCD 图像边缘检测方法. 光电工程, 2005, 32(3): 40-43.
12. Brust M, Schaefer C, Doerr R, et al. Rheology of human blood plasma: viscoelastic versus Newtonian behavior. Phys Rev Lett, 2013, 110(7): 078305.
13. Kim S, Namgung B, Ong P K, et al. Determination of rheological properties of whole blood with a scanning capillary-tube rheometer using constitutive models. Journal of Mechanical Science and Technology, 2009, 23(6): 1718-1726.

Journal of Biomedical Engineering

A capillary blood flow velocity detection system based on linear array charge-coupled devices

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