The analysis of event-related potentials in normal brain aging based on N-back cognitive tasks_Journal of Biomedical Engineering

Authors：

LIU Cong ¹ , XU Xiaodong ² , DAI Haoyun ² ,  HOU Fengzhen ¹

1. School of Science, China Pharmaceutical University, Nanjing 211198, P.R.China;
2. School of Foreign Languages and Cultures, Nanjing Normal University, Nanjing 210097, P.R.China;

Corresponding author：

HOU Fengzhen, Email: houfz@cpu.edu.cn

Keywords：

N-back cognitive tasks; the normal brain aging; the event-related potential

DOI：

10.7507/1001-5515.201704031

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Abstract Full text Figures/Tables Video References Cited by

The purpose of this study is to investigate the change of the whole brain event-related potentials(P300) in normal brain aging based on N-back cognitive tasks. The P300 of 15 normal young people and 10 normal old people were evaluated based on N-back cognitive tasks and analyzed. The results showed that the P300 latency of old people was longer in whole brain than young people, and amplitude was increased in the frontal-central region, while significantly increased in the pre-frontal region in the same load cognitive tasks. With the cognitive task load increasing, the amplitude of old people in high-load task was higher in the whole brain than that in low-load task, mainly in in the frontal region, but the difference was not statistically significant. The latency in the high-load task was shorter in the frontal-central region of right brain than the low-load task, and the difference was statistically significant. Thus, P300 showed that the normal brain aging process is mainly reflected in the pre-frontal region, and the high-load cognitive task could better reflect the change of brain function compared with the low-load cognitive task. The finding is of revelatory meaning for diagnosis of early dementia in patients.

Citation： LIU Cong, XU Xiaodong, DAI Haoyun, HOU Fengzhen. The analysis of event-related potentials in normal brain aging based on N-back cognitive tasks. Journal of Biomedical Engineering, 2017, 34(6): 824-830. doi: 10.7507/1001-5515.201704031 Copy

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13.	梁静, 曾波涛, 孟祥军. 首发抑郁症患者认知功能与事件相关电位 P300 研究. 中国健康心理学杂志, 2015(2): 172-174, 175.
14.	康慧聪;黄彬. P300 事件相关脑电位的临床应用. 神经损伤与功能重建, 2005, 25(2): 69-72.
15.	Folstein M F, Folstein S E, Mchugh P R. " Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 1975, 12(3): 189-198.
16.	Kirchner W K. Age differences in short-term retention of rapidly changing information. J Exp Psychol, 1958, 55(4): 352-358.
17.	Dolu N, Başar-Eroğlu C, Özesmi Ç, et al. An assessment of working memory using P300 wave in healthy subjects. International Congress, 2005, 1278: 7-10.
18.	王湘, Chen Bin, 刘鼎, 等. 不同记忆负荷水平下执行控制的 ERP 效应. 中国心理卫生杂志, 2008, 22(8): 576-582.
19.	庄丽频, 陈中鸣, 高菊萍, 等. 正常老年人定量脑电图与事件相关电位 P300 分析//中青年心理卫生学者学术研讨会, 2009: 256-260.
20.	苏玉盛, 马云川, 王红艳, 等. 正常脑老化进程中脑局部葡萄糖代谢减低的规律. CT 理论与应用研究, 2009, 18(4): 75-83.
21.	Tisserand D J, Pruessner J C, Sanz Arigita E J, et al. Regional frontal cortical volumes decrease differentially in aging: an MRI study to compare volumetric approaches and voxel-based morphometry. Neuroimage, 2002, 17(2): 657-669.
22.	Chawluk J B, Alavi A, Dann R, et al. Positron emission tomography in aging and dementia: effect of cerebral atrophy. J Nucl Med, 1987, 28(4): 431-437.

1. Huang Yadong, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell, 2012, 148(6): 1204-1222.
2. Bamidis P D, Vivas A B, Styliadis C, et al. A review of physical and cognitive interventions in aging. Neurosci Biobehav Rev, 2014, 44(SI): 206-220.
3. 宋宏珂. N-back 范式的演变与应用. 西南大学学报:社会科学版, 2011(s1): 81-82.
4. Dev S I, Moore R C, Soontornniyomkij B, et al. Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study. Int J Geriatr Psychiatry, 2017, 32(3): 341-349.
5. Li Huijie, Hou Xiaohui, Liu Hanhui, et al. Putting age-related task activation into large-scale brain networks: A meta-analysis of 114 fMRI studies on healthy aging. Neurosci Biobehav Rev, 2015, 57: 156-174.
6. Heinzel S, Lorenz R C, Brockhaus W R, et al. Working memory load-dependent brain response predicts behavioral training gains in older adults. J Neurosci, 2014, 34(4): 1224-1233.
7. Gajewski P D, Falkenstein M. Age-related effects on ERP and oscillatory EEG-dynamics in a 2-back task. J Psychophysiol, 2014, 28(3): 162-177.
8. Dong Shanshan, Reder L M, Yao Yuan, et al. Individual differences in working memory capacity are reflected in different ERP and EEG patterns to task difficulty. Brain Res, 2015, 1616: 146-156.
9. Padgaonkar N A, Zanto T P, Bollinger J, et al. Predictive cues and age-related declines in working memory performance. Neurobiol Aging, 2017, 49: 31-39.
10. 史欣, 周丽, 刘青蕊. 脑电图的临床应用. 现代电生理学杂志, 2012, 19(4): 241-250.
11. 朱莉, 曾佺, 蒋杨婷, 等. 注意缺陷多动障碍患儿事件相关脑电位研究. 生物医学工程学杂志, 2016(1): 161-166.
12. Tang Alva, Santesso D L, Segalowitz S J, et al. Distinguishing shyness and sociability in children: An event-related potential study. J Exp Child Psychol, 2016, 142: 291-311.
13. 梁静, 曾波涛, 孟祥军. 首发抑郁症患者认知功能与事件相关电位 P300 研究. 中国健康心理学杂志, 2015(2): 172-174, 175.
14. 康慧聪;黄彬. P300 事件相关脑电位的临床应用. 神经损伤与功能重建, 2005, 25(2): 69-72.
15. Folstein M F, Folstein S E, Mchugh P R. " Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 1975, 12(3): 189-198.
16. Kirchner W K. Age differences in short-term retention of rapidly changing information. J Exp Psychol, 1958, 55(4): 352-358.
17. Dolu N, Başar-Eroğlu C, Özesmi Ç, et al. An assessment of working memory using P300 wave in healthy subjects. International Congress, 2005, 1278: 7-10.
18. 王湘, Chen Bin, 刘鼎, 等. 不同记忆负荷水平下执行控制的 ERP 效应. 中国心理卫生杂志, 2008, 22(8): 576-582.
19. 庄丽频, 陈中鸣, 高菊萍, 等. 正常老年人定量脑电图与事件相关电位 P300 分析//中青年心理卫生学者学术研讨会, 2009: 256-260.
20. 苏玉盛, 马云川, 王红艳, 等. 正常脑老化进程中脑局部葡萄糖代谢减低的规律. CT 理论与应用研究, 2009, 18(4): 75-83.
21. Tisserand D J, Pruessner J C, Sanz Arigita E J, et al. Regional frontal cortical volumes decrease differentially in aging: an MRI study to compare volumetric approaches and voxel-based morphometry. Neuroimage, 2002, 17(2): 657-669.
22. Chawluk J B, Alavi A, Dann R, et al. Positron emission tomography in aging and dementia: effect of cerebral atrophy. J Nucl Med, 1987, 28(4): 431-437.

Journal of Biomedical Engineering

The analysis of event-related potentials in normal brain aging based on N-back cognitive tasks

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