Research progress on mesoporous bioactive glass_Journal of Biomedical Engineering

Authors：

WU Jingwen , YANG Lan , LI Yuanjing ,  GUO Luhua

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou 510140, P.R.China;

Corresponding author：

Keywords：

mesoporous bioactive glass; bioactivity; bone tissue engineering

DOI：

10.7507/1001-5515.201706091

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Bioactive glass (BG) has been widely used in bone tissue engineering due to its good osteogenic property and bioactivity, but it still has some deficiencies, such as poor cell adhesion and low osteogenic rate and so on. Mesoporous biological glass (MBG) is a kind of new material originated from BG and mesoporous silica (MS). Because of its large number of nano-channel, large specific surface area, easy degradation, good biocompatibility and biological activity, MBG has great application prospects in the field of bone tissue engineering. This review would present MBG preparation and experimental research in order to provide the theoretical basis and experimental reference for related researches.

Citation： WU Jingwen, YANG Lan, LI Yuanjing, GUO Luhua. Research progress on mesoporous bioactive glass. Journal of Biomedical Engineering, 2018, 35(4): 647-650. doi: 10.7507/1001-5515.201706091 Copy

1.	Hench L L, Splinter R J, Allen W C, et al. Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res A, 1971, 5(6): 117-141.
2.	Hench L L, Jones J R. Bioactive glasses: frontiers and challenges. Frontiers in bioengineering and biotechnology, 2015, 3: 194.
3.	马鹏飞, 李日红, 张龙. 溶胶-凝胶法制备高比表面积铝磷钙生物活性玻璃. 无机材料学报, 2017, 32(1): 107-112.
4.	周子燕, 何星. 载药介孔生物玻璃治疗骨髓炎的研究进展. 中华骨与关节外科杂志, 2016, 9(1): 84-86.
5.	余翠霞, 葛飞, 翁文剑, 等. 介/纳孔生物玻璃薄膜的孔结构调控及其 BSA 吸附. 稀有金属材料与工程, 2016, 45(s1): 567-571.
6.	Gentleman E, Fredholm Y C, Jell G, et al. The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro. Biomaterials, 2010, 31(14): 3949-3956.
7.	Innocenzi P, Malfatti L. Soler-Illia G J A A Hierarchical mesoporous films: from self-assembly to porosity with diferent length scales. Chemistry of Materials, 2011, 23(10): 2501-2509.
8.	Zhou Yinghong, Shi Mengchao, Jones J R, et al. Strategies to direct vascularisation using mesoporous bioactive glass-based biomaterials for bone regeneration. International Materials Reviews, 2017, 62(7): 392-414.
9.	Tsigkou O, Labbaf S, Stevens M M, et al. Monodispersed bioactive glass submicron particles and their effect on bone marrow and adipose tissue-derived stem cells. Adv Healthc Mater, 2014, 3(1): 115-125.
10.	Shah A T, Ain Q, Chaudhry A A, et al. A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass. Journal of Materials Science, 2015, 50(4): 1794-1804.
11.	Mathew R, Turdean-Ionescu C, Yu Yang, et al. Proton environments in biomimetic Calcium phosphates formed from mesoporous bioactive CaO-SiO₂-P₂O₅ glasses in vitro: insights from Solid-State NMR. J Phys Chem C Nanomater Interfaces, 2017, 121(24): 13223-13238.
12.	Hench L L. Bioceramics: from concept to clinic. Journal of the American Ceramic Society, 1991, 74(7): 1487-1510.
13.	Li B, Luo W, Wang Y, et al. Bioactive SiO₂-CaO-P₂O₅, hollow nanospheres for drug delivery. Journal of Non-Crystalline Solids, 2016, 447: 98-103.
14.	赵大洲. 掺杂 Eu³⁺ 球状介孔生物玻璃的药物缓释研究. 陕西师范大学学报: 自科版, 2016, 44(3): 64-68.
15.	Wu Chengtie, Xia Lunguo, Han Pingping, et al. Europium-Containing mesoporous bioactive glass scaffolds for stimulating in vitro and in vivo osteogenesis. ACS Appl Mater Interfaces, 2016, 8(18): 11342-11354.
16.	Wang Xiang, Zhang Ying, Lin Chuan, et al. Sol-gel derived terbium-containing mesoporous bioactive glasses nanospheres: in vitro hydroxyapatite formation and drug delivery. Colloids Surf B Biointerfaces, 2017, 160: 406-415.
17.	Bari A, Bloise N, Fiorilli S, et al. Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration. Acta Biomater, 2017, 55: 493-504.
18.	Khan P K, Mahato A, Kundu B, et al. Influence of single and binary doping of Strontium and lithium on in vivo biological properties of bioactive glass scaffolds. Sci Rep, 2016, 6: 32964.
19.	Sriranganathan D, Kanwal N, Hing K A, et al. Strontium substituted bioactive glasses for tissue engineered scaffolds: the importance of octacalcium phosphate. J Mater Sci Mater Med, 2016, 27(2): 39.
20.	Zhang Yufeng, Wei Lingfei, Wu Chengtie, et al. Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats. PLoS One, 2014, 9(8): e104527.
21.	Wu C, Chang J. Strontium-containing mesoporous bioactive glass for regeneration of osteoporotic bone and periodontal tissue// Nanobioceramics for Healthcare Applications. 2017: 187-212.
22.	Zhang Xingdi, Zeng Deliang, Li Nan, et al. Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration. Sci Rep, 2016, 6: 19361.
23.	Lee J H, Kang M S, Mahapatra C, et al. Effect of aminated mesoporous bioactive glass nanoparticles on the differentiation of dental pulp stem cells. PLoS One, 2016, 11(3): e0150727.
24.	Hsu F Y, Weng Ruchun, Lin H M, et al. A biomimetic extracellular matrix composed of mesoporous bioactive glass as a bone graft material. Microporous and Mesoporous Materials, 2015, 212: 56-65.
25.	郭志豪, 田林强, 刘槃, 等. 丝素蛋白/介孔生物玻璃陶瓷复合材料修复颅骨缺损. 中国组织工程研究, 2017, 21(2): 192-196.
26.	Chen Xiaohui, Zhao Yanbing, Geng S, et al. In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold. Int J Nanomedicine, 2015, 10: 839-846.
27.	李静静, 朱海霖, 雷彩虹, 等. 介孔生物玻璃/丝素蛋白复合多孔海绵的结构及止血性能研究. 功能材料, 2017, 48(2): 2096-2101.
28.	Qi Xin, Pei Peng, Zhu Min, et al. Three dimensional printing of calcium sulfate and mesoporous bioactive glass scaffolds for improving bone regeneration in vitro and in vivo. Sci Rep, 2017, 7: 42556.
29.	Cai Yanrong, Guo Lieping, Shen Hongxing, et al. Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer. Int J Nanomedicine, 2015, 10: 4125-4136.
30.	Li Nan, Jiang Chuan, Zhang Xingdi, et al. Preparation of an rhBMP-2 loaded mesoporous bioactive glass/calcium phosphate cement porous composite scaffold for rapid bone tissue regeneration. Journal of Materials Chemistry B, 2015, 3(43): 8558-8566.
31.	Kingshott P, Andersson G, Mcarthur S L, et al. Surface modification and chemical surface analysis of biomaterials. Curr Opin Chem Biol, 2011, 15(5): 667-676.
32.	Shi Mengchao, Zhai Dong, Zhao Lang, et al. Nanosized mesoporous bioactive glass/poly(lactic-co-glycolic acid) composite-coated CaSiO₃ scaffolds with multifunctional properties for bone tissue engineering. Biomed Research International, 2014, 2014: 323046.
33.	Zhang Yali, Xia Lunguo, Zhai Dong, et al. Mesoporous bioactive glass nanolayer-functionalized 3D-printed scaffolds for accelerating osteogenesis and angiogenesis. Nanoscale, 2015, 7(45): 19207-19221.
34.	Zhang Yali, Chen Lei, Shi Mengchao, et al. Mesoporous bioactive glass nanolayer-modified zirconia coatings on Ti-6Al-4V with improved in vitro bioactivity. International Journal of Applied Glass Science, 2016, 7(2): 216-228.
35.	Li Xian, Miao Guohou, Chen Xiaofeng, et al. Investigation of radial mesoporous bioactive glass particles as drug carriers for inhibition of tumor cells. Science of Advanced Materials, 2017, 9(3/4): 562-570.
36.	Zhang Quan, Zhang Y E, Chen Wenjun, et al. Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores. Experimental Therapeutic Medicine, 2013, 6(6): 1443-1448.

1. Hench L L, Splinter R J, Allen W C, et al. Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res A, 1971, 5(6): 117-141.
2. Hench L L, Jones J R. Bioactive glasses: frontiers and challenges. Frontiers in bioengineering and biotechnology, 2015, 3: 194.
3. 马鹏飞, 李日红, 张龙. 溶胶-凝胶法制备高比表面积铝磷钙生物活性玻璃. 无机材料学报, 2017, 32(1): 107-112.
4. 周子燕, 何星. 载药介孔生物玻璃治疗骨髓炎的研究进展. 中华骨与关节外科杂志, 2016, 9(1): 84-86.
5. 余翠霞, 葛飞, 翁文剑, 等. 介/纳孔生物玻璃薄膜的孔结构调控及其 BSA 吸附. 稀有金属材料与工程, 2016, 45(s1): 567-571.
6. Gentleman E, Fredholm Y C, Jell G, et al. The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro. Biomaterials, 2010, 31(14): 3949-3956.
7. Innocenzi P, Malfatti L. Soler-Illia G J A A Hierarchical mesoporous films: from self-assembly to porosity with diferent length scales. Chemistry of Materials, 2011, 23(10): 2501-2509.
8. Zhou Yinghong, Shi Mengchao, Jones J R, et al. Strategies to direct vascularisation using mesoporous bioactive glass-based biomaterials for bone regeneration. International Materials Reviews, 2017, 62(7): 392-414.
9. Tsigkou O, Labbaf S, Stevens M M, et al. Monodispersed bioactive glass submicron particles and their effect on bone marrow and adipose tissue-derived stem cells. Adv Healthc Mater, 2014, 3(1): 115-125.
10. Shah A T, Ain Q, Chaudhry A A, et al. A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass. Journal of Materials Science, 2015, 50(4): 1794-1804.
11. Mathew R, Turdean-Ionescu C, Yu Yang, et al. Proton environments in biomimetic Calcium phosphates formed from mesoporous bioactive CaO-SiO₂-P₂O₅ glasses in vitro: insights from Solid-State NMR. J Phys Chem C Nanomater Interfaces, 2017, 121(24): 13223-13238.
12. Hench L L. Bioceramics: from concept to clinic. Journal of the American Ceramic Society, 1991, 74(7): 1487-1510.
13. Li B, Luo W, Wang Y, et al. Bioactive SiO₂-CaO-P₂O₅, hollow nanospheres for drug delivery. Journal of Non-Crystalline Solids, 2016, 447: 98-103.
14. 赵大洲. 掺杂 Eu³⁺ 球状介孔生物玻璃的药物缓释研究. 陕西师范大学学报: 自科版, 2016, 44(3): 64-68.
15. Wu Chengtie, Xia Lunguo, Han Pingping, et al. Europium-Containing mesoporous bioactive glass scaffolds for stimulating in vitro and in vivo osteogenesis. ACS Appl Mater Interfaces, 2016, 8(18): 11342-11354.
16. Wang Xiang, Zhang Ying, Lin Chuan, et al. Sol-gel derived terbium-containing mesoporous bioactive glasses nanospheres: in vitro hydroxyapatite formation and drug delivery. Colloids Surf B Biointerfaces, 2017, 160: 406-415.
17. Bari A, Bloise N, Fiorilli S, et al. Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration. Acta Biomater, 2017, 55: 493-504.
18. Khan P K, Mahato A, Kundu B, et al. Influence of single and binary doping of Strontium and lithium on in vivo biological properties of bioactive glass scaffolds. Sci Rep, 2016, 6: 32964.
19. Sriranganathan D, Kanwal N, Hing K A, et al. Strontium substituted bioactive glasses for tissue engineered scaffolds: the importance of octacalcium phosphate. J Mater Sci Mater Med, 2016, 27(2): 39.
20. Zhang Yufeng, Wei Lingfei, Wu Chengtie, et al. Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats. PLoS One, 2014, 9(8): e104527.
21. Wu C, Chang J. Strontium-containing mesoporous bioactive glass for regeneration of osteoporotic bone and periodontal tissue// Nanobioceramics for Healthcare Applications. 2017: 187-212.
22. Zhang Xingdi, Zeng Deliang, Li Nan, et al. Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration. Sci Rep, 2016, 6: 19361.
23. Lee J H, Kang M S, Mahapatra C, et al. Effect of aminated mesoporous bioactive glass nanoparticles on the differentiation of dental pulp stem cells. PLoS One, 2016, 11(3): e0150727.
24. Hsu F Y, Weng Ruchun, Lin H M, et al. A biomimetic extracellular matrix composed of mesoporous bioactive glass as a bone graft material. Microporous and Mesoporous Materials, 2015, 212: 56-65.
25. 郭志豪, 田林强, 刘槃, 等. 丝素蛋白/介孔生物玻璃陶瓷复合材料修复颅骨缺损. 中国组织工程研究, 2017, 21(2): 192-196.
26. Chen Xiaohui, Zhao Yanbing, Geng S, et al. In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold. Int J Nanomedicine, 2015, 10: 839-846.
27. 李静静, 朱海霖, 雷彩虹, 等. 介孔生物玻璃/丝素蛋白复合多孔海绵的结构及止血性能研究. 功能材料, 2017, 48(2): 2096-2101.
28. Qi Xin, Pei Peng, Zhu Min, et al. Three dimensional printing of calcium sulfate and mesoporous bioactive glass scaffolds for improving bone regeneration in vitro and in vivo. Sci Rep, 2017, 7: 42556.
29. Cai Yanrong, Guo Lieping, Shen Hongxing, et al. Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer. Int J Nanomedicine, 2015, 10: 4125-4136.
30. Li Nan, Jiang Chuan, Zhang Xingdi, et al. Preparation of an rhBMP-2 loaded mesoporous bioactive glass/calcium phosphate cement porous composite scaffold for rapid bone tissue regeneration. Journal of Materials Chemistry B, 2015, 3(43): 8558-8566.
31. Kingshott P, Andersson G, Mcarthur S L, et al. Surface modification and chemical surface analysis of biomaterials. Curr Opin Chem Biol, 2011, 15(5): 667-676.
32. Shi Mengchao, Zhai Dong, Zhao Lang, et al. Nanosized mesoporous bioactive glass/poly(lactic-co-glycolic acid) composite-coated CaSiO₃ scaffolds with multifunctional properties for bone tissue engineering. Biomed Research International, 2014, 2014: 323046.
33. Zhang Yali, Xia Lunguo, Zhai Dong, et al. Mesoporous bioactive glass nanolayer-functionalized 3D-printed scaffolds for accelerating osteogenesis and angiogenesis. Nanoscale, 2015, 7(45): 19207-19221.
34. Zhang Yali, Chen Lei, Shi Mengchao, et al. Mesoporous bioactive glass nanolayer-modified zirconia coatings on Ti-6Al-4V with improved in vitro bioactivity. International Journal of Applied Glass Science, 2016, 7(2): 216-228.
35. Li Xian, Miao Guohou, Chen Xiaofeng, et al. Investigation of radial mesoporous bioactive glass particles as drug carriers for inhibition of tumor cells. Science of Advanced Materials, 2017, 9(3/4): 562-570.
36. Zhang Quan, Zhang Y E, Chen Wenjun, et al. Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores. Experimental Therapeutic Medicine, 2013, 6(6): 1443-1448.

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