Progress on neurogenesis mechanisms of endogenous adult neural stem cells_Journal of Biomedical Engineering

Authors：

YING Yibo , CHEN Min , ZHU Juanjuan , XIANG Guangheng , CHEN Mengji , MAO Yiwen , CHEN Ziqi ,  ZHU Sipin

The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R.China;

Corresponding author：

Keywords：

neural stem cells; neurogenesis; molecular mechanisms; differentiation; migration

DOI：

10.7507/1001-5515.201707005

Video：

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Abstract Full text Figures/Tables Video References Cited by

Endogenous adult neural stem cells are closely related to the normal physiological functions of the brain and many neurodegenerative diseases. Neurons are affected by factors such as extracellular microenvironment and intracellular signaling. In recent years, some specific signaling pathways have been found that affect the occurrence of neural stem cells in adult neural networks, including proliferation, differentiation, maturation, migration, and integration with host functions. In this paper, we summarize the signals and their molecular mechanisms, including the related signaling pathways, neurotrophic factors, neurotransmitters, intracellular transcription factors and epigenetic regulation of neuronal differentiation from both the extracellular and intracellular aspects, providing basic theoretical support for the treatment of central nervous system diseases through neural stem cells approach.

Citation： YING Yibo, CHEN Min, ZHU Juanjuan, XIANG Guangheng, CHEN Mengji, MAO Yiwen, CHEN Ziqi, ZHU Sipin. Progress on neurogenesis mechanisms of endogenous adult neural stem cells. Journal of Biomedical Engineering, 2018, 35(6): 986-992. doi: 10.7507/1001-5515.201707005 Copy

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13.	Swartling F J, Bolin S, Phillips J J, et al. Signals that regulate the oncogenic fate of neural stem cells and progenitors. Exp Neurol, 2014, 260: 56-68.
14.	Bothwell M. NGF, BDNF, NT₃, and NT₄. Exp Pharmacol, Neurotrophic Factors, 2014, 220: 3-15.
15.	Annenkov A, . Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development. Mol Neurobiol, 2014, 49(1): 440-471.
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17.	Yuan Honghua, Chen Renjin, Wu Lianlian, et al. The regulatory mechanism of neurogenesis by IGF-1 in adult mice. Mol Neurobiol, 2015, 51(2): 512-522.
18.	Tong C K, Alvarez-Buylla A. SnapShot: adult neurogenesis in the V-SVZ. Neuron, 2014, 81(1): 220-220.
19.	Volz M S, Finke C, Harms L, et al. Altered paired associative stimulation-induced plasticity in NMDAR encephalitis. Annals of clinical and translational neurology, 2016, 3(2): 101-113.
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21.	Park B N, Kim J H, Lee K, et al. Improved dopamine transporter binding activity after bone marrow mesenchymal stem cell transplantation in a rat model of Parkinson's disease: small animal positron emission tomography study with F-18 FP-CIT. Eur Radiol, 2015, 25(5): 1487-1496.
22.	Egeland M, Zunszain P A, Pariante C M. Molecular mechanisms in the regulation of adult neurogenesis during stress. Nat Rev Neurosci, 2015, 16(4): 189-200.
23.	Gan Q, Lee A, Suzuki R, et al. Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells, 2014, 32(1): 45-58.
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28.	Zhang Chunli, Zou Yuhua, He Weimin, et al. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature, 2008, 451(7181): 1004-1007.
29.	Roese-Koerner B, Stappert L, Berger T, et al. Reciprocal regulation between bifunctional miR-9/9 (*) and its transcriptional modulator notch in human neural stem cell self-renewal and differentiation. Stem Cell Reports, 2016, 7(2): 207-219.
30.	Matz-Soja M, Aleithe S, Marbach E, et al. Hepatic hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels, . Cell Commun Signal, 2014, 12: 11.

1. Smalley E. Neural stem cell trailblazer StemCells folds. Nat Biotechnol, 2016, 34(7): 677-678.
2. Seidel D, Obendorf J, Englich B, et al. Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays. Biosens Bioelectron, 2016, 86: 277-286.
3. Poser S W, Chenoweth J G, Colantuoni C, et al. Concise review: reprogramming, behind the scenes: noncanonical neural stem cell signaling pathways reveal new, unseen regulators of tissue plasticity with therapeutic implications. Stem Cells Transl Med, 2015, 4(11): 1251-1257.
4. Maraldi T, Bertoni L, Riccio M, et al. Human amniotic fluid stem cells: neural differentiation in vitro and in vivo. Cell Tissue Res, 2014, 357(1): 1-13.
5. Mckay R. Stem cells in the central nervous system. Science, 1997, 276(5309): 66-71.
6. Klein R S, Rubin J B, Gibson H D, et al. SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Development, 2001, 128(11): 1971-1981.
7. Palmer T D, Willhoite A R, Gage F H. Vascular niche for adult hippocampal neurogenesis. J Comp Neurol, 2000, 425(4): 479-494.
8. Monje M L, Mizumatsu S, Fike J R, et al. Irradiation induces neural precursor-cell dysfunction. Nat Med, 2002, 8(9): 955-962.
9. Mercier F, Kitasako J T, Hatton G I. Anatomy of the brain neurogenic zones revisited: fractones and the fibroblast/macrophage network. J Comp Neurol, 2002, 451(2): 170-188.
10. Miranda C J, Braun L, Jiang Yuying, et al. Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling. Aging Cell, 2012, 11(3): 542-552.
11. Xiao Ying, Thoresen D T, Williams J S, et al. Neural hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium. Proc Natl Acad Sci USA, 2015, 112(23): 7195-7200.
12. Lee S H, Lee S, Yang H, et al. Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis. Circ Res, 2014, 115(2): 215-226.
13. Swartling F J, Bolin S, Phillips J J, et al. Signals that regulate the oncogenic fate of neural stem cells and progenitors. Exp Neurol, 2014, 260: 56-68.
14. Bothwell M. NGF, BDNF, NT₃, and NT₄. Exp Pharmacol, Neurotrophic Factors, 2014, 220: 3-15.
15. Annenkov A, . Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development. Mol Neurobiol, 2014, 49(1): 440-471.
16. Elizabeth D K, Sandra E M, Wayne G S, et al. Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife, 2013, 2: e00362.
17. Yuan Honghua, Chen Renjin, Wu Lianlian, et al. The regulatory mechanism of neurogenesis by IGF-1 in adult mice. Mol Neurobiol, 2015, 51(2): 512-522.
18. Tong C K, Alvarez-Buylla A. SnapShot: adult neurogenesis in the V-SVZ. Neuron, 2014, 81(1): 220-220.
19. Volz M S, Finke C, Harms L, et al. Altered paired associative stimulation-induced plasticity in NMDAR encephalitis. Annals of clinical and translational neurology, 2016, 3(2): 101-113.
20. Boychuk C R, Gyarmati P, Xu Hong, et al. Glucose sensing by GABAergic neurons in the mouse nucleus tractus solitarii. J Neurophysiol, 2015, 114(2): 999-1007.
21. Park B N, Kim J H, Lee K, et al. Improved dopamine transporter binding activity after bone marrow mesenchymal stem cell transplantation in a rat model of Parkinson's disease: small animal positron emission tomography study with F-18 FP-CIT. Eur Radiol, 2015, 25(5): 1487-1496.
22. Egeland M, Zunszain P A, Pariante C M. Molecular mechanisms in the regulation of adult neurogenesis during stress. Nat Rev Neurosci, 2015, 16(4): 189-200.
23. Gan Q, Lee A, Suzuki R, et al. Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells, 2014, 32(1): 45-58.
24. Vasconcelos F, Castro D S. Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1, . Front Cell Neurosci, 2014, 8: 412.
25. Ozen I, Galichet C, Watts C, et al. Proliferating neuronal progenitors in the postnatal hippocampus transiently Express the proneural gene Ngn2. Eur J Neurosci, 2007, 25(9): 2591-2603.
26. Li Zhi, Zhao Wei, Liu Wei, et al. Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury. Neural Regeneration Research, 2014, 9(24): 2197-2204.
27. Faulkner R L, Wishard T J, Thompson C K, et al. FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles. eNeuro, 2015, 2(1): e0055.
28. Zhang Chunli, Zou Yuhua, He Weimin, et al. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature, 2008, 451(7181): 1004-1007.
29. Roese-Koerner B, Stappert L, Berger T, et al. Reciprocal regulation between bifunctional miR-9/9 (*) and its transcriptional modulator notch in human neural stem cell self-renewal and differentiation. Stem Cell Reports, 2016, 7(2): 207-219.
30. Matz-Soja M, Aleithe S, Marbach E, et al. Hepatic hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels, . Cell Commun Signal, 2014, 12: 11.

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