An event-related potential objective evaluation study of mental fatigue based on 2-back task_Journal of Biomedical Engineering

Authors：

FAN Xiaoli ¹ ,  ZHAO Chaoyi ¹ , LUO Hong ¹ , ZHANG Wei ²

1. AQSIQ Key Laboratory of Human Factors and Ergonomics, China National Institute of Standardization, Beijing 100191, P.R.China;
2. Department of Industrial Engineering, Tsinghua University, Beijing 100072, P.R.China;

Corresponding author：

ZHAO Chaoyi, Email: zhaocy@cnis.gov.cn

Keywords：

mental fatigue; event-related potential; 2-back; P300; error related negativity

DOI：

10.7507/1001-5515.201801064

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The electroencephalographic characteristics of mental fatigue, which was induced by long-term working memory task of 2-back, were studied by event-related potential (ERP) technology in order to obtain objective evaluation indicators for mental fatigue. Thirty-two healthy male subjects, 22–28 years old, were divided into two groups evenly, one is un-fatigue group and the other is fatigue group. The fatigue group performed a 2-back task for 100 min continuously, while the un-fatigue group just performed a 2-back task at the first and last 10 min respectively, and rested during the middle 80 min. The subjective levels of fatigue, task performance and electroencephalogram were recorded. The impaired thought and attention states, enhanced sleepy and fatigue feeling were found in the fatigue group, meanwhile their reaction time to 2-back task extended, and the accuracy decreased significantly. These results verified the validity of mental fatigue model induced by 2-back task, and then the ERP characteristic parameters were compared and analyzed between fatigue group and un-fatigue group. The results showed that the fatigue group’s amplitudes of P300 (F = 2.539, P < 0.05) and error-related negativity (ERN) ( F = 10.040, P < 0.05) decreased significantly along with the increase of fatigue comparing with the un-fatigue group, however, there were no significant change in other parameters (all P > 0.05). These results demonstrate that P300 and ERN can be considered as potential evaluation indictors for mental fatigue induced by long-term working memory task, which will provide basis for the future exploring of countermeasure for mental fatigue.

Citation： FAN Xiaoli, ZHAO Chaoyi, LUO Hong, ZHANG Wei. An event-related potential objective evaluation study of mental fatigue based on 2-back task. Journal of Biomedical Engineering, 2018, 35(6): 837-844. doi: 10.7507/1001-5515.201801064 Copy

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2.	Grandjean E. Fitting the task to the man. Physiotherapy, 1988, 84(5): 242.
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13.	Fowler B. P300 as a measure of workload during a simulated aircraft landing task. Hum Factors, 1994, 36(4): 670-683.
14.	Gosselin A, De Koninck J, Campbell K B. Total sleep deprivation and novelty processing: implications for frontal lobe functioning. Clin Neurophysiol, 2005, 116(1): 211-222.
15.	完颜笑如, 庄达民, 刘伟. 脑力负荷对前注意加工的影响与分析. 北京航空航天大学学报, 2012, 38(4): 497-501.
16.	Raz A, Deouell L Y, Bentin S. Is pre-attentive processing compromised by prolonged wakefulness? Effects of total sleep deprivation on the mismatch negativity. Psychophysiology, 2001, 38(5): 787-795.
17.	吕亦萱. 脑力疲劳对持续性注意的影响研究. 北京: 北京航空航天大学, 2015.
18.	Boksem M A, Meijman T F, Lorist M M. Effects of mental fatigue on attention: an ERP study. Brain Res Cogn Brain Res, 2005, 25(1): 107-116.
19.	Shigihara Y, Tanaka M, Ishii A, et al. Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways. Behav Brain Funct, 2013, 9(2): 1-12.
20.	Schapkin S A, Freude G. Neuronal mechanisms of working memory performance in younger and older employees//International Conference on Engineering Psychology and Cognitive Ergonomics. Heraklion, Crete, Greece, 2014: 70-81.
21.	Smith J L, Smith E A, Provost A L, et al. Sequence effects support the conflict theory of N200 and P3 in the go/nogo task. International Journal of Psychophysiology, 2015, 75(3): 217-226.
22.	Xiao Yi, Ma Feng, Lv Yixuan, et al. Sustained attention is associated with error processing impairment: evidence from mental fatigue study in four-choice reaction time task. PLoS One, 2015, 10(3): e0117837.
23.	Themanson J R, Ball A B, Khatcherian S M, et al. The effects of social exclusion on the ERN and the cognitive control of action monitoring. Psychophysiology, 2014, 51(3): 215-225.
24.	Pfabigan D M, Pintzinger N M, Siedek D R, et al. Feelings of helplessness increase ERN amplitudes in healthy individuals. Neuropsychologia, 2013, 51(4): 613-621.

1. Grandjean E. Fatigue in industry. Br J Ind Med, 1979, 36(3): 175-186.
2. Grandjean E. Fitting the task to the man. Physiotherapy, 1988, 84(5): 242.
3. Layzer R B. Asthenia and the chronic fatigue syndrome. Muscle Nerve, 1998, 21(12): 1609-1611.
4. Campagnolo N, Johnston S, Collatz A, et al. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review. J Hum Nutr Diet, 2017, 30(3): 247-259.
5. 苗丹民, 王京生, 刘立. 军事心理学手册. 北京: 中国轻工业出版社, 2004.
6. Ramkumar A, Stappers P J, Niessen W J, et al. Using GOMS and NASA-TLX to evaluate human-computer interaction process in interactive segmentation. Int J Hum Comput Interact, 2017, 33(2): 123-134.
7. 韩辉, 周音莲, 蔡文杰, 等. 日本《疲劳自觉症状调查表》在潜艇部队的适用性研究. 海军医学杂志, 2011, 32(5): 313-315.
8. Liu J C, Verhulst S, Massar S A, et al. Sleep deprived and sweating it out: the effects of total sleep deprivation on skin conductance reactivity to psychosocial stress. Sleep, 2015, 38(1): 155-159.
9. 宋国萍, 赵仑, 张侃. 连续 10h 驾驶对听觉非随意注意影响的 ERPs 研究. 航天医学与医学工程, 2006, 19(2): 147-149.
10. Biferno M. Mental workload measurement in operational air craft systems: two promising approaches. Designs Codes & Cryptography, 1987, 6(12): 67-75.
11. Larue G S, Rakotonirainy A, Pettitt A N. Driving performance impairments due to hypovigilance on monotonous roads. Accid Anal Prev, 2011, 43(6): 2037-2046.
12. Zhao Chunlin, Zhao Min, Liu Jianpin, et al. Electroencephalogram and electrocardiograph assessment of mental fatigue in a driving simulator. Accid Anal Prev, 2012, 45(1): 83-90.
13. Fowler B. P300 as a measure of workload during a simulated aircraft landing task. Hum Factors, 1994, 36(4): 670-683.
14. Gosselin A, De Koninck J, Campbell K B. Total sleep deprivation and novelty processing: implications for frontal lobe functioning. Clin Neurophysiol, 2005, 116(1): 211-222.
15. 完颜笑如, 庄达民, 刘伟. 脑力负荷对前注意加工的影响与分析. 北京航空航天大学学报, 2012, 38(4): 497-501.
16. Raz A, Deouell L Y, Bentin S. Is pre-attentive processing compromised by prolonged wakefulness? Effects of total sleep deprivation on the mismatch negativity. Psychophysiology, 2001, 38(5): 787-795.
17. 吕亦萱. 脑力疲劳对持续性注意的影响研究. 北京: 北京航空航天大学, 2015.
18. Boksem M A, Meijman T F, Lorist M M. Effects of mental fatigue on attention: an ERP study. Brain Res Cogn Brain Res, 2005, 25(1): 107-116.
19. Shigihara Y, Tanaka M, Ishii A, et al. Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways. Behav Brain Funct, 2013, 9(2): 1-12.
20. Schapkin S A, Freude G. Neuronal mechanisms of working memory performance in younger and older employees//International Conference on Engineering Psychology and Cognitive Ergonomics. Heraklion, Crete, Greece, 2014: 70-81.
21. Smith J L, Smith E A, Provost A L, et al. Sequence effects support the conflict theory of N200 and P3 in the go/nogo task. International Journal of Psychophysiology, 2015, 75(3): 217-226.
22. Xiao Yi, Ma Feng, Lv Yixuan, et al. Sustained attention is associated with error processing impairment: evidence from mental fatigue study in four-choice reaction time task. PLoS One, 2015, 10(3): e0117837.
23. Themanson J R, Ball A B, Khatcherian S M, et al. The effects of social exclusion on the ERN and the cognitive control of action monitoring. Psychophysiology, 2014, 51(3): 215-225.
24. Pfabigan D M, Pintzinger N M, Siedek D R, et al. Feelings of helplessness increase ERN amplitudes in healthy individuals. Neuropsychologia, 2013, 51(4): 613-621.

Journal of Biomedical Engineering

An event-related potential objective evaluation study of mental fatigue based on 2-back task

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