Experiments study on mechanical behavior of porcine lumbar intervertebral disc after nucleotomy under compression_Journal of Biomedical Engineering

Authors：

ZHU Songfeng ^1,2 ,  YANG Xiuping ^1,2 , LUAN Yichao ¹ , LIU Qing ¹ ,  ZHANG Chunqiu ¹

1. Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, Tianjin University of Technology, Tianjin 300384, P.R.China;
2. National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin 300384, P.R.China;

Corresponding author：

YANG Xiuping, Email: yhp420@sina.com; ZHANG Chunqiu, Email: 13012251281@126.com

Keywords：

nucleotomy; lumbar intervertebral disc; creep; constitutive model

DOI：

10.7507/1001-5515.201803053

Video：

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Abstract Full text Figures/Tables Video References Cited by

In order to study the mechanical behavior of degeneration and nucleotomy of lumbar intervertebral disc, compression experiments with porcine lumbar intervertebral discs were carried out. The lumbar intervertebral discs with trypsin-treated and nucleus nucleotomy served as the experimental group and the normal discs as the control group. Considering the effects of load magnitude and loading rate, the relationship between stress and strain, instantaneous elastic modulus and creep property of intervertebral disc were obtained. The creep constitutive model was established. The results show that the strain and creep strain of the experimental group increase significantly with the increase of compression load and loading rate, whereas the instantaneous elastic modulus decreases obviously, compared with the control group. It indicates that the effect of load magnitude and loading rate on load-bearing capacity of intervertebral disc after nucleotomy is larger obviously than that of normal disc. The creep behavior of the experimental group can be still predicted by the Kelvin three-parameter solid model. The results will provide theoretical foundation for clinical treatment and postoperative rehabilitation of intervertebral disc disease.

Citation： ZHU Songfeng, YANG Xiuping, LUAN Yichao, LIU Qing, ZHANG Chunqiu. Experiments study on mechanical behavior of porcine lumbar intervertebral disc after nucleotomy under compression. Journal of Biomedical Engineering, 2019, 36(4): 590-595. doi: 10.7507/1001-5515.201803053 Copy

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2.	Ellingson A M, Nuckley D J. Intervertebral disc viscoelastic parameters and residual mechanics spatially quantified using a hybrid confined/in situ indentation method. J Biomech, 2012, 45(3): 491-496.
3.	Jaramillo H E, Gómez L, García J J. A finite element model of the L4-L5-S1 human spine segment including the heterogeneity and anisotropy of the discs. Acta Bioeng Biomech, 2015, 17(2): 15-24.
4.	Nikkhoo M, Hsu Y C, Haghpanahi M, et al. A meta-model analysis of a finite element simulation for defining poroelastic properties of intervertebral discs. Proc Inst Mech Eng H, 2013, 227(6): 672-682.
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6.	Chu J Y, Skrzypiec D, Pollintine P, et al. Can compressive stress be measured experimentally within the annulus fibrosus of degenerated intervertebral discs?. Proc Inst Mech Eng H, 2008, 222(2): 161-170.
7.	Meakin J R, Hukins D W. Effect of removing the nucleus pulposus on the deformation of the annulus fibrosus during compression of the intervertebral disc. J Biomech, 2000, 33(5): 575-580.
8.	Kim K, Lee S K, Kim Y H. The biomechanical effects of variation in the maximum forces exerted by trunk muscles on the joint forces and moments in the lumbar spine: a finite element analysis. Proc Inst Mech Eng H, 2010, 224(10): 1165-1174.
9.	Huang Yongcan, Xiao Jun, Lu W W, et al. Lumbar intervertebral disc allograft transplantation: long-term mobility and impact on the adjacent segments. Eur Spine J, 2017, 26(3): 799-805.
10.	Fung Y C. Biomechanics. New York: Springer-Verlag, 1990: 382-451.
11.	O’Connell G D, Malhotra N R, Vresilovic E J, et al. The effect of nucleotomy and the dependence of degeneration of human intervertebral disc strain in axial compression. Spine (Phila Pa 1976), 2011, 36(21): 1765-1771.
12.	Cannella M, Arthur A, Allen S, et al. The role of the nucleus pulposus in neutral zone human lumbar intervertebral disc mechanics. J Biomech, 2008, 41(10): 2104-2111.
13.	Bezci S E, Nandy A, O’Connell G D. Effect of hydration on healthy intervertebral disc mechanical stiffness. J Biomech Eng, 2015, 137(10): 101007.
14.	Emanuel K S, van der Veen A J, Rustenburg C M E, et al. Osmosis and viscoelasticity both contribute to time-dependent behaviour of the intervertebral disc under compressive load: A caprine in vitro study. J Biomech, 2018, 70(3): 10-15.
15.	Vergroesen P A, Emanuel K S, Peeters M, et al. Are axial intervertebral disc biomechanics determined by osmosis?. J Biomech, 2018, 70(3): 4-9.
16.	裴葆青, 刘振瑶, 王唯, 等. 融合术后压缩载荷下腰椎粘弹性的研究. 福建师范大学学报: 自然科学版, 2017, 33(4): 52-58.
17.	张静静. 腰椎间盘力学行为仿真与蠕变实验研究. 天津: 天津理工大学, 2017.
18.	王爱玉, 陈维毅, 贺瑞, 等. 兔眼LASIK术后角膜生物力学特性的实验研究. 生物医学工程学杂志, 2009, 26(2): 323-326.

1. Castro A P, Wilson W, Huyghe J M, et al. Intervertebral disc creep behavior assessment through an open source finite element solver. J Biomech, 2014, 47(1): 297-301.
2. Ellingson A M, Nuckley D J. Intervertebral disc viscoelastic parameters and residual mechanics spatially quantified using a hybrid confined/in situ indentation method. J Biomech, 2012, 45(3): 491-496.
3. Jaramillo H E, Gómez L, García J J. A finite element model of the L4-L5-S1 human spine segment including the heterogeneity and anisotropy of the discs. Acta Bioeng Biomech, 2015, 17(2): 15-24.
4. Nikkhoo M, Hsu Y C, Haghpanahi M, et al. A meta-model analysis of a finite element simulation for defining poroelastic properties of intervertebral discs. Proc Inst Mech Eng H, 2013, 227(6): 672-682.
5. Liu J W, Abraham A C, Tang S Y. The high-throughput phenotyping of the viscoelastic behavior of whole mouse intervertebral discs using a novel method of dynamic mechanical testing. J Biomech, 2015, 48(10): 2189-2194.
6. Chu J Y, Skrzypiec D, Pollintine P, et al. Can compressive stress be measured experimentally within the annulus fibrosus of degenerated intervertebral discs?. Proc Inst Mech Eng H, 2008, 222(2): 161-170.
7. Meakin J R, Hukins D W. Effect of removing the nucleus pulposus on the deformation of the annulus fibrosus during compression of the intervertebral disc. J Biomech, 2000, 33(5): 575-580.
8. Kim K, Lee S K, Kim Y H. The biomechanical effects of variation in the maximum forces exerted by trunk muscles on the joint forces and moments in the lumbar spine: a finite element analysis. Proc Inst Mech Eng H, 2010, 224(10): 1165-1174.
9. Huang Yongcan, Xiao Jun, Lu W W, et al. Lumbar intervertebral disc allograft transplantation: long-term mobility and impact on the adjacent segments. Eur Spine J, 2017, 26(3): 799-805.
10. Fung Y C. Biomechanics. New York: Springer-Verlag, 1990: 382-451.
11. O’Connell G D, Malhotra N R, Vresilovic E J, et al. The effect of nucleotomy and the dependence of degeneration of human intervertebral disc strain in axial compression. Spine (Phila Pa 1976), 2011, 36(21): 1765-1771.
12. Cannella M, Arthur A, Allen S, et al. The role of the nucleus pulposus in neutral zone human lumbar intervertebral disc mechanics. J Biomech, 2008, 41(10): 2104-2111.
13. Bezci S E, Nandy A, O’Connell G D. Effect of hydration on healthy intervertebral disc mechanical stiffness. J Biomech Eng, 2015, 137(10): 101007.
14. Emanuel K S, van der Veen A J, Rustenburg C M E, et al. Osmosis and viscoelasticity both contribute to time-dependent behaviour of the intervertebral disc under compressive load: A caprine in vitro study. J Biomech, 2018, 70(3): 10-15.
15. Vergroesen P A, Emanuel K S, Peeters M, et al. Are axial intervertebral disc biomechanics determined by osmosis?. J Biomech, 2018, 70(3): 4-9.
16. 裴葆青, 刘振瑶, 王唯, 等. 融合术后压缩载荷下腰椎粘弹性的研究. 福建师范大学学报: 自然科学版, 2017, 33(4): 52-58.
17. 张静静. 腰椎间盘力学行为仿真与蠕变实验研究. 天津: 天津理工大学, 2017.
18. 王爱玉, 陈维毅, 贺瑞, 等. 兔眼LASIK术后角膜生物力学特性的实验研究. 生物医学工程学杂志, 2009, 26(2): 323-326.

Journal of Biomedical Engineering

Experiments study on mechanical behavior of porcine lumbar intervertebral disc after nucleotomy under compression

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