Simulation of the relationship between magnetic medium parameters and heating temperature in magnetic fluid hyperthermia_Journal of Biomedical Engineering

Authors：

QU Yingjiao ,  LU Mai , LIU Xi , LIN Yanping

Key Laboratory of Optoelectronic Technology and Intelligent Control of Ministry of Education, Lanzhou Jiaotong University, Lanzhou 730070, P.R.China;

Corresponding author：

LU Mai, Email: mai.lu@hotmail.com

Keywords：

tumor; magnetic fluid hyperthermia; magnetic medium; finite element analysis

DOI：

10.7507/1001-5515.201806014

Video：

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In this paper, we established magnetic fluid hyperthermia (MFH) model for rat tumor using the finite element software COMSOL based on the linear response theory. By analyzing four kinds of magnetic medium within relaxation mechanism, such as Fe₃O₄、FeCo、fccFePt and L1₀FePt, we studied the influence of the change of magnetic medium radius on dissipation power and temperature field, respectively. At the same time, the optimization method for the parameters of several magnetic medium is proposed, and the applications of four kinds of magnetic medium are given as well. By increasing the dissipation power of the magnetic medium as much as possible, the dose of magnetic medium used in the treatment can be reduced, meanwhile, the adverse effects on health tissue surrounding the tumor will be minimized. The conclusions of this paper can provide reference for magnetic medium preparation applied to MFH.

Citation： QU Yingjiao, LU Mai, LIU Xi, LIN Yanping. Simulation of the relationship between magnetic medium parameters and heating temperature in magnetic fluid hyperthermia. Journal of Biomedical Engineering, 2019, 36(2): 206-212. doi: 10.7507/1001-5515.201806014 Copy

1.	熊青青, 王建, 白杨. 纳米药物在肝癌治疗领域的研究进展. 生物医学工程学杂志, 2018, 35(2): 314-319.
2.	卓子寒, 翟伟明, 蔡东阳, 等. 肿瘤感应热疗计划系统与现代医疗信息系统集成应用研究. 生物医学工程学杂志, 2014, 31(1): 187-191.
3.	薛阳, 赵凌云, 唐劲天, 等. 金纳米复合材料在生物医学中的应用研究进展. 生物医学工程学杂志, 2014, 31(2): 462-466.
4.	Kurgan E, Gas P. Analysis of electromagnetic heating in magnetic fluid deep hyperthermia//Proceedings of 2016 17th International Conference Computational Problems of Electrical Engineering (CPEE), 2016: 1-4.
5.	胡冠中. 磁流体热疗系统多物理场耦合分析与优化设计. 杭州: 浙江大学, 2016.
6.	John A P, Member L S, Petryk A A. Mumerical model study of in vivo magnetic nanoparticle tumor heating. Trans Biom Eng, 2017, 64(12): 2813-2823.
7.	邱庆伟. 磁性纳米颗粒电磁致热效应在医学中的应用研究. 北京: 北京理工大学, 2015.
8.	Lee J H, Jang J T, Choi J S, et al. Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol, 2011, 6(7): 418-422.
9.	Rosensweig R E. Heating magnetic fluid with alternating magnetic field. Journal of Magnetism and Magnetic Materials, 2002, 252: 370-374.
10.	Tang Y D, Jin T, Flesch R C. Numerical temperature analysis of magnetic hyperthermia considering nanoparticle clustering and blood vessels. IEEE Trans Magn, 2017, 53(10): 1-6.
11.	王军, 逯迈, 刘曦. 用于小动物磁感应热疗线圈的优化设计模拟. 航天医学与医学工程, 2018, 31(4): 380-387.
12.	Pavel M, Gradinariu G, Stancu A. Study of the optimum dose of ferromagnetic nanoparticles suitable for cancer therapy using MFH. IEEE Trans Magn, 2008, 44(11): 3205-3208.
13.	陆森, 钱建民, 黄海清, 等. 几种不同预测大鼠肝脏体积(重量)方法的比较. 中华实验外科杂志, 2002, 19(3): 252-253.
14.	Maenosono S, Saita S. Theoretical assessment of FePt nanoparticles as heating elements for magnetic hyperthermia. IEEE Trans Magn, 2006, 42(6): 1638-1641.
15.	Lv Yonggang, Deng Zhongshan S, Liu Jing. 3-D numerical study on the induced heating effects of embedded micro/nanoparticles on human body subject to external medical electromagnetic field. IEEE Trans Nanobiosci, 2005, 4(4): 284-294.
16.	Pavel M, Stancu A. Ferromagnetic nanoparticles dose based on tumor size in magnetic fluid hyperthermia cancer therapy. IEEE Trans Magn, 2009, 45(11): 5251-5254.
17.	Pavel M, Stancu A. Study of the optimum injection sites for a multiple metastases region in cancer therapy by using MFH. IEEE Trans Magn, 2009, 45(10): 4825-4828.
18.	COMSOL Multiphysics, AC/DC Module, User's Guide: 187-192.
19.	李康. 磁流体肿瘤热疗的理论与实验研究. 北京: 北京交通大学, 2017.
20.	Wu Lei, Cheng Jingjing, Liu Wenzhong, et al. Numerical analysis of electromagnetically induced heating and bioheat transfer for magnetic fluid hyperthermia. IEEE Trans Magn, 2015, 51(2): 1-4.
21.	Lahonian M, Colneshan A A. Numerical study of temperature distribution in a spherical tissue in magnetic fluid hyperthermia using boltzmann method. IEEE Trans Nanobiosci, 2011, 10(4): 262-268.

1. 熊青青, 王建, 白杨. 纳米药物在肝癌治疗领域的研究进展. 生物医学工程学杂志, 2018, 35(2): 314-319.
2. 卓子寒, 翟伟明, 蔡东阳, 等. 肿瘤感应热疗计划系统与现代医疗信息系统集成应用研究. 生物医学工程学杂志, 2014, 31(1): 187-191.
3. 薛阳, 赵凌云, 唐劲天, 等. 金纳米复合材料在生物医学中的应用研究进展. 生物医学工程学杂志, 2014, 31(2): 462-466.
4. Kurgan E, Gas P. Analysis of electromagnetic heating in magnetic fluid deep hyperthermia//Proceedings of 2016 17th International Conference Computational Problems of Electrical Engineering (CPEE), 2016: 1-4.
5. 胡冠中. 磁流体热疗系统多物理场耦合分析与优化设计. 杭州: 浙江大学, 2016.
6. John A P, Member L S, Petryk A A. Mumerical model study of in vivo magnetic nanoparticle tumor heating. Trans Biom Eng, 2017, 64(12): 2813-2823.
7. 邱庆伟. 磁性纳米颗粒电磁致热效应在医学中的应用研究. 北京: 北京理工大学, 2015.
8. Lee J H, Jang J T, Choi J S, et al. Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol, 2011, 6(7): 418-422.
9. Rosensweig R E. Heating magnetic fluid with alternating magnetic field. Journal of Magnetism and Magnetic Materials, 2002, 252: 370-374.
10. Tang Y D, Jin T, Flesch R C. Numerical temperature analysis of magnetic hyperthermia considering nanoparticle clustering and blood vessels. IEEE Trans Magn, 2017, 53(10): 1-6.
11. 王军, 逯迈, 刘曦. 用于小动物磁感应热疗线圈的优化设计模拟. 航天医学与医学工程, 2018, 31(4): 380-387.
12. Pavel M, Gradinariu G, Stancu A. Study of the optimum dose of ferromagnetic nanoparticles suitable for cancer therapy using MFH. IEEE Trans Magn, 2008, 44(11): 3205-3208.
13. 陆森, 钱建民, 黄海清, 等. 几种不同预测大鼠肝脏体积(重量)方法的比较. 中华实验外科杂志, 2002, 19(3): 252-253.
14. Maenosono S, Saita S. Theoretical assessment of FePt nanoparticles as heating elements for magnetic hyperthermia. IEEE Trans Magn, 2006, 42(6): 1638-1641.
15. Lv Yonggang, Deng Zhongshan S, Liu Jing. 3-D numerical study on the induced heating effects of embedded micro/nanoparticles on human body subject to external medical electromagnetic field. IEEE Trans Nanobiosci, 2005, 4(4): 284-294.
16. Pavel M, Stancu A. Ferromagnetic nanoparticles dose based on tumor size in magnetic fluid hyperthermia cancer therapy. IEEE Trans Magn, 2009, 45(11): 5251-5254.
17. Pavel M, Stancu A. Study of the optimum injection sites for a multiple metastases region in cancer therapy by using MFH. IEEE Trans Magn, 2009, 45(10): 4825-4828.
18. COMSOL Multiphysics, AC/DC Module, User's Guide: 187-192.
19. 李康. 磁流体肿瘤热疗的理论与实验研究. 北京: 北京交通大学, 2017.
20. Wu Lei, Cheng Jingjing, Liu Wenzhong, et al. Numerical analysis of electromagnetically induced heating and bioheat transfer for magnetic fluid hyperthermia. IEEE Trans Magn, 2015, 51(2): 1-4.
21. Lahonian M, Colneshan A A. Numerical study of temperature distribution in a spherical tissue in magnetic fluid hyperthermia using boltzmann method. IEEE Trans Nanobiosci, 2011, 10(4): 262-268.

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