A comparative study of viscoelasticity between normal cornea and keratoconus_Journal of Biomedical Engineering

Authors：

ZHAO Kechao ¹ ,  WANG Xiaojun ^1,2 , CHEN Weiyi ¹ , HE Rui ³ , LI Xiaona ¹ , GAO Yan ³

1. School of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R.China;
2. School of Mechanical and Transportation Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R.China;
3. Department of Excimer Laser, Shanxi Eye Hospital, Taiyuan 030002, P.R.China;

Corresponding author：

WANG Xiaojun, Email: wangxiaojun@tyut.edu.cn

Keywords：

corneal visualization Scheimpflug technology; standard linear solid model; elastic coefficient; viscous coefficient; keratoconus

DOI：

10.7507/1001-5515.201812052

Video：

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Study of the mechanical properties of in vivo corneal materials is an important basis for further study of corneal physiological and pathological phenomena by means of finite element method. In this paper, the elastic coefficient (E) and viscous coefficient (η) of normal cornea and keratoconus under pulse pressure are calculated by using standard linear solid model with the data provided by corneal visualization scheimpflug technology. The results showed that there was a significant difference of E and η between normal cornea and keratoconus cornea (P < 0.05). Receiver operating characteristic curve analysis showed that the area under curve (AUC) for E, η and their combined indicators were 0.776, 0.895 and 0.948, respectively, which indicated that keratoconus could be predicted by E and η. The results of this study may provide a reference for the early diagnosis of keratoconus and avoid the occurrence of keratoconus after operation, so it has a certain clinical value.

Citation： ZHAO Kechao, WANG Xiaojun, CHEN Weiyi, HE Rui, LI Xiaona, GAO Yan. A comparative study of viscoelasticity between normal cornea and keratoconus. Journal of Biomedical Engineering, 2019, 36(4): 613-618. doi: 10.7507/1001-5515.201812052 Copy

1.	赵梅生, 张忠君, 马洪顺, 等. 人眼角膜黏弹性实验研究. 生物医学工程学杂志, 2005, 22(3): 550-554.
2.	陈昕妍, 秦晓, 张海霞, 等. 可视化角膜生物力学分析仪在眼科临床中的应用. 中国医疗设备, 2018, 33(7): 101-106.
3.	Meek K M, Tuft S J, Huang Yifei, et al. Changes in collagen orientation and distribution in keratoconus corneas. Invest Ophthalmol Vis Sci, 2005, 46(6): 1948-1956.
4.	Gefen A, Shalom R, Elad D, et al. Biomechanical analysis of the keratoconic cornea. J Mech Behav Biomed Mater, 2009, 2(3): 224-236.
5.	Wang Like, Tian Lei, Huang Yanping, et al. Assessment of corneal biomechanical properties with inflation test using optical coherence tomography. Ann Biomed Eng, 2018, 46(2): 247-256.
6.	Huseynova T, Waring G O, Roberts C, et al. Corneal biomechanics as a function of intraocular pressure and pachymetry by dynamic infrared signal and Scheimpflug imaging analysis in normal eyes. Am J Ophthalmol, 2014, 157(4): 885-893.
7.	吴迪, 王雁. 角膜屈光手术后角膜生物力学变化特点的研究进展. 国际眼科纵览, 2012, 36(4): 260-265.
8.	Glass D H, Roberts C J, Litsky A S, et al. A viscoelastic biomechanical model of the cornea describing the effect of viscosity and elasticity on hysteresis. Invest Ophthalmol Vis Sci, 2008, 49(9): 3919-3926.
9.	Luce D A. Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg, 2005, 31(1): 156-162.
10.	Elsheikh A, Wang D, Brown M, et al. Assessment of corneal biomechanical properties and their variation with Ageh. Current Eye Researc, 2007, 32(1): 9.
11.	Andreassen T T, Simonsen A H, Oxlund H. Biomechanical properties of keratoconus and normal corneas. Exp Eye Res, 1980, 31(4): 435-441.
12.	Tian Lei, Huang Yifei, Wang Liqiang, et al. Corneal biomechanical assessment using corneal visualization Scheimpflug technology in keratoconic and normal eyes. J Ophthalmol, 2014: 1-8.
13.	Wang Like, Tian Lei, Zheng Yongping. Determining in vivo elasticity and viscosity with dynamic Scheimpflug imaging analysis in keratoconic and healthy eyes. J Biophotonics, 2016, 9(5): 454-463.
14.	Simonini I, Pandolfi A. The influence of intraocular pressure and air jet pressure on corneal contactless tonometry tests. J Mech Behav Biomed Mater, 2016, 58: 75-89.
15.	Joda A A, Shervin M M, Kook D A. Development and validation of a correction equation for Corvis tonometry. Comput Methods Biomech Biomed Engin, 2016, 19(9): 943-953.
16.	Hong Jiaxu, Xu Jianjiang, Wei Anji, et al. A new tonometer-the Corvis ST tonometer: clinical comparison with noncontact and Goldmann applanation tonometers. Invest Ophthalmol Vis Sci, 2013, 54(1): 659-665.
17.	Hon Y, Lam A K. Corneal deformation measurement using Scheimpflug noncontact tonometry. Optom Vis Sci, 2013, 90(1): e1-e8.
18.	马建霞, 高芬, 朱珂珂, 等. 电脑验光仪、IOL master 及 Pentacam 测量角膜曲率的对比分析. 河南医学研究, 2017, 26(10): 1738-1740.
19.	White T L, Lewis P N, Young R D, et al. Elastic microfibril distribution in the cornea: differences between normal and keratoconic stroma. Experimental Eye Research, 2017, 159: 40-48.
20.	Muller L J, Rama P, Merlin U, et al. In advanced stages of keratoconus the complex plywood arrangement of the anterior stroma is only slightly affected. Arvo Meeting Abstracts, 2004, 45(5): 3824.

1. 赵梅生, 张忠君, 马洪顺, 等. 人眼角膜黏弹性实验研究. 生物医学工程学杂志, 2005, 22(3): 550-554.
2. 陈昕妍, 秦晓, 张海霞, 等. 可视化角膜生物力学分析仪在眼科临床中的应用. 中国医疗设备, 2018, 33(7): 101-106.
3. Meek K M, Tuft S J, Huang Yifei, et al. Changes in collagen orientation and distribution in keratoconus corneas. Invest Ophthalmol Vis Sci, 2005, 46(6): 1948-1956.
4. Gefen A, Shalom R, Elad D, et al. Biomechanical analysis of the keratoconic cornea. J Mech Behav Biomed Mater, 2009, 2(3): 224-236.
5. Wang Like, Tian Lei, Huang Yanping, et al. Assessment of corneal biomechanical properties with inflation test using optical coherence tomography. Ann Biomed Eng, 2018, 46(2): 247-256.
6. Huseynova T, Waring G O, Roberts C, et al. Corneal biomechanics as a function of intraocular pressure and pachymetry by dynamic infrared signal and Scheimpflug imaging analysis in normal eyes. Am J Ophthalmol, 2014, 157(4): 885-893.
7. 吴迪, 王雁. 角膜屈光手术后角膜生物力学变化特点的研究进展. 国际眼科纵览, 2012, 36(4): 260-265.
8. Glass D H, Roberts C J, Litsky A S, et al. A viscoelastic biomechanical model of the cornea describing the effect of viscosity and elasticity on hysteresis. Invest Ophthalmol Vis Sci, 2008, 49(9): 3919-3926.
9. Luce D A. Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg, 2005, 31(1): 156-162.
10. Elsheikh A, Wang D, Brown M, et al. Assessment of corneal biomechanical properties and their variation with Ageh. Current Eye Researc, 2007, 32(1): 9.
11. Andreassen T T, Simonsen A H, Oxlund H. Biomechanical properties of keratoconus and normal corneas. Exp Eye Res, 1980, 31(4): 435-441.
12. Tian Lei, Huang Yifei, Wang Liqiang, et al. Corneal biomechanical assessment using corneal visualization Scheimpflug technology in keratoconic and normal eyes. J Ophthalmol, 2014: 1-8.
13. Wang Like, Tian Lei, Zheng Yongping. Determining in vivo elasticity and viscosity with dynamic Scheimpflug imaging analysis in keratoconic and healthy eyes. J Biophotonics, 2016, 9(5): 454-463.
14. Simonini I, Pandolfi A. The influence of intraocular pressure and air jet pressure on corneal contactless tonometry tests. J Mech Behav Biomed Mater, 2016, 58: 75-89.
15. Joda A A, Shervin M M, Kook D A. Development and validation of a correction equation for Corvis tonometry. Comput Methods Biomech Biomed Engin, 2016, 19(9): 943-953.
16. Hong Jiaxu, Xu Jianjiang, Wei Anji, et al. A new tonometer-the Corvis ST tonometer: clinical comparison with noncontact and Goldmann applanation tonometers. Invest Ophthalmol Vis Sci, 2013, 54(1): 659-665.
17. Hon Y, Lam A K. Corneal deformation measurement using Scheimpflug noncontact tonometry. Optom Vis Sci, 2013, 90(1): e1-e8.
18. 马建霞, 高芬, 朱珂珂, 等. 电脑验光仪、IOL master 及 Pentacam 测量角膜曲率的对比分析. 河南医学研究, 2017, 26(10): 1738-1740.
19. White T L, Lewis P N, Young R D, et al. Elastic microfibril distribution in the cornea: differences between normal and keratoconic stroma. Experimental Eye Research, 2017, 159: 40-48.
20. Muller L J, Rama P, Merlin U, et al. In advanced stages of keratoconus the complex plywood arrangement of the anterior stroma is only slightly affected. Arvo Meeting Abstracts, 2004, 45(5): 3824.

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A comparative study of viscoelasticity between normal cornea and keratoconus

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