Research progress of decellularized extracellular matrix hydrogel in regenerative medicine_Journal of Biomedical Engineering

Authors：

JIANG Jingyu ¹ , ZHANG Chi ^1,2 , ZHANG Tingxia ¹ ,  ZHAO Jiyuan ¹

1. Key Laboratory of Pathophysiology and Technology Research, Medicine School, Ningbo University, Ningbo, Zhejiang 315211, P.R.China;
2. Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R.China;

Corresponding author：

Keywords：

decellularized extracellular matrix; hydrogel; tissue engineering; regenerative medicine

DOI：

10.7507/1001-5515.201907027

Video：

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Decellularized extracellular matrix (dECM) has been widely used as a scaffold for regenerative medicine due to its high biomimetic and excellent biocompatibility. As a functional polymer material with high water content and controlled fluidity, hydrogel is very promising for some minimally invasive surgery in clinical practice. In recent years, with the rapid development of hydrogel theory and technology, dECM hydrogel has gradually become a research hotspot in the field of regenerative medicine. In this paper, the related researches in recent years are reviewed regarding the preparation of dECM hydrogel and its preclinical application. The future clinical use is also prospected.

Citation： JIANG Jingyu, ZHANG Chi, ZHANG Tingxia, ZHAO Jiyuan. Research progress of decellularized extracellular matrix hydrogel in regenerative medicine. Journal of Biomedical Engineering, 2020, 37(1): 179-184. doi: 10.7507/1001-5515.201907027 Copy

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2.	Li M, Zhang C, Mao Y, et al. A cell-engineered small intestinal submucosa-based bone mimetic construct for bone regeneration. Tissue Eng Part A, 2018, 24(13-14): 1099-1111.
3.	Li M, Zhang C, Cheng M, et al. Small intestinal submucosa: A potential osteoconductive and osteoinductive biomaterial for bone tissue engineering. Mater Sci Eng C Mater Biol Appl, 2017, 75: 149-156.
4.	Costa A, Naranjo J D, Londono R, et al. Biologic scaffolds. Cold Spring Harb Perspect Med, 2017, 7(9): a025676.
5.	Saldin L T, Cramer M C, Velankar S S, et al. Extracellular matrix hydrogels from decellularized tissues: Structure and function. Acta Biomater, 2017, 49: 1-15.
6.	Spang M T, Christman K L. Extracellular matrix hydrogel therapies: In vivo applications and development. Acta Biomaterialia, 2018, 68: 1-14.
7.	Keane T J, Dziki J, Sobieski E, et al. Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: Potential therapy for ulcerative colitis. J Crohns Colitis, 2017, 11(3): 360-368.
8.	Seo Y, Jung Y, Kim S H. Decellularized heart ecm hydrogel using supercritical carbon dioxide for improved angiogenesis. Acta Biomater, 2018, 67: 270-281.
9.	Baghalishahi M, Efthekhar-Vaghefi S H, Piryaei A, et al. Cardiac extracellular matrix hydrogel together with or without inducer cocktail improves human adipose tissue-derived stem cells differentiation into cardiomyocyte-like cells. Biochem Biophys Res Commun, 2018, 502(2): 215-225.
10.	Singelyn J M, Dequach J A, Seif-Naraghi S B, et al. Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. Biomaterials, 2009, 30(29): 5409-5416.
11.	Jang J, Park H J, Kim S W, et al. 3d printed complex tissue construct using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair. Biomaterials, 2017, 112: 264-274.
12.	Becker M, Maring J A, Schneider M, et al. Towards a novel patch material for cardiac applications: Tissue-specific extracellular matrix introduces essential key features to decellularized amniotic membrane. Int J Mol Sci, 2018, 19(4). DOI: 10.3390/ijms19041032.
13.	Saheli M, Sepantafar M, Pournasr B, et al. Three-dimensional liver-derived extracellular matrix hydrogel promotes liver organoids function. J Cell Biochem, 2018, 119(6): 4320-4333.
14.	梁成宵, 古瑞, 李婷, 等. 肝脏基质水凝胶的制备及其细胞相容性研究. 解放军医学杂志, 2018, 43(5): 55-59.
15.	Nagao R J, Xu J, Luo P, et al. Decellularized human kidney cortex hydrogels enhance kidney microvascular endothelial cell maturation and quiescence. Tissue Engineering Part A, 2016, 22(19-20). DOI: 10.1089/ten.tea.2016.0213.
16.	Wu J, Ding Q, Dutta A, et al. An injectable extracellular matrix derived hydrogel for meniscus repair and regeneration. Acta Biomater, 2015, 16: 49-59.
17.	Sackett S D, Tremmel D M, Ma F, et al. Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas. Sci Rep, 2018, 8(1): 10452.
18.	Chaimov D, Baruch L, Krishtul S, et al. Innovative encapsulation platform based on pancreatic extracellular matrix achieve substantial insulin delivery. J Control Release, 2017, 257: 91-101.
19.	许洁, 金冰慧, 赵应征. 大鼠子宫去细胞支架及其细胞外基质凝胶的制备. 生物医学工程学杂志, 2018, 35(2): 237-243.
20.	Lin T, Liu S, Chen S, et al. Hydrogel derived from porcine decellularized nerve tissue as a promising biomaterial for repairing peripheral nerve defects. Acta Biomater, 2018, 73: 326-338.
21.	Prest T A, Yeager E, Lopresti S T, et al. Nerve-specific, xenogeneic extracellular matrix hydrogel promotes recovery following peripheral nerve injury. J Biomed Mater Res A, 2018, 106(2): 450-459.
22.	Mahoney C M, Kelmindi-Doko A, Snowden M J, et al. Adipose derived delivery vehicle for encapsulated adipogenic factors. Acta Biomater, 2017, 58: 26-33.
23.	Faust A, Kandakatla A, Van Der Merwe Y, et al. Urinary bladder extracellular matrix hydrogels and matrix-bound vesicles differentially regulate central nervous system neuron viability and axon growth and branching. J Biomater Appl, 2017, 31(9): 1277-1295.
24.	Ungerleider J L, Johnson T D, Rao N, et al. Fabrication and characterization of injectable hydrogels derived from decellularized skeletal and cardiac muscle. Methods, 2015, 84: 53-59.
25.	Koci Z, Vyborny K, Dubisova J, et al. Extracellular matrix hydrogel derived from human umbilical cord as a scaffold for neural tissue repair and its comparison with extracellular matrix from porcine tissues. Tissue Eng Part C Methods, 2017, 23(6): 333-345.
26.	Mcgoldrick R, Chattopadhyay A, Crowe C, et al. The tissue-engineered tendon-bone interface: In vitro and in vivo synergistic effects of adipose-derived stem cells, platelet-rich plasma, and extracellular matrix hydrogel. Plast Reconstr Surg, 2017, 140(6): 1169-1184.
27.	Rothrauff B B, Yang G, Tuan R S. Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells. Stem Cell Res Ther, 2017, 8(1): 133.
28.	Zhao Y, Fan J, Bai S L. Biocompatibility of injectable hydrogel from decellularized human adipose tissue in vitro and in vivo. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2019, 107(5): 1684-1694.
29.	Zhang D, Tan Q, Luo J, et al. Evaluating the angiogenic potential of a novel temperature-sensitive gel scaffold derived from porcine skeletal muscle tissue. Biomed Mater, 2018, 13(5): 055003.
30.	Ahearne M, Lynch A P. Early observation of extracellular matrix-derived hydrogels for corneal stroma regeneration. Tissue Eng Part C Methods, 2015, 21(10): 1059-1069.
31.	Wang B, Li W, Dean D, et al. Enhanced hepatogenic differentiation of bone marrow derived mesenchymal stem cells on liver ecm hydrogel. J Biomed Mater Res A, 2018, 106(3): 829-838.
32.	Freytes D O, Martin J, Velankar S S, et al. Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix. Biomaterials, 2008, 29(11): 1630-1637.
33.	Uriel S, Labay E, Francis-Sedlak M, et al. Extraction and assembly of tissue-derived gels for cell culture and tissue engineering. Tissue Eng Part C Methods, 2009, 15(3): 309-321.

1. Theocharis A D, Skandalis S S, Gialeli C, et al. Extracellular matrix structure. Adv Drug Deliv Rev, 2016, 97: 4-27.
2. Li M, Zhang C, Mao Y, et al. A cell-engineered small intestinal submucosa-based bone mimetic construct for bone regeneration. Tissue Eng Part A, 2018, 24(13-14): 1099-1111.
3. Li M, Zhang C, Cheng M, et al. Small intestinal submucosa: A potential osteoconductive and osteoinductive biomaterial for bone tissue engineering. Mater Sci Eng C Mater Biol Appl, 2017, 75: 149-156.
4. Costa A, Naranjo J D, Londono R, et al. Biologic scaffolds. Cold Spring Harb Perspect Med, 2017, 7(9): a025676.
5. Saldin L T, Cramer M C, Velankar S S, et al. Extracellular matrix hydrogels from decellularized tissues: Structure and function. Acta Biomater, 2017, 49: 1-15.
6. Spang M T, Christman K L. Extracellular matrix hydrogel therapies: In vivo applications and development. Acta Biomaterialia, 2018, 68: 1-14.
7. Keane T J, Dziki J, Sobieski E, et al. Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: Potential therapy for ulcerative colitis. J Crohns Colitis, 2017, 11(3): 360-368.
8. Seo Y, Jung Y, Kim S H. Decellularized heart ecm hydrogel using supercritical carbon dioxide for improved angiogenesis. Acta Biomater, 2018, 67: 270-281.
9. Baghalishahi M, Efthekhar-Vaghefi S H, Piryaei A, et al. Cardiac extracellular matrix hydrogel together with or without inducer cocktail improves human adipose tissue-derived stem cells differentiation into cardiomyocyte-like cells. Biochem Biophys Res Commun, 2018, 502(2): 215-225.
10. Singelyn J M, Dequach J A, Seif-Naraghi S B, et al. Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. Biomaterials, 2009, 30(29): 5409-5416.
11. Jang J, Park H J, Kim S W, et al. 3d printed complex tissue construct using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair. Biomaterials, 2017, 112: 264-274.
12. Becker M, Maring J A, Schneider M, et al. Towards a novel patch material for cardiac applications: Tissue-specific extracellular matrix introduces essential key features to decellularized amniotic membrane. Int J Mol Sci, 2018, 19(4). DOI: 10.3390/ijms19041032.
13. Saheli M, Sepantafar M, Pournasr B, et al. Three-dimensional liver-derived extracellular matrix hydrogel promotes liver organoids function. J Cell Biochem, 2018, 119(6): 4320-4333.
14. 梁成宵, 古瑞, 李婷, 等. 肝脏基质水凝胶的制备及其细胞相容性研究. 解放军医学杂志, 2018, 43(5): 55-59.
15. Nagao R J, Xu J, Luo P, et al. Decellularized human kidney cortex hydrogels enhance kidney microvascular endothelial cell maturation and quiescence. Tissue Engineering Part A, 2016, 22(19-20). DOI: 10.1089/ten.tea.2016.0213.
16. Wu J, Ding Q, Dutta A, et al. An injectable extracellular matrix derived hydrogel for meniscus repair and regeneration. Acta Biomater, 2015, 16: 49-59.
17. Sackett S D, Tremmel D M, Ma F, et al. Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas. Sci Rep, 2018, 8(1): 10452.
18. Chaimov D, Baruch L, Krishtul S, et al. Innovative encapsulation platform based on pancreatic extracellular matrix achieve substantial insulin delivery. J Control Release, 2017, 257: 91-101.
19. 许洁, 金冰慧, 赵应征. 大鼠子宫去细胞支架及其细胞外基质凝胶的制备. 生物医学工程学杂志, 2018, 35(2): 237-243.
20. Lin T, Liu S, Chen S, et al. Hydrogel derived from porcine decellularized nerve tissue as a promising biomaterial for repairing peripheral nerve defects. Acta Biomater, 2018, 73: 326-338.
21. Prest T A, Yeager E, Lopresti S T, et al. Nerve-specific, xenogeneic extracellular matrix hydrogel promotes recovery following peripheral nerve injury. J Biomed Mater Res A, 2018, 106(2): 450-459.
22. Mahoney C M, Kelmindi-Doko A, Snowden M J, et al. Adipose derived delivery vehicle for encapsulated adipogenic factors. Acta Biomater, 2017, 58: 26-33.
23. Faust A, Kandakatla A, Van Der Merwe Y, et al. Urinary bladder extracellular matrix hydrogels and matrix-bound vesicles differentially regulate central nervous system neuron viability and axon growth and branching. J Biomater Appl, 2017, 31(9): 1277-1295.
24. Ungerleider J L, Johnson T D, Rao N, et al. Fabrication and characterization of injectable hydrogels derived from decellularized skeletal and cardiac muscle. Methods, 2015, 84: 53-59.
25. Koci Z, Vyborny K, Dubisova J, et al. Extracellular matrix hydrogel derived from human umbilical cord as a scaffold for neural tissue repair and its comparison with extracellular matrix from porcine tissues. Tissue Eng Part C Methods, 2017, 23(6): 333-345.
26. Mcgoldrick R, Chattopadhyay A, Crowe C, et al. The tissue-engineered tendon-bone interface: In vitro and in vivo synergistic effects of adipose-derived stem cells, platelet-rich plasma, and extracellular matrix hydrogel. Plast Reconstr Surg, 2017, 140(6): 1169-1184.
27. Rothrauff B B, Yang G, Tuan R S. Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells. Stem Cell Res Ther, 2017, 8(1): 133.
28. Zhao Y, Fan J, Bai S L. Biocompatibility of injectable hydrogel from decellularized human adipose tissue in vitro and in vivo. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2019, 107(5): 1684-1694.
29. Zhang D, Tan Q, Luo J, et al. Evaluating the angiogenic potential of a novel temperature-sensitive gel scaffold derived from porcine skeletal muscle tissue. Biomed Mater, 2018, 13(5): 055003.
30. Ahearne M, Lynch A P. Early observation of extracellular matrix-derived hydrogels for corneal stroma regeneration. Tissue Eng Part C Methods, 2015, 21(10): 1059-1069.
31. Wang B, Li W, Dean D, et al. Enhanced hepatogenic differentiation of bone marrow derived mesenchymal stem cells on liver ecm hydrogel. J Biomed Mater Res A, 2018, 106(3): 829-838.
32. Freytes D O, Martin J, Velankar S S, et al. Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix. Biomaterials, 2008, 29(11): 1630-1637.
33. Uriel S, Labay E, Francis-Sedlak M, et al. Extraction and assembly of tissue-derived gels for cell culture and tissue engineering. Tissue Eng Part C Methods, 2009, 15(3): 309-321.

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Research progress of decellularized extracellular matrix hydrogel in regenerative medicine

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