Development and prospect of tissue engineering in urology_Journal of Biomedical Engineering

Authors：

YANG Ming ,  FU Qiang

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China;

Corresponding author：

Keywords：

tissue engineering; kidney; ureter; bladder; urethra

DOI：

10.7507/1001-5515.201910058

Video：

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Tissue engineering technology and stem cell research based on tissue engineering have made great progresses in overcoming the problems of tissue and organ damage, functional loss and surgical complications. Traditional method is to use biological substitute materials to repair tissues, while tissue engineering technology focuses on combining seed cells with biological materials to form biological tissues with the same structure and function as its own to repair tissue defects. The advantage is that such tissue engineering organs and tissues can solve the problem that the donor material is limited, and effectively reduce complications. The purpose of tissue engineering is to find suitable seed cells and biomaterials which can replace the biological function of original tissue and build suitable microenvironment in vivo. This paper mainly describes current technologies of tissue engineering in various fields of urology, and discusses the future trend of tissue engineering technology in the treatment of complex urinary diseases. The results of this study show that although there are relatively few clinical trials, the good results of the existing studies on animal models reveal a bright future of tissue engineering technology for the treatment of various urinary diseases.

Citation： YANG Ming, FU Qiang. Development and prospect of tissue engineering in urology. Journal of Biomedical Engineering, 2020, 37(2): 193-199. doi: 10.7507/1001-5515.201910058 Copy

1.	Song L, Murphy S V, Yang B, et al. Bladder acellular matrix and its application in bladder augmentation. Tissue Eng Part B Rev, 2014, 20(2): 163-172.
2.	Shafiee A, Atala A. Printing technologies for medical applications. Trends Mol Med, 2016, 22(3): 254-265.
3.	Moon K H, Ko I K, Yoo J J, et al. Kidney diseases and tissue engineering. Methods, 2016, 99: 112-119.
4.	Setayeshmehr M, Esfandiari E, Rafieinia M, et al. Hybrid and composite scaffolds based on extracellular matrices for cartilage tissue engineering. Tissue Eng Part B Rev, 2019, 25(3): 202-224.
5.	Song J J, Guyette J P, Gilpin S E, et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med, 2013, 19(5): 646-651.
6.	Ko I K, Abolbashari M, Huling J, et al. Enhanced re-endothelialization of acellular kidney scaffolds for whole organ engineering via antibody conjugation of vasculatures. Technology, 2014, 2(03): 243-253.
7.	Lertkiatmongkol P, Liao D, Mei H, et al. Endothelial functions of platelet/endothelial cell adhesion molecule-1(CD31). Curr Opin Hematol, 2016, 23(3): 253-259.
8.	Machiguchi T, Nakamura T. Nephron generation in kidney cortices through injection of pretreated mesenchymal stem cell-differentiated tubular epithelial cells. Biochem Biophys Res Commun, 2019, 518(1): 141-147.
9.	Zhang J, Li K, Kong F, et al. Induced intermediate mesoderm combined with decellularized kidney scaffolds for functional engineering kidney. Tissue Engineering and Regenerative Medicine, 2019, 16(5): 501-512.
10.	Orlando G, Booth C, Wang Z, et al. Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies. Biomaterials, 2013, 34(24): 5915-5925.
11.	Koch H, Hammer N, Ossmann S, et al. Tissue engineering of ureteral grafts: preparation of biocompatible crosslinked ureteral scaffolds of porcine origin. Frontiers in Bioengineering and Biotechnology, 2015, 3: 89.
12.	Zhao Z, Yu H, Xiao F, et al. Differentiation of adipose-derived stem cells promotes regeneration of smooth muscle for ureteral tissue engineering. J Surg Res, 2012, 178(1): 55-62.
13.	Engel O, Petriconi R D, Volkmer B G, et al. The feasibility of ureteral tissue engineering using autologous veins: an orthotopic animal model with long term results. J Negat Results Biomed, 2014, 13(1): 1-9.
14.	Lam Van Ba O, Aharony S., Loutochin O., et al Bladder tissue engineering: a literature review. Adv Drug Deliv Rev, 2015, 82-83: 31-37.
15.	Shakhssalim N, Soleimani M, Dehghan M M, et al. Bladder smooth muscle cells on electrospun poly(ɛ-caprolactone)/poly(l-lactic acid) scaffold promote bladder regeneration in a canine model. Materials Science and Engineering: C, 2017, 75: 877-884.
16.	Subramaniam R, Hinley J, Stahlschmidt J, et al. Tissue engineering potential of urothelial cells from diseased bladders. Journal of Urology, 2011, 186(5): 2014-2020.
17.	Adamowicz J, Kloskowski T, Tworkiewicz J, et al. Urine is a highly cytotoxic agent: does it influence stem cell therapies in urology?. Transplant Proc, 2012, 44(5): 1439-1441.
18.	Sharma A K, Bury M I, Fuller N J, et al. Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration. Proc Natl Acad Sci U S A, 2013, 110(10): 4003-4008.
19.	Zhao Feng, Zhou Lliuhua, Xu Zhongle, et al. Hypoxia-preconditioned adipose-derived endothelial progenitor cells promote bladder augmentation. Tissue Eng Part A, 2019.
20.	Adamowicz J, Pokrywczynska M, Vontelin V S, et al. Concise review: tissue engineering of urinary bladder; we still have a long way to go?. Stem Cells Transl Med, 2017, 6(11): 2033-2043.
21.	Bouhout S, Gauvin R, Gibot L, et al. Bladder substitute reconstructed in a physiological pressure environment. J Pediatr Urol, 2011, 7(3): 276-282.
22.	Liao W, Yang S, Song C, et al. Tissue-engineered tubular graft for urinary diversion after radical cystectomy in rabbits. Journal of Surgical Research, 2013, 182(2): 185-191.
23.	Basu J, Jayo M J, Ilagan R M, et al. Regeneration of native-like neo-urinary tissue from nonbladder cell sources. Tissue Eng Part A, 2012, 18(9-10): 1025.
24.	Bouhout S., Chabaud S., Bolduc S. Collagen hollow structure for bladder tissue engineering. Materials Science and Engineering: C, 2019, 102: 228-237.
25.	Nakayama K H, Luqia H, Huang N F. Role of extracellular matrix signaling cues in modulating cell fate commitment for cardiovascular tissue engineering. Adv Healthc Mater, 2014, 3(5): 628-641.
26.	Vishwakarma A, Bhise N S, Evangelista M B, et al. Engineering immunomodulatory biomaterials to tune the inflammatory response. Trends Biotechnol, 2016, 34(6): 470-482.
27.	Zhang Deying, Wei Guanghui, Li Peng, et al. Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine. Genes & diseases, 2014, 1(1): 8-17.
28.	Qin D, Long Ting, Deng Junhong, et al. Urine-derived stem cells for potential use in bladder repair. Stem Cell Res Ther, 2014, 5(3): 69.
29.	Wang Y, Fu Q, Zhao R Y, et al. Muscular tubes of urethra engineered from adipose-derived stem cells and polyglycolic acid mesh in a bioreactor. Biotechnol Lett, 2014, 36(9): 1909-1916.
30.	Fu Q, Deng C L, Zhao R Y, et al. The effect of mechanical extension stimulation combined with epithelial cell sorting on outcomes of implanted tissue-engineered muscular urethras. Biomaterials, 2014, 35(1): 105-112.
31.	Zhang K., Fu Q., Yoo J., et al 3D bioprinting of urethra with PCL/PLCL blend and dual autologous cells in fibrin hydrogel: an in vitro evaluation of biomimetic mechanical property and cell growth environment. Acta Biomater, 2017, 50: 154-164.
32.	Simoes I N, Vale P, Soker S, et al. Acellular urethra bioscaffold: decellularization of whole urethras for tissue engineering applications. Sci Rep, 2017, 7: 41934.
33.	Raya-Rivera A, Esquiliano D R, Yoo J J, et al. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet, 2011, 377(9772): 1175-1182.
34.	Chapple C. Tissue engineering of the urethra: where are we in 2019?. World J Urol, 2019. https://doi.org/10.1007/s00345-019-02826-3.
35.	Anthony A, Bauer S B, Shay S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet, 2006, 367(9518): 1241-1246.

1. Song L, Murphy S V, Yang B, et al. Bladder acellular matrix and its application in bladder augmentation. Tissue Eng Part B Rev, 2014, 20(2): 163-172.
2. Shafiee A, Atala A. Printing technologies for medical applications. Trends Mol Med, 2016, 22(3): 254-265.
3. Moon K H, Ko I K, Yoo J J, et al. Kidney diseases and tissue engineering. Methods, 2016, 99: 112-119.
4. Setayeshmehr M, Esfandiari E, Rafieinia M, et al. Hybrid and composite scaffolds based on extracellular matrices for cartilage tissue engineering. Tissue Eng Part B Rev, 2019, 25(3): 202-224.
5. Song J J, Guyette J P, Gilpin S E, et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med, 2013, 19(5): 646-651.
6. Ko I K, Abolbashari M, Huling J, et al. Enhanced re-endothelialization of acellular kidney scaffolds for whole organ engineering via antibody conjugation of vasculatures. Technology, 2014, 2(03): 243-253.
7. Lertkiatmongkol P, Liao D, Mei H, et al. Endothelial functions of platelet/endothelial cell adhesion molecule-1(CD31). Curr Opin Hematol, 2016, 23(3): 253-259.
8. Machiguchi T, Nakamura T. Nephron generation in kidney cortices through injection of pretreated mesenchymal stem cell-differentiated tubular epithelial cells. Biochem Biophys Res Commun, 2019, 518(1): 141-147.
9. Zhang J, Li K, Kong F, et al. Induced intermediate mesoderm combined with decellularized kidney scaffolds for functional engineering kidney. Tissue Engineering and Regenerative Medicine, 2019, 16(5): 501-512.
10. Orlando G, Booth C, Wang Z, et al. Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies. Biomaterials, 2013, 34(24): 5915-5925.
11. Koch H, Hammer N, Ossmann S, et al. Tissue engineering of ureteral grafts: preparation of biocompatible crosslinked ureteral scaffolds of porcine origin. Frontiers in Bioengineering and Biotechnology, 2015, 3: 89.
12. Zhao Z, Yu H, Xiao F, et al. Differentiation of adipose-derived stem cells promotes regeneration of smooth muscle for ureteral tissue engineering. J Surg Res, 2012, 178(1): 55-62.
13. Engel O, Petriconi R D, Volkmer B G, et al. The feasibility of ureteral tissue engineering using autologous veins: an orthotopic animal model with long term results. J Negat Results Biomed, 2014, 13(1): 1-9.
14. Lam Van Ba O, Aharony S., Loutochin O., et al Bladder tissue engineering: a literature review. Adv Drug Deliv Rev, 2015, 82-83: 31-37.
15. Shakhssalim N, Soleimani M, Dehghan M M, et al. Bladder smooth muscle cells on electrospun poly(ɛ-caprolactone)/poly(l-lactic acid) scaffold promote bladder regeneration in a canine model. Materials Science and Engineering: C, 2017, 75: 877-884.
16. Subramaniam R, Hinley J, Stahlschmidt J, et al. Tissue engineering potential of urothelial cells from diseased bladders. Journal of Urology, 2011, 186(5): 2014-2020.
17. Adamowicz J, Kloskowski T, Tworkiewicz J, et al. Urine is a highly cytotoxic agent: does it influence stem cell therapies in urology?. Transplant Proc, 2012, 44(5): 1439-1441.
18. Sharma A K, Bury M I, Fuller N J, et al. Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration. Proc Natl Acad Sci U S A, 2013, 110(10): 4003-4008.
19. Zhao Feng, Zhou Lliuhua, Xu Zhongle, et al. Hypoxia-preconditioned adipose-derived endothelial progenitor cells promote bladder augmentation. Tissue Eng Part A, 2019.
20. Adamowicz J, Pokrywczynska M, Vontelin V S, et al. Concise review: tissue engineering of urinary bladder; we still have a long way to go?. Stem Cells Transl Med, 2017, 6(11): 2033-2043.
21. Bouhout S, Gauvin R, Gibot L, et al. Bladder substitute reconstructed in a physiological pressure environment. J Pediatr Urol, 2011, 7(3): 276-282.
22. Liao W, Yang S, Song C, et al. Tissue-engineered tubular graft for urinary diversion after radical cystectomy in rabbits. Journal of Surgical Research, 2013, 182(2): 185-191.
23. Basu J, Jayo M J, Ilagan R M, et al. Regeneration of native-like neo-urinary tissue from nonbladder cell sources. Tissue Eng Part A, 2012, 18(9-10): 1025.
24. Bouhout S., Chabaud S., Bolduc S. Collagen hollow structure for bladder tissue engineering. Materials Science and Engineering: C, 2019, 102: 228-237.
25. Nakayama K H, Luqia H, Huang N F. Role of extracellular matrix signaling cues in modulating cell fate commitment for cardiovascular tissue engineering. Adv Healthc Mater, 2014, 3(5): 628-641.
26. Vishwakarma A, Bhise N S, Evangelista M B, et al. Engineering immunomodulatory biomaterials to tune the inflammatory response. Trends Biotechnol, 2016, 34(6): 470-482.
27. Zhang Deying, Wei Guanghui, Li Peng, et al. Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine. Genes & diseases, 2014, 1(1): 8-17.
28. Qin D, Long Ting, Deng Junhong, et al. Urine-derived stem cells for potential use in bladder repair. Stem Cell Res Ther, 2014, 5(3): 69.
29. Wang Y, Fu Q, Zhao R Y, et al. Muscular tubes of urethra engineered from adipose-derived stem cells and polyglycolic acid mesh in a bioreactor. Biotechnol Lett, 2014, 36(9): 1909-1916.
30. Fu Q, Deng C L, Zhao R Y, et al. The effect of mechanical extension stimulation combined with epithelial cell sorting on outcomes of implanted tissue-engineered muscular urethras. Biomaterials, 2014, 35(1): 105-112.
31. Zhang K., Fu Q., Yoo J., et al 3D bioprinting of urethra with PCL/PLCL blend and dual autologous cells in fibrin hydrogel: an in vitro evaluation of biomimetic mechanical property and cell growth environment. Acta Biomater, 2017, 50: 154-164.
32. Simoes I N, Vale P, Soker S, et al. Acellular urethra bioscaffold: decellularization of whole urethras for tissue engineering applications. Sci Rep, 2017, 7: 41934.
33. Raya-Rivera A, Esquiliano D R, Yoo J J, et al. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet, 2011, 377(9772): 1175-1182.
34. Chapple C. Tissue engineering of the urethra: where are we in 2019?. World J Urol, 2019. https://doi.org/10.1007/s00345-019-02826-3.
35. Anthony A, Bauer S B, Shay S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet, 2006, 367(9518): 1241-1246.

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Development and prospect of tissue engineering in urology

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