Detection method of nonlinear magnetized harmonic signal of medical magnetic nanoparticles_Journal of Biomedical Engineering

Authors：

LIU Yangyang ,  KE Li , DU Qiang , ZU Wanni , JIANG Ce , ZHANG Yulu

School of Electrical Engineering, Shenyang University of Technology, Shenyang 110870, P.R.China;

Corresponding author：

KE Li, Email: keli@sut.edu.cn

Keywords：

medical magnetic nanoparticles; magnetization characteristics; third harmonic; signal detection

DOI：

10.7507/1001-5515.201911010

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Medical magnetic nanoparticles are nano-medical materials with superparamagnetism, which can be collected in the tumor tissue through blood circulation, and magnetic particle imaging technology can be used to visualize the concentration of magnetic nanoparticles in the living body to achieve the purpose of tumor imaging. Based on the nonlinear magnetization characteristics of magnetic particles and the frequency characteristics of their magnetization, a differential detection method for the third harmonic of magnetic particle detection signals is proposed. It was modeled and analyzed, to study the nonlinear magnetization response characteristics of magnetic particles under alternating field, and the spectral characteristics of magnetic particle signals. At the same time, the relationship between each harmonic and the amount of medical magnetic nanoparticle samples was studied. On this basis, a signal detection experimental system was built to analyze the spectral characteristics and power spectral density of the detected signal, and to study the relationship between the signal and the excitation frequency. The signal detection experiment was carried out by the above method. The experimental results showed that under the alternating excitation field, the medical magnetic nanoparticles would generate a spike signal higher than the background sensing signal, and the magnetic particle signal existed in the odd harmonics of the detected signal spectrum. And the spectral energy was concentrated at the third harmonic, that is, the third harmonic magnetic particle signal detection that meets the medical detection requirement could be realized. In addition, the relationship between each harmonic and the particle sample volume had a positive growth relationship, and the detected medical magnetic nanoparticle sample volume could be determined according to the relationship. At the same time, the selection of the excitation frequency was limited by the sensitivity of the system, and the detection peak of the third harmonic of the detection signal was reached at the excitation frequency of 1 kHz. It provides theoretical and technical support for the detection of medical magnetic nanoparticle imaging signals in magnetic particle imaging research.

Citation： LIU Yangyang, KE Li, DU Qiang, ZU Wanni, JIANG Ce, ZHANG Yulu. Detection method of nonlinear magnetized harmonic signal of medical magnetic nanoparticles. Journal of Biomedical Engineering, 2021, 38(1): 56-64. doi: 10.7507/1001-5515.201911010 Copy

1.	Knopp T, Buzug T M. Magnetic particle imaging: An introduction to imaging principles and scanner instrumentation. New York: Springer, 2012: 12-25.
2.	Jeffrey D K, Huanyu D, Justin M, et al. Nanotechnology: A focus on nanoparticles as a drug delivery system. J Neuroimmune Pharm, 2006, 1(3): 340-350.
3.	Bourrinet P, Bengele H H, Bonnemain B, et al. Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent. Invest Radiol, 2006, 41(3): 313-324.
4.	Gleich B, Weizenecker J. Tomographic imaging using the nonlinear response of magnetic particles. Nature, 2005, 435(7046): 1214-1217.
5.	Bulte J W M, Walczak P, Bernard S, et al. Developing cellular MPI: initial experience// International Workshop on Magnetic Nanoparticles-particle Science, Imaging Technology. Lübeck: IEEE, 2010: 201-204.
6.	Cetin S, Saritas E U, Unal G. Vessel tractography for magnetic particle imaging angiography// IEEE 2015 5th International Workshop on Magnetic Particle Imaging (IWMPI). Istanbul: IEEE, 2015: 1.
7.	Sigovan M, Boussel L, Sulaiman A, et al. Rapid-clearance iron nanoparticles for inflammation imaging of atherosclerotic plaque: initial experience in animal model. Radiology, 2009, 252(2): 401-409.
8.	Ludwig F, Eberbeck D, Löwa N, et al. Characterization of magnetic nanoparticle systems with respect to their magnetic particle imaging performance. Biomedizinische Technik/Biomedical Engineering, 2013, 58(6): 535-545.
9.	Biederer S, Knopp T, Sattel T F, et al. Magnetization response spectroscopy of superparamagnetic nanoparticles for magnetic particle imaging. J Phys D Appl Phys, 2009, 42(20): 205007-1-7.
10.	Weaver J B, Rauwerdink A M, Sullivan C R, et al. Frequency distribution of the nanoparticle magnetization in the presence of a static as well as a harmonic magnetic field. Med Phys, 2008, 35(5): 1988-1994.
11.	Sasayama T, Tsujita Y, Morishita M, et al. Three-dimensional magnetic nanoparticle imaging using small field gradient and multiple pickup coils. J Magn Magn Mater, 2017, 427(1): 144-150.
12.	Murase K, Shimada K. Lock-in-amplifier model for analyzing the behavior of signal harmonics in magnetic particle imaging. Open J Appl Sci, 2018, 8(5): 170-183.
13.	张朴, 成鹏, 刘文中. 基于 SQUID 的磁纳米粒子磁特性测量研究. 计量与测试技术, 2016, 43(8): 56-58.
14.	范慧丹. 磁纳米粒子交流磁化率测量方法研究及系统设计. 武汉: 华中科技大学, 2016.
15.	Rahmer J, Weizenecker J, Gleich B, et al. Signal encoding in magnetic particle imaging: properties of the system function. BMC Med Imag, 2009, 9(4): 1-21.

1. Knopp T, Buzug T M. Magnetic particle imaging: An introduction to imaging principles and scanner instrumentation. New York: Springer, 2012: 12-25.
2. Jeffrey D K, Huanyu D, Justin M, et al. Nanotechnology: A focus on nanoparticles as a drug delivery system. J Neuroimmune Pharm, 2006, 1(3): 340-350.
3. Bourrinet P, Bengele H H, Bonnemain B, et al. Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent. Invest Radiol, 2006, 41(3): 313-324.
4. Gleich B, Weizenecker J. Tomographic imaging using the nonlinear response of magnetic particles. Nature, 2005, 435(7046): 1214-1217.
5. Bulte J W M, Walczak P, Bernard S, et al. Developing cellular MPI: initial experience// International Workshop on Magnetic Nanoparticles-particle Science, Imaging Technology. Lübeck: IEEE, 2010: 201-204.
6. Cetin S, Saritas E U, Unal G. Vessel tractography for magnetic particle imaging angiography// IEEE 2015 5th International Workshop on Magnetic Particle Imaging (IWMPI). Istanbul: IEEE, 2015: 1.
7. Sigovan M, Boussel L, Sulaiman A, et al. Rapid-clearance iron nanoparticles for inflammation imaging of atherosclerotic plaque: initial experience in animal model. Radiology, 2009, 252(2): 401-409.
8. Ludwig F, Eberbeck D, Löwa N, et al. Characterization of magnetic nanoparticle systems with respect to their magnetic particle imaging performance. Biomedizinische Technik/Biomedical Engineering, 2013, 58(6): 535-545.
9. Biederer S, Knopp T, Sattel T F, et al. Magnetization response spectroscopy of superparamagnetic nanoparticles for magnetic particle imaging. J Phys D Appl Phys, 2009, 42(20): 205007-1-7.
10. Weaver J B, Rauwerdink A M, Sullivan C R, et al. Frequency distribution of the nanoparticle magnetization in the presence of a static as well as a harmonic magnetic field. Med Phys, 2008, 35(5): 1988-1994.
11. Sasayama T, Tsujita Y, Morishita M, et al. Three-dimensional magnetic nanoparticle imaging using small field gradient and multiple pickup coils. J Magn Magn Mater, 2017, 427(1): 144-150.
12. Murase K, Shimada K. Lock-in-amplifier model for analyzing the behavior of signal harmonics in magnetic particle imaging. Open J Appl Sci, 2018, 8(5): 170-183.
13. 张朴, 成鹏, 刘文中. 基于 SQUID 的磁纳米粒子磁特性测量研究. 计量与测试技术, 2016, 43(8): 56-58.
14. 范慧丹. 磁纳米粒子交流磁化率测量方法研究及系统设计. 武汉: 华中科技大学, 2016.
15. Rahmer J, Weizenecker J, Gleich B, et al. Signal encoding in magnetic particle imaging: properties of the system function. BMC Med Imag, 2009, 9(4): 1-21.

Journal of Biomedical Engineering

Detection method of nonlinear magnetized harmonic signal of medical magnetic nanoparticles

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content