Study on the thermal field distribution of cholangiocarcinoma model by magnetic fluid hyperthermia_Journal of Biomedical Engineering

Authors：

CAI Zhongxiang ,  LU Mai

Key Laboratory of Optoelectronic Technology and Intelligent Control Ministry of Education, Lanzhou Jiaotong University, Lanzhou 730070, P.R.China;

Corresponding author：

LU Mai, Email: mai.lu@hotmail.com

Keywords：

cholangiocarcinoma; tumor; magnetic fluid hyperthermia; finite element analysis; magnetic nanoparticles

DOI：

10.7507/1001-5515.202005046

Video：

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Cholangiocarcinoma is a highly malignant tumor. It is not sensitive to radiotherapy and chemotherapy and has a poor prognosis. At present, there is no effective treatment. As a new method for treating cancer, magnetic fluid hyperthermia has been clinically applied to a variety of cancers in recent years. This article introduces it to the cholangiocarcinoma model and systematically studies the effect of magnetic fluid hyperthermia on cholangiocarcinoma. Starting from the theory of magnetic fluid heating, the electromagnetic and heat transfer models were constructed in the finite element simulation software COMSOL using the Pennes biological heat transfer equation. The Helmholtz coil was used as an alternating magnetic field generating device. The relationship between the magnetic fluid-related properties and the heating power was analyzed according to Rosensweig’s theory. After the multiphysics coupling simulation was performed, the electromagnetic field and thermal field distribution in the hyperthermia region were obtained. The results showed that the magnetic field distribution in the treatment area was uniform, and the thermal field distribution met the requirements of hyperthermia. After the magnetic fluid injection, the cholangiocarcinoma tissue warmed up rapidly, and the temperature of tumor tissues could reach above 42 °C, but the surrounding healthy tissues did not heat up significantly. At the same time, it was verified that the large blood vessels around the bile duct, the overflow of the magnetic fluid, and the eddy current heat had little effect on thermotherapy. The results of this article can provide a reference for the clinical application of magnetic fluid hyperthermia for cholangiocarcinoma.

Citation： CAI Zhongxiang, LU Mai. Study on the thermal field distribution of cholangiocarcinoma model by magnetic fluid hyperthermia. Journal of Biomedical Engineering, 2021, 38(3): 528-538, 548. doi: 10.7507/1001-5515.202005046 Copy

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1. 李康, 张亚萍, 张秀敏, 等. 磁流体肿瘤热疗技术的研究进展. 现代生物医学进展, 2017, 17(5): 964-967, 957.
2. Jordan A, Wust P, Fähling H, et al. Inductive heating of ferrimagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia. Int J Hyperthermia, 1993, 9(1): 51-68.
3. Liu Xiaoli, Zhang Yifan, Wang Yanyun, et al. Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy. Theranostics, 2020, 10(8): 3793-3815.
4. Stauffer P R, Sneed P K. Practical induction heating coil designs for clinical hyperthermia with ferromagnetic implants. IEEE Trans Biomed Eng, 1994, 41(1): 17-28.
5. 唐劲天, 郭静, 阳兵, 等. 热疗的发展历程与展望. 科技导报, 2014, 32(30): 15-18.
6. 屈英佼, 逯迈, 刘曦, 等. 磁感应热疗中磁介质参数与加热温度关系的模拟仿真. 生物医学工程学杂志, 2019, 36(2): 36-42.
7. Das P, Colombo M, Prosperi D. Recent advances in magnetic fluid hyperthermia for cancer therapy. Colloids Surf B, 2019, 174: 42-55.
8. Banales J M, Marin J J G, Lamarca A, et al. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol, 2020, 17(9): 557-588.
9. 谢炬平, 梁浩, 张大伟, 等. 内镜下射频消融联合金属支架植入对不可切除胆管癌的疗效. 实用医学杂志, 2018, 34(9): 93-95, 104.
10. Zacharoulis D, Lazoura O, Sioka E, et al. Habib EndoHPB: a novel endobiliary radiofrequency ablation device. An experimental study. J Invest Surg, 2013, 26(1): 6-10.
11. da Costa Filipe J D P, de Almeida T R O. Numerical modelling of magnetic induction heating of a tubular implant for hyperthermia procedures//2017 18th International Symposium on Electromagnetic Fields in Mechatronics, Electrical and Electronic Engineering (ISEF). Lodz: IEEE, 2017: 1-2.
12. 曹智刚. 温热治疗胆管癌的相关实验研究. 沈阳: 中国医科大学, 2006.
13. 刘晓红, 赵东林, 姚冉冉, 等. 超顺磁纳米Fe₃O₄磁性流体的制备及其在交变磁场中的发热性能. 北京化工大学学报: 自然科学版, 2016, 43(1): 40-44.
14. Rosensweig R E. Heating magnetic fluid with alternating magnetic field. J Magn Magn Mater, 2002, 252: 370-374.
15. Pennes H H. Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol, 1948, 1(2): 93-122.
16. Tang Y, Jin T, Flesch R C C. Numerical temperature analysis of magnetic hyperthermia considering nanoparticle clustering and blood vessels. IEEE Trans Magn, 2017, 53(10): 1-6.
17. 胡冠中. 磁流体热疗系统多物理场耦合分析与优化设计. 杭州: 浙江大学, 2016.
18. 武建安, 吴祖河, 王亨, 等. 基于有限元仿真的磁感应肿瘤治疗设备线圈优化设计. 清华大学学报: 自然科学版, 2016, 56(4): 406-410, 416.
19. Wu Lei, Cheng Jingjing, Liu Wenzhong, et al. Numerical analysis of electromagnetically induced heating and bioheat transfer for magnetic fluid hyperthermia. IEEE Trans Magn, 2015, 51(2): 1-4.
20. Li J, Yao H, Lei Y, et al. Numerical simulation of magnetic fluid hyperthermia based on multiphysics coupling and recommendation on preferable treatment conditions. Curr Appl Phys, 2019, 19: 1031-1039.
21. 0daydown. Human Anatomy Models[DB/OL]. (2014-02-28)[2020-05-25]. https://www.0daydown.com/02/140863.html.
22. 王荇, 李相成. 胆管癌姑息治疗的研究进展. 临床肝胆病杂志, 2016, 32(5): 208-211.
23. Lv Y G, Deng Z S, Liu J. 3-D numerical study on the induced heating effects of embedded micro/nanoparticles on human body subject to external medical electromagnetic field. IEEE Trans Nanobiosci, 2005, 4(4): 284-294.
24. Khandhar A P, Ferguson R M, Krishnan K M. Monodispersed magnetite nanoparticles optimized for magnetic fluid hyperthermia: Implications in biological systems. J Appl Phys, 2011, 109: 07B310.1-07B310.3.
25. 张达, 刘永雄, 顾万清, 等. 微波热疗对犬正常胆管结构影响的实验研究. 中华肝胆外科杂志, 1999, 5(4): 241-244.
26. Rivolta B, Inzoli F, Mantero S, et al. Evaluation of temperature distribution during hyperthermia treatment in biliary tumors: A computational approach. J Biomech Eng, 1999, 121: 141-147.

Journal of Biomedical Engineering

Study on the thermal field distribution of cholangiocarcinoma model by magnetic fluid hyperthermia

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