An electroencephalogram-based study of resting-state spectrogram and attention in tinnitus patients_Journal of Biomedical Engineering

Authors：

HUANG Haiyun ^1,3 , CAI Yuexin ² , FENG Xueji ¹ ,  LI Yuanqing ^1,3

1. School of Automation Science and Engineering, South China University of Technology, Guangzhou 510000, P.R.China;
2. Department of Otolaryngology Head and Neck Surgery, Sun Yat-sen University, Guangzhou 510520, P.R.China;
3. Brain Computer Intelligence Research Center, Pazhou Lab, Guangzhou 510330, P.R.China;

Corresponding author：

LI Yuanqing, Email: auyqli@scut.edu.cn

Keywords：

tinnitus; resting state; spectrum analysis; electroencephalogram; attention

DOI：

10.7507/1001-5515.202012015

Video：

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The incidence of tinnitus is very high, which can affect the patient’s attention, emotion and sleep, and even cause serious psychological distress and suicidal tendency. Currently, there is no uniform and objective method for tinnitus detection and therapy, and the mechanism of tinnitus is still unclear. In this study, we first collected the resting state electroencephalogram (EEG) data of tinnitus patients and healthy subjects. Then the power spectrum topology diagrams were compared of in the band of δ (0.5–3 Hz), θ (4–7 Hz), α (8–13 Hz), β (14–30 Hz) and γ (31–50 Hz) to explore the central mechanism of tinnitus. A total of 16 tinnitus patients and 16 healthy subjects were recruited to participate in the experiment. The results of resting state EEG experiments found that the spectrum power value of tinnitus patients was higher than that of healthy subjects in all concerned frequency bands. The t-test results showed that the significant difference areas were mainly concentrated in the right temporal lobe of the θ and α band, and the temporal lobe, parietal lobe and forehead area of the β and γ band. In addition, we designed an attention-related task experiment to further study the relationship between tinnitus and attention. The results showed that the classification accuracy of tinnitus patients was significantly lower than that of healthy subjects, and the highest classification accuracies were 80.21% and 88.75%, respectively. The experimental results indicate that tinnitus may cause the decrease of patients’ attention.

Citation： HUANG Haiyun, CAI Yuexin, FENG Xueji, LI Yuanqing. An electroencephalogram-based study of resting-state spectrogram and attention in tinnitus patients. Journal of Biomedical Engineering, 2021, 38(3): 492-497. doi: 10.7507/1001-5515.202012015 Copy

1.	Jastreboff P. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci Res, 1990, 8(4): 221-254.
2.	Tunkel D, Bauer C, Sun G, et al. Clinical practice guideline: tinnitus. J Otolaryngol-Head N, 2014, 151(6): 1995-2010.
3.	王洪田. 耳鸣的诊断治疗新进展. 实用医学杂志, 2005, 21(2): 114-116.
4.	Hoffman H J, Reed G W. Epidemiology of tinnitus// Snow J B. Tinnitus: Theory and management. London: BC Decker Inc, 2004: 16-41.
5.	Moazami-Goudarzi M, Michels L, Weisz N, et al. Temporo-insular enhancement of EEG low and high frequencies in patients with chronic tinnitus. QEEG study of chronic tinnitus patients. BMC Neurosci, 2010, 11(1): 1-12.
6.	Lanting C, Kleine E, Dijk P. Neural activity underlying tinnitus generation: results from PET and fMRI. Hear Res, 2009, 255(1-2): 1-13.
7.	蔡跃新, 李佳鸿, 杨海弟, 等. 主观性耳鸣患者静息态脑电地形图功率频谱研究. 中国耳鼻咽喉头颈外科, 2018, 25(7): 358.
8.	Tseng M, Henderson A, Chow S, et al. Relationship between motor proficiency, attention, impulse, and activity in children with ADHD. Dev Med Child Neurol, 2004, 46(6): 381-388.
9.	Rossiter S, Stevens C, Walker G. Tinnitus and its effect on working memory and attention. J Speech Lang Hear Res, 2006, 49(1): 150-160.
10.	Stevens C, Walker G, Boyer M, et al. Severe tinnitus and its effect on selective and divided attention. Int J Audiol, 2007, 46(5): 208-216.
11.	Cuny C, Norena A, Massioui F, et al. Reduced attention shift in response to auditory changes in subjects with tinnitus. Audiol Neurotol Extra, 2004, 9(5): 294-302.
12.	Yao D. A method to standardize a reference of scalp EEG recordings to a point at infinity. Physiol Meas, 2001, 22(4): 693-711.
13.	Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods, 2004, 134(1): 9-21.
14.	Linas R, Ribary U, Jeanmonod D, et al. Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography. P Natl Acad Sci, 1999, 96(26): 15222-15227.
15.	Herraiz C, Diges I, Cobo P, et al. Cortical reorganisation and tinnitus: principles of auditory discrimination training for tinnitus management. Eur Arch Oto-Rhino-L, 2009, 266(1): 9.
16.	金玲, 赵小虎, 王培军, 等. 耳鸣的功能性磁共振成像研究. 中国耳鼻咽喉头颈外科, 2011, 18(4): 174-177.
17.	Houdayer E, Teggi R, Velikova S, et al. Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study. J Clin Neurophysiol, 2015, 126(12): 2356-2365.
18.	van der Loo E, Gais S, Congedo M, et al. Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS One, 2009, 4(10): e7396.
19.	Schlee W, Lorenz I, Hartmann T, et al. A global brain model of tinnitus// Møller A R. Textbook of tinnitus. New York: Springer, 2011: 161-169.
20.	Schlee W, Weisz N, Bertrand O, et al. Using auditory steady state responses to outline the functional connectivity in the tinnitus brain. PLoS One, 2008, 3(11): e3720.
21.	Zheng Weilong, Lu Baoliang. A multimodal approach to estimating vigilance using EEG and forehead EOG. J Neural Eng, 2017, 14(2): 026017.
22.	Klimesch W, Doppelmayr M, Russegger H, et al. Induced alpha band power changes in the human EEG and attention. Neurosci Lett, 1998, 244(2): 73-76.
23.	Isiten N, Cebi M, Sutcubasi B, et al. Medication effects on EEG biomarkers in attention-deficit/hyperactivity disorder. Clin EEG Neurosci, 2017, 48(4): 246-250.
24.	Putman P, Verkuil B, Arias-Garcia E, et al. EEG theta/beta ratio as a potential biomarker for attentional control and resilience against deleterious effects of stress on attention. Cogn Affect Behav Neurosci, 2014, 14(2): 782-791.

1. Jastreboff P. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci Res, 1990, 8(4): 221-254.
2. Tunkel D, Bauer C, Sun G, et al. Clinical practice guideline: tinnitus. J Otolaryngol-Head N, 2014, 151(6): 1995-2010.
3. 王洪田. 耳鸣的诊断治疗新进展. 实用医学杂志, 2005, 21(2): 114-116.
4. Hoffman H J, Reed G W. Epidemiology of tinnitus// Snow J B. Tinnitus: Theory and management. London: BC Decker Inc, 2004: 16-41.
5. Moazami-Goudarzi M, Michels L, Weisz N, et al. Temporo-insular enhancement of EEG low and high frequencies in patients with chronic tinnitus. QEEG study of chronic tinnitus patients. BMC Neurosci, 2010, 11(1): 1-12.
6. Lanting C, Kleine E, Dijk P. Neural activity underlying tinnitus generation: results from PET and fMRI. Hear Res, 2009, 255(1-2): 1-13.
7. 蔡跃新, 李佳鸿, 杨海弟, 等. 主观性耳鸣患者静息态脑电地形图功率频谱研究. 中国耳鼻咽喉头颈外科, 2018, 25(7): 358.
8. Tseng M, Henderson A, Chow S, et al. Relationship between motor proficiency, attention, impulse, and activity in children with ADHD. Dev Med Child Neurol, 2004, 46(6): 381-388.
9. Rossiter S, Stevens C, Walker G. Tinnitus and its effect on working memory and attention. J Speech Lang Hear Res, 2006, 49(1): 150-160.
10. Stevens C, Walker G, Boyer M, et al. Severe tinnitus and its effect on selective and divided attention. Int J Audiol, 2007, 46(5): 208-216.
11. Cuny C, Norena A, Massioui F, et al. Reduced attention shift in response to auditory changes in subjects with tinnitus. Audiol Neurotol Extra, 2004, 9(5): 294-302.
12. Yao D. A method to standardize a reference of scalp EEG recordings to a point at infinity. Physiol Meas, 2001, 22(4): 693-711.
13. Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods, 2004, 134(1): 9-21.
14. Linas R, Ribary U, Jeanmonod D, et al. Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography. P Natl Acad Sci, 1999, 96(26): 15222-15227.
15. Herraiz C, Diges I, Cobo P, et al. Cortical reorganisation and tinnitus: principles of auditory discrimination training for tinnitus management. Eur Arch Oto-Rhino-L, 2009, 266(1): 9.
16. 金玲, 赵小虎, 王培军, 等. 耳鸣的功能性磁共振成像研究. 中国耳鼻咽喉头颈外科, 2011, 18(4): 174-177.
17. Houdayer E, Teggi R, Velikova S, et al. Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study. J Clin Neurophysiol, 2015, 126(12): 2356-2365.
18. van der Loo E, Gais S, Congedo M, et al. Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS One, 2009, 4(10): e7396.
19. Schlee W, Lorenz I, Hartmann T, et al. A global brain model of tinnitus// Møller A R. Textbook of tinnitus. New York: Springer, 2011: 161-169.
20. Schlee W, Weisz N, Bertrand O, et al. Using auditory steady state responses to outline the functional connectivity in the tinnitus brain. PLoS One, 2008, 3(11): e3720.
21. Zheng Weilong, Lu Baoliang. A multimodal approach to estimating vigilance using EEG and forehead EOG. J Neural Eng, 2017, 14(2): 026017.
22. Klimesch W, Doppelmayr M, Russegger H, et al. Induced alpha band power changes in the human EEG and attention. Neurosci Lett, 1998, 244(2): 73-76.
23. Isiten N, Cebi M, Sutcubasi B, et al. Medication effects on EEG biomarkers in attention-deficit/hyperactivity disorder. Clin EEG Neurosci, 2017, 48(4): 246-250.
24. Putman P, Verkuil B, Arias-Garcia E, et al. EEG theta/beta ratio as a potential biomarker for attentional control and resilience against deleterious effects of stress on attention. Cogn Affect Behav Neurosci, 2014, 14(2): 782-791.

Journal of Biomedical Engineering

An electroencephalogram-based study of resting-state spectrogram and attention in tinnitus patients

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