Material design and temperature field simulation analysis of tumor radiofrequency ablation needle_Journal of Biomedical Engineering

Authors：

CHEN Zile ,  CUI Haipo , LU Yingxi , LANG Jingcheng

Shanghai Institute for Minimally Invasive Therapy, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China;

Corresponding author：

CUI Haipo, Email: h_b_cui@163.com

Keywords：

Radiofrequency ablation; Electrode needle; Material design; Temperature field simulation

DOI：

10.7507/1001-5515.202202012

Video：

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To solve the problems of small one-time ablation range and easy charring of the tissue around the electrode associated with the tumor radiofrequency ablation needle, based on the multiphysical field coupling analysis software COMSOL, the effects of needle material, the number of sub needles and the bending angle of sub needles on the ablation effect of radiofrequency ablation electrode needle were studied. The results show that compared with titanium alloy and stainless steel, nickel titanium alloy has better radiofrequency energy transmission efficiency and it is the best material for electrode needle. The number of sub needles has a great influence on the average necrosis depth and the maximum necrosis diameter. Under the same conditions, the more the number of sub needles, the larger the volume of coagulation necrosis area. The bending angle of the needle has a great effect on the maximum diameter of the coagulated necrotic area, but has little effect on the average necrotic depth. Under the same other conditions, the coagulation necrosis area formed by ablation increased with the increase of the bending angle of the sub needle. For the three needles with bending angles of 60 °, 90 ° and 120 ° analyzed in this paper, the one with bending angle of 120 ° can obtain the largest coagulation necrosis area. In general, the design of nickel titanium alloy with 120 ° bending 8-pin is the optimal. The average depth of radiofrequency ablation necrosis area is 32.40 mm, and the maximum necrosis diameter is 52.65 mm. The above optimized design parameters can provide guidance for the structure and material design of tumor radiofrequency ablation needle.

Citation： CHEN Zile, CUI Haipo, LU Yingxi, LANG Jingcheng. Material design and temperature field simulation analysis of tumor radiofrequency ablation needle. Journal of Biomedical Engineering, 2022, 39(5): 958-965. doi: 10.7507/1001-5515.202202012 Copy

1.	Pascual S, Herrera I, Irurzun J. New advances in hepatocellular carcinoma. World J Hepatol, 2016, 8(9): 421-438.
2.	Chen Wanqing, Zheng Rongshou, Baade P D, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016, 66(2): 115-132.
3.	俞巍, 张洪义, 王鹏辉. 射频消融治疗肝癌的研究进展. 中国临床医生杂志, 2021, 49(4): 385-387.
4.	方正. 射频消融物理和化学增强方法的研究. 上海: 华东理工大学, 2020.
5.	张兴亚, 胡喜云. 射频消融治疗肝脏良性肿瘤的应用及有效性分析. 中国农村卫生, 2021, 13(10): 40-41.
6.	Wang S, Jiang K. Advances of thermal effect in radiofrequency ablation of liver cancer. World Cancer Res J, 2016, 6(4): 31-35.
7.	Caspani B, Ierardi A M, Motta F, et al. Small nodular hepatocellular carcinoma treated by laser thermal ablation in high risk locations: preliminary results. Eur Radiol, 2010, 20(9): 2286-2292.
8.	Groeschl R T, Pilgrim C H, Hanna E M, et al. Microwave ablation for hepatic malignancies: a multiinstitutional analysis. Ann Surg, 2014, 259(6): 1195-1200.
9.	Kim Y S, Lim H K, Rhim H, et al. Ten-year outcomes of percutaneous radiofrequency ablation as first-line therapy of early hepatocellular carcinoma: analysis of prognostic factors. J Hepatol, 2013, 58(1): 89-97.
10.	韩春起. 射频消融术治疗肝细胞癌研究进展. 山西医药杂志, 2020, 49(9): 1104-1106.
11.	赵镇南, 李丰彤. 肿瘤射频热疗比吸收率与温度场仿真及影响参数的研究. 生物医学工程学杂志, 2005, 22(5): 901-905.
12.	王娟. 肿瘤微波精准热消融仿真技术研究. 南京: 南京航空航天大学, 2020.
13.	McWilliams J P, Yamamoto S, Raman S S, et al. Percutaneous ablation of hepatocellular carcinoma: current status. J Vasc Interv Radiol, 2010, 21(8 Suppl): S204-213.
14.	黄维. 人体肝脏温控射频消融仿真研究. 重庆: 重庆大学, 2014.
15.	姜安娜, 杨薇. 肝肿瘤射频消融电极针研究进展. 介入放射学杂志, 2017, 26(5): 466-470.
16.	Rossi S, Fornari F, Pathies C, et al. Thermal lesions induced by 480 kHZ localized current field in guineapig and pigliver. Tumori, 1990, 76: 54-57.
17.	Rossi S, Fornari F, Buscarini L. Percutaneous ultrasound guided radiofrequency electrocautery for the treatment of small hepatocellular carcinoma. Interv Radiol, 1993, 8: 97-103.
18.	李鑫, 梁萍. 超声引导下肝癌热消融治疗的现状与进展. 临床肝胆病杂志, 2021, 37(3): 510-514.
19.	McGahan J P, Gu W Z, Brock J M, et al. Hepatic ablation using bipolar radiofrequency electrocautery. Acad Radiol, 1996, 3(5): 418-422.
20.	Goldberg S N. Radiofrequency tumor ablation: principles and techniques. Eur J Ultrasound, 2001, 13(2): 129-147.
21.	Goldberg S N, Gazelle G S, Halpern E F, et al. Radiofrequency tissue ablation: importance of local temperature along the electrode tip exposure in determining lesion shape and size. Acad Radiol, 1996, 3(3): 212-218.
22.	Ooi E H, Lee K W, Yap S, et al. The effects of electrical and thermal boundary condition on the simulation of radiofrequency ablation of liver cancer for tumours located near to the liver boundary. Comput Biol Med, 2019, 106: 12-23.
23.	Lee E S, Lee J M, Kim W S, et al. Multiple-electrode radiofrequency ablations using Octopus® electrodes in an in vivo porcine liver model. Brit J Radiol, 2012, 85(10): 609-615.
24.	罗洪艳, 黄维, 潘进洪, 等. 射频消融建模仿真的研究进展. 激光杂志, 2014, 35(1): 1-4.
25.	张萌, 田甄, 程妍妍, 等. 双曲线传热模型在微波消融治疗房颤中的应用研究. 生物医学工程学杂志, 2021, 38(5): 885-892.
26.	洪焦, 高宏建, 吴水才. 脑组织射频消融的有限元仿真与分析. 北京生物医学工程, 2012, 31(1): 10-15.
27.	Rossmanna C, Haemmerich D. Review of temperature dependence of thermal properties, dielectric properties, and perfusion of biological tissues at hyperthermic and ablation temperatures. Crit Rev Biomed Eng, 2014, 42(6): 467-492.
28.	王笑茹. 肝肿瘤射频消融温度场仿真及手术辅助系统研究. 北京: 北京工业大学, 2019.
29.	Bernardi P, Cavagnaro M, Lin J C, et al. Distribution of SAR andtemperature elevation induced in a phantom by a microwave cardiac ablation catheter. IEEE T Microw Theory, 2004, 52(8): 1978-1986.
30.	聂佳力, 谷雪莲, 周流斌. 肩关节软组织低温等离子射频消融电极的材料改进. 生物医学工程研究, 2020, 39(1): 41-48.
31.	于文博. 超弹性镍钛合金支架设计优化及有限元分析. 西安: 西安电子科技大学, 2019.
32.	杨阳. 超声引导下射频消融术治疗肝癌的临床疗效分析. 吉林: 吉林大学, 2020.
33.	胡涛, 肖家华. 子宫内膜双极多探针射频消融的有限元分析. 北京生物医学工程, 2014, 33(2): 111-116.

1. Pascual S, Herrera I, Irurzun J. New advances in hepatocellular carcinoma. World J Hepatol, 2016, 8(9): 421-438.
2. Chen Wanqing, Zheng Rongshou, Baade P D, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016, 66(2): 115-132.
3. 俞巍, 张洪义, 王鹏辉. 射频消融治疗肝癌的研究进展. 中国临床医生杂志, 2021, 49(4): 385-387.
4. 方正. 射频消融物理和化学增强方法的研究. 上海: 华东理工大学, 2020.
5. 张兴亚, 胡喜云. 射频消融治疗肝脏良性肿瘤的应用及有效性分析. 中国农村卫生, 2021, 13(10): 40-41.
6. Wang S, Jiang K. Advances of thermal effect in radiofrequency ablation of liver cancer. World Cancer Res J, 2016, 6(4): 31-35.
7. Caspani B, Ierardi A M, Motta F, et al. Small nodular hepatocellular carcinoma treated by laser thermal ablation in high risk locations: preliminary results. Eur Radiol, 2010, 20(9): 2286-2292.
8. Groeschl R T, Pilgrim C H, Hanna E M, et al. Microwave ablation for hepatic malignancies: a multiinstitutional analysis. Ann Surg, 2014, 259(6): 1195-1200.
9. Kim Y S, Lim H K, Rhim H, et al. Ten-year outcomes of percutaneous radiofrequency ablation as first-line therapy of early hepatocellular carcinoma: analysis of prognostic factors. J Hepatol, 2013, 58(1): 89-97.
10. 韩春起. 射频消融术治疗肝细胞癌研究进展. 山西医药杂志, 2020, 49(9): 1104-1106.
11. 赵镇南, 李丰彤. 肿瘤射频热疗比吸收率与温度场仿真及影响参数的研究. 生物医学工程学杂志, 2005, 22(5): 901-905.
12. 王娟. 肿瘤微波精准热消融仿真技术研究. 南京: 南京航空航天大学, 2020.
13. McWilliams J P, Yamamoto S, Raman S S, et al. Percutaneous ablation of hepatocellular carcinoma: current status. J Vasc Interv Radiol, 2010, 21(8 Suppl): S204-213.
14. 黄维. 人体肝脏温控射频消融仿真研究. 重庆: 重庆大学, 2014.
15. 姜安娜, 杨薇. 肝肿瘤射频消融电极针研究进展. 介入放射学杂志, 2017, 26(5): 466-470.
16. Rossi S, Fornari F, Pathies C, et al. Thermal lesions induced by 480 kHZ localized current field in guineapig and pigliver. Tumori, 1990, 76: 54-57.
17. Rossi S, Fornari F, Buscarini L. Percutaneous ultrasound guided radiofrequency electrocautery for the treatment of small hepatocellular carcinoma. Interv Radiol, 1993, 8: 97-103.
18. 李鑫, 梁萍. 超声引导下肝癌热消融治疗的现状与进展. 临床肝胆病杂志, 2021, 37(3): 510-514.
19. McGahan J P, Gu W Z, Brock J M, et al. Hepatic ablation using bipolar radiofrequency electrocautery. Acad Radiol, 1996, 3(5): 418-422.
20. Goldberg S N. Radiofrequency tumor ablation: principles and techniques. Eur J Ultrasound, 2001, 13(2): 129-147.
21. Goldberg S N, Gazelle G S, Halpern E F, et al. Radiofrequency tissue ablation: importance of local temperature along the electrode tip exposure in determining lesion shape and size. Acad Radiol, 1996, 3(3): 212-218.
22. Ooi E H, Lee K W, Yap S, et al. The effects of electrical and thermal boundary condition on the simulation of radiofrequency ablation of liver cancer for tumours located near to the liver boundary. Comput Biol Med, 2019, 106: 12-23.
23. Lee E S, Lee J M, Kim W S, et al. Multiple-electrode radiofrequency ablations using Octopus® electrodes in an in vivo porcine liver model. Brit J Radiol, 2012, 85(10): 609-615.
24. 罗洪艳, 黄维, 潘进洪, 等. 射频消融建模仿真的研究进展. 激光杂志, 2014, 35(1): 1-4.
25. 张萌, 田甄, 程妍妍, 等. 双曲线传热模型在微波消融治疗房颤中的应用研究. 生物医学工程学杂志, 2021, 38(5): 885-892.
26. 洪焦, 高宏建, 吴水才. 脑组织射频消融的有限元仿真与分析. 北京生物医学工程, 2012, 31(1): 10-15.
27. Rossmanna C, Haemmerich D. Review of temperature dependence of thermal properties, dielectric properties, and perfusion of biological tissues at hyperthermic and ablation temperatures. Crit Rev Biomed Eng, 2014, 42(6): 467-492.
28. 王笑茹. 肝肿瘤射频消融温度场仿真及手术辅助系统研究. 北京: 北京工业大学, 2019.
29. Bernardi P, Cavagnaro M, Lin J C, et al. Distribution of SAR andtemperature elevation induced in a phantom by a microwave cardiac ablation catheter. IEEE T Microw Theory, 2004, 52(8): 1978-1986.
30. 聂佳力, 谷雪莲, 周流斌. 肩关节软组织低温等离子射频消融电极的材料改进. 生物医学工程研究, 2020, 39(1): 41-48.
31. 于文博. 超弹性镍钛合金支架设计优化及有限元分析. 西安: 西安电子科技大学, 2019.
32. 杨阳. 超声引导下射频消融术治疗肝癌的临床疗效分析. 吉林: 吉林大学, 2020.
33. 胡涛, 肖家华. 子宫内膜双极多探针射频消融的有限元分析. 北京生物医学工程, 2014, 33(2): 111-116.

Journal of Biomedical Engineering

Material design and temperature field simulation analysis of tumor radiofrequency ablation needle

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