Bionic optic nerve based on perovskite (CsPbBr<sub>3</sub>) quantum-dots_Journal of Biomedical Engineering

Authors：

ZENG Pingjun ¹ , JIN Xudong ² , PENG Yubo ¹ , ZHAO Min ² ,  GAO Zhipeng ¹ , LI Xiaona ¹ , JI Jianlong ³ , CHEN Weiyi ¹

1. College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China;
2. Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, P. R. China;
3. College of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, P. R. China;

Corresponding author：

GAO Zhipeng, Email: gaozhipeng@tyut.edu.cn

Keywords：

Optical synapse; Organic electrochemical transistors; Perovskite quantum dot

DOI：

10.7507/1001-5515.202211045

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The bionic optic nerve can mimic human visual physiology and is a future treatment for visual disorders. Photosynaptic devices could respond to light stimuli and mimic normal optic nerve function. By modifying (Poly(3,4-ethylenedioxythio-phene):poly (styrenesulfonate)) active layers with all-inorganic perovskite quantum dots, with an aqueous solution as the dielectric layer in this paper, we developed a photosynaptic device based on an organic electrochemical transistor (OECT). The optical switching response time of OECT was 3.7 s. To improve the optical response of the device, a 365 nm, 300 mW·cm⁻² UV light source was used. Basic synaptic behaviors such as postsynaptic currents (0.225 mA) at a light pulse duration of 4 s and double pulse facilitation at a light pulse duration of 1 s and pulse interval of 1 s were simulated. By changing the way light stimulates, for example, by adjusting the intensity of the light pulses from 180 to 540 mW·cm⁻², the duration from 1 to 20 s, and the number of light pulses from 1 to 20, the postsynaptic currents were increased by 0.350 mA, 0.420 mA, and 0.466 mA, respectively. As such, we realized the effective shift from short-term synaptic plasticity (100 s recovery of initial value) to long-term synaptic plasticity (84.3% of 250 s decay maximum). This optical synapse has a high potential for simulating the human optic nerve

Citation： ZENG Pingjun, JIN Xudong, PENG Yubo, ZHAO Min, GAO Zhipeng, LI Xiaona, JI Jianlong, CHEN Weiyi. Bionic optic nerve based on perovskite (CsPbBr₃) quantum-dots. Journal of Biomedical Engineering, 2023, 40(3): 522-528. doi: 10.7507/1001-5515.202211045 Copy

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13.	Wang Z, Zhou H, Chen W, et al. Dually synergetic network hydrogels with integrated mechanical stretchability, thermal responsiveness, and electrical conductivity for strain sensors and temperature alertors. ACS Appl Mater Interfaces, 2018, 10(16): 14045-14054.
14.	Ma C, Luo H, Liu M, et al. Preparation of intrinsic flexible conductive PEDOT: PSS@ionogel composite film and its application for touch panel. Chem Eng J, 2021, 425: 131542.
15.	Cavallo A, Losi P, Buscemi M, et al. Biocompatible organic electrochemical transistor on polymeric scaffold for wound healing monitoring. Flex Print Electron, 2022, 7(3): 035009.
16.	Bai J, Liu D, Tian X, et al. Tissue-like organic electrochemical transistors. J Mater Chem C, 2022, 10(37): 13303-13311.
17.	Ashton N J, Janelidze S, Al Khleifat A, et al. A multicentre validation study of the diagnostic value of plasma neurofilament light. Nat Commun, 2021, 12(1): 3400.
18.	Shi Y, Zhou Y, Shen R, et al. Solution-based synthesis of PEDOT: PSS films with electrical conductivity over 6300 S/cm. J Ind Eng Chem, 2021, 101: 414-422.
19.	Ye Y, Wang J, Qiu Y, et al. Ultra-low EQE roll-off and marvelous efficiency perovskite quantum-dots light-emitting-diodes achieved by ligand passivation. Nano Energy, 2021, 90: 106583.
20.	Proctor C M, Rivnay J, Malliaras G G. Understanding volumetric capacitance in conducting polymers. J Polym Sci Pol Phys, 2016, 54(15): 1433-1436.
21.	Fang L, Dai S, Zhao Y, et al. Light-stimulated artificial synapses based on 2D organic field-effect transistors. Adv Electron Mater, 2020, 6(1): 1901217.
22.	Kim M K, Lee J S. Short-term plasticity and long-term potentiation in artificial biosynapses with diffusive dynamics. ACS Nano, 2018, 12(2): 1680-1687.
23.	Ahmed T, Kuriakose S, Mayes E L H, et al. Optically stimulated artificial synapse based on layered black phosphorus. Small, 2019, 15(22): 1900966.

1. Gao S, Liu G, Yang H, et al. An oxide Schottky junction artificial optoelectronic synapse. ACS Nano, 2019, 13(2): 2634-2642.
2. Lenaers G, Neutzner A, Le Dantec Y, et al. Dominant optic atrophy: Culprit mitochondria in the optic nerve. Prog Retin Eye Res, 2021, 83: 100935.
3. Steinsapir K D, Goldberg R A. Traumatic optic neuropathy. Surv Ophthalmol, 1994, 38(6): 487-518.
4. Gu L, Poddar S, Lin Y, et al. A biomimetic eye with a hemispherical perovskite nanowire array retina. Nature, 2020, 581(7808): 278-282.
5. Benner A F, Ignatowski M, Kash J A, et al. Exploitation of optical interconnects in future server architectures. IBM J Res Dev, 2005, 49(4.5): 755-775.
6. Yang Y, He Y, Nie S, et al. Light stimulated IGZO-based electric-double-layer transistors for photoelectric neuromorphic devices. IEEE Electr Device L, 2018, 39(6): 897-900.
7. Kwon S M, Cho S W, Kim M, et al. Environment-adaptable artificial visual perception behaviors using a light-adjustable optoelectronic neuromorphic device array. Adv Mater, 2019, 31(52): 1906433.
8. Agnus G, Zhao W, Derycke V, et al. Two-terminal carbon nanotube programmable devices for adaptive architectures. Adv Mater, 2010, 6(22): 702-706.
9. 何立铧, 李恩龙, 俞礽坚, 等. 基于铁电材料P(VDF-TrFE)调控的多级光突触晶体管. 光子学报, 2021, 50(9): 260-267.
10. Hao D, Zhang J, Dai S, et al. Perovskite/organic semiconductor-based photonic synaptic transistor for artificial visual system. ACS Appl Mater Interfaces, 2020, 12(35): 39487-39495.
11. Subramanian Periyal S, Jagadeeswararao M, Ng S E, et al. Halide perovskite quantum dots photosensitized-amorphous oxide transistors for multimodal synapses. Adv Mater Technol, 2020, 5(11): 2000514.
12. Giovannitti A, Nielsen C B, Sbircea D T, et al. N-type organic electrochemical transistors with stability in water. Nat Commun, 2016, 7(1): 13066.
13. Wang Z, Zhou H, Chen W, et al. Dually synergetic network hydrogels with integrated mechanical stretchability, thermal responsiveness, and electrical conductivity for strain sensors and temperature alertors. ACS Appl Mater Interfaces, 2018, 10(16): 14045-14054.
14. Ma C, Luo H, Liu M, et al. Preparation of intrinsic flexible conductive PEDOT: PSS@ionogel composite film and its application for touch panel. Chem Eng J, 2021, 425: 131542.
15. Cavallo A, Losi P, Buscemi M, et al. Biocompatible organic electrochemical transistor on polymeric scaffold for wound healing monitoring. Flex Print Electron, 2022, 7(3): 035009.
16. Bai J, Liu D, Tian X, et al. Tissue-like organic electrochemical transistors. J Mater Chem C, 2022, 10(37): 13303-13311.
17. Ashton N J, Janelidze S, Al Khleifat A, et al. A multicentre validation study of the diagnostic value of plasma neurofilament light. Nat Commun, 2021, 12(1): 3400.
18. Shi Y, Zhou Y, Shen R, et al. Solution-based synthesis of PEDOT: PSS films with electrical conductivity over 6300 S/cm. J Ind Eng Chem, 2021, 101: 414-422.
19. Ye Y, Wang J, Qiu Y, et al. Ultra-low EQE roll-off and marvelous efficiency perovskite quantum-dots light-emitting-diodes achieved by ligand passivation. Nano Energy, 2021, 90: 106583.
20. Proctor C M, Rivnay J, Malliaras G G. Understanding volumetric capacitance in conducting polymers. J Polym Sci Pol Phys, 2016, 54(15): 1433-1436.
21. Fang L, Dai S, Zhao Y, et al. Light-stimulated artificial synapses based on 2D organic field-effect transistors. Adv Electron Mater, 2020, 6(1): 1901217.
22. Kim M K, Lee J S. Short-term plasticity and long-term potentiation in artificial biosynapses with diffusive dynamics. ACS Nano, 2018, 12(2): 1680-1687.
23. Ahmed T, Kuriakose S, Mayes E L H, et al. Optically stimulated artificial synapse based on layered black phosphorus. Small, 2019, 15(22): 1900966.

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