Design of a dynamic measurement system for Bl factor spatial distribution of resonant blood viscoelastic sensor_Journal of Biomedical Engineering

Authors：

QIAN Jun ^1,2 , SUN Haixuan ^2,3 ,  WANG Bidou ²

1. Division of Life Sciences and Medicine, School of Biomedical Engineering (Suzhou), University of Science and Technology of China, Suzhou, Jiangsu 215163, P. R. China;
2. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu 215163, P. R. China;
3. Jinan Guoke Medical Technology Development Co., Ltd., Jinan 250102, P. R. China;

Corresponding author：

WANG Bidou, Email: wangbd@sibet.ac.cn

Keywords：

Blood viscoelastic sensor; Bl factor; Laser displacement; Motional impedance; Spectral leakage

DOI：

10.7507/1001-5515.202301019

Video：

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Abstract Full text Figures/Tables Video References Cited by

Bl factor is a key system parameter of the resonant blood viscoelastic sensor. In this paper, a dynamic measurement system for the spatial distribution of Bl factor based on velocity amplitude and motional impedance was designed. The system extracted the velocity amplitude and motional impedance of the coil under the dynamic condition of driving the sensor to generate simple harmonic oscillations using laser displacement and impedance analysis combined with in-phase/quadrature demodulation algorithm, and controlled the equilibrium position of the coil by adjusting the direct current component of the excitation current to realize the position scanning. In the position interval of [−240, 240] μm, the maximum coefficient of variation of the measurement results was 0.077 3%, and the maximum relative error to the simulation results was 2.937 9%, with a linear fitting correlation coefficient R² = 0.996 8. The system can be used to accurately measure the spatial distribution of Bl factor of the resonant blood viscoelastic sensor, which provides a technical support for the verification of the design of the sensor magnetic circuit.

Citation： QIAN Jun, SUN Haixuan, WANG Bidou. Design of a dynamic measurement system for Bl factor spatial distribution of resonant blood viscoelastic sensor. Journal of Biomedical Engineering, 2023, 40(5): 965-972. doi: 10.7507/1001-5515.202301019 Copy

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26.	Tang S, Li C L, Hou Y Q. A suppressing method for spur caused by amplitude quantization in DDS. IEEE Access, 2019, 7: 62344-62351.
27.	南卓江, 陶卫, 赵辉. 激光三角测量技术的应用与前景. 自动化仪表, 2019, 40(12): 1-5.
28.	Yang H W, Tao W, Zhang Z Q, et al. Reduction of the influence of laser beam directional dithering in a laser triangulation displacement probe. Sensors, 2017, 17(5): 1126-1136.
29.	Li Z, Chen X, Liu Y Z, et al. Temperature compensation of laser triangular displacement sensor// 2019 Chinese Automation Congress (CAC2019). Hangzhou: IEEE, 2019: 4661-4667.
30.	Antunes F, Felix L B. Comparison of signal preprocessing techniques for avoiding spectral leakage in auditory steady-state responses. Res Biomed Eng, 2019, 35(2): 251-256.
31.	李刚, 汤宏颖, 林凌. 运用过采样与成形信号技术提高检测灵敏度. 天津大学学报, 2010, 43(10): 901-905.

1. Pryzdial E L G, Lee F M H, Lin B H, et al. Blood coagulation dissected. Transfus Apher Sci, 2018, 57(4): 449-457.
2. Furie B, Furie B C. Mechanisms of disease: mechanisms of thrombus formation. New Engl J Med, 2008, 359(9): 938-949.
3. Salinas D. Viscoelastic studies: effective tools for trauma and surgical resuscitation efforts. AORN J, 2017, 105(4): 370-383.
4. Faraoni D, Dinardo J A. Viscoelastic hemostatic assays: update on technology and clinical applications. Am J Hematol, 2021, 96(10): 1331-1337.
5. Shen L, Tabaie S, Ivascu N. Viscoelastic testing inside and beyond the operating room. J Thorac Dis, 2017, 9(S4): S299-S308.
6. Volod O, Bunch C M, Zackariya N, et al. Viscoelastic hemostatic assays: a primer on legacy and new generation devices. J Clin Med, 2022, 11(3): 860-881.
7. Hoffman M, Monroe D M III. A cell-based model of hemostasis. J Thromb Haemost, 2001, 85(6): 958-965.
8. Chapin J C, Hajjar K A. Fibrinolysis and the control of blood coagulation. Blood Rev, 2015, 29(1): 17-24.
9. Johnson S, Chueh J, Gounis M, et al. Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment. J Neurointerv Surg, 2020, 12(9): 853-857.
10. Tomaiuolo G, Carciati A, Caserta S, et al. Blood linear viscoelasticity by small amplitude oscillatory flow. Rheol Acta, 2016, 55(6): 485-495.
11. 王哲, 于源华, 于占江, 等. 电磁振动式凝血过程动态测试传感器. 仪器仪表学报, 2018, 39(1): 127-135.
12. Wang Z, Yu YH, Yu Z J, et al. Spring support electromagnetic induction-based detection sensor for the coagulation process. Microsyst Technol, 2019, 25(7): 2683-2692.
13. Henderson J H. Robust transducer for viscoelastic measurement: US5895842. 1999-04-20.
14. 中国科学院苏州生物医学工程技术研究所. 一种基于振动传感器的血液黏弹性测量方法: 20211120151.X. 2021-11-12.
15. Demkin V P, Mel’nichuk S V, Rudenko T V, et al. Analysis of viscoelastic parameters of fluids by low-frequency piezoelastography. Bull Exp Biol Med, 2020, 168(3): 413-417.
16. Hartmann J, Murphy M, Dias J D. Viscoelastic hemostatic assays: moving from the laboratory to the site of care-a review of established and emerging technologies. Diagnostics, 2020, 10(2): 118-131.
17. Clark D. Precision measurement of loudspeaker parameters. J Audio Eng Soc, 1997, 45(3): 129-141.
18. Dickason V. Loudspeaker design cookbook. 7th ed. Peterborough: Audio Amateur Press, 2006: 4-5, 201-202.
19. Appolito J D, Raichel D R. Testing loudspeakers. J Acoust Soc Am, 1999, 106(2): 539-540.
20. 薛政. 动圈扬声器非线性参数辨识. 南京: 南京大学, 2018.
21. 孔晓鹏. 电动扬声器分数阶建模及非线性失真分析. 长沙: 国防科学技术大学, 2015.
22. Klippel W. Scanning the magnetic field of electro-dynamic transducers. J Audio Eng Soc, 2012, 60(6): 452-458.
23. Merit B, Novak A. Magnet-only loudspeaker magnetic circuits: a solution for significantly lower current distortion. J Audio Eng Soc, 2015, 63(6): 463-474.
24. Koerner L J, Secord T W. An embedded electrical impedance analyzer based on the AD5933 for the determination of voice coil motor mechanical properties. Sensor Actuat A Phys, 2019, 295: 99-112.
25. Maundy B J, Elwakil A S, Gift S J G. Enhancing the improved Howland circuit. Int J Circ Theor App, 2019, 47(4): 532-541.
26. Tang S, Li C L, Hou Y Q. A suppressing method for spur caused by amplitude quantization in DDS. IEEE Access, 2019, 7: 62344-62351.
27. 南卓江, 陶卫, 赵辉. 激光三角测量技术的应用与前景. 自动化仪表, 2019, 40(12): 1-5.
28. Yang H W, Tao W, Zhang Z Q, et al. Reduction of the influence of laser beam directional dithering in a laser triangulation displacement probe. Sensors, 2017, 17(5): 1126-1136.
29. Li Z, Chen X, Liu Y Z, et al. Temperature compensation of laser triangular displacement sensor// 2019 Chinese Automation Congress (CAC2019). Hangzhou: IEEE, 2019: 4661-4667.
30. Antunes F, Felix L B. Comparison of signal preprocessing techniques for avoiding spectral leakage in auditory steady-state responses. Res Biomed Eng, 2019, 35(2): 251-256.
31. 李刚, 汤宏颖, 林凌. 运用过采样与成形信号技术提高检测灵敏度. 天津大学学报, 2010, 43(10): 901-905.

Journal of Biomedical Engineering

Design of a dynamic measurement system for Bl factor spatial distribution of resonant blood viscoelastic sensor

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