Research advances of biomedical polymeric microneedles for non-transdermal local drug delivery_Journal of Biomedical Engineering

Authors：

LI Haiyan , HAN Hongjuan , WANG Lu , YAO Jingzhi ,  XIAO Wenqian ,  LI Bo

Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331, R. R. China;

Corresponding author：

Keywords：

Microneedle; Non-transdermal; Drug delivery

DOI：

10.7507/1001-5515.202307038

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Microneedles have emerged as the new class of local drug delivery system that has broad potential for development. Considering that the microneedles can penetrate tissue barriers quickly, and provide localized and targeted drug delivery, their applications have gradually expanded to non-transdermal drug delivery recently, which are capable of providing rapid and effective treatment for injuries and diseases of organs or tissues. However, a literature search revealed that there is a lack of summaries of the latest developments in non-transdermal drug delivery research by using biomedical polymeric microneedles. The review first described the materials and fabrication methods for the polymeric microneedles, and then reviewed a representative application of microneedles for non-transdermal drug delivery, with the primary focus being on treating and repairing the tissues or organs such as oral cavity, ocular tissues, blood vessels and heart. At the end of the article, the opportunities and challenges associated with microneedles for non-transdermal drug delivery were discussed, along with its future development, in order to provide reference for researchers in the relevant field.

Citation： LI Haiyan, HAN Hongjuan, WANG Lu, YAO Jingzhi, XIAO Wenqian, LI Bo. Research advances of biomedical polymeric microneedles for non-transdermal local drug delivery. Journal of Biomedical Engineering, 2024, 41(2): 406-412, 420. doi: 10.7507/1001-5515.202307038 Copy

1.	Zheng M, Sheng T, Yu J, et al. Microneedle biomedical devices. Nat Rev Bioeng, 2023: 1-19. DOI: 10.1038/s44222-023-00141-6..
2.	AL-Japairai K A S, Mahmood S, Almurisi S H, et al. Current trends in polymer microneedle for transdermal drug delivery. Int J Pharm, 2020, 587: 119673..
3.	Zhang S, Yang L, Liu J, et al. Microneedle systems: cell, exosome, and nucleic acid based strategies. Biomater Sci, 2023, 11(21): 7018-7033..
4.	Lee K, Goudie M J, Tebon P, et al. Non-transdermal microneedles for advanced drug delivery. Adv Drug Deliv Rev, 2019, 165-166: 41-59..
5.	Cao X, Chen G. Advances in microneedles for non-transdermal applications. Expert Opin Drug Deliv, 2022, 19(9): 1081-1097..
6.	Le Z, Yu J, Quek Y J, et al. Design principles of microneedles for drug delivery and sampling applications. Mater Today, 2022, 63: 137-169..
7.	Mbituyimana B, Ma G, Shi Z, et al. Polymer-based microneedle composites for enhanced non-transdermal drug delivery. Appl Mater, 2022, 29: 101659..
8.	Lyu S, Dong Z, Xu X, et al. Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration. Bioact Mater, 2023, 27: 303-326..
9.	Zhi C B, Ting H Y, Qiang Z Z, et al. Strategies to develop polymeric microneedles for controlled drug release. Adv Drug Delivery Rev, 2023, 203: 115109..
10.	Pooyan M, Aziz M, Majid S, et al. Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications. Matter, 2022, 5(2): 390-429..
11.	Zhang X, Wang Y, Chi J, et al. Smart microneedles for therapy and diagnosis. Research, 2020, 2020: 7462915..
12.	蒲兴群, 巨晓洁, 谢锐, 等. 聚合物阵列微针及其在透皮给药系统的应用. 化工学报, 2020, 71(1): 43-53..
13.	王洁, 王欢, 吴文渊, 等. 微针加工技术的最新研究进展. 微纳电子技术, 2020, 57(11): 918-930..
14.	Panda A, Matadh V A, Suresh S, et al. Non-dermal applications of microneedle drug delivery systems. Drug Deliv Transl Re, 2021, 12(1): 67-68..
15.	Eshaghi B, Schudel A, Sadeghi I, et al. The role of engineered materials in mucosal vaccination strategies. Nat Rev Mater, 2024, 9(1): 29-45..
16.	Caffarel-Salvador E, Kim S, Soares V, et al. A microneedle platform for buccal macromolecule delivery. Sci Adv, 2021, 7(4): e2620..
17.	Zhu Z, Wang J, Pei X, et al. Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery. Sci Adv, 2023, 9(25): h2213..
18.	Kwon T, Lamster I B, Levin L. Current concepts in the management of periodontitis. Int Dent J, 2020, 71(6): 462-476..
19.	Zhang X, Hasani-Sadrabadi M M, Zarubova J, et al. Immunomodulatory microneedle patch for periodontal tissue regeneration. Matter, 2021, 5(2): 666-682..
20.	Seeni R Z, Zheng M, Lio D C S, et al. Targeted delivery of anesthetic agents to bone tissues using conductive microneedles enhanced iontophoresis for painless dental anesthesia. Adv Funct Mater, 2021, 31(47): 2105686..
21.	Zhou R, Yu J, Gu Z, et al. Microneedle-mediated therapy for cardiovascular diseases. Drug Deliv Transl Re, 2021, 12(2): 472-483..
22.	Lee K, Lee J, Lee S G, et al. Microneedle drug eluting balloon for enhanced drug delivery to vascular tissue. J Controlled Release, 2020, 321: 174-183..
23.	Zhang X, Cheng Y, Liu R, et al. Globefish-inspired balloon catheter with intelligent microneedle coating for endovascular drug delivery. Adv Sci, 2022, 9(34): e2204497..
24.	Mylonaki I, Allémann É, Saucy F, et al. Perivascular medical devices and drug delivery systems: Making the right choices. Biomaterials, 2017, 128: 56-68..
25.	Lee J, Jang E H, Kim J H, et al. Highly flexible and porous silk fibroin microneedle wraps for perivascular drug delivery. J Controlled Release, 2021, 340: 125-135..
26.	Tang J, Wang J, Huang K, et al. Cardiac cell-integrated microneedle patch for treating myocardial infarction. Sci Adv, 2018, 4(11): t9365..
27.	Sun L, Zhu X, Zhang X, et al. Induced cardiomyocytes-integrated conductive microneedle patch for treating myocardial infarction. Chem Eng J, 2021, 414: 128723..
28.	Shi H, Xue T, Yang Y, et al. Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease. Sci Adv, 2020, 6(25): z3621..
29.	Fathi-Karkan S, Heidarzadeh M, Narmi M T, et al. Exosome-loaded microneedle patches: Promising factor delivery route. Int J Biol Macromol, 2023, 243: 125232..
30.	Yuan J, Yang H, Liu C, et al. Microneedle patch loaded with exosomes containing microRNA-29b prevents cardiac fibrosis after myocardial infarction. Adv Healthcare Mater, 2023, 12(13): e2202959..
31.	Mandal A, Pal D, Agrahari V, et al. Ocular delivery of proteins and peptides: Challenges and novel formulation approaches. Adv Drug Delivery Rev, 2018, 126: 67-95..
32.	Glover K, Mishra D, Gade S, et al. Microneedles for advanced ocular drug delivery. Adv Drug Delivery Rev, 2023, 201: 115082..
33.	Shi H, Zhou J, Wang Y, et al. A rapid corneal healing microneedle for efficient ocular drug delivery. Small, 2021, 18(4): e2104657..
34.	Than A, Liu C, Chang H, et al. Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nat Commun, 2018, 9(1): 4433..
35.	Park S, Lee K, Kang H, et al. Single administration of a biodegradable, separable microneedle can substitute for repeated application of eyedrops in the treatment of infectious keratitis. Adv Healthcare Mater, 2021, 10(11): e2002287..
36.	Wang Z, Yang Z, Jiang J, et al. Silk microneedle patch capable of on-demand multidrug delivery to the brain for glioblastoma treatment. Adv Mater, 2022, 34(1): 2270008..
37.	Liu Y, Long L, Zhang F, et al. Microneedle-mediated vascular endothelial growth factor delivery promotes angiogenesis and functional recovery after stroke. J Controlled Release, 2021, 338: 610-622..
38.	Zhang X, Chen G, Fu X, et al. Magneto-responsive microneedle robots for intestinal macromolecule delivery. Adv Mater, 2021, 33(44): 2104932..

1. Zheng M, Sheng T, Yu J, et al. Microneedle biomedical devices. Nat Rev Bioeng, 2023: 1-19. DOI: 10.1038/s44222-023-00141-6..
2. AL-Japairai K A S, Mahmood S, Almurisi S H, et al. Current trends in polymer microneedle for transdermal drug delivery. Int J Pharm, 2020, 587: 119673..
3. Zhang S, Yang L, Liu J, et al. Microneedle systems: cell, exosome, and nucleic acid based strategies. Biomater Sci, 2023, 11(21): 7018-7033..
4. Lee K, Goudie M J, Tebon P, et al. Non-transdermal microneedles for advanced drug delivery. Adv Drug Deliv Rev, 2019, 165-166: 41-59..
5. Cao X, Chen G. Advances in microneedles for non-transdermal applications. Expert Opin Drug Deliv, 2022, 19(9): 1081-1097..
6. Le Z, Yu J, Quek Y J, et al. Design principles of microneedles for drug delivery and sampling applications. Mater Today, 2022, 63: 137-169..
7. Mbituyimana B, Ma G, Shi Z, et al. Polymer-based microneedle composites for enhanced non-transdermal drug delivery. Appl Mater, 2022, 29: 101659..
8. Lyu S, Dong Z, Xu X, et al. Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration. Bioact Mater, 2023, 27: 303-326..
9. Zhi C B, Ting H Y, Qiang Z Z, et al. Strategies to develop polymeric microneedles for controlled drug release. Adv Drug Delivery Rev, 2023, 203: 115109..
10. Pooyan M, Aziz M, Majid S, et al. Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications. Matter, 2022, 5(2): 390-429..
11. Zhang X, Wang Y, Chi J, et al. Smart microneedles for therapy and diagnosis. Research, 2020, 2020: 7462915..
12. 蒲兴群, 巨晓洁, 谢锐, 等. 聚合物阵列微针及其在透皮给药系统的应用. 化工学报, 2020, 71(1): 43-53..
13. 王洁, 王欢, 吴文渊, 等. 微针加工技术的最新研究进展. 微纳电子技术, 2020, 57(11): 918-930..
14. Panda A, Matadh V A, Suresh S, et al. Non-dermal applications of microneedle drug delivery systems. Drug Deliv Transl Re, 2021, 12(1): 67-68..
15. Eshaghi B, Schudel A, Sadeghi I, et al. The role of engineered materials in mucosal vaccination strategies. Nat Rev Mater, 2024, 9(1): 29-45..
16. Caffarel-Salvador E, Kim S, Soares V, et al. A microneedle platform for buccal macromolecule delivery. Sci Adv, 2021, 7(4): e2620..
17. Zhu Z, Wang J, Pei X, et al. Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery. Sci Adv, 2023, 9(25): h2213..
18. Kwon T, Lamster I B, Levin L. Current concepts in the management of periodontitis. Int Dent J, 2020, 71(6): 462-476..
19. Zhang X, Hasani-Sadrabadi M M, Zarubova J, et al. Immunomodulatory microneedle patch for periodontal tissue regeneration. Matter, 2021, 5(2): 666-682..
20. Seeni R Z, Zheng M, Lio D C S, et al. Targeted delivery of anesthetic agents to bone tissues using conductive microneedles enhanced iontophoresis for painless dental anesthesia. Adv Funct Mater, 2021, 31(47): 2105686..
21. Zhou R, Yu J, Gu Z, et al. Microneedle-mediated therapy for cardiovascular diseases. Drug Deliv Transl Re, 2021, 12(2): 472-483..
22. Lee K, Lee J, Lee S G, et al. Microneedle drug eluting balloon for enhanced drug delivery to vascular tissue. J Controlled Release, 2020, 321: 174-183..
23. Zhang X, Cheng Y, Liu R, et al. Globefish-inspired balloon catheter with intelligent microneedle coating for endovascular drug delivery. Adv Sci, 2022, 9(34): e2204497..
24. Mylonaki I, Allémann É, Saucy F, et al. Perivascular medical devices and drug delivery systems: Making the right choices. Biomaterials, 2017, 128: 56-68..
25. Lee J, Jang E H, Kim J H, et al. Highly flexible and porous silk fibroin microneedle wraps for perivascular drug delivery. J Controlled Release, 2021, 340: 125-135..
26. Tang J, Wang J, Huang K, et al. Cardiac cell-integrated microneedle patch for treating myocardial infarction. Sci Adv, 2018, 4(11): t9365..
27. Sun L, Zhu X, Zhang X, et al. Induced cardiomyocytes-integrated conductive microneedle patch for treating myocardial infarction. Chem Eng J, 2021, 414: 128723..
28. Shi H, Xue T, Yang Y, et al. Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease. Sci Adv, 2020, 6(25): z3621..
29. Fathi-Karkan S, Heidarzadeh M, Narmi M T, et al. Exosome-loaded microneedle patches: Promising factor delivery route. Int J Biol Macromol, 2023, 243: 125232..
30. Yuan J, Yang H, Liu C, et al. Microneedle patch loaded with exosomes containing microRNA-29b prevents cardiac fibrosis after myocardial infarction. Adv Healthcare Mater, 2023, 12(13): e2202959..
31. Mandal A, Pal D, Agrahari V, et al. Ocular delivery of proteins and peptides: Challenges and novel formulation approaches. Adv Drug Delivery Rev, 2018, 126: 67-95..
32. Glover K, Mishra D, Gade S, et al. Microneedles for advanced ocular drug delivery. Adv Drug Delivery Rev, 2023, 201: 115082..
33. Shi H, Zhou J, Wang Y, et al. A rapid corneal healing microneedle for efficient ocular drug delivery. Small, 2021, 18(4): e2104657..
34. Than A, Liu C, Chang H, et al. Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nat Commun, 2018, 9(1): 4433..
35. Park S, Lee K, Kang H, et al. Single administration of a biodegradable, separable microneedle can substitute for repeated application of eyedrops in the treatment of infectious keratitis. Adv Healthcare Mater, 2021, 10(11): e2002287..
36. Wang Z, Yang Z, Jiang J, et al. Silk microneedle patch capable of on-demand multidrug delivery to the brain for glioblastoma treatment. Adv Mater, 2022, 34(1): 2270008..
37. Liu Y, Long L, Zhang F, et al. Microneedle-mediated vascular endothelial growth factor delivery promotes angiogenesis and functional recovery after stroke. J Controlled Release, 2021, 338: 610-622..
38. Zhang X, Chen G, Fu X, et al. Magneto-responsive microneedle robots for intestinal macromolecule delivery. Adv Mater, 2021, 33(44): 2104932..

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