Mass transfer of bilirubin and bovine serum albumin in hollow fiber membrane module of artificial liver_Journal of Biomedical Engineering

Authors：

WANG Ziheng ^1,2 ,  XU Shaofeng ¹ , YU Yifan ³ , LU JunJie ¹ , ZHANG Xuechang ¹

1. School of Mechatronics and Energy Engineering, NingboTech University, Ningbo, Zhejiang 315100, P. R. China;
2. School of Mechanical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. China;
3. School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, P. R. China;

Corresponding author：

XU Shaofeng, Email: shaofengxu@nit.zju.edu.cn

Keywords：

Artificial liver; Hollow fiber membrane module; Bilirubin; Bovine serum albumin; Mass transfer

DOI：

10.7507/1001-5515.202311011

Video：

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Understanding the mass transfer behaviors in hollow fiber membrane module of artificial liver is important for improving toxin removal efficiency. A three-dimensional numerical model was established to study the mass transfer of small molecule bilirubin and macromolecule bovine serum albumin (BSA) in the hollow fiber membrane module. Effects of tube-side flow rate, shell-side flow rate, and hollow fiber length on the mass transfer of bilirubin and BSA were discussed. The simulation results showed that the clearance of bilirubin was significantly affected by both convective and diffusive solute transport, while the clearance of macromolecule BSA was dominated by convective solute transport. The clearance rates of bilirubin and BSA increasd with the increase of tube-side flow rate and hollow fiber length. With the increase of shell-side flow rate, the clearance rate of bilirubin first rose rapidly, then slowly rose to an asymptotic value, while the clearance rate of BSA gradually decreased. The results can provide help for designing structures of hollow fiber membrane module and operation parameters of clinical treatment.

Citation： WANG Ziheng, XU Shaofeng, YU Yifan, LU JunJie, ZHANG Xuechang. Mass transfer of bilirubin and bovine serum albumin in hollow fiber membrane module of artificial liver. Journal of Biomedical Engineering, 2024, 41(4): 742-750. doi: 10.7507/1001-5515.202311011 Copy

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1. 中国医学会感染病学分会, 中华医学会肝病学分会. 慢性乙型肝炎防治指南(2019版). 中国医学前沿杂志(电子版), 2019, 11(12): 51-77.
2. 崔富强, 庄辉. 解读《2021年艾滋病病毒、病毒性肝炎和性传播感染全球进展报告》: 消除病毒性肝炎进展. 中国医学前沿杂志(电子版), 2021, 13(10): 1-4.
3. Liu J, Liang W, Jing W, et al. Countdown to 2030: eliminating hepatitis B disease, China. Bull Word Health Organ, 2019, 97(3): 230-238.
4. World Health Organization (WHO). Global progress report on HIV, viral hepatitis and sexually transmitted infections 2021—Accountability for the global health sector strategies 2016-2021: actions for impact. Geneva: World Health Organization, 2021.
5. 胡钰玲, 李晓阳, 尧捷, 等. 慢性乙型肝炎中医证型与现代医学诊断的相关性研究进展. 中医药导报, 2023, 29(12): 96-101.
6. 裘佳. 全球每30秒就有1人死于病毒性肝炎相关疾病: 三院士呼吁加速肝炎防控进程. 医师报, 2022-7-28(B02).
7. 李兰娟. 人工肝脏. 杭州: 浙江大学出版社, 2012.
8. Ilaria E D N, Elisabetta M Z, Gionata F, et al. Transports modeling of convection-enhanced hollow fiber membrane bioreactors for therapeutic applications. J Membrane Sci, 2014, 471: 347-361.
9. Curcio E, Bartolo L D, Barbieri G, et al. Diffusive and convective transport through hollow fiber membranes for liver cell culture. J Biotechnol, 2005, 117: 309-321.
10. Raff M, Ertl T, Krause B, et al. Mass transfer in artificial liver membrane devices. Desalintion, 2006, 199: 234-235.
11. Donato D, Storr M, Krause B. Design optimization of hollow fiber dialyzers to enhance internal filtration based on a mathematical model. J Membrane Sci, 2020, 598: 117690.
12. Nedredal G I, Amiot B P, Nyderg P, et al. Optimization of mass transfer for toxin removal and immunoprotection of hepatocytes in a bioartificial liver. Biotechnol Bioeng, 2009, 104(5): 995-1003.
13. Sorrell I, Shipley R J, Regan S, et al. Mathematical modelling of a liver hollow fiber bioreactor. J Theoret Biol, 2019, 475: 25-33.
14. Lorenzin A, Neri M, Lupi A, et al. Quantification of internal filtration in hollow fiber hemodialyzers with medium cut-off membrane. Blood Purificat, 2018, 46: 196-204.
15. Macias N, Vega A, Adad S, et al. Middle molecule elimination in expanded haemodialysis: only convective tranports?. Clin Kidney J, 2019, 12(3): 447-455.
16. 庄黎伟. 中空纤维膜组件中流动均布模型与模拟. 上海: 华东理工大学, 2016.
17. Ding W, He L, Zhao G, et al. Effect of distribution tabs on mass transfer of artificial kidney. AIChE Journal, 2004, 50(4): 786-790.
18. Ding W, Li W, Sun S, et al. Three-dimensional simulation of mass transfer in artificial kidneys. Artif Organs, 2015, 39(6): E79-E89.
19. Sangeetha M S, Kandaswamy A, Deepika C L, et al. Finite element analysis for comparing the performance of straight and undulated fibers in altering the filtering efficiency of hemodialyzer membranes. J Mech Med Biol, 2019, 19(5): 1850063.
20. Menshutina N V, Guseva E V, Safarov R R, et al. Modelling of hollow fiber membrane bioreactor for mammalian cell cultivation using computational hydrodynamics. Bioproc Biosyst Eng, 2020, 43: 549-567.
21. Ding W P, He L Q, Gang Z, et al. Double porous media model for mass transfer of hemodialyzers. Int J Heat Mass Transfer, 2004, 47: 4849-4855.
22. Lu J, Lu W Q. A numerical simulation for mass transfer through the porous membrane of parallel straight channels. Int J Heat Mass Tran, 2010, 53(11-12): 2404-2413.
23. Kedem O, Katchalsky A. Thermodynamic analysis of the permeability of biological membranes to non-electrolytes 1958. Biochim Biophys Acta, 1989, 1000: 413-430.
24. Anderson J L. Configurational effect on the reflection coefficient for rigid solutes in capillary pores. J Theoret Biol, 1981, 90(3): 405-426.
25. Anderson J L, Malone D M. Mechanism of osmotic flow in porous membranes. Biophys J, 1974, 14(12): 957-982.
26. Yamamoto K I, Hayama M, Matsuda M, et al. Evaluation of asymmetrical structure dialysis membrane by tortuous capillary pore diffusion model. J Membrane Sci, 2007, 287(1): 88-93.
27. Preston B N, Comper W D, Hughes A E, et al. Diffusion of dextran at intermediate concentrations. J Chem Soc Faraday Trans, 1982, 78(4): 1209-1221.
28. Ding W, Zou L, Sun S, et al. A new method to increase the adsorption of protein-bound toxins in artificial liver support systems. Artif Organs, 2015, 38(11): 954-962.
29. Magalhaes H L F, Gomez R S, Leite B E, et al. Investigating the dialysis treatment using hollow fiber membrane: A new approach by CFD. Membranes, 2022, 12(7): 710.
30. Yaqoob T, Ahsan M, Hussain A, et al. Computational fluid dynamics (CFD) modeling and simulation of flow regulatory mechanism in artificial kidney using finite element method. Membranes, 2020, 10(7): 139.

Journal of Biomedical Engineering

Mass transfer of bilirubin and bovine serum albumin in hollow fiber membrane module of artificial liver

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