Simulation study on parameter optimization of transcranial direct current stimulation based on rat brain slices_Journal of Biomedical Engineering

Authors：

HE Shiji ^1,2 , ZHANG Guanghao ^1,2 , WU Changzhe ^1,2 , HUO Xiaolin ^1,2 , ZHANG Lijun ^1,2 , ZHANG Jingxi ^1,2 ,  ZHANG Cheng ^1,2

1. Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China;
2. School of Electronics, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China;

Corresponding author：

ZHANG Cheng, Email: zhangchengcc@mail.iee.ac.cn

Keywords：

Transcranial direct current stimulation; Rat brain slice; Stimulation parameters

DOI：

10.7507/1001-5515.202402007

Video：

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Transcranial direct current stimulation (tDCS) is an important method for treating mental illnesses and neurodegenerative diseases. This paper reconstructed two ex vivo brain slice models based on rat brain slice staining images and magnetic resonance imaging (MRI) data respectively, and the current densities of hippocampus after cortical tDCS were obtained through finite element calculation. Subsequently, a neuron model was used to calculate the response of rat hippocampal pyramidal neuron under these current densities, and the neuronal responses of the two models under different stimulation parameters were compared. The results show that a minimum stimulation voltage of 17 V can excite hippocampal pyramidal neuron in the model based on brain slice staining images, while 24 V is required in the MRI-based model. The results indicate that the model based on brain slice staining images has advantages in precision and electric field propagation simulation, and its results are closer to real measurements, which can provide guidance for the selection of tDCS parameters and scientific basis for precise stimulation.

Citation： HE Shiji, ZHANG Guanghao, WU Changzhe, HUO Xiaolin, ZHANG Lijun, ZHANG Jingxi, ZHANG Cheng. Simulation study on parameter optimization of transcranial direct current stimulation based on rat brain slices. Journal of Biomedical Engineering, 2024, 41(5): 945-950. doi: 10.7507/1001-5515.202402007 Copy

1.	Johnson K A, Okun M S, Scangos K W, et al. Deep brain stimulation for refractory major depressive disorder: a comprehensive review. Mol Psychiatry, 2024, 29(4): 1075-1087.
2.	Braun J A, Patel M, Henderson L A, et al. Electrical stimulation of the ventromedial prefrontal cortex modulates muscle sympathetic nerve activity and blood pressure. Cereb Cortex, 2024, 34(1): bhad422.
3.	Chmiel J, Rybakowski F, Leszek J. Effect of transcranial direct current stimulation (tDCS) on depression in Parkinson's disease-a narrative review. J Clin Med, 2024, 13(3): 699.
4.	Yang S, Yi Y G, Chang M C. The effect of transcranial alternating current stimulation on functional recovery in patients with stroke: a narrative review. Front Neurol, 2024, 14: 1327383.
5.	Bikson M, Grossman P, Thomas C, et al. Safety of transcranial direct current stimulation: evidence based update 2016. Brain Stimul, 2016, 9(5): 641-661.
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7.	Nitsche M A, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol, 2000, 527(Pt 3): 633-639.
8.	Monte-Silva K, Kuo M F, Hessenthaler S, et al. Induction of late LTP-like plasticity in the human motor cortex by repeated non-invasive brain stimulation. Brain Stimul, 2013, 6(3): 424-432.
9.	Reinhart R M, Cosman J D, Fukuda K, et al. Using transcranial direct-current stimulation (tDCS) to understand cognitive processing. Atten Percept Psychophys, 2017, 79(1): 3-23.
10.	Vergallito A, Feroldi S, Pisoni A, et al. Inter-individual variability in tDCS effects: a narrative review on the contribution of stable, variable, and contextual factors. Brain Sci, 2022, 12(5): 522.
11.	Grossman P, Woods A J, Knotkova H, et al. Safety of transcranial direct current stimulation //Knotkova H, Nitsche M A, Bikson M, et al. Practical Guide to Transcranial Direct Current Stimulation: Principles, Procedures and Applications. Cham; Springer International Publishing. 2019: 167-195.
12.	Davis S E, Smith G A. Transcranial direct current stimulation use in warfighting: benefits, risks, and future prospects. Front Hum Neurosci, 2019, 13: 114.
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14.	Day P, Twiddy J, Dubljević V. Present and emerging ethical issues with tDCS use: a summary and review. Neuroethics, 2023, 16: 1.
15.	Evans C, Johnstone A, Zich C, et al. The impact of brain lesions on tDCS-induced electric fields. Sci Rep, 2023, 13(1): 19430.
16.	Jackson M P, Rahman A, Lafon B, et al. Animal models of transcranial direct current stimulation: methods and mechanisms. Clin Neurophysiol, 2016, 127(11): 3425-3454.
17.	Qi X R, Verwer R W H, Bao A M, et al. Human brain slice culture: a useful tool to study brain disorders and potential therapeutic compounds. Neurosci Bull, 2019, 35(2): 244-252.
18.	YalC'in Y D, Luttge R. Electrical monitoring approaches in 3-dimensional cell culture systems: toward label-free, high spatiotemporal resolution, and high-content data collection in vitro. Organs Chip, 2021, 3: 100006.
19.	Oblasov I, Idzhilova O, Balaban P, et al. Cell culture models for epilepsy research and treatment. Explor Med, 2024, 5: 65-75.
20.	Cho S, Wood A, Bowlby M R. Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics. Curr Neuropharmacol, 2007, 5(1): 19-33.
21.	Esmaeilpour Z, Marangolo P, Hampstead B M, et al. Incomplete evidence that increasing current intensity of tDCS boosts outcomes. Brain Stimul, 2018, 11(2): 310-321.
22.	Saypol J M, Roth B J, Cohen L G, et al. A theoretical comparison of electric and magnetic stimulation of the brain. Ann Biomed Eng, 1991, 19(3): 317-328.
23.	Cerri G, De Leo R, Moglie F, et al. An accurate 3-D model for magnetic stimulation of the brain cortex. J Med Eng Technol, 1995, 19(1): 7-16.
24.	钟刚亮, 张广浩, 任艳萍, 等. 真实头模型中改良电休克与磁休克治疗的电场仿真分析. 生物医学工程学杂志, 2018, 35(4): 564-570, 577.
25.	Nadeem M, Thorlin T, Gandhi O P, et al. Computation of electric and magnetic stimulation in human head using the 3-D impedance method. IEEE Trans Biomed Eng, 2003, 50(7): 900-907.
26.	郑建斌, 霍小林. 经颅磁刺激中大鼠真实头模型感应电场分布的研究. 北京生物医学工程, 2006, 25(5): 490-492.
27.	杜百川. 基于真实小鼠头模型的经颅磁刺激线圈仿真分析与设计. 天津: 河北工业大学, 2022.
28.	周乾. 基于DTI的大鼠默认网络神经纤维构建及实验验证. 北京: 中国科学院大学, 2023.
29.	Ward L C, Brantlov S. Bioimpedance basics and phase angle fundamentals. Rev Endocr Metab Disord, 2023, 24(3): 381-391.
30.	Datta A, Dmochowski J P, Guleyupoglu B, et al. Cranial electrotherapy stimulation and transcranial pulsed current stimulation: a computer based high-resolution modeling study. Neuroimage, 2013, 65: 280-287.
31.	Cutsuridis V, Cobb S, Graham B P. Encoding and retrieval in a model of the hippocampal CA1 microcircuit. Hippocampus, 2010, 20(3): 423-446.
32.	Goubran M, Leuze C, Hsueh B, et al. Multimodal image registration and connectivity analysis for integration of connectomic data from microscopy to MRI. Nat Commun, 2019, 10(1): 5504.

1. Johnson K A, Okun M S, Scangos K W, et al. Deep brain stimulation for refractory major depressive disorder: a comprehensive review. Mol Psychiatry, 2024, 29(4): 1075-1087.
2. Braun J A, Patel M, Henderson L A, et al. Electrical stimulation of the ventromedial prefrontal cortex modulates muscle sympathetic nerve activity and blood pressure. Cereb Cortex, 2024, 34(1): bhad422.
3. Chmiel J, Rybakowski F, Leszek J. Effect of transcranial direct current stimulation (tDCS) on depression in Parkinson's disease-a narrative review. J Clin Med, 2024, 13(3): 699.
4. Yang S, Yi Y G, Chang M C. The effect of transcranial alternating current stimulation on functional recovery in patients with stroke: a narrative review. Front Neurol, 2024, 14: 1327383.
5. Bikson M, Grossman P, Thomas C, et al. Safety of transcranial direct current stimulation: evidence based update 2016. Brain Stimul, 2016, 9(5): 641-661.
6. Peterchev A V, Wagner T A, Miranda P C, et al. Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices. Brain Stimul, 2012, 5(4): 435-453.
7. Nitsche M A, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol, 2000, 527(Pt 3): 633-639.
8. Monte-Silva K, Kuo M F, Hessenthaler S, et al. Induction of late LTP-like plasticity in the human motor cortex by repeated non-invasive brain stimulation. Brain Stimul, 2013, 6(3): 424-432.
9. Reinhart R M, Cosman J D, Fukuda K, et al. Using transcranial direct-current stimulation (tDCS) to understand cognitive processing. Atten Percept Psychophys, 2017, 79(1): 3-23.
10. Vergallito A, Feroldi S, Pisoni A, et al. Inter-individual variability in tDCS effects: a narrative review on the contribution of stable, variable, and contextual factors. Brain Sci, 2022, 12(5): 522.
11. Grossman P, Woods A J, Knotkova H, et al. Safety of transcranial direct current stimulation //Knotkova H, Nitsche M A, Bikson M, et al. Practical Guide to Transcranial Direct Current Stimulation: Principles, Procedures and Applications. Cham; Springer International Publishing. 2019: 167-195.
12. Davis S E, Smith G A. Transcranial direct current stimulation use in warfighting: benefits, risks, and future prospects. Front Hum Neurosci, 2019, 13: 114.
13. Buchanan D M, Bogdanowicz T, Khanna N, et al. Systematic review on the safety and tolerability of transcranial direct current stimulation in children and adolescents. Brain Sci, 2021, 11(2): 212.
14. Day P, Twiddy J, Dubljević V. Present and emerging ethical issues with tDCS use: a summary and review. Neuroethics, 2023, 16: 1.
15. Evans C, Johnstone A, Zich C, et al. The impact of brain lesions on tDCS-induced electric fields. Sci Rep, 2023, 13(1): 19430.
16. Jackson M P, Rahman A, Lafon B, et al. Animal models of transcranial direct current stimulation: methods and mechanisms. Clin Neurophysiol, 2016, 127(11): 3425-3454.
17. Qi X R, Verwer R W H, Bao A M, et al. Human brain slice culture: a useful tool to study brain disorders and potential therapeutic compounds. Neurosci Bull, 2019, 35(2): 244-252.
18. YalC'in Y D, Luttge R. Electrical monitoring approaches in 3-dimensional cell culture systems: toward label-free, high spatiotemporal resolution, and high-content data collection in vitro. Organs Chip, 2021, 3: 100006.
19. Oblasov I, Idzhilova O, Balaban P, et al. Cell culture models for epilepsy research and treatment. Explor Med, 2024, 5: 65-75.
20. Cho S, Wood A, Bowlby M R. Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics. Curr Neuropharmacol, 2007, 5(1): 19-33.
21. Esmaeilpour Z, Marangolo P, Hampstead B M, et al. Incomplete evidence that increasing current intensity of tDCS boosts outcomes. Brain Stimul, 2018, 11(2): 310-321.
22. Saypol J M, Roth B J, Cohen L G, et al. A theoretical comparison of electric and magnetic stimulation of the brain. Ann Biomed Eng, 1991, 19(3): 317-328.
23. Cerri G, De Leo R, Moglie F, et al. An accurate 3-D model for magnetic stimulation of the brain cortex. J Med Eng Technol, 1995, 19(1): 7-16.
24. 钟刚亮, 张广浩, 任艳萍, 等. 真实头模型中改良电休克与磁休克治疗的电场仿真分析. 生物医学工程学杂志, 2018, 35(4): 564-570, 577.
25. Nadeem M, Thorlin T, Gandhi O P, et al. Computation of electric and magnetic stimulation in human head using the 3-D impedance method. IEEE Trans Biomed Eng, 2003, 50(7): 900-907.
26. 郑建斌, 霍小林. 经颅磁刺激中大鼠真实头模型感应电场分布的研究. 北京生物医学工程, 2006, 25(5): 490-492.
27. 杜百川. 基于真实小鼠头模型的经颅磁刺激线圈仿真分析与设计. 天津: 河北工业大学, 2022.
28. 周乾. 基于DTI的大鼠默认网络神经纤维构建及实验验证. 北京: 中国科学院大学, 2023.
29. Ward L C, Brantlov S. Bioimpedance basics and phase angle fundamentals. Rev Endocr Metab Disord, 2023, 24(3): 381-391.
30. Datta A, Dmochowski J P, Guleyupoglu B, et al. Cranial electrotherapy stimulation and transcranial pulsed current stimulation: a computer based high-resolution modeling study. Neuroimage, 2013, 65: 280-287.
31. Cutsuridis V, Cobb S, Graham B P. Encoding and retrieval in a model of the hippocampal CA1 microcircuit. Hippocampus, 2010, 20(3): 423-446.
32. Goubran M, Leuze C, Hsueh B, et al. Multimodal image registration and connectivity analysis for integration of connectomic data from microscopy to MRI. Nat Commun, 2019, 10(1): 5504.

Journal of Biomedical Engineering

Simulation study on parameter optimization of transcranial direct current stimulation based on rat brain slices

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