Analysis on the Risk Factors of Hyperuricemia in Chengdu Area_West China Medical Journal

Authors：

SUN Aijuan ¹ , QU Bangrong ² , GUO Jiaojiao ² ,  WANG Youjuan. ²

1. Out-patient Department; 2. Center of Health Examination Service; West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WANG Youjuan., Email: aijuans@gmail.com

Keywords：

高尿酸血症; 危险因素; Logistic回归

DOI：

10.7507/1002-0179.20130005

Video：

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目的　探讨成都地区高尿酸血症发生的危险因素。方法　收集2009年10月－2010年4月在四川大学华西医院体检中心进行健康体检的36 639人的临床资料，对资料进行单因素分析和多因素logistic回归分析。结果　进行健康体检的36 639人，其中男21 175人，女15 464人。高尿酸血症患者5 233例，患病率为14.3%。年龄＞50岁、男性、饮酒、糖尿病、高血压病、甘油三酯增高、低密度脂蛋白增高和血清肌酐水平增高与高尿酸血症的发生有关。Logistic回归分析显示男性（OR=13.300，P=0.000）、饮酒（OR=4.219，P=0.009）、糖尿病（OR=3.609，P=0.024）是发生高尿酸血症独立危险因素。结论　成都地区高尿酸血症的患病率略高于全国平均水平，临床治疗和护理高尿酸血症的患者时应积极控制与高尿酸血症发生密切相关的危险因素。

Citation： SUN Aijuan,QU Bangrong,GUO Jiaojiao,WANG Youjuan.. Analysis on the Risk Factors of Hyperuricemia in Chengdu Area. West China Medical Journal, 2013, 28(1): 18-20. doi: 10.7507/1002-0179.20130005 Copy

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1. 　Richette P, Bardin T. Gout[J]. Lancet, 2010, 375(9711): 318-328.
2. 　Lee SJ, Terkeltaub RA. New developments in clinically relevant mechanisms and treatment of hyperuricemia[J]. Curr Rheumatol Rep, 2006, 8(3): 224-230.
3. 　陈灏珠. 实用内科学（下册）[M]. 12版. 北京: 人民卫生出版社, 2005: 2602-2610.
4. 　Choi HK. A prescription for lifestyle change in patients with hyperuricemia and gout[J]. Curr Opin Rheumatol, 2010, 22(2): 165-172.
5. 　Kang DH, Nakagawa T. Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease[J]. Semin Nephrol, 2005, 25(1): 43-49.
6. 　Miao Z, Li C, Chen Y, et al. Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China [J]. J Rheumatol, 2008, 35(9): 1859-1864.
7. 　陆青青, 赖尾兰. 福州市8 083名健康体检者高尿酸血症的流行病学调查[J]. 福建医药杂志, 2008, 30(3): 133.
8. 　Becker MA, Jolly M. Hyperuricemia and associated diseases[J]. Rheum Dis Clin North Am, 2006, 32(2): 275-293.
9. 　Choi HK, Atkinson K, Karlson EW, et al. Alcohol intake and risk of incident gout in men: a prospective study[J]. Lancet, 2004, 363(9417): 1277-1281.
10. 　Rodríguez G, Soriano LC, Choi HK. Impact of diabetes against the future risk of developing gout[J]. Ann Rheum Dis, 2010, 69(12): 2090-2094.

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