肝纤维化无创性诊断的研究进展_West China Medical Journal

Authors：

卢利霞 , 杨碧伟 ,  王丽春

Corresponding author：

王丽春, Email: lulx12358@163.com

Keywords：

肝纤维化; 无创性诊断; FibroScan联合

DOI：

10.7507/1002-0179.20130048

Video：

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肝纤维化是慢性肝病的重要病理阶段，也是进一步向肝硬化发展的主要中间环节，目前的研究认为肝纤维化是可逆的，而肝硬化是不可逆的。因此肝纤维化的早期诊断和及时干预对于疾病的进展及预后的改善极为重要。近年来肝纤维化的诊断手段与技术方面得到了很大的发展，尤其是无创性诊断方法。现对肝纤维化无创性诊断的研究进展作一综述。

Citation： 卢利霞,杨碧伟,王丽春. 肝纤维化无创性诊断的研究进展. West China Medical Journal, 2013, 28(1): 148-151. doi: 10.7507/1002-0179.20130048 Copy

1.	Han KN, Yoon KT. Mew diagnostic method for liver fibrosis and cirrhosis[J]. Intervirology, 2008, 51(1): 11-16.
2.	Patel K. Noninvasive tools to assess liver disease[J]. Curr Opin Gastroenterol, 2010, 26(3): 227-233.
3.	Wong GL, Wong VW, Choi, et al. Development of a noninvasive algorithm with transient elastography(FibroScan)and serum test formula for advanced liver fibrosis in chronic hepatitis B[J]. Aliment Pharm Ther, 2010, 31(10): 1095-1103.
4.	Cadranel JF, Rufat P, Degos F. Practices of liver biopsy in France:results of a prospective nationwide survey[J]. Hepatology, 2000, 32(3): 477-481.
5.	Sebastiani G. Non-invasive assessment of liver fibrosis in chronic liver diseases: implementation in clinical practice and decisional[J]. World J Gastroenterol, 2009, 15(18): 2190-2203.
6.	王军, 赵权, 路颖, 等. 血清层粘连蛋白水平检测对肝病患者肝纤维化的诊断意义[J]. 实用医药杂志, 2011, 28(2): 106-107.
7.	姜菲菲, 王文静, 赵秀英, 等. 国产化学发光试剂检测4项血清肝纤维化标志物对肝纤维化诊断的应用分析[J]. 北京医学, 2012, 34(3): 164-168.
8.	赵治凤, 贾秋龙. 肝纤维化四项联合检测对410例慢性肝炎诊断的临床意义[J]. 中国民康医学, 2012, 24(7): 798-799.
9.	Jarcuska P, Janicko M, Veseliny E, et al. Circulating markers of liver fibrosis progression[J]. Clin Chim Acta, 2010, 411(15-16): 1009-1017.
10.	李丽, 展玉涛. 肝纤维化无创性诊断研究进展[J]. 实用肝脏病杂志, 2010, 13(2): 145-147.
11.	Myers RP, Tainturier MH, Ratziu V, et al. Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B[J]. Hepatology, 2003, 39(2): 222-230.
12.	Anais VP, Vincent M, Bertrand N, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and Fibro Test[J]. Hepatology, 2007, 46(1): 33-36.
13.	张彦亮, 洪定玲, 边维良, 等. FIB-4指数对慢性乙型肝炎患者肝纤维化的诊断价值[J]. 胃肠病学和肝病学杂志, 2009, 18(3): 213-214.
14.	张文胜, 王宝恩, 王泰领, 等. 慢性乙型肝炎肝纤维化无创性诊断模型的建立[J]. 中华肝脏病杂志, 2006, 14(3): 169-173.
15.	Li WX, Zhao XT, Wm C, et al. Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography[J]. J Digest Dis, 2010, 11(4): 215-223.
16.	Wang Y, Ganger DR, Levitsky J, et al. Assessment of chronic hepatitis and fibrosis: comparison of Mr elastography and diffusion-weighted imaging[J]. Am J Roentgenol, 2011, 196(3): 553-561.
17.	朱霞, 唐红. 瞬时弹性扫描仪在肝纤维化诊断中的应用价值[J]. 世界华人消化杂志, 2010, 18(9): 906-912.
18.	Jung MK, Cho HJ, Lee HC, et al. Comparison of transient elastography and hepatic fibrosis assessed by histology in chronic liver disease[J]. Korean J Gastroenterol, 2008, 51(4): 241-247.
19.	Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis[J]. Ultrasound Med Biol, 2003, 29(12): 1705-1713.
20.	Coco B, Oliveri F, Maina AM, et al. Transient elastography:a new surrogate marker of liver fibrosis influenced by major changes of transaminases[J]. J Viral Hepat, 2007, 14(5): 360-369.
21.	Kim SU, Han KH, Park IY, et al. Liver stiffness measurement using FibroScan is influenced by serum total bilirubin in acute hepatitis[J]. Liver Int, 2009, 29(6): 810-815.
22.	Millonig G, Reimann FM, Friedrich S, et al. Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis[J]. Hepatology, 2008, 48(5): 1718-1723.
23.	Scott DR, Levy MT. Liver transient elastography (Fibroscan): a place in the management algorithms of chronic viral hepatitis[J]. Antivir Ther, 2010, 15(1): 1-11.
24.	杨爱婷, 白艳锋, 尤红. Fibroscan对乙型肝炎肝纤维化诊断的研究进展[J]. 实用肝脏病杂志, 2009, 12(2): 142-144.
25.	Alisi A, Pinzani M, Nobili V. Diagnostic power of FibroScan in predicting liver fibrosis in nonalcoholic fatty liver disease[J]. Hepatology, 2009, 50(6): 2048-2049.
26.	薛芳, 施裕新, 李桂明, 等. 瞬时弹性成像对肝纤维化的诊断价值[J]. 中国临床医学, 2012, 19(1): 77-79.
27.	Fraquelli M, Rigamonti C, Casazza G, et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease[J]. Gut, 2007, 56(7): 968-973.
28.	Salles N, Dussarat P, Foucher J, et al. Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients[J]. Gastroenterol Clin Biol, 2009, 33(2): 126-132.
29.	Roulot D, Czernichow S, Le CH, et al. Liver stiffness values in apparently healthy subjects: influence of gender and metabolic syndrome[J]. J Hepatol, 2008, 48(4): 606-613.
30.	Chang PE, Lui HF, Chau YP, et al. Prospective evaluation of transient elastography for the diagnosis of hepatic fibrosis in Asians: comparison with liver biopsy and aspartate transaminase platelet ratio index[J]. Aliment Pharm Therap, 2008, 28(1): 51-56.
31.	Castera L, Vergniol J, Foucher J, et al. Prospective comparison of transient elastography, fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C[J]. Gastroenterology, 2005, 128(2): 343-350.
32.	Fraquelli M, Rigamonti C, Casazza G, et al. A sequential predictive algorithm combining APRI and transient elastography (TE) for diagnosing liver fibrosis in chronic hepatitis C[J]. Hepatology, 2008, 48(Suppl 4): 1195A.
33.	纪冬, 邵清, 韩萍, 等. 瞬时弹性成像联合血清学标志物检测对肝纤维化的诊断疗效分析[J]. 解放军医学杂志, 2011, 36(11): 1136-1138.
34.	李继昌, 顿国亮. 肝纤维化诊断中肝穿病理分期及非创伤性指标相关性研究[J]. 中国现代医生, 2010, 48(12): 33.
35.	林沪, 陈黎明, 叶文华, 等. 肝纤维化无创性诊断技术应用的新进展[J]. 传染病信息, 2010, 23(3): 187-190.

1. 　Han KN, Yoon KT. Mew diagnostic method for liver fibrosis and cirrhosis[J]. Intervirology, 2008, 51(1): 11-16.
2. 　Patel K. Noninvasive tools to assess liver disease[J]. Curr Opin Gastroenterol, 2010, 26(3): 227-233.
3. 　Wong GL, Wong VW, Choi, et al. Development of a noninvasive algorithm with transient elastography(FibroScan)and serum test formula for advanced liver fibrosis in chronic hepatitis B[J]. Aliment Pharm Ther, 2010, 31(10): 1095-1103.
4. 　Cadranel JF, Rufat P, Degos F. Practices of liver biopsy in France:results of a prospective nationwide survey[J]. Hepatology, 2000, 32(3): 477-481.
5. 　Sebastiani G. Non-invasive assessment of liver fibrosis in chronic liver diseases: implementation in clinical practice and decisional[J]. World J Gastroenterol, 2009, 15(18): 2190-2203.
6. 　王军, 赵权, 路颖, 等. 血清层粘连蛋白水平检测对肝病患者肝纤维化的诊断意义[J]. 实用医药杂志, 2011, 28(2): 106-107.
7. 　姜菲菲, 王文静, 赵秀英, 等. 国产化学发光试剂检测4项血清肝纤维化标志物对肝纤维化诊断的应用分析[J]. 北京医学, 2012, 34(3): 164-168.
8. 　赵治凤, 贾秋龙. 肝纤维化四项联合检测对410例慢性肝炎诊断的临床意义[J]. 中国民康医学, 2012, 24(7): 798-799.
9. 　Jarcuska P, Janicko M, Veseliny E, et al. Circulating markers of liver fibrosis progression[J]. Clin Chim Acta, 2010, 411(15-16): 1009-1017.
10. 　李丽, 展玉涛. 肝纤维化无创性诊断研究进展[J]. 实用肝脏病杂志, 2010, 13(2): 145-147.
11. 　Myers RP, Tainturier MH, Ratziu V, et al. Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B[J]. Hepatology, 2003, 39(2): 222-230.
12. 　Anais VP, Vincent M, Bertrand N, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and Fibro Test[J]. Hepatology, 2007, 46(1): 33-36.
13. 　张彦亮, 洪定玲, 边维良, 等. FIB-4指数对慢性乙型肝炎患者肝纤维化的诊断价值[J]. 胃肠病学和肝病学杂志, 2009, 18(3): 213-214.
14. 　张文胜, 王宝恩, 王泰领, 等. 慢性乙型肝炎肝纤维化无创性诊断模型的建立[J]. 中华肝脏病杂志, 2006, 14(3): 169-173.
15. 　Li WX, Zhao XT, Wm C, et al. Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography[J]. J Digest Dis, 2010, 11(4): 215-223.
16. 　Wang Y, Ganger DR, Levitsky J, et al. Assessment of chronic hepatitis and fibrosis: comparison of Mr elastography and diffusion-weighted imaging[J]. Am J Roentgenol, 2011, 196(3): 553-561.
17. 　朱霞, 唐红. 瞬时弹性扫描仪在肝纤维化诊断中的应用价值[J]. 世界华人消化杂志, 2010, 18(9): 906-912.
18. 　Jung MK, Cho HJ, Lee HC, et al. Comparison of transient elastography and hepatic fibrosis assessed by histology in chronic liver disease[J]. Korean J Gastroenterol, 2008, 51(4): 241-247.
19. 　Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis[J]. Ultrasound Med Biol, 2003, 29(12): 1705-1713.
20. 　Coco B, Oliveri F, Maina AM, et al. Transient elastography:a new surrogate marker of liver fibrosis influenced by major changes of transaminases[J]. J Viral Hepat, 2007, 14(5): 360-369.
21. 　Kim SU, Han KH, Park IY, et al. Liver stiffness measurement using FibroScan is influenced by serum total bilirubin in acute hepatitis[J]. Liver Int, 2009, 29(6): 810-815.
22. 　Millonig G, Reimann FM, Friedrich S, et al. Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis[J]. Hepatology, 2008, 48(5): 1718-1723.
23. 　Scott DR, Levy MT. Liver transient elastography (Fibroscan): a place in the management algorithms of chronic viral hepatitis[J]. Antivir Ther, 2010, 15(1): 1-11.
24. 　杨爱婷, 白艳锋, 尤红. Fibroscan对乙型肝炎肝纤维化诊断的研究进展[J]. 实用肝脏病杂志, 2009, 12(2): 142-144.
25. 　Alisi A, Pinzani M, Nobili V. Diagnostic power of FibroScan in predicting liver fibrosis in nonalcoholic fatty liver disease[J]. Hepatology, 2009, 50(6): 2048-2049.
26. 　薛芳, 施裕新, 李桂明, 等. 瞬时弹性成像对肝纤维化的诊断价值[J]. 中国临床医学, 2012, 19(1): 77-79.
27. 　Fraquelli M, Rigamonti C, Casazza G, et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease[J]. Gut, 2007, 56(7): 968-973.
28. 　Salles N, Dussarat P, Foucher J, et al. Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients[J]. Gastroenterol Clin Biol, 2009, 33(2): 126-132.
29. 　Roulot D, Czernichow S, Le CH, et al. Liver stiffness values in apparently healthy subjects: influence of gender and metabolic syndrome[J]. J Hepatol, 2008, 48(4): 606-613.
30. 　Chang PE, Lui HF, Chau YP, et al. Prospective evaluation of transient elastography for the diagnosis of hepatic fibrosis in Asians: comparison with liver biopsy and aspartate transaminase platelet ratio index[J]. Aliment Pharm Therap, 2008, 28(1): 51-56.
31. 　Castera L, Vergniol J, Foucher J, et al. Prospective comparison of transient elastography, fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C[J]. Gastroenterology, 2005, 128(2): 343-350.
32. 　Fraquelli M, Rigamonti C, Casazza G, et al. A sequential predictive algorithm combining APRI and transient elastography (TE) for diagnosing liver fibrosis in chronic hepatitis C[J]. Hepatology, 2008, 48(Suppl 4): 1195A.
33. 　纪冬, 邵清, 韩萍, 等. 瞬时弹性成像联合血清学标志物检测对肝纤维化的诊断疗效分析[J]. 解放军医学杂志, 2011, 36(11): 1136-1138.
34. 　李继昌, 顿国亮. 肝纤维化诊断中肝穿病理分期及非创伤性指标相关性研究[J]. 中国现代医生, 2010, 48(12): 33.
35. 　林沪, 陈黎明, 叶文华, 等. 肝纤维化无创性诊断技术应用的新进展[J]. 传染病信息, 2010, 23(3): 187-190.

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