Expression and Pathological Significance of E-Cadherin and Uridylyl Phosphate Adenosine in Breast Carcinoma_West China Medical Journal

Authors：

ZHOU Li , YU Jiahai , LU Jiafeng.

Department of Pathology, Maternal and Child Health Hospital of Weifang City, Weifang, Shandong 261011, P. R. China;

Corresponding author：

Keywords：

上皮细胞钙黏蛋白; 尿激酶型纤溶酶原激活剂; 乳腺癌; 免疫组织化学

DOI：

10.7507/1002-0179.20130065

Video：

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目的　探讨上皮细胞钙黏蛋白（E-Cadherin）、尿激酶型纤溶酶原激活剂（uPA）表达与乳腺癌的浸润、淋巴结转移的关系。方法　采用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶连接法对乳腺纤维腺瘤、乳腺腺病和乳腺癌各40例蜡块中E-Cadherin、uPA表达进行研究。结果　乳腺纤维腺瘤、腺病和乳腺癌中E-Cadherin阳性率分别为85.0%、82.5%和20.0%，三者差异有统计学意义（P＜0.05）；E-Cadherin表达阴性患者淋巴结转移率（90.6%）高于E-Cadherin表达阳性者（25.0%），差异有统计学意义（P＜0.01）。uPA在乳腺纤维腺瘤、腺病均呈阴性表达，在乳腺癌中的阳性率为60.0%，三者差异有统计学意义（P＜0.05）；uPA表达阳性患者淋巴结转移率（88.5%）显著高于阴性者（50.0%），两者的表达差异有统计学意义（P＜0.05）。结论　E-Cadherin和uPA的表达与乳腺癌的浸润转移密切相关，同步检测其在乳腺癌组织中的表达并综合分析二者之间的关系，对评价乳腺癌细胞的侵袭转移能力及预后判断具有一定价值。uPA在乳腺癌中表达率较高，而且和乳腺癌的生物学特性有关，它对提示预后和开展靶向治疗有指导意义。

Citation： ZHOU Li,YU Jiahai,LU Jiafeng.. Expression and Pathological Significance of E-Cadherin and Uridylyl Phosphate Adenosine in Breast Carcinoma. West China Medical Journal, 2013, 28(2): 204-207. doi: 10.7507/1002-0179.20130065 Copy

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5.	Kamai T, Takagi K, Asami H, et al. Decreasing of p27 (kip1) and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer[J]. Br J Cancer, 2001, 84(9): 1242-1251.
6.	Zbar AP, Simopoulos C, Karayiannakis AJ. Cadherins: an integral role in inflammatory bowel disease and mucosal restitution[J]. J Gastroenterol, 2004, 39(5): 413-421.
7.	Bornman DM, Mathew S, Alsruhe J, et al. Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals[J]. Am J Pathol, 2001, 159(3): 831-835.
8.	Omran OM. CD10 and E-Cad expression in urinary bladder urothelial and squamous cell carcinoma[J]. J Environ Pathol Toxicol Oncol, 2012, 31(3): 203-212.
9.	Sun GY, Wu JX, Wu JS, et al. Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis[J]. Chin J Cancer Res, 2012, 24(1): 23-28.
10.	Wei Y, Lukashev M, Simon DI, et al. Regulation of integrin function by the urokinase receptor[J]. Science, 1996, 273(5281): 1551-1555.
11.	韩艳春, 刘鲁英, 杨东霞, 等. 人乳腺癌中p-P38信号分子与UPA表达增强[J]. 基础医学与临床, 2009, 29(2): 170.
12.	Jiang JT, Zhang LF, Zhou B, et al. Relationships of uPA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis[J]. Asian Pac J Cancer Prev, 2012, 13(7): 3379-3383.
13.	黄金凤, 何志明, 李炜霞. 乳腺癌组织UPA和nm23表达及其临床意义的研究[J]. 中华肿瘤防治杂志, 2008, 6(15): 830-831.
14.	肖继平, 张莉, 齐云, 等. UPA及VEGF在乳腺癌中的表达及意义[J]. 中国普通外科杂志, 2007, 16(1): 96-98.
15.	高凤霞. TGF-β1与UPA在乳腺癌中的表达及其相关性的研究[J]. 青岛医药卫生, 2009, 41(1): 1-4.

1. 　金向明, 陈耀平, 王宁菊. 乳腺癌患者血浆uPA、uPAR检测的临床意义[J]. 宁夏医学杂志, 2008, 30(7): 580-581.
2. 　Siitonen SM, Kononen JT, Helin HJ, et al. Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer[J]. Am J Clin Pathol, 1996, 105(4): 394-402.
3. 　Maguire TM, Shering SG, Mcdermott EW, et al. Assay of E-cadherin by ELISA in human breast cancers[J]. Eur J Cancer, 1997, 33(3): 404-408.
4. 　丁印鲁, 赵荣宇, 由翠珍, 等. E-cadherin和PCNA在肝细胞癌中表达关系的研究[J]. 肿瘤防治杂志, 2002, 9(3): 255-256.
5. 　Kamai T, Takagi K, Asami H, et al. Decreasing of p27 (kip1) and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer[J]. Br J Cancer, 2001, 84(9): 1242-1251.
6. 　Zbar AP, Simopoulos C, Karayiannakis AJ. Cadherins: an integral role in inflammatory bowel disease and mucosal restitution[J]. J Gastroenterol, 2004, 39(5): 413-421.
7. 　Bornman DM, Mathew S, Alsruhe J, et al. Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals[J]. Am J Pathol, 2001, 159(3): 831-835.
8. 　Omran OM. CD10 and E-Cad expression in urinary bladder urothelial and squamous cell carcinoma[J]. J Environ Pathol Toxicol Oncol, 2012, 31(3): 203-212.
9. 　Sun GY, Wu JX, Wu JS, et al. Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis[J]. Chin J Cancer Res, 2012, 24(1): 23-28.
10. 　Wei Y, Lukashev M, Simon DI, et al. Regulation of integrin function by the urokinase receptor[J]. Science, 1996, 273(5281): 1551-1555.
11. 　韩艳春, 刘鲁英, 杨东霞, 等. 人乳腺癌中p-P38信号分子与UPA表达增强[J]. 基础医学与临床, 2009, 29(2): 170.
12. 　Jiang JT, Zhang LF, Zhou B, et al. Relationships of uPA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis[J]. Asian Pac J Cancer Prev, 2012, 13(7): 3379-3383.
13. 　黄金凤, 何志明, 李炜霞. 乳腺癌组织UPA和nm23表达及其临床意义的研究[J]. 中华肿瘤防治杂志, 2008, 6(15): 830-831.
14. 　肖继平, 张莉, 齐云, 等. UPA及VEGF在乳腺癌中的表达及意义[J]. 中国普通外科杂志, 2007, 16(1): 96-98.
15. 　高凤霞. TGF-β1与UPA在乳腺癌中的表达及其相关性的研究[J]. 青岛医药卫生, 2009, 41(1): 1-4.

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West China Medical Journal

Expression and Pathological Significance of E-Cadherin and Uridylyl Phosphate Adenosine in Breast Carcinoma

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