肺癌患者血清中脂质运载蛋白-2的表达及临床意义_West China Medical Journal

Authors：

王宇 ¹ , 陈伟 ² ,  曾婷婷 ³

Corresponding author：

曾婷婷, Email: lilichen1999@sohu.com

Keywords：

肺癌; 脂质运载蛋白-2; 酶联免疫吸附试验

DOI：

10.7507/1002-0179.20130137

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的　检测脂质运载蛋白-2（Lipocalin-2）在肺癌患者血清中的表达情况及与临床指标的关系。方法　2012年1月－5月采用酶联免疫吸附试验（ELISA）定量检测42例肺癌患者和27例正常人血清中Lipocalin-2蛋白的表达水平。结果　肺癌组和正常对照组血清中Lipocalin-2蛋白含量分别为（89.63 ± 21.32）、（62.44 ± 18.25） ng/mL，差异有统计学意义（P＜0.05）。Lipocalin-2在小细胞癌组表达水平最高[（117.73 ± 8.76） ng/mL]，显著高于腺癌组[（80.33 ± 16.6） ng/mL]和鳞癌组[（89.22 ± 18.53 ng/mL]，差异有统计学意义（P＜0.05）。Ⅲ＋Ⅳ期肺癌组的Lipocalin-2水平[（95.72 ± 15.33） ng/mL]，显著高于Ⅰ期[（65.7 ± 8.77） ng/mL]和Ⅱ期[（72.75 ± 10.77） ng/mL]，差异有统计学意义（P＜0.05）。淋巴节转移组的Lipocalin-2水平[（94.28 ± 20.92） ng/mL]，显著高于未转移组[（72.55 ± 12.69） ng/mL]，差异有统计学意义（P＜0.05）。结论　Lipocalin-2蛋白在肺癌患者血清中表达上调，该蛋白与肺癌的发生发展有关。

Citation： 王宇,陈伟,曾婷婷. 肺癌患者血清中脂质运载蛋白-2的表达及临床意义. West China Medical Journal, 2013, 28(3): 428-430. doi: 10.7507/1002-0179.20130137 Copy

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9.	BauerM, Eickhoff JC, GouldMN, et al. Neutrophil gelatinase-associated lipocalin (NGAL) is a p redictor of poor p rognosis in human primary breast cancer[J]. Breast Cancer Res Treat, 2008, 108(3): 389-397.
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11.	郭艳, 苑中甫. NGAL和MMP-9在卵巢上皮性癌中的表达及相关性研究[J]. 现代妇产科进展, 2012, 21(6): 440-443.
12.	Mannelqvist M, Stefansson I, Wik E, et al. Lipocalin 2 expression is associated with aggressive features of endometrial Cancer[J]. BMC Cancer, 2012, 12(5): 169.
13.	张秀峰, 张筱骅, 周素梅, 等. NGAL在83例结、直肠癌中的表达及其临床意义[J]. 肿瘤学杂志, 2009, 15(2): 115-119.

1. 　张金山, 罗良平. 血清NSE、CYFRA21-1、CEA和CA50联检诊断肺癌及其与肺癌病理分型的关系[J]. 放射免疫学杂志, 2010, 23(4): 365-368.
2. 　Flower DR. The lipocalin protein family:structure and function[J]. Biochem J, 1996, 318(Pt 1): 1-14.
3. 　曾婷婷, 王宇. Lipocalin-2 蛋白在SD大鼠脑组织中的表达情况[J]. 现代预防医学, 2010, 37(2): 318-323.
4. 　Tong ZM, Wu XL, Ovcharenko D, et al. Neutrophil genatinase-associated lipocalin as a survival factor[J]. Biochem J, 2005, 391(Pt2): 441-448.
5. 　Grundy SM. The metabolic syndrome:inflammation,diabetes mellitus,and cardiovascular disease[J]. Am J Cardio, 2006, 97(1): 3A-11A.
6. 　林忆阳, 翁忠, 屈天生. 糖尿病肾病患者血清中性粒细胞明胶酶相关脂质运载蛋白的改变及其临床意义[J]. 细胞与分子免疫学杂志, 2010, 26(11): 1113-1115.
7. 　Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly[J]. Circ Res, 2002, 90(3): 251-262.
8. 　Stoesz SP, Friedl A, Haag JD, et al. Heterogeneous expression of the lipocalin NGAL in primary breast cancers[J]. Int J Cancer, 1998, 79(6): 565-572.
9. 　BauerM, Eickhoff JC, GouldMN, et al. Neutrophil gelatinase-associated lipocalin (NGAL) is a p redictor of poor p rognosis in human primary breast cancer[J]. Breast Cancer Res Treat, 2008, 108(3): 389-397.
10. 　Syrjanen S, Naud P, Sarian L, et al. Up-regulation of lipocalin 2 is associated with high-risk human papillomavirus and grade of cervical lesion at baseline but does not predict outcomes of infections or incident cervical intraepithelial neoplasia[J]. Am J Clin Pathol, 2010, 134(1): 50-59.
11. 　郭艳, 苑中甫. NGAL和MMP-9在卵巢上皮性癌中的表达及相关性研究[J]. 现代妇产科进展, 2012, 21(6): 440-443.
12. 　Mannelqvist M, Stefansson I, Wik E, et al. Lipocalin 2 expression is associated with aggressive features of endometrial Cancer[J]. BMC Cancer, 2012, 12(5): 169.
13. 　张秀峰, 张筱骅, 周素梅, 等. NGAL在83例结、直肠癌中的表达及其临床意义[J]. 肿瘤学杂志, 2009, 15(2): 115-119.

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West China Medical Journal

肺癌患者血清中脂质运载蛋白-2的表达及临床意义

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