脑干胶质瘤的干细胞研究进展_West China Medical Journal

Authors：

杨翔 ,  张跃康

Corresponding author：

张跃康, Email: yangxiangcool2008@qq.com

Keywords：

脑干胶质瘤; 神经肿瘤干细胞; 信号通路; 靶向治疗

DOI：

10.7507/1002-0179.20130198

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

脑干胶质瘤是威胁人类健康的重要疾病，尤其是弥漫内生性桥脑胶质瘤，对儿童的影响更是致命性的。脑干胶质瘤占儿童后颅窝肿瘤的30%，而弥漫内生性桥脑胶质瘤占儿童脑肿瘤15%左右。后者其中位生存时间几乎不超过1年。由于过去在其生物学特性等方面研究欠缺导致此类肿瘤的治疗几乎无实质性进展。但随着近年脑干胶质瘤干细胞及其相关信号通路、细胞因子等方面的基础研究兴起，治疗方面取得了一定的成绩。在此，我们将就近几年在弥漫内生性桥脑胶质瘤基础方面的研究进展作相关综述及讨论。

Citation： 杨翔,张跃康. 脑干胶质瘤的干细胞研究进展. West China Medical Journal, 2013, 28(4): 627-630. doi: 10.7507/1002-0179.20130198 Copy

1.	Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells[J]. Nature, 2001, 414(6859) : 105-111.
2.	Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice[J]. Nature, 1994, 367(6464): 645-648.
3.	Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells[J]. Nature, 2004, 432(7015): 396-401.
4.	Lee J, Kotliarova S, Kotliarov Y, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines[J]. Cancer Cell, 2006, 9(5): 391-403.
5.	Nicolis SK. Cancer stem cells and “stemness” genes in neuro-oncology[J]. Neurobiol Dis, 2007, 25(2): 217-229.
6.	Zhang XP, Zheng G, Zou L, et al. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells[J]. Mol Cell Biochem, 2008, 307(1-2): 101-108.
7.	Fan X, Matsui W, Khaki L, et al. Notch Pathway Inhibition Depletes Stem-like Cells and Blocks Engraftment in Embryonal Brain Tumors[J]. Cancer Res , 2006, 66(15): 7445-7452 .
8.	Diamandis P, Wildenhain J, Clarke ID, et al. Chemical genetics reveals a complex functional ground state of neural stem cells[J]. Nat Chem Biol, 2007, 3(5): 268-273.
9.	Singh SK, Clarke ID, Hide T, et al. Cancer stem cells in nervous system tumors[J]. Oncogene, 2004, 23(43): 7267-7273.
10.	Yang ZJ, Ellis T, Markant SL, et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells[J]. Cancer Cell, 2008, 14(2): 135-145.
11.	Masui K, Suzuki SO, Torisu R,et al. Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation[J]. Glia , 2010, 58(9): 1050-1065.
12.	Monje M, Mitra SS, Freret ME, et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma[J]. Proc Natl Acad Sci USA, 2011, 108 (11): 4453-4458.
13.	Mazur MD, Couldwell WT. Investigating a candidate cell of origin for diffuse intrinsic pontine glioma[J]. World Neurosurg, 2011, 76(5): 368-369.
14.	Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products[J]. Curr Opin Genet Dev, 1999, 9(1) 1: 22-30.
15.	Marino S. Medulloblastoma: developmental mechanisms out of control[J]. Trends Mol Med, 2005, 11(1): 17-22.
16.	Bar EE, Chaudhry A, Lin A, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma[J].Stem cells, 2007, 25(10): 2524-2533.
17.	Ehtesham M, Sarangi A, Valadez JG, et al. Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells[J].Oncogene, 2007, 26 (39): 5752-5761.
18.	Zarghooni M, Bartels U, Lee E, et al.Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor and poly (ADP-ribose) polymerase as potential therapeutic targets[J]. J Clin Oncol, 2010, 28(8): 1337-1344.
19.	Grill J, Puget S, Andreiuolo F, et al. Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma[J]. Pediatr Blood Cancer, 2012, 58(4): 489-491.
20.	Masui K, Suzuki SO, Torisu R, et al. Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation[J]. Glia , 2010, 58(9): 1050-1065.
21.	Clement V, Sanchez P, de Tribolet N, et al. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity[J]. Curr Biol, 2007, 17(2): 165-172.
22.	Kondo T, Raff M. Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells[J]. Genes Dev, 2004, 18(23): 2963-2972.
23.	Wu G, Broniscer A, McEachron TA, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas[J]. Nat Genet, 2012, 44(3): 251-253.
24.	Schmidt NO, Przylecki W, Yang W, et al. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor[J]. Neoplasia, 2005, 7(6): 623-629.
25.	Schmidt NO, Koeder D, Messing M, et al. Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche[J]. Brain Res, 2009, 1268: 24-37.
26.	Kim SK, Kim SU, Park IH, et al. Human neural stem cellstarget experimental intracranial medulloblastoma and deliver atherapeutic gene leading totumor regression[J]. Clin Cancer Res, 2006, 12(18): 5550-5556.
27.	Choi SA, Lee JY, Wang KC, et al. Human adipose tissue-derived mesenchymal stem cells:Characteristics and therapeutic potential as cellular vehicles for prodrug gene therapy against brainstem gliomas[J]. Eur J Cancer, 2012, 48(1): 129-137.
28.	Li G, Mitra SS, Monje M, et al. Expression of epidermal growth factor variantⅢ(EGFRvⅢ) in pediatric diffuse intrinsic pontine gliomas[J]. J Neurooncol , 2012, 108(3): 395-402.

1. 　Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells[J]. Nature, 2001, 414(6859) : 105-111.
2. 　Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice[J]. Nature, 1994, 367(6464): 645-648.
3. 　Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells[J]. Nature, 2004, 432(7015): 396-401.
4. 　Lee J, Kotliarova S, Kotliarov Y, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines[J]. Cancer Cell, 2006, 9(5): 391-403.
5. 　Nicolis SK. Cancer stem cells and “stemness” genes in neuro-oncology[J]. Neurobiol Dis, 2007, 25(2): 217-229.
6. 　Zhang XP, Zheng G, Zou L, et al. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells[J]. Mol Cell Biochem, 2008, 307(1-2): 101-108.
7. 　Fan X, Matsui W, Khaki L, et al. Notch Pathway Inhibition Depletes Stem-like Cells and Blocks Engraftment in Embryonal Brain Tumors[J]. Cancer Res , 2006, 66(15): 7445-7452 .
8. 　Diamandis P, Wildenhain J, Clarke ID, et al. Chemical genetics reveals a complex functional ground state of neural stem cells[J]. Nat Chem Biol, 2007, 3(5): 268-273.
9. 　Singh SK, Clarke ID, Hide T, et al. Cancer stem cells in nervous system tumors[J]. Oncogene, 2004, 23(43): 7267-7273.
10. 　Yang ZJ, Ellis T, Markant SL, et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells[J]. Cancer Cell, 2008, 14(2): 135-145.
11. 　Masui K, Suzuki SO, Torisu R,et al. Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation[J]. Glia , 2010, 58(9): 1050-1065.
12. 　Monje M, Mitra SS, Freret ME, et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma[J]. Proc Natl Acad Sci USA, 2011, 108 (11): 4453-4458.
13. 　Mazur MD, Couldwell WT. Investigating a candidate cell of origin for diffuse intrinsic pontine glioma[J]. World Neurosurg, 2011, 76(5): 368-369.
14. 　Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products[J]. Curr Opin Genet Dev, 1999, 9(1) 1: 22-30.
15. 　Marino S. Medulloblastoma: developmental mechanisms out of control[J]. Trends Mol Med, 2005, 11(1): 17-22.
16. 　Bar EE, Chaudhry A, Lin A, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma[J].Stem cells, 2007, 25(10): 2524-2533.
17. 　Ehtesham M, Sarangi A, Valadez JG, et al. Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells[J].Oncogene, 2007, 26 (39): 5752-5761.
18. 　Zarghooni M, Bartels U, Lee E, et al.Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor and poly (ADP-ribose) polymerase as potential therapeutic targets[J]. J Clin Oncol, 2010, 28(8): 1337-1344.
19. 　Grill J, Puget S, Andreiuolo F, et al. Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma[J]. Pediatr Blood Cancer, 2012, 58(4): 489-491.
20. 　Masui K, Suzuki SO, Torisu R, et al. Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation[J]. Glia , 2010, 58(9): 1050-1065.
21. 　Clement V, Sanchez P, de Tribolet N, et al. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity[J]. Curr Biol, 2007, 17(2): 165-172.
22. 　Kondo T, Raff M. Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells[J]. Genes Dev, 2004, 18(23): 2963-2972.
23. 　Wu G, Broniscer A, McEachron TA, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas[J]. Nat Genet, 2012, 44(3): 251-253.
24. 　Schmidt NO, Przylecki W, Yang W, et al. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor[J]. Neoplasia, 2005, 7(6): 623-629.
25. 　Schmidt NO, Koeder D, Messing M, et al. Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche[J]. Brain Res, 2009, 1268: 24-37.
26. 　Kim SK, Kim SU, Park IH, et al. Human neural stem cellstarget experimental intracranial medulloblastoma and deliver atherapeutic gene leading totumor regression[J]. Clin Cancer Res, 2006, 12(18): 5550-5556.
27. 　Choi SA, Lee JY, Wang KC, et al. Human adipose tissue-derived mesenchymal stem cells:Characteristics and therapeutic potential as cellular vehicles for prodrug gene therapy against brainstem gliomas[J]. Eur J Cancer, 2012, 48(1): 129-137.
28. 　Li G, Mitra SS, Monje M, et al. Expression of epidermal growth factor variantⅢ(EGFRvⅢ) in pediatric diffuse intrinsic pontine gliomas[J]. J Neurooncol , 2012, 108(3): 395-402.

Previous Article
髓母细胞瘤中相关信号通路与靶向抑制剂研究进展
Next Article
临床分离的耐碳青霉烯类肠杆菌科细菌的研究进展

West China Medical Journal

脑干胶质瘤的干细胞研究进展

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content