A Clinical Study on Arsenic Trioxide Combined with Cisplatin in the Treatment of Malignant Pleural Effusion_West China Medical Journal

Authors：

Department of Oncology, Chengdu Fifth People’s Hospital, Chengdu, Sichuan 611130, P. R. China;

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Keywords：

三氧化二砷; 顺铂; 胸腔内灌注; 恶性胸腔积液

DOI：

10.7507/1002-0179.20130221

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目的　观察三氧化二砷联合顺铂腔内注射治疗恶性胸腔积液的疗效和毒副反应。方法　2011年9月－2012年9月，将恶性胸腔积液患者60例，随机分为治疗组和对照组，每组各30例。在胸腔积液充分引流后，治疗组胸腔内注射三氧化二砷20 mg联合顺铂60 mg；对照组只给予胸腔灌注顺铂60 mg，胸腔灌注化学疗法药物两组均1次/周，共3次。观察疗效及不良反应。结果　治疗组和对照组的有效率分别为93.3%和56.7%（P＜0.05）。治疗组和对照组的一般状况改善率分别为70.0%和40.0%（P＜0.05）。两组的不良反应相近。结论　三氧化二砷联合顺铂腔内注射治疗恶性胸腔积液具有协同增效作用，不良反应小。

Citation： YANG XueMei,CHEN YuanHang,ZENG Shouqun,DAI Gangyi,ZENG Guilin,MENG Yousheng.. A Clinical Study on Arsenic Trioxide Combined with Cisplatin in the Treatment of Malignant Pleural Effusion. West China Medical Journal, 2013, 28(5): 707-709. doi: 10.7507/1002-0179.20130221 Copy

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2.	孙燕, 石远凯. 临床肿瘤内科手册[M]. 5版. 北京：人民卫生出版社, 2007: 147-149.
3.	殷蔚伯, 余子豪, 徐国镇, 等. 肿瘤放射治疗学[M]. 4版. 北京:中国协和医科大学出版社: 2007: 1349.
4.	Steger V, Mika U, Toomes H, et al. Who gain most? A 10-year experience with 611 thoracoscopic talc pleurodeses[J]. J Ann Thorac Surg, 2007, 83(6): 1940-1945.
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6.	Neragi Miandoab S. Malignant pleural effusion current and evolving approaches for its diagnosis and management[J]. Lung Cancer, 2006, 54(1): 1-9.
7.	Cerimagic Z, Guska S, Pilav I, et al. The using doxycycline in procedure chemical pleurodesis of malignancy pleural effusion[J]. Med Arh, 2006, 60(6): 360-363.
8.	林新义, 刘海燕, 张丹, 等. 三氧化二砷治疗恶性胸腔积液15例[J]. 丹东医药, 2007, 1: 18.
9.	Nemeti B, Gregus Z. Reduction of arsenate to arsenite in hepatic cytosol[J]. Toxicol Sci, 2002, 70: 4-12.
10.	黄小军. 三氧化二砷诱导细胞凋亡的调节. 中国血液病杂志, 1999, 19(5): 52.
11.	Saurai T, Ochiai M, Kojima C, et al. Role of glutathione in dimethy-larsinic acid-induced apoptosis[J]. Toxicol Appl Pharmacol, 2004, 198: 354-365.
12.	张鹏, 王树叶, 胡龙虎, 等. 三氧化二砷注射液治疗72例急性早幼粒细胞白血病[J]. 中华血液学杂志, 1996, 17(2): 58-61.
13.	Shen ZX, Chen GQ, Ni JH, et al. Use of arsenic trioxide(As2O3)in the treatment of acute promyelocytic leukemia(APL):Ⅱ. Clinical efficacy and pharmacokinetics in relapsed patients[J]. Blood, 1997, 89(9): 3354-3360.
14.	Han B, Zhou G, Zhang Q, et al. Effect of arsenic trioxide (ATO) on human lung carcinoma PG cell line: ATO induced apoptosis of PG cells and decreased expression of Bcl-2, Pgp[J]. J Exp Ther Oncol, 2004, 4(4): 335-342.
15.	Matsui W, Smith BD, Vala M, et al. Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukemia[J]. Br J Haematol, 2005, 128(6): 853-862.
16.	Karasulu HY, Karabulut B, Kantarci G, et al. Preparation of arsenic trioxide loaded microemulsion and its enhanced cytotoxicity on MCF-7 breast carcinoma cell line[J]. Drug Deliv, 2004, 11(6): 345-350.
17.	Kang SH, Song JH, Kang HK, et al. arsenic trioxide-induced apoptosis is in dependent of stress-responsive signaling pathway but sensitive to inhibition of inducible nitric oxide synthase in HepG2 cell[J]. Exp Mol Med, 2003, 35(2): 83-90.
18.	顾琴龙, 沈佰华, 李宁丽, 等.氧化砷诱导胃癌细胞株凋亡的初步研究[J]. 中华消化杂志, 1998, 18(2): 69-71.
19.	刘静冰, 秦叔逵, 钱钧, 等.三氧化二砷注射液治疗晚期胰腺癌的临床研究[J].临床肿瘤学杂志, 2005, 10(2): 117-119.
20.	刘连新, 朱安龙, 陈炜, 等. 三氧化二砷对原发性肝癌的作用及其机理研究[J].中华外科杂志, 2005, 43(1): 33-36.
21.	张莉, 王玲, 宋维华, 等.三氧化二砷通过升高细胞内钙离子浓度介导肺癌细胞凋亡[J]. 中华药理学通报, 2004, 20(8): 867-870.
22.	魏虎来, 姚小健, 李宇宁, 等. 三氧化二砷抑制K562/ADM细胞P-糖蛋白表达并提高化疗药物的敏感性[J]. 中华血液学杂志, 2003, 24(1): 28-31.
23.	王秀丽, 孔力, 赵瑾瑶, 等. 三氧化二砷逆转人乳腺癌MCF-7/ADM细胞耐药的机制研究[J]. 中华肿瘤杂志, 2002, 24(4): 339-343.
24.	赵园园, 金锋, 梁军, 等. 三氧化二砷对人胃癌耐药细胞系SGC7901/ADM耐药逆转及凋亡诱导作用的探讨[J]. 中国肿瘤临床, 2005, 32(11): 611-613.
25.	Li H, Zhu X, Zhang Y, et al. Arsenic trioxide exerts synergistic effects with cisplatin on non-small cell lung cancer cells via apoptosis induction[J]. J Exp Clin Cancer Res, 2009, 28: 110.
26.	韩冰, 石玉枝, 雷建民. 三氧化二砷对肺腺癌细胞凋亡及肺耐药蛋白基因多药耐药蛋白基因表达的影响[J]. 中国实用内科杂志, 2005, 25(3): 243-244.

1. 　Muduly D, Deo S, Subi Ts, et al. An update in the management of malignant pleural effusion[J]. Indian J Palliat Care, 2011, 17(2): 98-103.
2. 　孙燕, 石远凯. 临床肿瘤内科手册[M]. 5版. 北京：人民卫生出版社, 2007: 147-149.
3. 　殷蔚伯, 余子豪, 徐国镇, 等. 肿瘤放射治疗学[M]. 4版. 北京:中国协和医科大学出版社: 2007: 1349.
4. 　Steger V, Mika U, Toomes H, et al. Who gain most? A 10-year experience with 611 thoracoscopic talc pleurodeses[J]. J Ann Thorac Surg, 2007, 83(6): 1940-1945.
5. 　Aelony Y. Dry talc pleurodesis via chest tube[J]. Chest, 2003, 123(1): 308.
6. 　Neragi Miandoab S. Malignant pleural effusion current and evolving approaches for its diagnosis and management[J]. Lung Cancer, 2006, 54(1): 1-9.
7. 　Cerimagic Z, Guska S, Pilav I, et al. The using doxycycline in procedure chemical pleurodesis of malignancy pleural effusion[J]. Med Arh, 2006, 60(6): 360-363.
8. 　林新义, 刘海燕, 张丹, 等. 三氧化二砷治疗恶性胸腔积液15例[J]. 丹东医药, 2007, 1: 18.
9. 　Nemeti B, Gregus Z. Reduction of arsenate to arsenite in hepatic cytosol[J]. Toxicol Sci, 2002, 70: 4-12.
10. 　黄小军. 三氧化二砷诱导细胞凋亡的调节. 中国血液病杂志, 1999, 19(5): 52.
11. 　Saurai T, Ochiai M, Kojima C, et al. Role of glutathione in dimethy-larsinic acid-induced apoptosis[J]. Toxicol Appl Pharmacol, 2004, 198: 354-365.
12. 　张鹏, 王树叶, 胡龙虎, 等. 三氧化二砷注射液治疗72例急性早幼粒细胞白血病[J]. 中华血液学杂志, 1996, 17(2): 58-61.
13. 　Shen ZX, Chen GQ, Ni JH, et al. Use of arsenic trioxide(As2O3)in the treatment of acute promyelocytic leukemia(APL):Ⅱ. Clinical efficacy and pharmacokinetics in relapsed patients[J]. Blood, 1997, 89(9): 3354-3360.
14. 　Han B, Zhou G, Zhang Q, et al. Effect of arsenic trioxide (ATO) on human lung carcinoma PG cell line: ATO induced apoptosis of PG cells and decreased expression of Bcl-2, Pgp[J]. J Exp Ther Oncol, 2004, 4(4): 335-342.
15. 　Matsui W, Smith BD, Vala M, et al. Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukemia[J]. Br J Haematol, 2005, 128(6): 853-862.
16. 　Karasulu HY, Karabulut B, Kantarci G, et al. Preparation of arsenic trioxide loaded microemulsion and its enhanced cytotoxicity on MCF-7 breast carcinoma cell line[J]. Drug Deliv, 2004, 11(6): 345-350.
17. 　Kang SH, Song JH, Kang HK, et al. arsenic trioxide-induced apoptosis is in dependent of stress-responsive signaling pathway but sensitive to inhibition of inducible nitric oxide synthase in HepG2 cell[J]. Exp Mol Med, 2003, 35(2): 83-90.
18. 　顾琴龙, 沈佰华, 李宁丽, 等.氧化砷诱导胃癌细胞株凋亡的初步研究[J]. 中华消化杂志, 1998, 18(2): 69-71.
19. 　刘静冰, 秦叔逵, 钱钧, 等.三氧化二砷注射液治疗晚期胰腺癌的临床研究[J].临床肿瘤学杂志, 2005, 10(2): 117-119.
20. 　刘连新, 朱安龙, 陈炜, 等. 三氧化二砷对原发性肝癌的作用及其机理研究[J].中华外科杂志, 2005, 43(1): 33-36.
21. 　张莉, 王玲, 宋维华, 等.三氧化二砷通过升高细胞内钙离子浓度介导肺癌细胞凋亡[J]. 中华药理学通报, 2004, 20(8): 867-870.
22. 　魏虎来, 姚小健, 李宇宁, 等. 三氧化二砷抑制K562/ADM细胞P-糖蛋白表达并提高化疗药物的敏感性[J]. 中华血液学杂志, 2003, 24(1): 28-31.
23. 　王秀丽, 孔力, 赵瑾瑶, 等. 三氧化二砷逆转人乳腺癌MCF-7/ADM细胞耐药的机制研究[J]. 中华肿瘤杂志, 2002, 24(4): 339-343.
24. 　赵园园, 金锋, 梁军, 等. 三氧化二砷对人胃癌耐药细胞系SGC7901/ADM耐药逆转及凋亡诱导作用的探讨[J]. 中国肿瘤临床, 2005, 32(11): 611-613.
25. 　Li H, Zhu X, Zhang Y, et al. Arsenic trioxide exerts synergistic effects with cisplatin on non-small cell lung cancer cells via apoptosis induction[J]. J Exp Clin Cancer Res, 2009, 28: 110.
26. 　韩冰, 石玉枝, 雷建民. 三氧化二砷对肺腺癌细胞凋亡及肺耐药蛋白基因多药耐药蛋白基因表达的影响[J]. 中国实用内科杂志, 2005, 25(3): 243-244.

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A Clinical Study on Arsenic Trioxide Combined with Cisplatin in the Treatment of Malignant Pleural Effusion

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