Relationship between Serum Total Prostate-specific Antigen and Serum Growth Hormone in Men Aged over 60 years with Abnormal Weight_West China Medical Journal

Authors：

SUN Yan , LIAO Shuping , WU Weiqing.

Health Care Center, Shenzhen People’ s Hospital, the Second Affiliated Hospital, Jinan Medical University, Shenzhen, Guangdong 518020, P. R. China;

Corresponding author：

Keywords：

体质量指数; 血清前列腺特异性抗原; 血清生长激素; 老年男性

DOI：

10.7507/1002-0179.20130276

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目的　观察与分析体重异常老年男性血清前列腺特异性抗原（T-PSA）与生长激素（GH）水平及影响因素。方法　以2009年1月－2012年6月，血清GH＜5 ng/mL、血清T-PSA＜4.5 ng/mL的老年男性共296例作为观察对象，依据体质量指数分为低体重组、正常体重组、超重组及肥胖组。依据年龄分为60～64、65～69、70～74及≥75岁四组。测定296例入选对象的血清T-PSA及GH并进行分析。结果　随着年龄增长，血清T-PSA、GH渐增高。≥75岁年龄组血清T-PSA高于其他三组，差异无统计学意义（P＞0.05）。≥75岁年龄组血清GH高于其他三组，差异有统计学意义（P＜0.01）。超重组及肥胖组血清T-PSA低于正常体重组，差异有统计学意义（P＜0.01）。低体重组血清T-PSA稍低于正常体重组，差异无统计学意义（P＞0.05）。肥胖组血清GH低于超重及正常体重组，差异无统计学意义（P＞0.05）。低体重组血清GH低于正常体重组，差异无统计学意义（P＞0.05）。单因素相关分析显示血清T-PSA与年龄、GH正相关；与BMI负相关；与收缩压（SBP）、舒张压（DBP）、空腹血糖（FPG）及血脂不相关。血清GH与年龄、T-PSA、SBP、DBP正相关；与BMI、FPG及血脂不相关。校正年龄、BMI后，血清T-PSA与GH仍呈正相关。结论　随着年龄增长，老年男性血清T-PSA、GH渐增高。老年男性非肢端肥大症者血清T-PSA与血清GH水平及BMI有关联，血清GH水平较高者，血清T-PSA也较高；血清T-PSA与BMI负相关。

Citation： SUN Yan,LIAO Shuping,WU Weiqing.. Relationship between Serum Total Prostate-specific Antigen and Serum Growth Hormone in Men Aged over 60 years with Abnormal Weight. West China Medical Journal, 2013, 28(6): 884-887. doi: 10.7507/1002-0179.20130276 Copy

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11.	Untergasser G, Rumpold H, Hermann M, et al. Proliferative disorders of the aging human prostate: involvement of protein hormones and their receptors[J]. Exp Gerontol, 1999, 34(2): 275-287.
12.	Vermeulen A, Kaufman JM, Giagulli VA. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males[J]. J Clin Endocrinol Metab, 1996, 81(5): 1821-1826.
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1. 　Stenman UH, Leinonen J, Wm Z, et al. Prostate-specific antigen[J]. Semin Cancer Biol, 1999, 9(2): 83-93.
2. 　López Fontana C, Maselli ME, Pérez Elizalde R, et al. Obesity modifies prostatic specific antigen in men over 45 years[J]. Arch Esp Urol, 2001, 64(1): 35-42.
3. 　Ie RC, Monson JP, Chew SL, et al. Increased serum prostate-specific antigen in acromegaly–a cross-sectional study(abstract)[J]. J Endocrinol, 2000, 164: 128.
4. 　Jenkins PJ. Cancers associated with acromegaly[J]. Neuroendocrinology, 2006, 83: 218-223.
5. 　康冬梅, 林杨, 史虹莉. 生长激素在健康老年人中的抗衰老作用[J]. 国际内分泌代谢杂志, 2009, 29(2): 97-100.
6. 　Fuhrman B, Barba M, Schünemann HJ, et al. Basal growth hormone concentrations in blood and the risk for prostate cancer: a case-control study[J]. Prostate, 2005, 64(2): 109-115.
7. 　Beers MH, Berkow R, Bogin RM, et al. 默克老年病手册[M]// 陈灏珠, 王赞舜, 刘厚钰, 等, 译. 3版. 北京: 人民卫生出版社, 2002: 978-979.
8. 　叶任高, 陆再英. 内科学[M]. 6版. 北京: 人民卫生出版社, 2006: 841-845.
9. 　Cola A, Somma CD, Spiezia S, et al. Effect of growth hormone (GH)and/or testosterone replacement on the prostate in GH-deficient adult patients[J]. J Clin Endocrinol Metab, 2003, 88(1): 88-94.
10. 　朱海涛, 杨德同. 生长激素-胰岛素样生长因子与肿瘤关系研究进展(文献综述)[J]. 国外医学·外科学分册, 2002, 29(6): 337-340.
11. 　Untergasser G, Rumpold H, Hermann M, et al. Proliferative disorders of the aging human prostate: involvement of protein hormones and their receptors[J]. Exp Gerontol, 1999, 34(2): 275-287.
12. 　Vermeulen A, Kaufman JM, Giagulli VA. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males[J]. J Clin Endocrinol Metab, 1996, 81(5): 1821-1826.
13. 　胡志全, 章咏裳. PSA生物化学的研究进展[J].国外医学·泌尿系统分册, 1996, 16(5): 195-198.

West China Medical Journal

Relationship between Serum Total Prostate-specific Antigen and Serum Growth Hormone in Men Aged over 60 years with Abnormal Weight

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