Mismatch Negativity in Patients with Obsessive-Compulsive Disorder_West China Medical Journal

Authors：

ZHOU Jing , ZHENG Zhong , KUANG Weihong , ZHENG Bo ,  YANG Yanchun.

Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YANG Yanchun., Email: zhoujing2010jw@126.com

Keywords：

强迫症; 失匹配负波; 认知功能

DOI：

10.7507/1002-0179.20130278

Video：

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目的　探讨强迫症患者失匹配负波（MMN）的特征以及强迫症可能存在的认知功能障碍。方法　2010年9月－2012年3月将符合纳入标准的21例强迫症患者（OCD）进行耶鲁-布朗强迫症状量表（Y-BOCS）评分，使用日本Nihon Kohden脑诱发电位仪，记录21例OCD患者、21例性别相匹配的正常对照组进行Cz导联MMN潜伏期以及波幅的测定，并将数据进行t检验、相关性分析等处理。结果　强迫症与正常人组间比较存在MMN潜伏期（t=2.834，P=0.007）延长，波幅增高，但较正常对照组比较无统计学意义，MMN潜伏期与病程以及Y-BOCS评分无相关性。结论　强迫症患者在大脑处理信息的早期阶段存在认知的自动加工功能的损害，与病程长短以及病情的严重程度无明显相关性。MMN是检测认知功能比较敏感的指标。

Citation： ZHOU Jing,ZHENG Zhong,KUANG Weihong,ZHENG Bo,YANG Yanchun.. Mismatch Negativity in Patients with Obsessive-Compulsive Disorder. West China Medical Journal, 2013, 28(6): 891-893. doi: 10.7507/1002-0179.20130278 Copy

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1. 　魏景汉, 罗跃嘉. 事件相关电位原理与技术[M].北京: 科学出版社, 2010: 55-63.
2. 　罗跃嘉. 认知神经科学[M].北京: 北京大学出版社, 2006: 151.
3. 　Weissman MM, Bland RC, Canino GJ, et al. The cross national epidemiology of obsessive-compulsive disorder.The Cross National Collaborative Group[J]. J Clin Psych, 1994, 55(suppl): 5-10.
4. 　林永清, 谢蓓芳, 懂允夫. 氯氮平所致强迫症状的临床探讨[J]. 中国行为医学科学, 2002, 11(1): 52-53.
5. 　Näätänen R, Gaillard AW, Mantysalo S. Early selective-attention effect on evoked potential reinterpreted[J]. Acta Psychologica, 1978, 42(4): 313-329.
6. 　Lu YZ, Zong WB, Dong HZ, et al. Characterization of event-related potentials in obsessive compulsive disorder patients Comparison with depression and generalized anxiety disorder patients[J]. Neural Regeneration Research,2010, 5(12): 938-941.
7. 　Alain C, Woods DL, Knight RT. A distributed cortical network for auditory sensory memory in humans[J]. Brain Research, 1998, 812(1-2): 23-37.
8. 　Näätänen R, Paavilainen P, Rinne T, et al. The mismatch negativity (MMN) in basic research of central auditory processing: a review[J]. Clin Neuroph, 2007, 118(12): 2544-2590.
9. 　Czigler I, Sulykos I .Visual mismatch negativity to irrelevant changes is sensitive to task-relevant changes[J]. Neuropsychologia, 2010, 48(5): 1277-1282.
10. 　Kekoni J, Hämläinen H, Saarinen M, et al. Rate effect and mismatch responses in the somatosensory system: ERP-recordings in humans[J]. Biol Psych, 1997, 46(2): 125-142.
11. 　Pause BM, Krauel K.Chemosensory event-related potentials (CSERP) as a key to the psychology of odors[J]. Psychophysiology, 2000, 36(2): 105-122.
12. 　罗跃嘉, 吴宗耀, 魏景汉. 跨通路选择性注意脑内记忆痕迹的位置[J]. 第三军医大学学报, 1998, 20(4): 299-300.
13. 　Kohlmetz C, Altenmüller E, Schuppert M, et al. Deficit in automatic sound-change detection may underlie some music perception deficits after acute hemispheric stoke[J]. Neuropsychologia , 2001, 39(11): 1121-1124.
14. 　G ö lgeli A, Süer C, Ozesmi C, et al. The effect of sex differences on event-related potentials in young adults[J]. Intern J Neurosci, 1999, 99(1-4): 69-77.
15. 　Bodatsch M, Ruhrmann S, Wagner M, et al. Prediction of psychosis by mismatch negativity[J]. Biological Psychiatry , 2011, 69(10): 959-966.

West China Medical Journal

Mismatch Negativity in Patients with Obsessive-Compulsive Disorder

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