白细胞介素-33在自身免疫性疾病发病机制中的作用研究进展_West China Medical Journal

Authors：

张茹珂 ,  武永康

Corresponding author：

武永康, Email: 172539430@qq.com

Keywords：

白细胞介素33; 自身免疫性疾病; 研究进展

DOI：

10.7507/1002-0179.20130295

Video：

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自身免疫性疾病（AID）是由自身免疫应答引起的慢性炎症性疾病，该类疾病大多数原因不明，可能与遗传、感染及环境等因素有关。白细胞介素-33（IL-33）作为一种炎性细胞因子，通过IL-33/ST2信号通路调节免疫应答，从而参与疾病的发生和发展。AID的病程一般较长并反复迁延，临床治疗困难。研究IL-33与AID之间的关系，为AID致病机理的研究、疾病的诊断和治疗提供新的方向。

Citation： 张茹珂,武永康. 白细胞介素-33在自身免疫性疾病发病机制中的作用研究进展. West China Medical Journal, 2013, 28(6): 937-939. doi: 10.7507/1002-0179.20130295 Copy

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2.	Tominaga S. A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1receptor[J]. FEBS Lett, 1989, 258(2): 301-304．.
3.	Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex[J].Immunol, 2007, 179 (4): 2551-2555.
4.	Dinarello CA. An IL-l family member requires caspase-1 processing and signals through the ST2 receptor[J].Immunity, 2005, 23(5): 46l-462.
5.	Ali S, Huber M, Kollewe C, Bischoff SC, et al. IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells[J]. Proc Natl Acad Sci USA, 2007, 104(47): 18660-18665.
6.	Rank MA, Kobayashi T, Kozaki H, et al. IL-33-activated dendritic cells induce an atypical TH2-type response[J]. J Allergy Clin Immunol, 2009, 123(5): 1047-1054.
7.	Miller AM, Xu D, Asquith DL, et al. IL-33 reduces the development of atherosclerosis[J]. J Exp Med, 2008, 205(2): 339-346.
8.	Komai-Koma M, Gilchrist DS, McKenzie AN, et al. IL-33 activates B1 cells and exacerbates contact sensitivity[J]. J Immunol, 2011, 186(4): 2584-2591.
9.	Kurowska-Stolarska M, Kewin P, Murphy G, et al. IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4[J]. J Immunol, 2008, 181(7): 4780-4790.
10.	Xu D, Jiang HR, Kewin P, et a1. IL-33 exacerbates antigen-induced arthritis by activating mast cells[J]. Proc Natl Acad Sci USA, 2008, 105(31): l0913-109l8．.
11.	陈立辉, 张源潮, 孟红艳.检测早期类风湿关节炎(RA)患者血清中IL-33水平的临床意义[J].中国医药指南, 2012, 15(10): 424-425.
12.	刘玥,周迎春,黄钟.类风湿性关节炎患者IL-33水平变化与疾病严重程度的关系[J].医学检验与临床, 2012, 23(3): 54-56.
13.	黄鹤卿, 穆荣, 刘霞, 等．白细胞介素-33的测定及其与早期类风湿关节炎相关性的研究[J]. 中华风湿病学杂志, 2010, 14(7): 446-448.
14.	施巍宇, 杨再兴. 血清IL-33与系统性红斑狼疮的关系研究[J]. 现代检验医学杂志, 2010, 25(5): 5-7.
15.	Mok MY, Huang FP, Lp WK, et al. Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus[J]. Rheumatology (Oxford), 2010, 49(3): 520-527.
16.	Manetti M, Ibba-Manneschi L, Liakouli V, et al. The IL1-like cytokine IL 33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis[J]. Ann Rheum Dis, 2010, 69(3): 598-605.
17.	Yanaba K, Yoshizaki A, Asano Y, et al. Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis[J]. Clin Rheumatol, 2011, 30(6): 825-830.
18.	Manetti M, Guiducci S, Ceccarelli C, et al. Increased circulating levels of interleukin 33 in systemic sclerosis correlate with early disease stage and microvascular involvement[J]. Ann Rheum Dis, 2011, 70(10): 1876-1878.
19.	Rankin AL, Mumm JB, Murphy E, et al. IL-33 induces IL-13-dependent cutaneous fibrosis[J]. J Immunol, 2010, 184(3): 1526-1535.
20.	Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation[J]. J Clin Invest, 2006, 116(5): 1218-1222.
21.	IHan GW, Zeng LW, Liang CX, et al. Serum levels of IL-33 is increased in patients with ankylosing spondylitis[J]. Clin Rheumatol, 2011, 30(12): 1583-1588.
22.	ITalabot-Ayer D, McKee T, Gindre P, et al. Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis[J]. Joint Bone Spine, 2012, 79(1): 32-37.

1. 　Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-l receptor-related protein ST2 and induces T helper type 2-associated cytokines[J]. Immunity, 2005, 23(5): 479-490．.
2. 　Tominaga S. A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1receptor[J]. FEBS Lett, 1989, 258(2): 301-304．.
3. 　Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex[J].Immunol, 2007, 179 (4): 2551-2555.
4. 　Dinarello CA. An IL-l family member requires caspase-1 processing and signals through the ST2 receptor[J].Immunity, 2005, 23(5): 46l-462.
5. 　Ali S, Huber M, Kollewe C, Bischoff SC, et al. IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells[J]. Proc Natl Acad Sci USA, 2007, 104(47): 18660-18665.
6. 　Rank MA, Kobayashi T, Kozaki H, et al. IL-33-activated dendritic cells induce an atypical TH2-type response[J]. J Allergy Clin Immunol, 2009, 123(5): 1047-1054.
7. 　Miller AM, Xu D, Asquith DL, et al. IL-33 reduces the development of atherosclerosis[J]. J Exp Med, 2008, 205(2): 339-346.
8. 　Komai-Koma M, Gilchrist DS, McKenzie AN, et al. IL-33 activates B1 cells and exacerbates contact sensitivity[J]. J Immunol, 2011, 186(4): 2584-2591.
9. 　Kurowska-Stolarska M, Kewin P, Murphy G, et al. IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4[J]. J Immunol, 2008, 181(7): 4780-4790.
10. 　Xu D, Jiang HR, Kewin P, et a1. IL-33 exacerbates antigen-induced arthritis by activating mast cells[J]. Proc Natl Acad Sci USA, 2008, 105(31): l0913-109l8．.
11. 　陈立辉, 张源潮, 孟红艳.检测早期类风湿关节炎(RA)患者血清中IL-33水平的临床意义[J].中国医药指南, 2012, 15(10): 424-425.
12. 　刘玥,周迎春,黄钟.类风湿性关节炎患者IL-33水平变化与疾病严重程度的关系[J].医学检验与临床, 2012, 23(3): 54-56.
13. 　黄鹤卿, 穆荣, 刘霞, 等．白细胞介素-33的测定及其与早期类风湿关节炎相关性的研究[J]. 中华风湿病学杂志, 2010, 14(7): 446-448.
14. 　施巍宇, 杨再兴. 血清IL-33与系统性红斑狼疮的关系研究[J]. 现代检验医学杂志, 2010, 25(5): 5-7.
15. 　Mok MY, Huang FP, Lp WK, et al. Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus[J]. Rheumatology (Oxford), 2010, 49(3): 520-527.
16. 　Manetti M, Ibba-Manneschi L, Liakouli V, et al. The IL1-like cytokine IL 33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis[J]. Ann Rheum Dis, 2010, 69(3): 598-605.
17. 　Yanaba K, Yoshizaki A, Asano Y, et al. Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis[J]. Clin Rheumatol, 2011, 30(6): 825-830.
18. 　Manetti M, Guiducci S, Ceccarelli C, et al. Increased circulating levels of interleukin 33 in systemic sclerosis correlate with early disease stage and microvascular involvement[J]. Ann Rheum Dis, 2011, 70(10): 1876-1878.
19. 　Rankin AL, Mumm JB, Murphy E, et al. IL-33 induces IL-13-dependent cutaneous fibrosis[J]. J Immunol, 2010, 184(3): 1526-1535.
20. 　Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation[J]. J Clin Invest, 2006, 116(5): 1218-1222.
21. 　IHan GW, Zeng LW, Liang CX, et al. Serum levels of IL-33 is increased in patients with ankylosing spondylitis[J]. Clin Rheumatol, 2011, 30(12): 1583-1588.
22. 　ITalabot-Ayer D, McKee T, Gindre P, et al. Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis[J]. Joint Bone Spine, 2012, 79(1): 32-37.

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白细胞介素-33在自身免疫性疾病发病机制中的作用研究进展

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