临床抗菌药物滥用现状分析及对策研究_West China Medical Journal

Authors：

罗颖 ,  曾以萍

Corresponding author：

曾以萍, Email: luoying-v@163.com

Keywords：

抗菌药物; 滥用; 对策

DOI：

10.7507/1002-0179.20130350

Video：

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针对感染性疾病，临床上选择最佳抗菌药物用药方案对于实现疗效最大化和耐药性最小化至关重要。通过聚焦、分析临床上抗菌药物滥用现状及后果，旨在为临床更加合理使用抗菌药物对感染性疾病的预防、治疗和控制等提供参考。

Citation： 罗颖,曾以萍. 临床抗菌药物滥用现状分析及对策研究. West China Medical Journal, 2013, 28(7): 1127-1131. doi: 10.7507/1002-0179.20130350 Copy

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2.	Alanis AJ. Resistance to antibiotics: are we in the post-antibiotic era?[J]. Arch Med Res， 2005， 36(6): 697-705.
3.	李雪兰. 临床抗生素滥用的危害及应对措施[J]. 中国卫生产业， 2011， 8(10): 127.
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5.	Yezli S， Li H. Antibiotic resistance amongst healthcare-associated pathogens in China[J]. Int J Antimicrob Agents， 2012， 40(5): 389-397.
6.	徐银川. 临床抗生素滥用分析及对策[J]. 临床和实验医学杂志， 2007， 6(4): 183.
7.	李成玲，贾正民，王兴华，等. 从管理角度谈控制抗生素滥用[J]. 中国卫生质量管理， 2002， (2): 61.
8.	Lode HM. Rational antibiotic therapy and the position of ampicillin/sulbactam[J]. Int J Antimicrob Agents， 2008， 32(1): 10-28.
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10.	Okeke IN， Klugman KP， Bhutta ZA， et al. Antimicrobial resistance in developing countries Part II: strategies for containment[J]. Lancet Infect Dis， 2005， 5(9): 568-580.
11.	Tunger O， Dinc G， Ozbakkaloglu B， et al. Evaluation of rational antibiotic use[J]. Int J Antimicrob Agents， 2000， 15(2): 131-135.
12.	Zhang W， Shen X， Bergman U， et al. Drug utilisation 90% (DU90%) profiles of antibiotics in five Chinese children’s hospitals (2002–2006)[J]. Int J Antimicrob Agents， 2008， 32(3): 250-255.
13.	Dohmen PM. Antibiotic resistance in common pathogens reinforces the need to minimise surgical site infections[J]. J Hosp Infect， 2008， 70(S2): 15-20.
14.	Hedrick TL， Smith PW， Gazoni LM， et al. The appropriate use of antibiotics in surgery: a review of surgical infections[J]. Curr Probl Surg， 2007， 44(10): 635-675.
15.	French GL. The continuing crisis in antibiotic resistance[J]. Int J Antimicrob Agents， 2010， 36(S3): S3-S7.
16.	Hulscher ME， Grol RP， Meer JW. Antibiotic prescribing in hospitals: a social and behavioural scientific approach[J]. Lancet Infect Dis， 2010， 10(3): 167-175.
17.	Twomey C. Antibiotic resistance-an alarming health care issue[J]. AORN J， 2000， 72(1): 64-75.
18.	McDonalda MC， Lauderdale TL， Shiau YR， et al. The status of antimicrobial resistance in Taiwan among Gram-positive pathogens: the Taiwan Surveillance of Antimicrobial Resistance (TSAR) programme[J]. Int J Antimicrob Agents， 2004， 23(4): 362-370.
19.	Chong Y， Lee K. Present situation of antimicrobial resistance in Korea[J]. J Infect Chemother， 2000， 6(4): 189-195.
20.	崔兰贵. 抗生素滥用与医院内感染[J]. 武警医学， 2000， 11(2): 86-88.
21.	王骜锋. 合理使用抗生素控制医院感染[J]. 临床合理用药， 2011， 4(2B): 103.
22.	Rouveix B. Antibiotic safety assessment[J]. Int J Antimicrob Agents， 2003， 21(3): 215-221.
23.	张俊. 防止抗生素滥用的对策[J]. 药学与临床研究， 2008， 16(3): 230-232.
24.	Freire-Moran L， Aronsson B， Manz C， et al. Shortage of new antibiotics in development against multidrug-resistant bacteria--time to react is now[J]. Drug Resist Updat， 2011， 14(2): 118-124.
25.	Karlowsky JA， Sahm DF. Antibiotic resistance-is resistance detected by surveillance relevant to predicting resistance in the clinical setting?[J]. Curr Opin Pharmacol， 2002， 2(5): 1-6.
26.	Reynolds L， McKee M. Factors influencing antibiotic prescribing in China: an exploratory analysis[J]. Health Policy， 2009， 90(1): 32-36.
27.	Ho M， Hsiung CA， Yu HT， et al. Changes before and after a policy to restrict antimicrobial usage in upper respiratory infections in Taiwan[J]. Int J Antimicrob Agents， 2004， 23(5): 438-445.
28.	Mazzeo F， CapuanoA， Avolio A， et al. Hospital-based intensive monitoring of antibiotic-induced adverse events in a university hospital[J]. Pharm Res， 2005， 51(3): 269-274.
29.	Cagri BA， Ermertcan S， Hosgor-Limoncu M. Rational antibiotic use and academic staff[J]. Int J Antimicrob Agents， 2003， 21(1): 63-66.
30.	Currie J， Linb W， Zhang W. Patient knowledge and antibiotic abuse: evidence from an audit study in China [J]. J Health Econ， 2011， 30(5): 933-949.
31.	邱家学. 浅析我国抗生素滥用现状及危害[J]. 上海医药， 2006， 27(12): 555-556.

1. 　Erbay A， Colpan A， Bodur H， et al. Evaluation of antibiotic use in a hospital with an antibiotic restriction Policy[J]. Int J Antimicrob Agents， 2003， 21(4): 308-312.
2. 　Alanis AJ. Resistance to antibiotics: are we in the post-antibiotic era?[J]. Arch Med Res， 2005， 36(6): 697-705.
3. 　李雪兰. 临床抗生素滥用的危害及应对措施[J]. 中国卫生产业， 2011， 8(10): 127.
4. 　肖林添. 抗生素滥用原因分析及合理应用的建议[J]. 第一军医大学分校学报， 2001， 24(2): 142-143.
5. 　Yezli S， Li H. Antibiotic resistance amongst healthcare-associated pathogens in China[J]. Int J Antimicrob Agents， 2012， 40(5): 389-397.
6. 　徐银川. 临床抗生素滥用分析及对策[J]. 临床和实验医学杂志， 2007， 6(4): 183.
7. 　李成玲，贾正民，王兴华，等. 从管理角度谈控制抗生素滥用[J]. 中国卫生质量管理， 2002， (2): 61.
8. 　Lode HM. Rational antibiotic therapy and the position of ampicillin/sulbactam[J]. Int J Antimicrob Agents， 2008， 32(1): 10-28.
9. 　Karageorgopoulosa DE， Falagas ME. New antibiotics: optimal use in current clinical practice[J]. Int J Antimicrob Agents， 2009， 34(S4): S55-S62.
10. 　Okeke IN， Klugman KP， Bhutta ZA， et al. Antimicrobial resistance in developing countries Part II: strategies for containment[J]. Lancet Infect Dis， 2005， 5(9): 568-580.
11. 　Tunger O， Dinc G， Ozbakkaloglu B， et al. Evaluation of rational antibiotic use[J]. Int J Antimicrob Agents， 2000， 15(2): 131-135.
12. 　Zhang W， Shen X， Bergman U， et al. Drug utilisation 90% (DU90%) profiles of antibiotics in five Chinese children’s hospitals (2002–2006)[J]. Int J Antimicrob Agents， 2008， 32(3): 250-255.
13. 　Dohmen PM. Antibiotic resistance in common pathogens reinforces the need to minimise surgical site infections[J]. J Hosp Infect， 2008， 70(S2): 15-20.
14. 　Hedrick TL， Smith PW， Gazoni LM， et al. The appropriate use of antibiotics in surgery: a review of surgical infections[J]. Curr Probl Surg， 2007， 44(10): 635-675.
15. 　French GL. The continuing crisis in antibiotic resistance[J]. Int J Antimicrob Agents， 2010， 36(S3): S3-S7.
16. 　Hulscher ME， Grol RP， Meer JW. Antibiotic prescribing in hospitals: a social and behavioural scientific approach[J]. Lancet Infect Dis， 2010， 10(3): 167-175.
17. 　Twomey C. Antibiotic resistance-an alarming health care issue[J]. AORN J， 2000， 72(1): 64-75.
18. 　McDonalda MC， Lauderdale TL， Shiau YR， et al. The status of antimicrobial resistance in Taiwan among Gram-positive pathogens: the Taiwan Surveillance of Antimicrobial Resistance (TSAR) programme[J]. Int J Antimicrob Agents， 2004， 23(4): 362-370.
19. 　Chong Y， Lee K. Present situation of antimicrobial resistance in Korea[J]. J Infect Chemother， 2000， 6(4): 189-195.
20. 　崔兰贵. 抗生素滥用与医院内感染[J]. 武警医学， 2000， 11(2): 86-88.
21. 　王骜锋. 合理使用抗生素控制医院感染[J]. 临床合理用药， 2011， 4(2B): 103.
22. 　Rouveix B. Antibiotic safety assessment[J]. Int J Antimicrob Agents， 2003， 21(3): 215-221.
23. 　张俊. 防止抗生素滥用的对策[J]. 药学与临床研究， 2008， 16(3): 230-232.
24. 　Freire-Moran L， Aronsson B， Manz C， et al. Shortage of new antibiotics in development against multidrug-resistant bacteria--time to react is now[J]. Drug Resist Updat， 2011， 14(2): 118-124.
25. 　Karlowsky JA， Sahm DF. Antibiotic resistance-is resistance detected by surveillance relevant to predicting resistance in the clinical setting?[J]. Curr Opin Pharmacol， 2002， 2(5): 1-6.
26. 　Reynolds L， McKee M. Factors influencing antibiotic prescribing in China: an exploratory analysis[J]. Health Policy， 2009， 90(1): 32-36.
27. 　Ho M， Hsiung CA， Yu HT， et al. Changes before and after a policy to restrict antimicrobial usage in upper respiratory infections in Taiwan[J]. Int J Antimicrob Agents， 2004， 23(5): 438-445.
28. 　Mazzeo F， CapuanoA， Avolio A， et al. Hospital-based intensive monitoring of antibiotic-induced adverse events in a university hospital[J]. Pharm Res， 2005， 51(3): 269-274.
29. 　Cagri BA， Ermertcan S， Hosgor-Limoncu M. Rational antibiotic use and academic staff[J]. Int J Antimicrob Agents， 2003， 21(1): 63-66.
30. 　Currie J， Linb W， Zhang W. Patient knowledge and antibiotic abuse: evidence from an audit study in China [J]. J Health Econ， 2011， 30(5): 933-949.
31. 　邱家学. 浅析我国抗生素滥用现状及危害[J]. 上海医药， 2006， 27(12): 555-556.

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临床抗菌药物滥用现状分析及对策研究

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