Association between Interleukin-1α Polymorphisms and Risk of Intracranial Aaneurysm_West China Medical Journal

Authors：

SIMA Xiutian , LIU Hao , ZHOU Peizhi , HU Xin , ZHONG Weiying ,  YOUChao.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YOUChao., Email: simaxiutian@163.com

Keywords：

白细胞介素1α; 多态性; 颅内动脉瘤

DOI：

10.7507/1002-0179.20130528

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目的　探讨白细胞介素1α（IL-1α）基因多态性与颅内动脉瘤发生的关系。方法　以2010年6月－2012年3月145例颅内动脉瘤患者和181例正常对照者为研究对象，采用聚合酶链反应-限制性片段长度多态性检测IL-1α-889C/T和+4845G/T多态性，统计分析基因多态性与颅内动脉瘤的相关性。结果　IL-1α-889C/T位点：CT/TT基因型在颅内动脉瘤组中的频率为32.4%，显著高于其在对照组中的频率（21.5%），两组相比差异有统计学意义（χ2=4.90，P＜0.05）；T等位基因在颅内动脉瘤组中的频率为16.9%，显著高于其在对照组中的频率（10.8%），两组相比差异有统计学意义（χ2=5.17，P＜0.05）。IL-1α+4845G/T多态性在两组人群中的分布差异无统计学意义（P＞0.05）。结论　IL-1α -889C/T多态性与颅内动脉瘤的发病有关，-889T等位基因可能是颅内动脉瘤的遗传易感基因。

Citation： SIMA Xiutian,LIU Hao,ZHOU Peizhi,HU Xin,ZHONG Weiying,YOUChao.. Association between Interleukin-1α Polymorphisms and Risk of Intracranial Aaneurysm. West China Medical Journal, 2013, 28(11): 1668-1670. doi: 10.7507/1002-0179.20130528 Copy

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1. 　张国忠, 冯文峰, 黄理金, 等. 白细胞介素-1β基因多态性与颅内动脉瘤的关系[J]. 广东医学, 2008, 29(12): 2016-2018.
2. 　Slowik A, Borratynska A, Turaj W, et al. Interleukin 1beta-511 C/T polymorphism and risk of aneurysmal subarachnoid haemorrhage[J]. J Neurol Neurosurg Psychiat, 2006, 77(2): 279-280.
3. 　Wang B, Zhou S, Wang J, et al. Lack of association between interleukin-1a gene (IL-1a) C(-889) T variant and polycystic ovary syndrome in Chinese women[J]. Endocrine, 2009, 35(2): 198-203.
4. 　Archana PM, Salman AA, Kumar TS, et al. Association between interleukin-1 gene polymorphism and severity of chronic periodontitis in a south Indian population group[J]. J Indian Soc Periodontol, 2012, 16(2): 174-178.
5. 　Li L, Sima X, Bai P, et al. Interactions of miR-34b/c and TP53 polymorphisms on the risk of intracranial aneurysm[J]. Clin Dev Immunol, 2012: 567-586.
6. 　Hendryk S, Jarzab B, Josko J. Increase of the IL-1 beta and IL-6 levels in CSF in patients with vasospasm following aneurysmal SAH[J]. Neuro Endocrinol Lett, 2004, 25(1-2): 141-147.
7. 　Fontanella M, Rubino E, Crobeddu E, et al. Brain arteriovenous malformations are associated with interleukin-1 cluster gene polymorphisms[J]. Neurosurgery, 2012, 70(1): 12-17.
8. 　Fontanella M, Rainero I, Gallone S, et al. Interleukin-1 cluster gene polymorphisms and aneurysmal subarachnoid hemorrhage[J]. Neurosurgery, 2010, 66(6): 1058-1062.

West China Medical Journal

Association between Interleukin-1α Polymorphisms and Risk of Intracranial Aaneurysm

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