• 1. Department of Gynaecology, Shenzhen Xixiang People’s Hospital of Baoan District, Shenzhen, Guangdong 518102, P. R. China; 2. Department of Orthopedics, Shenzhen Baoan District Chinese Medicine Hospital, Shenzhen, Guangdong 518133, P. R. China;
XIANG Keming., Email: 952558249@qq.com
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目的  探讨独活寄生汤联合唑来膦酸治疗绝经后肝肾亏虚型骨质疏松症(PO)的疗效。 方法  选取2009年2月-2012年12月收治的210例绝经后肝肾亏虚型PO患者,且所有患者均愿意接受研究。采用随机对照试验法,将患者分为A、B、C 3组各70例。A组采用独活寄生汤联合唑来膦酸治疗;B组采用唑来膦酸治疗;C组采用独活寄生汤治疗。观察3组患者治疗前后骨密度、骨源性碱性磷酸酶(NBAP)、骨钙素(BGP)、雌二醇(E2)变化,疗效及不良反应。 结果  骨密度、NBAP、BGP、E2各项指标,治疗前3组患者比较差异无统计学意义(P>0.05);治疗后A组各项指标明显优于B组、C组(P<0.05);B组与C组对比,差异无统计学意义(P>0.05);治疗后A组总有效率为97.14%,与B组、C组对比,差异有统计学意义(P<0.05)。3组均未见严重不良反应。 结论  独活寄生汤联合唑来膦酸治疗绝经后肝肾亏虚型PO疗效显著,可有效提高患者骨密度、BGP、E2含量,降低骨源性碱性磷酸酶含量,缓解骨质疏松,且无严重不良反应发生,值得临床推广。

Citation: ZHUANG Qiong,XIANG Keming.. Curative Effect Observation of Duhuojisheng Decoction Combined with Zoledronic Acid in the Treatment of Menopausal Liver-Kidney Asthenia Osteoporosis. West China Medical Journal, 2013, 28(12): 1846-1849. doi: 10.7507/1002-0179.20130584 Copy

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