降钙素原对胰腺炎感染早期预测的研究进展_West China Medical Journal

Authors：

张晓鑫 ,  夏庆

Corresponding author：

夏庆, Email: zhangxxmed@163.com

Keywords：

急性胰腺炎; 降钙素原; 动物研究; 临床研究; 抗生素

DOI：

10.7507/1002-0179.20130617

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

急性胰腺炎为急腹症常见疾病，大多为轻症。胰腺坏死超过30%的患者中有30%～40%发生感染，其病情凶险，病死率高。因而早期对急性胰腺炎感染进行预测，识别感染患者并给予早期积极治疗至关重要。近年来降钙素原作为炎症及感染的标志物受到广泛关注，现对降钙素原预测急性胰腺炎感染的动物基础研究、临床研究和抗生素管理方面的研究进行综述。

Citation： 张晓鑫,夏庆. 降钙素原对胰腺炎感染早期预测的研究进展. West China Medical Journal, 2013, 28(12): 1952-1954. doi: 10.7507/1002-0179.20130617 Copy

1.	Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis-2012: revision of the Atlanta classification and definitions by international consensus[J]. Gut, 2013, 62(1): 102-111.
2.	Yousaf M, Mccallion K, Diamond T. Management of severe acute pancreatitis[J]. Br J Surg, 2003, 90(4): 407-420.
3.	Dambrauskas Z, Gulbinas A, Pundzius J, et al. Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing pancreatitis[J]. Medicina (Kaunas), 2007, 43(4): 291-300.
4.	Lavrentieva A, Papadopoulou S, Kioumis J, et al. PCT as a diagnostic and prognostic tool in burn patients. Whether time course has a role in monitoring sepsis treatment[J]. Burns, 2012, 38(3): 356-363.
5.	Cheval C, Timsit JF, Garrouste-Orgeas M, et al. Procalcitonin (PCT) is useful in predicting the bacterial origin of an acute circulatory failure in critically ill patients[J]. Intensive Care Med, 2000, 26(Suppl 2): S153-S158.
6.	Haasper C, Kalmbach M, Dikos GD, et al. Prognostic value of procalcitonin (PCT) and/or interleukin-6 (IL-6) plasma levels after multiple trauma for the development of multi organ dysfunction syndrome (MODS) or sepsis[J]. Technol Health Care, 2010, 18(2): 89-100.
7.	Nakamura A, Wada H, Ikejiri M, et al. Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit[J]. Shock, 2009, 31(6): 586-591.
8.	Snider JH, Nylen ES, Becker KL. Procalcitonin and its component peptides in systemic inflammation: immunochemical characterization[J]. J Investig Med, 1997, 45(9): 552-560.
9.	Morgenthaler NG, Struck J, Chancerelle Y, et al. Production of procalcitonin (PCT) in non-thyroidal tissue after LPS injection[J]. Horm Metab Res, 2003, 35(5): 290-295.
10.	Kylänpää-Bäck ML, Takala A, Kemppainen EA, et al. Procalcitonin, soluble interleukin-2 receptor, and soluble E-selectin in predicting the severity of acute pancreatitis[J]. Crit Care Med, 2001, 29(1): 63-69.
11.	Watkins RR, Lemonovich TL. Serum procalcitonin in the diagnosis and management of intra-abdominal infections[J]. Expert Rev Anti Infect Ther, 2012, 10(2): 197-205.
12.	田晓波, 吴薇, 陈锐, 等. 降钙素原和C反应蛋白检测在重症急性胰腺炎患者中的临床意义[J]. 临床荟萃, 2012, 27(14): 1251-1252.
13.	Nylen ES, Whang KT, Snider RH, et al. Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis[J]. Crit Care Med, 1998, 26(6): 1001-1006.
14.	Yonetci N, Sungurtekin U, Oruc N, et al. Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis?[J]. ANZ J Surg, 2004, 74(7): 591-595.
15.	Meisner M, Müller V, Khakpour Z, et al. Induction of procalcitonin and proinflammatory cytokines in an anhepatic baboon endotoxin shock model[J]. Shock, 2003, 19(2): 187-190.
16.	Riché FC, Cholley BP, Laisné MJ, et al. Inflammatory cytokines, C reactive protein, and procalcitonin as early predictors of necrosis infection in acute necrotizing pancreatitis[J]. Surgery, 2003, 133(3): 257-262.
17.	Mofidi R, Suttie SA, Patil PV, et al. The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: systematic review[J]. Surgery, 2009, 146(1): 72-81.
18.	Rau BM, Kemppainen EA, Gumbs AA, et al. Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT): a prospective international multicenter study[J]. Ann Surg, 2007, 245(5): 745-754.
19.	贾国葆, 吴建胜, 黄庆科, 等. 降钙素原和C反应蛋白在急性胰腺炎中的意义[J]. 中华内科杂志, 2005, 44(10): 781-782.
20.	Oláh A, Belágyi T, Issekutz A, et al. Value of procalcitonin quick test in the differentiation between sterile and infected forms of acute pancreatitis[J]. Hepatogastroenterology, 2005, 52(61): 243-245.
21.	Schuetz P, Amin DN, Greenwald JL. Role of procalcitonin in managing adult patients with respiratory tract infections[J]. Chest, 2012, 141(4): 1063-1073.
22.	Schroeder S, Hochreiter M, Koehler T, et al. Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study[J]. Langenbecks Arch Surg, 2009, 394(2): 221-226.
23.	Altunhan H, Annagür A, Örs R, et al. Procalcitonin measurement at 24 hours of age maybe helpful in the prompt diagnosis of early-onset neonatal sepsis[J]. Int J Infect Dis, 2011, 15(12): 854-858.
24.	Fritz S, Hartwig W, Lehmann R, et al. Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis[J]. Crit Care, 2008, 12(6): R141.
25.	Jiang K, Huang W, Yang XN, et al. Present and future of prophylactic antibiotics for severe acute pancreatitis[J]. World J Gastroenterol, 2012, 18(3): 279-284.
26.	De Waele JJ. A role for prophylactic antibiotics in necrotizing pancreatitis? Why we may never know the answer[J]. Crit Care, 2008, 12(6): 195.
27.	Qu R, Ji Y, Ling Y, et al. Procalcitonin is a good tool to guide duration of antibiotic therapy in patients with severe acute pancreatitis. A randomized prospective single-center controlled trial[J]. Saudi Med J, 2012, 33(4): 382-387.
28.	Dambrauskas Z, Gulbinas A, Pundzius J, et al. Value of routine clinical tests in predicting the development of infected pancreatic necrosis in severe acute pancreatitis[J]. Scand J Gastroenterol, 2007, 42(10): 1256-1264.

1. 　Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis-2012: revision of the Atlanta classification and definitions by international consensus[J]. Gut, 2013, 62(1): 102-111.
2. 　Yousaf M, Mccallion K, Diamond T. Management of severe acute pancreatitis[J]. Br J Surg, 2003, 90(4): 407-420.
3. 　Dambrauskas Z, Gulbinas A, Pundzius J, et al. Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing pancreatitis[J]. Medicina (Kaunas), 2007, 43(4): 291-300.
4. 　Lavrentieva A, Papadopoulou S, Kioumis J, et al. PCT as a diagnostic and prognostic tool in burn patients. Whether time course has a role in monitoring sepsis treatment[J]. Burns, 2012, 38(3): 356-363.
5. 　Cheval C, Timsit JF, Garrouste-Orgeas M, et al. Procalcitonin (PCT) is useful in predicting the bacterial origin of an acute circulatory failure in critically ill patients[J]. Intensive Care Med, 2000, 26(Suppl 2): S153-S158.
6. 　Haasper C, Kalmbach M, Dikos GD, et al. Prognostic value of procalcitonin (PCT) and/or interleukin-6 (IL-6) plasma levels after multiple trauma for the development of multi organ dysfunction syndrome (MODS) or sepsis[J]. Technol Health Care, 2010, 18(2): 89-100.
7. 　Nakamura A, Wada H, Ikejiri M, et al. Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit[J]. Shock, 2009, 31(6): 586-591.
8. 　Snider JH, Nylen ES, Becker KL. Procalcitonin and its component peptides in systemic inflammation: immunochemical characterization[J]. J Investig Med, 1997, 45(9): 552-560.
9. 　Morgenthaler NG, Struck J, Chancerelle Y, et al. Production of procalcitonin (PCT) in non-thyroidal tissue after LPS injection[J]. Horm Metab Res, 2003, 35(5): 290-295.
10. 　Kylänpää-Bäck ML, Takala A, Kemppainen EA, et al. Procalcitonin, soluble interleukin-2 receptor, and soluble E-selectin in predicting the severity of acute pancreatitis[J]. Crit Care Med, 2001, 29(1): 63-69.
11. 　Watkins RR, Lemonovich TL. Serum procalcitonin in the diagnosis and management of intra-abdominal infections[J]. Expert Rev Anti Infect Ther, 2012, 10(2): 197-205.
12. 　田晓波, 吴薇, 陈锐, 等. 降钙素原和C反应蛋白检测在重症急性胰腺炎患者中的临床意义[J]. 临床荟萃, 2012, 27(14): 1251-1252.
13. 　Nylen ES, Whang KT, Snider RH, et al. Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis[J]. Crit Care Med, 1998, 26(6): 1001-1006.
14. 　Yonetci N, Sungurtekin U, Oruc N, et al. Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis?[J]. ANZ J Surg, 2004, 74(7): 591-595.
15. 　Meisner M, Müller V, Khakpour Z, et al. Induction of procalcitonin and proinflammatory cytokines in an anhepatic baboon endotoxin shock model[J]. Shock, 2003, 19(2): 187-190.
16. 　Riché FC, Cholley BP, Laisné MJ, et al. Inflammatory cytokines, C reactive protein, and procalcitonin as early predictors of necrosis infection in acute necrotizing pancreatitis[J]. Surgery, 2003, 133(3): 257-262.
17. 　Mofidi R, Suttie SA, Patil PV, et al. The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: systematic review[J]. Surgery, 2009, 146(1): 72-81.
18. 　Rau BM, Kemppainen EA, Gumbs AA, et al. Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT): a prospective international multicenter study[J]. Ann Surg, 2007, 245(5): 745-754.
19. 　贾国葆, 吴建胜, 黄庆科, 等. 降钙素原和C反应蛋白在急性胰腺炎中的意义[J]. 中华内科杂志, 2005, 44(10): 781-782.
20. 　Oláh A, Belágyi T, Issekutz A, et al. Value of procalcitonin quick test in the differentiation between sterile and infected forms of acute pancreatitis[J]. Hepatogastroenterology, 2005, 52(61): 243-245.
21. 　Schuetz P, Amin DN, Greenwald JL. Role of procalcitonin in managing adult patients with respiratory tract infections[J]. Chest, 2012, 141(4): 1063-1073.
22. 　Schroeder S, Hochreiter M, Koehler T, et al. Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study[J]. Langenbecks Arch Surg, 2009, 394(2): 221-226.
23. 　Altunhan H, Annagür A, Örs R, et al. Procalcitonin measurement at 24 hours of age maybe helpful in the prompt diagnosis of early-onset neonatal sepsis[J]. Int J Infect Dis, 2011, 15(12): 854-858.
24. 　Fritz S, Hartwig W, Lehmann R, et al. Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis[J]. Crit Care, 2008, 12(6): R141.
25. 　Jiang K, Huang W, Yang XN, et al. Present and future of prophylactic antibiotics for severe acute pancreatitis[J]. World J Gastroenterol, 2012, 18(3): 279-284.
26. 　De Waele JJ. A role for prophylactic antibiotics in necrotizing pancreatitis? Why we may never know the answer[J]. Crit Care, 2008, 12(6): 195.
27. 　Qu R, Ji Y, Ling Y, et al. Procalcitonin is a good tool to guide duration of antibiotic therapy in patients with severe acute pancreatitis. A randomized prospective single-center controlled trial[J]. Saudi Med J, 2012, 33(4): 382-387.
28. 　Dambrauskas Z, Gulbinas A, Pundzius J, et al. Value of routine clinical tests in predicting the development of infected pancreatic necrosis in severe acute pancreatitis[J]. Scand J Gastroenterol, 2007, 42(10): 1256-1264.

Previous Article
索拉非尼在中晚期肝癌的临床应用进展
Next Article
静脉滴注甘露醇注射液所致静脉炎的预防

West China Medical Journal

降钙素原对胰腺炎感染早期预测的研究进展

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content