Pathogens and Antibiotic Resistance Analysis of Primary Nephrotic Syndrome Complicated with Urinary Tract Infection in Children_West China Medical Journal

Authors：

 LIBo , PENGQian , ZHENGZhi , CHENWan-yuan

Department of Pediatrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

Keywords：

Child; Primary nephrotic syndrome; Urinary tract infection; Pathogens; Resistance

DOI：

10.7507/1002-0179.20140015

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Objective To investigate the distribution and antibiotic resistance of pathogens isolated from children with primary nephrotic syndrome (PNS) complicated with urinary tract infection (UTI), so as to provide references for reasonable use of anti-infective agents in clinical practice. Methods A total of 218 eligible patients who hospitalized in our department between January 2009 and December 2012 were included, and the data of distribution and antibiotic resistance of pathogens were analyzed retrospectively. Results In this cohort, asymptomatic UTI in children with PNS accounted for 75.7% (165/218). And a total of 249 pathogenic strains were isolated and cultivated. The main pathogens of those subjects were G^- bacilli, accounting for 64.3% (160/249), and 63.8% (102/160) of G^- bacilli was Escherichia coli (E.coli); G⁺ cocci accounted for 31.7% (79/249), and 59.5% (47/79) of them was Enterococci faecalis; and fungi accounted for only 4.0%. Drug-susceptibility testing suggested that E.coli had a high resistance rate to hydroxyl ampicillin, cefazolin and ceftriaxone (>50%), but had lower resistance rate to cefoperazone/sulbactam and imipenem (<10%). Enterococci faecalis had a high resistance rate to rifampicin (74.6%), but had low resistance to vancomycin and linezolid (<10%). Conclusion Asymptomatic UTI is common in children with PNS. E.coli is the major pathogen and the proportion of enterococcus infection is also not low, and these pathogens have a high antibiotic resistance and most of them are multi-resistant.

Citation： LIBo, PENGQian, ZHENGZhi, CHENWan-yuan. Pathogens and Antibiotic Resistance Analysis of Primary Nephrotic Syndrome Complicated with Urinary Tract Infection in Children. West China Medical Journal, 2014, 29(1): 54-56. doi: 10.7507/1002-0179.20140015 Copy

1.	刘丽辉. 儿童原发性肾病综合征复发危险因素分析[J]. 临床医学工程, 2012, 19(8):1313-1314.
2.	李志娟, 王墨. 61例小儿原发性肾病综合征合并尿路感染的病原菌及耐药性分析[J]. 中国药业, 2010, 19(9):7-9.
3.	郭德明. 无症状性菌尿对原发性肾病综合征疗效的影响[J]. 实用儿科临床杂志, 2001, 16(5):293-294.
4.	高晓洁, 李永柏, 赵维玲, 等. 儿童泌尿感染的临床特点、病原菌分布及耐药性分析[J].实用儿科临床杂志, 2010, 25(5):330-332.
5.	中华医学会儿科学分会肾脏病学组. 小儿肾小球疾病的临床分类、诊断及治疗[J]. 中华儿科杂志, 2001, 39(12):746-747.
6.	胡亚美, 江载芳. 诸福棠实用儿科学[M]. 7版. 北京:人民卫生出版社, 2002:1667-1672.
7.	Adedoyin OT, Ojuawo IA, Odimayo MS, et al. Urinary tract infections in children with primary nephrotic syndrome and acute glomerulonephritis[J]. West Afr J Med, 2010, 29(4):235-238.
8.	关富山. 儿童肾病综合征医院感染的病因与预防措施[J]. 中国现代儿科志, 2005, 2(3):249-250.
9.	伍尚平, 陈仕银, 樊均明, 等. 原发性肾病综合征合并尿路感染的病原菌及耐药性分析[J]. 四川省卫生管理干部学院学报, 2005, 24(4):272-273.
10.	宋少娜, 张碧丽, 王文红, 等. 97例肾病综合征合并尿路感染患儿的病原菌分布及药敏分析[J]. 中国当代儿科杂志, 2012, 14(9):657-660.
11.	徐锦雯, 张唯真, 张爱华, 等. 儿童肾病综合征伴尿路感染的临床分析[J]. 南京医科大学学报·自然科学版, 2010, 30(4):530-532.
12.	舒雪芹, 薛利霞, 石娜, 等. 产ESBLs大肠埃希氏菌医院尿路感染调查及预防护理措施[J]. 现代预防医学, 2006, 33(3):323-324.

1. 刘丽辉. 儿童原发性肾病综合征复发危险因素分析[J]. 临床医学工程, 2012, 19(8):1313-1314.
2. 李志娟, 王墨. 61例小儿原发性肾病综合征合并尿路感染的病原菌及耐药性分析[J]. 中国药业, 2010, 19(9):7-9.
3. 郭德明. 无症状性菌尿对原发性肾病综合征疗效的影响[J]. 实用儿科临床杂志, 2001, 16(5):293-294.
4. 高晓洁, 李永柏, 赵维玲, 等. 儿童泌尿感染的临床特点、病原菌分布及耐药性分析[J].实用儿科临床杂志, 2010, 25(5):330-332.
5. 中华医学会儿科学分会肾脏病学组. 小儿肾小球疾病的临床分类、诊断及治疗[J]. 中华儿科杂志, 2001, 39(12):746-747.
6. 胡亚美, 江载芳. 诸福棠实用儿科学[M]. 7版. 北京:人民卫生出版社, 2002:1667-1672.
7. Adedoyin OT, Ojuawo IA, Odimayo MS, et al. Urinary tract infections in children with primary nephrotic syndrome and acute glomerulonephritis[J]. West Afr J Med, 2010, 29(4):235-238.
8. 关富山. 儿童肾病综合征医院感染的病因与预防措施[J]. 中国现代儿科志, 2005, 2(3):249-250.
9. 伍尚平, 陈仕银, 樊均明, 等. 原发性肾病综合征合并尿路感染的病原菌及耐药性分析[J]. 四川省卫生管理干部学院学报, 2005, 24(4):272-273.
10. 宋少娜, 张碧丽, 王文红, 等. 97例肾病综合征合并尿路感染患儿的病原菌分布及药敏分析[J]. 中国当代儿科杂志, 2012, 14(9):657-660.
11. 徐锦雯, 张唯真, 张爱华, 等. 儿童肾病综合征伴尿路感染的临床分析[J]. 南京医科大学学报·自然科学版, 2010, 30(4):530-532.
12. 舒雪芹, 薛利霞, 石娜, 等. 产ESBLs大肠埃希氏菌医院尿路感染调查及预防护理措施[J]. 现代预防医学, 2006, 33(3):323-324.

West China Medical Journal

Pathogens and Antibiotic Resistance Analysis of Primary Nephrotic Syndrome Complicated with Urinary Tract Infection in Children

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