内源性神经干细胞在中枢神经系统创伤修复中的研究进展_West China Medical Journal

Authors：

 梁锐超 ,  方芳

四川大学华西医院神经外科（成都，610041）;

Corresponding author：

方芳, Email: merrisn@hotmail.com

Keywords：

内源性神经干细胞; 中枢神经系统; 创伤; 修复

DOI：

10.7507/1002-0179.20140047

Video：

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Abstract Full text Figures/Tables Video References Cited by

自上世纪60年代发现神经再生现象以来，神经科学领域专家学者做了大量关于神经再生的研究，包括体外分离培养神经干细胞并探索神经干细胞增殖、分化、迁移的规律和机制，以期最终应用于中枢神经系统疾病的治疗，如干细胞移植和神经生长因子诱导治疗等。脑脊髓损伤是死残率高、经济负担重的临床常见疾患，现撰文主要就目前神经科学领域有关调控内源性神经干细胞参与脑脊髓损伤神经再生修复的研究进展作一综述。

Citation： 梁锐超, 方芳. 内源性神经干细胞在中枢神经系统创伤修复中的研究进展. West China Medical Journal, 2014, 29(1): 150-154. doi: 10.7507/1002-0179.20140047 Copy

1.	Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats[J]. J Comp Neurol, 1965, 124(3):319-335.
2.	Goldman SA, Nottebohm F. Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain[J]. Proc Natl Acad Sci USA, 1983, 80(8):2390-2394.
3.	Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system[J]. Science, 1992, 255(5052):1707-1710.
4.	Weiss S, Dunne C, Hewson J, et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis[J]. J Neurosci, 1996, 16(23):7599-7609.
5.	Zheng W, Zhuge Q, Zhong M, et al. Neurogenesis in adult human brain after traumatic brain injury[J]. J Neurotrauma, 2013, 30(22):1872-1880.
6.	Jordan JD, Ma DK, Ming GL, et al. Cellular niches for endogenous neural stem cells in the adult brain[J]. CNS Neurol Disord Drug Targets, 2007, 6(5):336-341.
7.	Baumann K. Stem cells:holding tight onto the niche[J]. Nat Rev Mol Cell Biol, 2012, 13(5):278-279.
8.	Imura T. Stem cells and cancer stem cells:Vol 4[M]. Dordrecht:Springer, 2012:77-84.
9.	Yuan Q, Liu H, Wu X, et al. Characteristics of acute treatment costs of traumatic brain injury in Eastern China a multi-centre prospective observational study[J]. Injury, 2012, 43(12):2094-2099.
10.	Wislet-Gendebien S, Poulet C, Neirinckx V, et al. In vivo tumorigenesis was observed after injection of in vitro expanded neural crest stem cells isolated from adult bone marrow[J]. PLoS One, 2012, 7(10):e46425.
11.	Kowalczyk T, Pontious A, Englund C, et al. Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex[J]. Cereb Cortex, 2009, 19(10):2439-2450.
12.	刘靖, 曲静, 徐晓静, 等. 神经干细胞迁移的研究进展[J]. 中国细胞生物学学报, 2012, 34(3):201-211.
13.	Rao MS, Carpenter M, Vemuri MC. Neural development and stem cells[M]. 3ed. New York:Springer, 2012:289-328.
14.	顾恩妍, 哈福, 李林凤, 等. 神经干细胞的鉴定方法[J]. 中国组织工程研究与临床康复, 2009, 13(10):1947-1950.
15.	Chojnacki A, Cusulin C, Weiss S. Adult periventricular neural stem cells:outstanding progress and outstanding issues[J]. Dev Neurobiol, 2012, 72(7):972-989.
16.	Ma DK, Ma BD, Ming GL, et al. Adult neural stem cells in the mammalian central nervous system[J]. Cell Res, 2009, 19(6):672-682.
17.	Sanai N, Nguyen T, Ihrie RA, et al. Corridors of migrating neurons in the human brain and their decline during infancy[J]. Nature, 2011, 478(7369):382-386.
18.	Chambers RA, Potenza MN, Hoffman RE, et al. Simulated apoptosis/neurogenesis regulates learning and memory capabilities of adaptive neural networks[J]. Neuropsychopharmacology, 2004, 29(4):747-758.
19.	Sun W, Kim H, Moon Y. Control of neuronal migration through rostral migration stream in mice[J]. Anat Cell Biol, 2010, 43(4):269-279.
20.	Khodosevich K, Monyer H. Signaling in migrating neurons:from molecules to networks[J]. Front Neurosci, 2011, 5:28.
21.	Deng W, Aimone JB, Gage FH. New neurons and new memories:how does adult hippocampal neurogenesis affect learning and memory?[J]. Nat Rev Neurosci, 2010, 11(5):339-350.
22.	Sabelström H, Stenudd M, Frisén J. Neural stem cells in the adult spinal cord[J/OL]. Exp Neurol, (2013-01-30)[2013-04-01]. http://dx.doi.org/10.1016/j.expneuro/.2013.01.026.
23.	Alfaro-Cervello C, Soriano-Navarro M, Mirzadeh Z, et al. Biciliated ependymal cell proliferation contributes to spinal cord growth[J]. J Comp Neurol, 2012, 520(15):3528-3552.
24.	Santos T, Maia J, Agasse F, et al. Nanomedicine boosts neurogenesis:new strategies for brain repair[J]. Integr Biol (Camb), 2012, 4(9):973-981.
25.	Bye N, Carron S, Han X, et al. Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats[J]. J Neurosci Res, 2011, 89(7):986-1000.
26.	Zhao W, Huan L, Zhao Y, et al. Endogenous adult neurogenesis and cognitive function recovery following traumatic brain injury in the rat hippocampus[J]. Neural Regen Res, 2010, 5(9):645-650.
27.	Sorci G, Bianchi R, Riuzzi F, et al. S100B protein, a damage-associated molecular pattern protein in the brain and heart, and beyond[J/OL]. Cardiovasc Psychiatry Neurol, 2010,[2010-08-18]. http://www.ncbi.n/m.nih.gov/pubmeel/20827421.
28.	Gerrard-Morris A, Taylor HG, Yeates KO, et al. Cognitive development after traumatic brain injury in young children[J]. J Int Neuropsychol Soc, 2010, 16(1):157-168.
29.	Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice[J]. Nature, 2000, 405(6789):951-955.
30.	Lledo PM, Alonso M, Grubb MS. Adult neurogenesis and functional plasticity in neuronal circuits[J]. Nat Rev Neurosci, 2006, 7(3):179-193.
31.	Sonksen P, Hillier S. A patient's journey spinal cord injury[J/OL]. BMJ, 2010(340):b5204[2013-04-16]. http://dx.doi.org/10.1136/bmj.b5204.
32.	Shah SK, Jimenez F, Walker PA. Progenitor cell therapy for neurological injury[M]. Totowa:Humana Press, 2011:69-95.
33.	陈太邦, 赵建华. 内源性NSPCs与脊髓损伤治疗的研究进展[J]. 创伤外科杂志, 2012, 14(4):373-376.
34.	Barnabé-Heider F, Göritz C, Sabelström H, et al. Origin of new glial cells in intact and injured adult spinal cord[J]. Cell Stem Cell, 2010, 7(4):470-482.
35.	Johanson C, Stopa E, Baird A, et al. Traumatic brain injury and recovery mechanisms:peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus[J]. J Neural Transm, 2011, 118(1):115-133.
36.	Åberg D. Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis[J]. Endocr Dev, 2010(17):63-76.
37.	Parent JM, Murphy GG. Mechanisms and functional significance of aberrant seizure induced hippocampal neurogenesis[J]. Epilepsia, 2008, 49(s5):19-25.
38.	Zhang L, Yang X, Yang S, et al. The Wnt/β-catenin signaling pathway in the adult neurogenesis[J]. Eur J Neurosci, 2011, 33(1):1-8.
39.	Ables JL, Breunig JJ, Eisch AJ, et al. Not(ch) just development:Notch signalling in the adult brain[J]. Nat Rev Neurosci, 2011, 12(5):269-283.

1. Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats[J]. J Comp Neurol, 1965, 124(3):319-335.
2. Goldman SA, Nottebohm F. Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain[J]. Proc Natl Acad Sci USA, 1983, 80(8):2390-2394.
3. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system[J]. Science, 1992, 255(5052):1707-1710.
4. Weiss S, Dunne C, Hewson J, et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis[J]. J Neurosci, 1996, 16(23):7599-7609.
5. Zheng W, Zhuge Q, Zhong M, et al. Neurogenesis in adult human brain after traumatic brain injury[J]. J Neurotrauma, 2013, 30(22):1872-1880.
6. Jordan JD, Ma DK, Ming GL, et al. Cellular niches for endogenous neural stem cells in the adult brain[J]. CNS Neurol Disord Drug Targets, 2007, 6(5):336-341.
7. Baumann K. Stem cells:holding tight onto the niche[J]. Nat Rev Mol Cell Biol, 2012, 13(5):278-279.
8. Imura T. Stem cells and cancer stem cells:Vol 4[M]. Dordrecht:Springer, 2012:77-84.
9. Yuan Q, Liu H, Wu X, et al. Characteristics of acute treatment costs of traumatic brain injury in Eastern China a multi-centre prospective observational study[J]. Injury, 2012, 43(12):2094-2099.
10. Wislet-Gendebien S, Poulet C, Neirinckx V, et al. In vivo tumorigenesis was observed after injection of in vitro expanded neural crest stem cells isolated from adult bone marrow[J]. PLoS One, 2012, 7(10):e46425.
11. Kowalczyk T, Pontious A, Englund C, et al. Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex[J]. Cereb Cortex, 2009, 19(10):2439-2450.
12. 刘靖, 曲静, 徐晓静, 等. 神经干细胞迁移的研究进展[J]. 中国细胞生物学学报, 2012, 34(3):201-211.
13. Rao MS, Carpenter M, Vemuri MC. Neural development and stem cells[M]. 3ed. New York:Springer, 2012:289-328.
14. 顾恩妍, 哈福, 李林凤, 等. 神经干细胞的鉴定方法[J]. 中国组织工程研究与临床康复, 2009, 13(10):1947-1950.
15. Chojnacki A, Cusulin C, Weiss S. Adult periventricular neural stem cells:outstanding progress and outstanding issues[J]. Dev Neurobiol, 2012, 72(7):972-989.
16. Ma DK, Ma BD, Ming GL, et al. Adult neural stem cells in the mammalian central nervous system[J]. Cell Res, 2009, 19(6):672-682.
17. Sanai N, Nguyen T, Ihrie RA, et al. Corridors of migrating neurons in the human brain and their decline during infancy[J]. Nature, 2011, 478(7369):382-386.
18. Chambers RA, Potenza MN, Hoffman RE, et al. Simulated apoptosis/neurogenesis regulates learning and memory capabilities of adaptive neural networks[J]. Neuropsychopharmacology, 2004, 29(4):747-758.
19. Sun W, Kim H, Moon Y. Control of neuronal migration through rostral migration stream in mice[J]. Anat Cell Biol, 2010, 43(4):269-279.
20. Khodosevich K, Monyer H. Signaling in migrating neurons:from molecules to networks[J]. Front Neurosci, 2011, 5:28.
21. Deng W, Aimone JB, Gage FH. New neurons and new memories:how does adult hippocampal neurogenesis affect learning and memory?[J]. Nat Rev Neurosci, 2010, 11(5):339-350.
22. Sabelström H, Stenudd M, Frisén J. Neural stem cells in the adult spinal cord[J/OL]. Exp Neurol, (2013-01-30)[2013-04-01]. http://dx.doi.org/10.1016/j.expneuro/.2013.01.026.
23. Alfaro-Cervello C, Soriano-Navarro M, Mirzadeh Z, et al. Biciliated ependymal cell proliferation contributes to spinal cord growth[J]. J Comp Neurol, 2012, 520(15):3528-3552.
24. Santos T, Maia J, Agasse F, et al. Nanomedicine boosts neurogenesis:new strategies for brain repair[J]. Integr Biol (Camb), 2012, 4(9):973-981.
25. Bye N, Carron S, Han X, et al. Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats[J]. J Neurosci Res, 2011, 89(7):986-1000.
26. Zhao W, Huan L, Zhao Y, et al. Endogenous adult neurogenesis and cognitive function recovery following traumatic brain injury in the rat hippocampus[J]. Neural Regen Res, 2010, 5(9):645-650.
27. Sorci G, Bianchi R, Riuzzi F, et al. S100B protein, a damage-associated molecular pattern protein in the brain and heart, and beyond[J/OL]. Cardiovasc Psychiatry Neurol, 2010,[2010-08-18]. http://www.ncbi.n/m.nih.gov/pubmeel/20827421.
28. Gerrard-Morris A, Taylor HG, Yeates KO, et al. Cognitive development after traumatic brain injury in young children[J]. J Int Neuropsychol Soc, 2010, 16(1):157-168.
29. Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice[J]. Nature, 2000, 405(6789):951-955.
30. Lledo PM, Alonso M, Grubb MS. Adult neurogenesis and functional plasticity in neuronal circuits[J]. Nat Rev Neurosci, 2006, 7(3):179-193.
31. Sonksen P, Hillier S. A patient's journey spinal cord injury[J/OL]. BMJ, 2010(340):b5204[2013-04-16]. http://dx.doi.org/10.1136/bmj.b5204.
32. Shah SK, Jimenez F, Walker PA. Progenitor cell therapy for neurological injury[M]. Totowa:Humana Press, 2011:69-95.
33. 陈太邦, 赵建华. 内源性NSPCs与脊髓损伤治疗的研究进展[J]. 创伤外科杂志, 2012, 14(4):373-376.
34. Barnabé-Heider F, Göritz C, Sabelström H, et al. Origin of new glial cells in intact and injured adult spinal cord[J]. Cell Stem Cell, 2010, 7(4):470-482.
35. Johanson C, Stopa E, Baird A, et al. Traumatic brain injury and recovery mechanisms:peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus[J]. J Neural Transm, 2011, 118(1):115-133.
36. Åberg D. Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis[J]. Endocr Dev, 2010(17):63-76.
37. Parent JM, Murphy GG. Mechanisms and functional significance of aberrant seizure induced hippocampal neurogenesis[J]. Epilepsia, 2008, 49(s5):19-25.
38. Zhang L, Yang X, Yang S, et al. The Wnt/β-catenin signaling pathway in the adult neurogenesis[J]. Eur J Neurosci, 2011, 33(1):1-8.
39. Ables JL, Breunig JJ, Eisch AJ, et al. Not(ch) just development:Notch signalling in the adult brain[J]. Nat Rev Neurosci, 2011, 12(5):269-283.

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内源性神经干细胞在中枢神经系统创伤修复中的研究进展

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