棕色脂肪组织与肥胖研究进展_West China Medical Journal

Authors：

 候丽琼 ,  赵铁耘 , 张伊祎

四川大学华西医院内分泌代谢科（成都，610041）;

Corresponding author：

赵铁耘, Email: hjh560205@263.net

Keywords：

棕色脂肪组织; 脂代谢; 肥胖

DOI：

10.7507/1002-0179.20140051

Video：

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Abstract Full text Figures/Tables Video References Cited by

棕色脂肪组织（BAT）是一个产热器官，在人类新生儿和冬眠动物的非战栗产热中起关键作用。以往研究认为成人体内没有BAT，然而最近研究表明成年人体内存在BAT，且具有代谢活性。BAT能清除体内过多的脂肪，进入BAT的脂肪酸能诱导BAT的活性和质量，脂肪酸既是BAT产热的产物，又是BAT的激活剂。而通过增加人体内BAT的活性和质量来消耗多余的能量可能成为降低血中甘油三酯和治疗肥胖的一个有效的方法。现对BAT的功能、调控机制，BAT与脂代谢及肥胖症的关系作一综述。

Citation： 候丽琼, 赵铁耘, 张伊祎. 棕色脂肪组织与肥胖研究进展. West China Medical Journal, 2014, 29(1): 168-171. doi: 10.7507/1002-0179.20140051 Copy

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1. Flegal KM, Carroll MD, Kit BK, et al. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010[J]. JAMA, 2012, 307(5):491-497.
2. Kastorini CM, Milionis HJ, Ioannidi A, et al. Adherence to the Mediterranean diet in relation to acute coronary syndrome or stroke nonfatal events:a comparative analysis of a case/case-control study[J]. Am Heart J, 2011, 162(4):717-724.
3. Enerbäck S. The origins of brown adipose tissue[J]. N Engl J Med, 2009, 360(19):2012-2023.
4. Seale P, Kajimura S, Yang W, et al. Transcriptional control of brown fat determination by PRDM16[J]. Cell Metab, 2007, 6(1):38-54.
5. Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch[J]. Nature, 2008, 454(7207):961-967.
6. Schulz TJ, Huang TL, Tran TT, et al. Identification of inolucible brown adipocyee progenitors resicling in skeletal muscle and white fat[J]. Proc Natl Acact Sci USA, 2011, 108(1):143-148.
7. Dlasková A, Clarke KJ, Porter RK. The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue[J]. Biochim Biophys Acta, 2010, 1797(8):1470-1476.
8. Tseng YH, Kokkotou E, Schulz TJ, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure[J]. Nature, 2008, 454(7207):1000-1004.
9. Kajimura S, Seale P, Tomaru T, et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex[J]. Genes Dev, 2008, 22(10):1397-1409.
10. Heaton JM. The distribution of brown adipose tissue in the human[J]. J Anat, 1972, 112(1):35-39.
11. Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults[J]. N Engl J Med, 2009, 360(15):1518-1525.
12. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men[J]. N Engl J Med, 2009, 360(15):1500-1508.
13. Pfannenberg C, Werner MK, Ripkens S, et al. Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans[J]. Diabetes, 2010, 59(7):1789-1793.
14. Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance[J]. Nat Med, 2011, 17(2):200-205.
15. Hagberg CE, Falkevall A, Wang X, et al. Vascular endothelial growth factor B controls endothelial fatty acid uptake[J]. Nature, 2010, 464(7290):917-921.
16. Haemmerle G, Lass A, Zimmermann R, et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase[J]. Science, 2006, 312(5774):734-737.
17. Vergnes L, Chin R, Young SG, et al. Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance[J]. J Biol Chem, 2011, 286(1):380-390.
18. Ahmadian M, Abbott MJ, Tang T, et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype[J]. Cell Metab, 2011, 13(6):739-748.
19. Huang SG. Binding of fatty acids to the uncoupling protein from brown adipose tissue mitochondria[J]. Arch Biochem Biophys, 2003, 412(1):142-146.
20. Vegiopoulos A, Müller-Decker K, Strzoda D, et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes[J]. Science, 2010, 328(5982):1158-1161.
21. Gesta S, Tseng YH, Kahn CR. Developmental origin of fat:tracking obesity to its source[J]. Cell, 2007, 131(2):242-256.
22. Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice[J]. J Clin Invest, 2011, 121(1):96-105.
23. Schulz TJ, Huang TL, Tran TT, et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat[J]. Proc Natl Acad Sci USA, 2011, 108(1):143-148.

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