• Pharmacy of Chengdu Fifth People's Hospital, Chengdu, Sichuan 611137, P. R. China;
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Objective To study on the compatible stability of brevescapine injection in common solvents. Methods Brevescapine injection was added into 0.9% sodium chloride injection,5% glucose injection,10% glucose injection (100,250,and 500 mL) respectively at room temperature.The pH value and visual appearance of the admixture were observed at immediate 0,1,2,4,6 hours after Brevescapine injection was added into the solvents.Scutellarin concentration was determined by the method of high performance liquid chromatography (HPLC). Results No significant change was found in appearance and pH value of the admixture.And Scutellarin concentration changed obviously in the admixture of 100 mL 0.9% sodium chloride injection,100 mL 10% glucose injection and the three types of 5% glucose injection. Conclusion Brevescapine injections have better compatibility with 250 mL and 500 mL 0.9% sodium chloride injection,and it is incompatible with 5% glucose injection.In addition,the admixture injection should be finished within six hours.

Citation: WANGXia, MEILing. Study on the Compatible Stability of Brevescapine Injection in Common Solvents. West China Medical Journal, 2014, 29(2): 293-296. doi: 10.7507/1002-0179.20140089 Copy

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