循环肿瘤细胞的研究进展及其在宫颈癌的研究前景_West China Medical Journal

Authors：

 杨光琼 ,  杨沛

四川大学华西妇产儿童医院妇科（成都，610041）;

Corresponding author：

杨沛, Email: 568708096@qq.com

Keywords：

宫颈癌; 循环肿瘤细胞; 研究进展

DOI：

10.7507/1002-0179.20140115

Video：

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宫颈癌是女性恶性肿瘤中最常见的肿瘤之一。目前，宫颈癌的治疗手段是手术辅以放射治疗（放疗）加化学治疗（化疗），且术后复发率较高。在宫颈癌早期可选用手术治疗，同步放、化疗适合于肿瘤各期；部分患者术后根据病理结果，如有高危因素者可能需要补充放、化疗。但现在尚无可靠的无创性指标来预测该疾病的复发，转移和预后。循环肿瘤细胞（CTCs）是存在于患者外周血循环的肿瘤细胞，是肿瘤发生转移的关键。因此，宫颈癌外周血CTCs的检测将有助于临床工作者制定更加个体化的治疗方案，减少复发和转移，改善患者预后。本文就CTCs的研究进展及在宫颈癌的发展前景作一综述。

Citation： 杨光琼, 杨沛. 循环肿瘤细胞的研究进展及其在宫颈癌的研究前景. West China Medical Journal, 2014, 29(2): 374-376. doi: 10.7507/1002-0179.20140115 Copy

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1. 曹泽毅.中华妇产科学[M].北京:人民卫生出版社,1999:602.
2. Ashworth TR.A case of cancer in which cells similar to those in the tumors were seen in the blood after death[J].Australian Med J (14):146-149.
3. Riethdorf S,Fritsche H,Müller V,et al.Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer:a validation study of the CellSearch system[J].Clin Cancer Res,2007,13(3):920-928.
4. HeloP,Cronin AM,Danila DC,et al.Circulating prostate tumor cells detected by transcription PCR in men with localized or castration refractory prostate cancer:bone metastases and with survival[J].Clin Chem,2009,55(4):765-773.
5. Cristofanilli M,Garcia-Saenz JA,Maestro D,et al.Circulating tumor cells,disease progression,and survival in metastatic breast cancer[J].N Engl Med,2004,351(8):781-791.
6. Liu VW,Tsang P,Yip A,et al.Low incidence of HPV DNA in sera of pretreatment cervical cancer patients[J].Gynecol Oncol,2001,82(2):269-272.
7. Pao CC,Hor JJ,Yang FP,et al.Detection of human papillomavirus mRNA and cervical cancer cells in peripheral blood of cervical cancer patients with metastasis[J].J Clin Oncol,1997,15(3):1008-1012.
8. Duk JM,Groenier KH,de Bruijn HW,et al.Pretreatment serum squamous cell carcinoma antigen:a newly identified prognostic factor in early-stage cervical carcinoma[J].J Clin Oncol,1996,14(1):111-118.
9. Stenman J,Lintula S,Hotakainen K,et al.Detection of squamous-cell carcinoma antigen-expressing tumour cells in blood by reverse transcriptase-polymerase chain reaction in cancer of the uterine cervix[J].Int J Cancer,1997,74(1):75-80.
10. 赵新玲,卢爱妮,廖予妹.早期宫颈癌外周血MAGE_(A3)和hSTC_1 mRNA的检测及意义[J].中国现代医生,2009,47(12):13-15.
11. 陈鲁,高永良,冯建国.临床早期宫颈癌外周血CK19 mRNA的表达[J].肿瘤防治杂志,2005,12(1):56-58,61.
12. Kimura H,Kato H,Faried A,et al.Prognostic significance of EpCAM expression in human esophageal cancer[J].Int J Oncol,2007,30(1):171-179.
13. 严颖,程建平,邸立军,等.转移性乳腺癌上皮特异性细胞粘附分子(EpCAM) mRNA阳性循环肿瘤细胞检测及其临床价值[J].北京大学学报·医学版,2012,44(2):275-280.
14. Fong S,Itahana Y,Sumida T,et al.Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis[J].Proc Natl Acad Sci USA,2003,100(23):13543-13548.
15. Yu DS,Hsieh DS,Chang SY.Increasing expression of GST-pi MIF,and ID1 genes in chemoresistant prostate cancer cells[J].Arch Androl,2006,52(4):275-281.
16. Leon SA,Shapiro B,Sklaroff DM,et al.Free DNA in the serum of cancer patients and the effect of therapy[J].Cancer Res,1977,37(3):646-650.

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循环肿瘤细胞的研究进展及其在宫颈癌的研究前景

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