基质金属蛋白酶-26的生理及病理作用_West China Medical Journal

Authors：

 王清松 ¹ ,  吴小候 ¹ , 罗春丽 ² , 张龙 ¹ , 陈雄 ¹

1. ;
2. ;

Corresponding author：

吴小候, Email: wuxiaohou80@hotmail.com

Keywords：

基质金属蛋白酶-26; 胚胎植入; 皮肤损伤愈合; 肿瘤; 综述

DOI：

10.7507/1002-0179.20140176

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基质金属蛋白酶家族属于锌蛋白酶，能裂解多种蛋白底物，在一些正常生理过程中起重要作用；其活性及表达异常也与多种疾病的发生发展相关。基质金属蛋白酶-26（MMP-26）是该家族最新发现的成员，现有研究尚少。该综述主要归纳了MMP-26在胚胎植入、皮肤损伤愈合以及子宫内膜癌、乳腺癌、非小细胞肺癌、前列腺癌等多种肿瘤中的研究进展和可能的机制；提示其可能在多种生理及病理过程中起作用，并且有潜力成为一些疾病的诊断标志物或者治疗靶点。

Citation： 王清松, 吴小候, 罗春丽, 张龙, 陈雄. 基质金属蛋白酶-26的生理及病理作用. West China Medical Journal, 2014, 29(3): 588-591. doi: 10.7507/1002-0179.20140176 Copy

1.	Klein T, Bischoff R. Physiology and pathophysiology of matrix metalloproteases[J]. Amino Acids, 2011, 41(2):271-290.
2.	Savinov AY, Remacle AG, Golubkov VS, et al. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients[J]. Cancer Res, 2006, 66(5):2716-2724.
3.	Marchenko GN, Ratnikov BI, Rozanov DV, et al. Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin[J]. Biochem J, 2001, 356(Pt 3):705-718.
4.	Chegini N, Rhoton-Vlasak A, Williams RS. Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout the normal menstrual cycle and alteration in users of levonorgestrel implants who experience irregular uterine bleeding[J]. Fertil Steril, 2003, 80(3):564-570.
5.	Pilka R, Norata GD, Domanski H, et al. Matrix metalloproteinase-26(matrilysin-2) expression is high in endometrial hyperplasia and decreases with loss of histological differentiation in endometrial cancer[J]. Gynecol Oncol, 2004, 94(3):661-670.
6.	Pilka R, Domanski H, Hansson S, et al. Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26[J]. Mol Hum Reprod, 2004, 10(9):641-650.
7.	Tunuguntla R, Ripley D, Sang QX, et al. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer[J]. Gynecol Oncol, 2003, 89(3):453-459.
8.	Isaka K, Nishi H, Nakai H, et al. Matrix metalloproteinase-26 is expressed in human endometrium but not in endometrial carcinoma[J]. Cancer, 2003, 97(1):79-89.
9.	Qiao J, Wang L, Li R, et al. Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome[J]. Reprod Biomed Online, 2008, 17(3):425-435.
10.	王丽娜, 乔杰, 李蓉, 等. 多囊卵巢综合征患者种植窗口期子宫内膜容受性的研究[J]. 中华妇产科杂志, 2007, 42(5):298-301.
11.	Liu G, Zhang X, Lin H, et al. Expression of matrix metalloproteinase-26(MMP-26) mRNA in mouse uterus during the estrous cycle and early pregnancy[J]. Life Sci, 2005, 77(26):3355-3365.
12.	Li Q, Wang H, Zhao Y, et al. Identification and specific expression of matrix metalloproteinase-26 in rhesus monkey endometrium during early pregnancy[J]. Mol Hum Reprod, 2002, 8(10):934-940.
13.	Ripley D, Tunuguntla R, Susi L, et al. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinase-3 and -4 in normal ovary and ovarian carcinoma[J]. Int J Gynecol Cancer, 2006, 16(5):1794-1800.
14.	Liu J, Cao B, Li YX, et al. GnRHⅠ andⅡ up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts[J]. Reprod Biol Endocrinol, 2010, 8:5.
15.	Almeida-Francia CC, Keator CS, Mah K, et al. Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque[J]. Hum Reprod, 2012, 27(6):1723-1734.
16.	Ahokas K, Skoog T, Suomela S, et al. Matrilysin-2(matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis[J]. J Invest Dermatol, 2005, 124(4):849-856.
17.	Pirilä E, Korpi JT, Korkiamäki T, et al. Collagenase-2(MMP-8) and matrilysin-2(MMP-26) expression in human wounds of different etiologies[J]. Wound Repair Regen, 2007, 15(1):47-57.
18.	Bister V, Mäkitalo L, Jeskanen L, et al. Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum[J]. J Cutan Pathol, 2007, 34(12):889-898.
19.	Pilka R, Kudela M, Eriksson P, et al. MMP-26 mRNA and estrogen receptor alpha co-expression in normal and pathological endometrium[J]. Ceska Gynekol, 2005, 70(1):56-62.
20.	Li W, Savinov AY, Rozanov DV, et al. Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin[J]. Cancer Res, 2004, 64(23):8657-8665.
21.	Williams H, Johnson JL, Jackson CL, et al. MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis[J]. Cardiovasc Res, 2010, 87(1):137-146.
22.	de Lima JM, de Souza LG, da Silva ID, et al. E-cadherin and metalloproteinase-1 and -7 polymorphisms in colorectal cancer[J]. Int J Biol Markers, 2009, 24(2):99-106.
23.	Fujita-Hamabe W, Tokuyama S. The involvement of cleavage of neural cell adhesion molecule in neuronal death under oxidative stress conditions in cultured cortical neurons[J]. Biol Pharm Bull, 2012, 35(4):624-628.
24.	Man YG. Focal degeneration of aged or injured myoepithelial cells and the resultant auto-immunoreactions are trigger factors for breast tumor invasion[J]. Med Hypotheses, 2007, 69(6):1340-1357.
25.	Zhao YG, Xiao AZ, Park HI, et al. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4:a putative role in the initiation of breast cancer invasion[J]. Cancer Res, 2004, 64(2):590-598.
26.	Zhao YG, Xiao AZ, Ni J, et al. Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells[J]. Chin J Cancer, 2009, 28(11):1168-1175.
27.	Li L, Mei TH, Zhou XD, et al. Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer[J]. Chin J Cancer, 2009, 28(1):60-63.
28.	Zhang Y, Zhao H, Wang Y, et al. Non-small cell lung cancer invasion and metastasis promoted by MMP-26[J]. Mol Med Rep, 2011, 4(6):1201-1209.
29.	Barros SS, Henriques ÁC, Pereira KM, et al. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip[J]. Arch Oral Biol, 2011, 56(8):752-760.
30.	de Amorim RF, da Silveira EJ, Queiroz LM, et al. Matrilysins may not predict the metastatic potential in squamous cell carcinoma of the tongue[J]. Acta Odontol Scand, 2010, 68(4):228-231.
31.	Deng Y, Li W, Li Y, et al. Expression of matrix metalloproteinase-26 promotes human glioma U251 cell invasion in vitro and in vivo[J]. Oncol Rep, 2010, 23(1):69-78.
32.	Yamamoto H, Vinitketkumnuen A, Adachi Y, et al. Association of matrilysin-2(MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma[J]. Carcinogenesis, 2004, 25(12):2353-2360.
33.	Ahokas K, Karjalainen-Lindsberg ML, Sihvo E, et al. Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer[J]. Tumour Biol, 2006, 27(3):133-141.
34.	Zhao YG, Xiao AZ, Newcomer RG, et al. Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells[J]. J Biol Chem, 2003, 278(17):15056-15064.
35.	Lee S, Desai KK, Iczkowski KA, et al. Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor[J]. Cell Res, 2006, 16(9):750-758.
36.	Melendez-Zajgla J, Del Pozo L, Ceballos G, et al. Tissue inhibitor of metalloproteinases-4. The road less traveled[J]. Mol Cancer, 2008, 7(1):85.
37.	Souza Freitas V, Ferreira de Araújo CR, Alves PM, et al. Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009, 108(3):417-424.
38.	Cavalcante RB, Pereira KM, Nonaka CF, et al. Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2008, 106(1):99-105.
39.	Emingil G, Kuula H, Sorsa T, et al. Gingival crevicular fluid matrix metalloproteinase-25 and -26 levels in periodontal disease[J]. J Periodontol, 2006, 77(4):664-671.

1. Klein T, Bischoff R. Physiology and pathophysiology of matrix metalloproteases[J]. Amino Acids, 2011, 41(2):271-290.
2. Savinov AY, Remacle AG, Golubkov VS, et al. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients[J]. Cancer Res, 2006, 66(5):2716-2724.
3. Marchenko GN, Ratnikov BI, Rozanov DV, et al. Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin[J]. Biochem J, 2001, 356(Pt 3):705-718.
4. Chegini N, Rhoton-Vlasak A, Williams RS. Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout the normal menstrual cycle and alteration in users of levonorgestrel implants who experience irregular uterine bleeding[J]. Fertil Steril, 2003, 80(3):564-570.
5. Pilka R, Norata GD, Domanski H, et al. Matrix metalloproteinase-26(matrilysin-2) expression is high in endometrial hyperplasia and decreases with loss of histological differentiation in endometrial cancer[J]. Gynecol Oncol, 2004, 94(3):661-670.
6. Pilka R, Domanski H, Hansson S, et al. Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26[J]. Mol Hum Reprod, 2004, 10(9):641-650.
7. Tunuguntla R, Ripley D, Sang QX, et al. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer[J]. Gynecol Oncol, 2003, 89(3):453-459.
8. Isaka K, Nishi H, Nakai H, et al. Matrix metalloproteinase-26 is expressed in human endometrium but not in endometrial carcinoma[J]. Cancer, 2003, 97(1):79-89.
9. Qiao J, Wang L, Li R, et al. Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome[J]. Reprod Biomed Online, 2008, 17(3):425-435.
10. 王丽娜, 乔杰, 李蓉, 等. 多囊卵巢综合征患者种植窗口期子宫内膜容受性的研究[J]. 中华妇产科杂志, 2007, 42(5):298-301.
11. Liu G, Zhang X, Lin H, et al. Expression of matrix metalloproteinase-26(MMP-26) mRNA in mouse uterus during the estrous cycle and early pregnancy[J]. Life Sci, 2005, 77(26):3355-3365.
12. Li Q, Wang H, Zhao Y, et al. Identification and specific expression of matrix metalloproteinase-26 in rhesus monkey endometrium during early pregnancy[J]. Mol Hum Reprod, 2002, 8(10):934-940.
13. Ripley D, Tunuguntla R, Susi L, et al. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinase-3 and -4 in normal ovary and ovarian carcinoma[J]. Int J Gynecol Cancer, 2006, 16(5):1794-1800.
14. Liu J, Cao B, Li YX, et al. GnRHⅠ andⅡ up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts[J]. Reprod Biol Endocrinol, 2010, 8:5.
15. Almeida-Francia CC, Keator CS, Mah K, et al. Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque[J]. Hum Reprod, 2012, 27(6):1723-1734.
16. Ahokas K, Skoog T, Suomela S, et al. Matrilysin-2(matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis[J]. J Invest Dermatol, 2005, 124(4):849-856.
17. Pirilä E, Korpi JT, Korkiamäki T, et al. Collagenase-2(MMP-8) and matrilysin-2(MMP-26) expression in human wounds of different etiologies[J]. Wound Repair Regen, 2007, 15(1):47-57.
18. Bister V, Mäkitalo L, Jeskanen L, et al. Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum[J]. J Cutan Pathol, 2007, 34(12):889-898.
19. Pilka R, Kudela M, Eriksson P, et al. MMP-26 mRNA and estrogen receptor alpha co-expression in normal and pathological endometrium[J]. Ceska Gynekol, 2005, 70(1):56-62.
20. Li W, Savinov AY, Rozanov DV, et al. Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin[J]. Cancer Res, 2004, 64(23):8657-8665.
21. Williams H, Johnson JL, Jackson CL, et al. MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis[J]. Cardiovasc Res, 2010, 87(1):137-146.
22. de Lima JM, de Souza LG, da Silva ID, et al. E-cadherin and metalloproteinase-1 and -7 polymorphisms in colorectal cancer[J]. Int J Biol Markers, 2009, 24(2):99-106.
23. Fujita-Hamabe W, Tokuyama S. The involvement of cleavage of neural cell adhesion molecule in neuronal death under oxidative stress conditions in cultured cortical neurons[J]. Biol Pharm Bull, 2012, 35(4):624-628.
24. Man YG. Focal degeneration of aged or injured myoepithelial cells and the resultant auto-immunoreactions are trigger factors for breast tumor invasion[J]. Med Hypotheses, 2007, 69(6):1340-1357.
25. Zhao YG, Xiao AZ, Park HI, et al. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4:a putative role in the initiation of breast cancer invasion[J]. Cancer Res, 2004, 64(2):590-598.
26. Zhao YG, Xiao AZ, Ni J, et al. Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells[J]. Chin J Cancer, 2009, 28(11):1168-1175.
27. Li L, Mei TH, Zhou XD, et al. Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer[J]. Chin J Cancer, 2009, 28(1):60-63.
28. Zhang Y, Zhao H, Wang Y, et al. Non-small cell lung cancer invasion and metastasis promoted by MMP-26[J]. Mol Med Rep, 2011, 4(6):1201-1209.
29. Barros SS, Henriques ÁC, Pereira KM, et al. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip[J]. Arch Oral Biol, 2011, 56(8):752-760.
30. de Amorim RF, da Silveira EJ, Queiroz LM, et al. Matrilysins may not predict the metastatic potential in squamous cell carcinoma of the tongue[J]. Acta Odontol Scand, 2010, 68(4):228-231.
31. Deng Y, Li W, Li Y, et al. Expression of matrix metalloproteinase-26 promotes human glioma U251 cell invasion in vitro and in vivo[J]. Oncol Rep, 2010, 23(1):69-78.
32. Yamamoto H, Vinitketkumnuen A, Adachi Y, et al. Association of matrilysin-2(MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma[J]. Carcinogenesis, 2004, 25(12):2353-2360.
33. Ahokas K, Karjalainen-Lindsberg ML, Sihvo E, et al. Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer[J]. Tumour Biol, 2006, 27(3):133-141.
34. Zhao YG, Xiao AZ, Newcomer RG, et al. Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells[J]. J Biol Chem, 2003, 278(17):15056-15064.
35. Lee S, Desai KK, Iczkowski KA, et al. Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor[J]. Cell Res, 2006, 16(9):750-758.
36. Melendez-Zajgla J, Del Pozo L, Ceballos G, et al. Tissue inhibitor of metalloproteinases-4. The road less traveled[J]. Mol Cancer, 2008, 7(1):85.
37. Souza Freitas V, Ferreira de Araújo CR, Alves PM, et al. Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009, 108(3):417-424.
38. Cavalcante RB, Pereira KM, Nonaka CF, et al. Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2008, 106(1):99-105.
39. Emingil G, Kuula H, Sorsa T, et al. Gingival crevicular fluid matrix metalloproteinase-25 and -26 levels in periodontal disease[J]. J Periodontol, 2006, 77(4):664-671.

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