Diagnostic Value of T-SPOT.TB Assay in Patients with Hematological Disorders and Tuberculosis_West China Medical Journal

Authors：

 RENQian ,  JIAYong-qian , ZENGJi-sha

Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

JIAYong-qian, Email: jia_yq@163.com

Keywords：

T-SPOT.TB; Hematological disorders; Tuberculosis; Value of diagnosis

DOI：

10.7507/1002-0179.20140183

Video：

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Objective To evaluate the diagnostic value of T-SPOT.TB assay in patients with hematological disorders and tuberculosis. Methods A total of 82 patients with hematological disorders and suspected tuberculosis diagnosed between March 2012 and April 2013 received T-SPOT. TB assay in the peripheral blood mononuclear cells. Results The positive detection rate of T-SPOT.TB assay for patients with hematological disorders and tuberculosis was 59.09% (13/22), which was higher than the positive detection rate of anti-TB antibody test[13.64% (3/22)]. The sensibility and specificity of T-SPOT.TB assay for patients with hematological disorders and tuberculosis was 59.09% (13/22) and 68.33% (41/60), respectively. Conclusion T-SPOT.TB assay is of great value on diagnosis of tuberculosis for patients with hematological disorders and suspected tuberculosis. The diagnostic value of T-SPOT.TB assay is more important for tuberculosis infected patients; it can be used as an accessorial diagnostic method for patients with hematological disorder and suspected tuberculosis.

Citation： RENQian, JIAYong-qian, ZENGJi-sha. Diagnostic Value of T-SPOT.TB Assay in Patients with Hematological Disorders and Tuberculosis. West China Medical Journal, 2014, 29(4): 607-609. doi: 10.7507/1002-0179.20140183 Copy

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7.	中华医学会结核病学分会. 肺结核诊断和治疗指南[J]. 中华结核和呼吸杂志, 2001, 24(2):5-9.
8.	王立红, 付秀华, 张桂芝, 等. 结核感染T细胞斑点试验在结核病诊断中的应用价值[J]. 中国防痨杂志, 2013, 35(12):992-996.
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11.	Kobashi Y, Mouri K, Yagi S, et al. Clinical features of immunocompromised and nonimmunocompromised patients with pulmonary tuberculosis[J]. J Infect Chemother, 2007, 13(6):405-410.
12.	Aksoy DY, Turker A, Altundag MK, et al. Concomitant Mycobacterium tuberculosis and aspergillus Niger infection in a patient with acute myeloid leukemia[J]. Chemotherapy, 2003, 49(5):264-266.
13.	Al-Anazi KA, Al-Jasser AM, Evans DA. Infections caused by mycobacterium tuberculosis in patients with hematological disorders and in recipients of hematopoietic stem cell transplant, a twelve year retrospective study[J]. Ann Clin Microbiol Antimicrob, 2007, 6:16.
14.	Olaniyi JA, Aken'ova YA. Haematological profile of patients with pulmonary tuberculosis in Ibadan, Nigeria[J]. Afr J Med Med Sci, 2003, 32(3):239-242.
15.	Huebner RE, Schein MF, Bass JB Jr. The tuberculin skin test[J]. Clin Infect Dis, 1993, 17(6):968-975.
16.	Kim SH, Song KH, Choi SJ, et al. Diagnostic usefulness of a T-cell-based assay for extrapulmonary tuberculosis in immunocompromised patients[J]. Am J Med, 2009, 122(2):189-195.

1. Jasmer RM, Nahid P, Hopewell PC. Clinical practice. Latent tuberculosis infenction[J]. N Engl J Med, 2002, 347(23):1860-1866.
2. Long Q, Li Y, Wang Y, et al. Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China:a mixed methods study[J]. BMC Health Serv Res, 2008, 8:202.
3. 全国第五次结核病流行病学抽样调查办公室. 2010年全国第五次结核病流行病学抽样调查报告[J]. 中国防痨杂志, 2012, 34(8):485-508.
4. Chen CY, Sheng WH, Cheng A, et al. Clinical characteristics and outcomes of Mycobacterium tuberculosis disease in adult patients with hematological malignancies[J]. BMC Infect Dis, 2011, 11:324.
5. Fusegawa H, Miyachi H, Ohshima T, et al. Rapid diagnosis of tuberculosis by amplification of mycobacterial DNA in blood diseases[J]. Rinsho Ketsueki, 1992, 33(4):418-422.
6. ldashiva NE, Karachunskii MA, Pivnik AV. Various approaches to tuberculosis diagnosis in patients with hemoblastosis[J]. Ter Arkh, 2002, 74(4):35-38.
7. 中华医学会结核病学分会. 肺结核诊断和治疗指南[J]. 中华结核和呼吸杂志, 2001, 24(2):5-9.
8. 王立红, 付秀华, 张桂芝, 等. 结核感染T细胞斑点试验在结核病诊断中的应用价值[J]. 中国防痨杂志, 2013, 35(12):992-996.
9. WHO. The world health report 2004:changing history[R]. Geneva:World Health Organization, 2004.
10. Chen CY, Tang JL, Hsueh PR, et al. Trends and antimicrobial resistance of pathogens causing bloodstream infections among febrile neutropenic adults with hematological malignancy[J]. J Formos Med Assoc, 2004, 103(7):526-532.
11. Kobashi Y, Mouri K, Yagi S, et al. Clinical features of immunocompromised and nonimmunocompromised patients with pulmonary tuberculosis[J]. J Infect Chemother, 2007, 13(6):405-410.
12. Aksoy DY, Turker A, Altundag MK, et al. Concomitant Mycobacterium tuberculosis and aspergillus Niger infection in a patient with acute myeloid leukemia[J]. Chemotherapy, 2003, 49(5):264-266.
13. Al-Anazi KA, Al-Jasser AM, Evans DA. Infections caused by mycobacterium tuberculosis in patients with hematological disorders and in recipients of hematopoietic stem cell transplant, a twelve year retrospective study[J]. Ann Clin Microbiol Antimicrob, 2007, 6:16.
14. Olaniyi JA, Aken'ova YA. Haematological profile of patients with pulmonary tuberculosis in Ibadan, Nigeria[J]. Afr J Med Med Sci, 2003, 32(3):239-242.
15. Huebner RE, Schein MF, Bass JB Jr. The tuberculin skin test[J]. Clin Infect Dis, 1993, 17(6):968-975.
16. Kim SH, Song KH, Choi SJ, et al. Diagnostic usefulness of a T-cell-based assay for extrapulmonary tuberculosis in immunocompromised patients[J]. Am J Med, 2009, 122(2):189-195.

West China Medical Journal

Diagnostic Value of T-SPOT.TB Assay in Patients with Hematological Disorders and Tuberculosis

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