Gastric Cancer with Primary Manifestation of Myelodysplastic:A Case Report and Literatures Review_West China Medical Journal

Authors：

 DAIYang ¹ ,  WUYu ¹ , MUYi ² , YIHang ²

1. Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Digestion Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WUYu, Email: wuyulily@hotmail.com

Keywords：

Gastric cancer; Solid tumor; Anemia; Leukocytosis; Thrombocytosi

DOI：

10.7507/1002-0179.20140190

Video：

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Objective To explore the clinical manifestations, pathogenesis, prognosis and the therapeutic modalities of the patients with solid tumors combined with remarkable hematologic abnormalities. Methods Gastric cancer in a paitnet was diagnosed by endoscopy as well as pathological biopsy and myeloproliferative neoplasms (MPNs) were excluded through bone marrow examinations. Therefore, the primary and metastatic malignancies were excised. Results Although surgical operation improved the hematologic changes, the high tumor load caused the poor prognosis. Conclusion The solid tumors may present with hematologic manifestations which is similar to the symptoms of MPNs; it belongs to the para-neoplastic phenomenon and may be an independent poor prognostic factors.

Citation： DAIYang, WUYu, MUYi, YIHang. Gastric Cancer with Primary Manifestation of Myelodysplastic:A Case Report and Literatures Review. West China Medical Journal, 2014, 29(4): 630-634. doi: 10.7507/1002-0179.20140190 Copy

1.	Ferrigno D, Buccheri G. Hematologic counts and clinical correlates in 1201 newly diagnosed lung cancer patients[J]. Monaldi Arch Chest Dis, 2004, 59(3):193-198.
2.	Qiu MZ, Xu RH, Ruan DY, et al. Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China[J]. Tumour Biol, 2010, 31(6):633-641.
3.	Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, et al. An update on the etiology and diagnostic evaluation of a leukemoid reaction[J]. Eur J Intern Med, 2006, 17(6):394-398.
4.	Granger JM, Kontoyiannis DP. Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients:a retrospective, single-institution study[J]. Cancer, 2009, 115(17):3919-3923.
5.	Kasuga I, Makino S, Kiyokawa H, et al. Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma[J]. Cancer, 2001, 92(9):2399-2405.
6.	Yamano T, Morii E, Ikeda J, et al. Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor[J]. Jpn J Clin Oncol, 2007, 37(10):793-796.
7.	Berdel WE, Danhauser-Riedl S, Steinhauser G, et al. Various human hematopoietic growth factors (interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of nonhematopoietic tumor cells[J]. Blood, 1989, 73(1):80-83.
8.	Ikeda M, Furukawa H, Imamura H, et al. Poor prognosis associated with thrombocytosis in patients with gastric cancer[J]. Ann Surg Oncol, 2002, 9(3):287-291.
9.	Hwang SG, Kim KM, Cheong JH, et al. Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer[J]. Eur J Surg Oncol, 2012, 38(7):562-567.
10.	Kim M, Chang H, Yang HC, et al. Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer[J]. World J Surg Oncol, 2014, 12:37.
11.	Todenhöfer T, Renninger M, Schwentner C, et al. A new prognostic model for cancer-specific survival after radical cystectomy including pretreatment thrombocytosis and standard pathological risk factors[J]. BJU Int, 2012, 110(11 Pt B):E533-E540.
12.	Alexandrakis MG, Passam FH, Moschandrea IA, et al. Levels of serum cytokines and acute phase proteins in patients with essential and cancer-related thrombocytosis[J]. Am J Clin Oncol, 2003, 26(2):135-140.
13.	Kimura N, Ogasawara T, Asonuma S, et al. Granulocyte-colony stimulating factor- and interleukin 6-producing diffuse deciduoid peritoneal mesothelioma[J]. Mod Pathol, 2005, 18(3):446-450.
14.	Schmitter D, Lauber B, Fagg B, et al. Hematopoietic growth factors secreted by seven human pleural mesothelioma cell lines:interleukin-6 production as a common feature[J]. Int J Cancer, 1992, 51(2):296-301.
15.	Pinto S, Gori L, Gallo O, et al. Increased thromboxane A2 production at primary tumor site in metastasizing squamous cell carcinoma of the larynx[J]. Prostaglandins Leukot Essent Fatty Acids, 1993, 49(1):527-530.
16.	Zucchella M, Dezza L, Pacchiarini L, et al. Human tumor cells cultured "in vitro" activate platelet function by producing ADP or thrombin[J]. Haematologica, 1989, 74(6):541-545.
17.	Bambace NM, Holmes CE. The platelet contribution to cancer progression[J]. J Thromb Haemost, 2011, 9(2):237-249.
18.	Huang S, Van Arsdall M, Tedjarati S, et al. Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice[J]. J Natl Cancer Inst, 2002, 94(15):1134-1142.
19.	Gao F, Cheng K, Zhao F, et al. Prevalence and characteristics of anemia in patients with solid cancers at diagnosis in southwest China[J]. Asian Pac J Cancer Prev, 2011, 12(11):2825-2828.
20.	葛军娜, 于健春, 康维明, 等. 10218例消化系恶性肿瘤贫血情况调查[J]. 中华胃肠外科杂志, 2011, 14(5):340-342.
21.	Rauh MJ, Al Habeeb A, Chang H. Microangiopathic hemolytic anemia and leukoerythroblastic blood film heralding bone marrow metastatic gastroesophageal adenocarcinoma[J]. Pathol Res Pract, 2011, 207(2):121-123.
22.	Miller CB, Jones RJ, Piantadosi S, et al. Decreased erythropoietin response in patients with the anemia of cancer[J]. N Engl J Med, 1990, 322(24):1689-1692.
23.	Puthenparambil J, Lechner K, Kornek G. Autoimmune hemolytic anemia as a paraneoplastic phenomenon in solid tumors:a critical analysis of 52 cases reported in the literature[J]. Wien Klin Wochenschr, 2010, 122(7/8):229-236.
24.	Yang MH, Wu MZ, Chiou SH, et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis[J]. Nat Cell Biol, 2008, 10(3):295-305.

1. Ferrigno D, Buccheri G. Hematologic counts and clinical correlates in 1201 newly diagnosed lung cancer patients[J]. Monaldi Arch Chest Dis, 2004, 59(3):193-198.
2. Qiu MZ, Xu RH, Ruan DY, et al. Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China[J]. Tumour Biol, 2010, 31(6):633-641.
3. Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, et al. An update on the etiology and diagnostic evaluation of a leukemoid reaction[J]. Eur J Intern Med, 2006, 17(6):394-398.
4. Granger JM, Kontoyiannis DP. Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients:a retrospective, single-institution study[J]. Cancer, 2009, 115(17):3919-3923.
5. Kasuga I, Makino S, Kiyokawa H, et al. Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma[J]. Cancer, 2001, 92(9):2399-2405.
6. Yamano T, Morii E, Ikeda J, et al. Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor[J]. Jpn J Clin Oncol, 2007, 37(10):793-796.
7. Berdel WE, Danhauser-Riedl S, Steinhauser G, et al. Various human hematopoietic growth factors (interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of nonhematopoietic tumor cells[J]. Blood, 1989, 73(1):80-83.
8. Ikeda M, Furukawa H, Imamura H, et al. Poor prognosis associated with thrombocytosis in patients with gastric cancer[J]. Ann Surg Oncol, 2002, 9(3):287-291.
9. Hwang SG, Kim KM, Cheong JH, et al. Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer[J]. Eur J Surg Oncol, 2012, 38(7):562-567.
10. Kim M, Chang H, Yang HC, et al. Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer[J]. World J Surg Oncol, 2014, 12:37.
11. Todenhöfer T, Renninger M, Schwentner C, et al. A new prognostic model for cancer-specific survival after radical cystectomy including pretreatment thrombocytosis and standard pathological risk factors[J]. BJU Int, 2012, 110(11 Pt B):E533-E540.
12. Alexandrakis MG, Passam FH, Moschandrea IA, et al. Levels of serum cytokines and acute phase proteins in patients with essential and cancer-related thrombocytosis[J]. Am J Clin Oncol, 2003, 26(2):135-140.
13. Kimura N, Ogasawara T, Asonuma S, et al. Granulocyte-colony stimulating factor- and interleukin 6-producing diffuse deciduoid peritoneal mesothelioma[J]. Mod Pathol, 2005, 18(3):446-450.
14. Schmitter D, Lauber B, Fagg B, et al. Hematopoietic growth factors secreted by seven human pleural mesothelioma cell lines:interleukin-6 production as a common feature[J]. Int J Cancer, 1992, 51(2):296-301.
15. Pinto S, Gori L, Gallo O, et al. Increased thromboxane A2 production at primary tumor site in metastasizing squamous cell carcinoma of the larynx[J]. Prostaglandins Leukot Essent Fatty Acids, 1993, 49(1):527-530.
16. Zucchella M, Dezza L, Pacchiarini L, et al. Human tumor cells cultured "in vitro" activate platelet function by producing ADP or thrombin[J]. Haematologica, 1989, 74(6):541-545.
17. Bambace NM, Holmes CE. The platelet contribution to cancer progression[J]. J Thromb Haemost, 2011, 9(2):237-249.
18. Huang S, Van Arsdall M, Tedjarati S, et al. Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice[J]. J Natl Cancer Inst, 2002, 94(15):1134-1142.
19. Gao F, Cheng K, Zhao F, et al. Prevalence and characteristics of anemia in patients with solid cancers at diagnosis in southwest China[J]. Asian Pac J Cancer Prev, 2011, 12(11):2825-2828.
20. 葛军娜, 于健春, 康维明, 等. 10218例消化系恶性肿瘤贫血情况调查[J]. 中华胃肠外科杂志, 2011, 14(5):340-342.
21. Rauh MJ, Al Habeeb A, Chang H. Microangiopathic hemolytic anemia and leukoerythroblastic blood film heralding bone marrow metastatic gastroesophageal adenocarcinoma[J]. Pathol Res Pract, 2011, 207(2):121-123.
22. Miller CB, Jones RJ, Piantadosi S, et al. Decreased erythropoietin response in patients with the anemia of cancer[J]. N Engl J Med, 1990, 322(24):1689-1692.
23. Puthenparambil J, Lechner K, Kornek G. Autoimmune hemolytic anemia as a paraneoplastic phenomenon in solid tumors:a critical analysis of 52 cases reported in the literature[J]. Wien Klin Wochenschr, 2010, 122(7/8):229-236.
24. Yang MH, Wu MZ, Chiou SH, et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis[J]. Nat Cell Biol, 2008, 10(3):295-305.

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West China Medical Journal

Gastric Cancer with Primary Manifestation of Myelodysplastic:A Case Report and Literatures Review

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