The Influence of Paroxetine on Blood Sugar and Endocrine of Pre-diabetes Patients Associated with Anxiety and Depression_West China Medical Journal

Authors：

 FUXiao-qian ¹ , DONGZai-quan ¹ , LIXi-rong ² , ZHANGLan ¹ , TANGLei ³ , ZHANGXu ¹ , ZHANGYao-yin ¹ , JIANGFu-gui ¹ , LIJia-qi ⁴ , YUYe-rong ⁴ ,  SUNXue-li ¹

1. Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, P. R. China;
3. Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;
4. Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

SUNXue-li, Email: sunxueli58@163.com

Keywords：

Pre-diabetes; Anxiety; Depression; Paroxetine; Hypothalamic-pituitary-adrenal axis

DOI：

10.7507/1002-0179.20140202

Video：

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Objective To explore the association between paroxetine (Seroxat) and level of blood sugar and endocrine hormones in pre-diabetes patients with anxiety and depression. Methods Fifty-four pre-diabetes patients with anxiety and depression diagnosed from January 2010 to December 2012 were recruited. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess depression and anxiety. All the patients were treated by paroxetine. The glucose tolerance test (OGTT), ACTH and cortisol were tested in patients at baseline and within 24 weeks. Results After 24 weeks' treatment, the level of anxiety and depression as well as the OGTT 0.5 h (0.5 h PG), OGTT 1 h (1 h PG), OGTT 2 h (2 h PG), glycated hemoglobin (HbA1c), adrenocorticotropic hormone (ACTH) and cortisol were significantly decreased (P<0.05 or P<0.01). The glycated HbA1c had a positive correlation with adrenocorticotropic hormone (ACTH) and cortisol (F). Before and after treatment, the reduced rate of ACTH and reduced rate of cortisol respectively exhibited a positive correlation with the reduced rate of HbA1c, reduced rate of SAS and reduced rate of SDS. Conclusion Anti-anxiety depression treatment can lower blood sugar level in pre-diabetes patients with anxiety and depression significantly, which may be related to the activity of HPA axis.

Citation： FUXiao-qian, DONGZai-quan, LIXi-rong, ZHANGLan, TANGLei, ZHANGXu, ZHANGYao-yin, JIANGFu-gui, LIJia-qi, YUYe-rong, SUNXue-li. The Influence of Paroxetine on Blood Sugar and Endocrine of Pre-diabetes Patients Associated with Anxiety and Depression. West China Medical Journal, 2014, 29(4): 669-671. doi: 10.7507/1002-0179.20140202 Copy

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11.	仲爱芳, 王晓辉, 何益民, 等. 共患糖尿病的抑郁症患者皮质醇分泌节律的研究[J]. 东南国防医药, 2011, 13(2):140-142.
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13.	林东源, 刘志梅, 李剑军, 等. 2型糖尿病60例下丘脑-垂体-肾上腺轴功能的变化[J]. 内科, 2009, 4(2):235-237.
14.	仲爱芳, 王晓辉, 何益民, 等. 共患糖尿病的抑郁症患者皮质醇分泌节律的对照研究[J]. 实验与检验医学, 2010, 28(6):552-554.
15.	唐香花, 王桂玉, 田汝康, 等. 帕罗西汀联合降糖药物治疗2型糖尿病疗效观察[J]. 国际医药卫生导报, 2012, 18(9):1253-1255.
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1. Buysschaert M, Bergman M. Definition of prediabetes[J]. Med Clin North Am, 2011, 95(2):289-297.
2. Aroda VR, Ratner R. Approach to the patient with prediabetes[J]. J Clin Endocrinol Metab, 2008, 93(9):3259-3265.
3. Eriksson AK, Ekbom A, Granath F, et al. Psychological distress and risk of pre-diabetes and type 2 diabetes in a prospective study of Swedish middle-aged men and women[J]. Diabet Med, 2008, 25(7):834-842.
4. 查松柏, 钟志廷. 社区老年糖耐量异常患者180例心理健康状态的调查[J]. 中华全科医师杂志, 2006, 5(10):634-635.
5. 高金姣, 蔡建丽, 杨丹. 对糖耐量减退病人早期护理干预的研究[J]. 护理管理杂志, 2006, 6(7):5-6, 9.
6. Kyrios M, Moore SM, Hackworth N, et al. The influence of depression and anxiety on outcomes after an intervention for prediabetes[J]. Med J Aust, 2009, 190(7 Suppl):S81-S85.
7. Markowitz SM, Gonzalez JS, Wilkinson JL, et al. A review of treating depression in diabetes:emerging findings[J]. Psychosomatics, 2011, 52(1):1-18.
8. 周雪红, 赵彦民, 杨波, 等. 糖尿病患者抗抑郁、抗焦虑治疗血糖水平变化分析[J]. 中国现代药物应用, 2011, 5(18):45-46.
9. 任向东, 王科, 于建成. 帕罗西汀治疗2型糖尿病并发焦虑抑郁症的临床观察[J]. 临床和实验医学杂志, 2011, 10(22):1742-1743.
10. 李玲, 倪冬梅. 抗焦虑和抗抑郁治疗对2型糖尿病患者血糖水平的影响[J]. 基础医学与临床, 2011, 31(8):919-921.
11. 仲爱芳, 王晓辉, 何益民, 等. 共患糖尿病的抑郁症患者皮质醇分泌节律的研究[J]. 东南国防医药, 2011, 13(2):140-142.
12. Egede LE, Osborn CY. Role of motivation in the relationship between depression, self-care, and glycemic control in adults with type 2 diabetes[J]. Diabetes Educ, 2010, 36(2):276-283.
13. 林东源, 刘志梅, 李剑军, 等. 2型糖尿病60例下丘脑-垂体-肾上腺轴功能的变化[J]. 内科, 2009, 4(2):235-237.
14. 仲爱芳, 王晓辉, 何益民, 等. 共患糖尿病的抑郁症患者皮质醇分泌节律的对照研究[J]. 实验与检验医学, 2010, 28(6):552-554.
15. 唐香花, 王桂玉, 田汝康, 等. 帕罗西汀联合降糖药物治疗2型糖尿病疗效观察[J]. 国际医药卫生导报, 2012, 18(9):1253-1255.
16. 方桂兴, 陆珍珍, 汤武. 生活方式干预与糖耐量异常[J]. 医学综述, 2010, 16(2):277-279.

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The Influence of Paroxetine on Blood Sugar and Endocrine of Pre-diabetes Patients Associated with Anxiety and Depression

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